LOCUS       NM_178129               4267 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens P2Y receptor family member 8 (P2RY8), transcript
            variant 1, mRNA.
ACCESSION   NM_178129
VERSION     NM_178129.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4267)
  AUTHORS   Nurk,S., Koren,S., Rhie,A., Rautiainen,M., Bzikadze,A.V.,
            Mikheenko,A., Vollger,M.R., Altemose,N., Uralsky,L., Gershman,A.,
            Aganezov,S., Hoyt,S.J., Diekhans,M., Logsdon,G.A., Alonge,M.,
            Antonarakis,S.E., Borchers,M., Bouffard,G.G., Brooks,S.Y.,
            Caldas,G.V., Chen,N.C., Cheng,H., Chin,C.S., Chow,W., de Lima,L.G.,
            Dishuck,P.C., Durbin,R., Dvorkina,T., Fiddes,I.T., Formenti,G.,
            Fulton,R.S., Fungtammasan,A., Garrison,E., Grady,P.G.S.,
            Graves-Lindsay,T.A., Hall,I.M., Hansen,N.F., Hartley,G.A.,
            Haukness,M., Howe,K., Hunkapiller,M.W., Jain,C., Jain,M.,
            Jarvis,E.D., Kerpedjiev,P., Kirsche,M., Kolmogorov,M., Korlach,J.,
            Kremitzki,M., Li,H., Maduro,V.V., Marschall,T., McCartney,A.M.,
            McDaniel,J., Miller,D.E., Mullikin,J.C., Myers,E.W., Olson,N.D.,
            Paten,B., Peluso,P., Pevzner,P.A., Porubsky,D., Potapova,T.,
            Rogaev,E.I., Rosenfeld,J.A., Salzberg,S.L., Schneider,V.A.,
            Sedlazeck,F.J., Shafin,K., Shew,C.J., Shumate,A., Sims,Y.,
            Smit,A.F.A., Soto,D.C., Sovic,I., Storer,J.M., Streets,A.,
            Sullivan,B.A., Thibaud-Nissen,F., Torrance,J., Wagner,J.,
            Walenz,B.P., Wenger,A., Wood,J.M.D., Xiao,C., Yan,S.M., Young,A.C.,
            Zarate,S., Surti,U., McCoy,R.C., Dennis,M.Y., Alexandrov,I.A.,
            Gerton,J.L., O'Neill,R.J., Timp,W., Zook,J.M., Schatz,M.C.,
            Eichler,E.E., Miga,K.H. and Phillippy,A.M.
  TITLE     The complete sequence of a human genome
  JOURNAL   Science 376 (6588), 44-53 (2022)
   PUBMED   35357919
REFERENCE   2  (bases 1 to 4267)
  AUTHORS   He,Y., Gallman,A.E., Xie,C., Shen,Q., Ma,J., Wolfreys,F.D.,
            Sandy,M., Arsov,T., Wu,X., Qin,Y., Zhang,P., Jiang,S., Stanley,M.,
            Wu,P., Tan,J., Ding,H., Xue,H., Chen,W., Xu,J., Criswell,L.A.,
            Nititham,J., Adamski,M., Kitching,A.R., Cook,M.C., Cao,L., Shen,N.,
            Cyster,J.G. and Vinuesa,C.G.
  TITLE     P2RY8 variants in lupus patients uncover a role for the receptor in
            immunological tolerance
  JOURNAL   J Exp Med 219 (1) (2022)
   PUBMED   34889940
  REMARK    GeneRIF: P2RY8 variants in lupus patients uncover a role for the
            receptor in immunological tolerance.
REFERENCE   3  (bases 1 to 4267)
  AUTHORS   Zheng,Y.Z., LE,S.H., Zheng,H., Hua,X.L., Chen,Z.S., Zheng,L.,
            Chen,C., Li,M., Cai,C.X., Yang,J.H., Chen,Y.Q., Gao,Q.L.,
            Chen,Y.Y., Li,J. and Hu,J.D.
  TITLE     [Clinical Features and Prognosis of Acute Lymphoblastic Leukemia
            Children with P2RY8-CRLF2 Gene Rearrangement]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 29 (2), 311-315 (2021)
   PUBMED   33812392
  REMARK    GeneRIF: [Clinical Features and Prognosis of Acute Lymphoblastic
            Leukemia Children with P2RY8-CRLF2 Gene Rearrangement].
REFERENCE   4  (bases 1 to 4267)
  AUTHORS   Lu,E., Wolfreys,F.D., Muppidi,J.R., Xu,Y. and Cyster,J.G.
  TITLE     S-Geranylgeranyl-L-glutathione is a ligand for human B
            cell-confinement receptor P2RY8
  JOURNAL   Nature 567 (7747), 244-248 (2019)
   PUBMED   30842656
  REMARK    GeneRIF: S-Geranylgeranyl-L-glutathione(GGG) is identified as an
            intercellular signalling molecule that is involved in organizing
            and controlling germinal-centre responses; as the P2RY8 locus is
            modified in several other types of cancer in addition to GCB-DLBCL
            and Burkitt lymphoma, GGG might have organizing and
            growth-regulatory roles in multiple human tissues
REFERENCE   5  (bases 1 to 4267)
  AUTHORS   Dou,H., Chen,X., Huang,Y., Su,Y., Lu,L., Yu,J., Yin,Y. and Bao,L.
  TITLE     Prognostic significance of P2RY8-CRLF2 and CRLF2 overexpression may
            vary across risk subgroups of childhood B-cell acute lymphoblastic
            leukemia
  JOURNAL   Genes Chromosomes Cancer 56 (2), 135-146 (2017)
   PUBMED   27637012
  REMARK    GeneRIF: P2RY8-CRLF2 fusion is associated with childhood B-cell
            acute lymphoblastic leukemia.
REFERENCE   6  (bases 1 to 4267)
  AUTHORS   Cario,G., Zimmermann,M., Romey,R., Gesk,S., Vater,I., Harbott,J.,
            Schrauder,A., Moericke,A., Izraeli,S., Akasaka,T., Dyer,M.J.,
            Siebert,R., Schrappe,M. and Stanulla,M.
  TITLE     Presence of the P2RY8-CRLF2 rearrangement is associated with a poor
            prognosis in non-high-risk precursor B-cell acute lymphoblastic
            leukemia in children treated according to the ALL-BFM 2000 protocol
  JOURNAL   Blood 115 (26), 5393-5397 (2010)
   PUBMED   20378752
  REMARK    GeneRIF: Study reports an extremely high incidence of relapse (71%
            +/- 19%) in non-high-risk precursor B-cell acute lymphoblastic
            leukemia patients with P2RY8-CRLF2 rearrangement.
REFERENCE   7  (bases 1 to 4267)
  AUTHORS   Storlazzi,C.T., Albano,F., Lo Cunsolo,C., Doglioni,C.,
            Guastadisegni,M.C., Impera,L., Lonoce,A., Funes,S., Macri,E.,
            Iuzzolino,P., Panagopoulos,I., Specchia,G. and Rocchi,M.
  TITLE     Upregulation of the SOX5 by promoter swapping with the P2RY8 gene
            in primary splenic follicular lymphoma
  JOURNAL   Leukemia 21 (10), 2221-2225 (2007)
   PUBMED   17554380
  REMARK    GeneRIF: SOX5 is upregulated by promoter swapping with the P2RY8
            gene in primary splenic follicular lymphoma
REFERENCE   8  (bases 1 to 4267)
  AUTHORS   Fujiwara,S., Yamashita,Y., Choi,Y.L., Watanabe,H., Kurashina,K.,
            Soda,M., Enomoto,M., Hatanaka,H., Takada,S., Ozawa,K. and Mano,H.
  TITLE     Transforming activity of purinergic receptor P2Y, G protein
            coupled, 8 revealed by retroviral expression screening
  JOURNAL   Leuk Lymphoma 48 (5), 978-986 (2007)
   PUBMED   17487742
  REMARK    GeneRIF: P2RY8 is expressed in leukemic cells and has an unexpected
            role in the pathogenesis of acute leukemia
REFERENCE   9  (bases 1 to 4267)
  AUTHORS   Cantagrel,V., Lossi,A.M., Boulanger,S., Depetris,D., Mattei,M.G.,
            Gecz,J., Schwartz,C.E., Van Maldergem,L. and Villard,L.
  TITLE     Disruption of a new X linked gene highly expressed in brain in a
            family with two mentally retarded males
  JOURNAL   J Med Genet 41 (10), 736-742 (2004)
   PUBMED   15466006
REFERENCE   10 (bases 1 to 4267)
  AUTHORS   Adrian,K., Bernhard,M.K., Breitinger,H.G. and Ogilvie,A.
  TITLE     Expression of purinergic receptors (ionotropic P2X1-7 and
            metabotropic P2Y1-11) during myeloid differentiation of HL60 cells
  JOURNAL   Biochim Biophys Acta 1492 (1), 127-138 (2000)
   PUBMED   11004484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683870.15, BE245848.1,
            BC043610.1, AL833184.1, AI476104.1 and AK092956.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_178129.4.
            
            Summary: The protein encoded by this gene belongs to the family of
            G-protein coupled receptors, that are preferentially activated by
            adenosine and uridine nucleotides. This gene is moderately
            expressed in undifferentiated HL60 cells, and is located on both
            chromosomes X and Y. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043610.1, SRR1163658.305225.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2149004
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381297.10/ ENSP00000370697.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AL683870.15        158083-158123       c
            42-78               BE245848.1         2-38
            79-2239             BC043610.1         1-2161
            2240-3869           AL833184.1         537-2166
            3870-3870           AI476104.1         400-400             c
            3871-4267           AK092956.1         1690-2086
FEATURES             Location/Qualifiers
     source          1..4267
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /chromosome="Y"
                     /map="X"
                     /map="Y"
     gene            1..4267
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /note="P2Y receptor family member 8"
                     /db_xref="GeneID:286530"
                     /db_xref="HGNC:HGNC:15524"
                     /db_xref="MIM:300525"
     exon            1..265
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /inference="alignment:Splign:2.1.0"
     exon            266..4267
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /inference="alignment:Splign:2.1.0"
     CDS             290..1369
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /note="G-protein coupled purinergic receptor P2Y8; P2Y
                     purinoceptor 8; purinergic receptor P2Y, G-protein
                     coupled, 8"
                     /codon_start=1
                     /product="S-geranylgeranyl-glutathione receptor P2RY8"
                     /protein_id="NP_835230.1"
                     /db_xref="CCDS:CCDS14115.1"
                     /db_xref="GeneID:286530"
                     /db_xref="HGNC:HGNC:15524"
                     /db_xref="MIM:300525"
                     /translation="MQVPNSTGPDNATLQMLRNPAIAVALPVVYSLVAAVSIPGNLFS
                     LWVLCRRMGPRSPSVIFMINLSVTDLMLASVLPFQIYYHCNRHHWVFGVLLCNVVTVA
                     FYANMYSSILTMTCISVERFLGVLYPLSSKRWRRRRYAVAACAGTWLLLLTALSPLAR
                     TDLTYPVHALGIITCFDVLKWTMLPSVAMWAVFLFTIFILLFLIPFVITVACYTATIL
                     KLLRTEEAHGREQRRRAVGLAAVVLLAFVTCFAPNNFVLLAHIVSRLFYGKSYYHVYK
                     LTLCLSCLNNCLDPFVYYFASREFQLRLREYLGCRRVPRDTLDTRRESLFSARTTSVR
                     SEAGAHPEGMEGATRPGLQRQESVF"
     regulatory      4238..4243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /note="hexamer: ATTAAA"
     polyA_site      4267
                     /gene="P2RY8"
                     /gene_synonym="P2Y8"
                     /note="major polyA site"
ORIGIN      
        1 attcggagac agtcgtgcca gccggtgggc cacccagcga agcggccgcc tttgcaaggt
       61 tgctggacag atggaactgg aagggcagcc gtctgccgcc cacgaacacc ttctcaagca
      121 ctttgagtga ccacggcttg caagctggtg gctggccccc cgagtcccgg gctctgaggc
      181 acggccgtcg acttaagcgt tgcatcctgt tacctggaga ccctctgagc tctcacctgc
      241 tacttctgcc gctgcttctg cacagagccc gggcgaggac ccctccagga tgcaggtccc
      301 gaacagcacc ggcccggaca acgcgacgct gcagatgctg cggaacccgg cgatcgcggt
      361 ggccctgccc gtggtgtact cgctggtggc ggcggtcagc atcccgggca acctcttctc
      421 tctgtgggtg ctgtgccggc gcatggggcc cagatccccg tcggtcatct tcatgatcaa
      481 cctgagcgtc acggacctga tgctggccag cgtgttgcct ttccaaatct actaccattg
      541 caaccgccac cactgggtat tcggggtgct gctttgcaac gtggtgaccg tggcctttta
      601 cgcaaacatg tattccagca tcctcaccat gacctgtatc agcgtggagc gcttcctggg
      661 ggtcctgtac ccgctcagct ccaagcgctg gcgccgccgt cgttacgcgg tggccgcgtg
      721 tgcagggacc tggctgctgc tcctgaccgc cctgtccccg ctggcgcgca ccgatctcac
      781 ctacccggtg cacgccctgg gcatcatcac ctgcttcgac gtcctcaagt ggacgatgct
      841 ccccagcgtg gccatgtggg ccgtgttcct cttcaccatc ttcatcctgc tgttcctcat
      901 cccgttcgtg atcaccgtgg cttgttacac ggccaccatc ctcaagctgt tgcgcacgga
      961 ggaggcgcac ggccgggagc agcggaggcg cgcggtgggc ctggccgcgg tggtcttgct
     1021 ggcctttgtc acctgcttcg cccccaacaa cttcgtgctc ctggcgcaca tcgtgagccg
     1081 cctgttctac ggcaagagct actaccacgt gtacaagctc acgctgtgtc tcagctgcct
     1141 caacaactgt ctggacccgt ttgtttatta ctttgcgtcc cgggaattcc agctgcgcct
     1201 gcgggaatat ttgggctgcc gccgggtgcc cagagacacc ctggacacgc gccgcgagag
     1261 cctcttctcc gccaggacca cgtccgtgcg ctccgaggcc ggtgcgcacc ctgaagggat
     1321 ggagggagcc accaggcccg gcctccagag gcaggagagt gtgttctgag tcccgggggc
     1381 gcagcttgga gagccggggg cgcagcttgg agatccaggg gcgcatggag aggccacggt
     1441 gccagaggtt cagggagaac agctgcgttg ctcccaggca ctgcagaggc ccggtgggga
     1501 agggtctcca ggctttattc ctcccaggca ctgcagaggc accggtgagg aagggtctcc
     1561 aggcttcact cagggtagag aaacaagcaa agcccagcag cgcacagggt gcttgttatc
     1621 ctgcagaggg tgcctctgcc tctctgtgtc aggggacagc ttgtgtcacc acgcccggct
     1681 aatttttgta ttttttttag tagagctggg ctgtcacccc cgagctcctt agacactcct
     1741 cacacctgtc catacccgag ggtggatatt caaccagccc caccgcctac ccgactcggt
     1801 ttctggatat cctccgtggg cgaactgcga gccccattcc cagctcttct ccctgctgac
     1861 atcgtccctt agttgtggtt ctggccttct ccattctcct ccaggggttc tggtctccgt
     1921 agcccggtgc acgccgaaat ttctgtttat ttcactcagg ggcactgtgg ttgctgtggt
     1981 tggaattctt ctttcagagg agcgcctggg gctcctgcaa gtcagctact ctccgtgccc
     2041 acttcccccc acacacacac cccaccctgt tgctgaccaa ggtgattttt ggcacatttg
     2101 ttctggcctg gcttggtggg accccacccc tattctgctt ctgtgagtcc ctgatagaga
     2161 aggaggtccc atcaggcccc tggaacacac tcaggcttcc ctgactcagg acaaggacca
     2221 cgggaggccc aggtgcggaa aggaggctcc gtgagatggg gtccagccca tcccaacaca
     2281 agggtgcagc ttgattcggg agttccccac ctcctgccca ttctccgcgt ccttttaccc
     2341 catggagagc ctcagccatg gcaagtccat ctggagtcca ggaagcaggc aactggcctg
     2401 acccatgaga ccgtttggag accaagcagc agatgcaggt gtggacccca ggaacctaca
     2461 ggggtgtcag ccgctgagcc ccctccctgc tgtgtgggtg gtgagcaggc tgggtctttg
     2521 tctgtcttct tctacacggc atgtgcctgc accagcccca acacctgagc tggtttagcg
     2581 caaagaagag ctctgactct ccaggggtgc tgggacatca cgtggaattg gatcccaggc
     2641 tctcttgggc gagaaagacc attctggagg tgggagtggg agagctgcct gtctgcccac
     2701 gggctctgcg tctccgcagt gggtggcctt ggatgcccgg cccctccctt tctgtgcact
     2761 ggggacgctg atggaggctg aagctgctgt tcggaggccc tctattggtg cctctctcct
     2821 gccgtcatca ctatggcagg aaaacagaga tggtttagta atgaattatc attcccaaac
     2881 ccgtgtccac ctggaacatc aggatgggac catgtttgaa aatcgggtct ttccaaatgt
     2941 aattaagtaa ggcgaggcca tactgcattt acaatgggcc caatccagtg tccctatgag
     3001 agacggaaga ggagacacag acacaaagca ggaggccaca taaagacaga ggcagagact
     3061 gaagtgatgc tgccccaagc ccagggatgc ctggagtccc caggagctgg gagaggcagg
     3121 aaggaccctc ccctagagtc tctggaggga actggataca attgcagagt gcactaaaca
     3181 gttgccccag aaagacatgt cttgttttaa agcccagaac ctgaaattat tatagatttt
     3241 attcggtaat aaggaacttt gcatgtgtaa ttacttaagg atatgaagat gagattgtgc
     3301 tggattatta agcaccctaa atgccatgac aggtgtcctt ccaagagaca gaagaggaga
     3361 cacagacaca gagcaggagg acacgtggag acagaggcag actggagtga tgcggccaca
     3421 agcccaggga cacctggagc ccccaggagc tgggagaggc aggaaggatc ctcccctaga
     3481 gcctccaggg ggaactggag gatgcgtaag agacccagaa cttccacaga aggaggaaaa
     3541 ttaacctcct gcttctctag actgttccaa agctgaaccc tagaaagcaa agctgataca
     3601 gaagcatcca ggctgcagga gtacaggtcg caagtgctga gcgtgggcct tgggtgtgtc
     3661 tcatggggga aaaaaaactg tgaaaaacct cagagtagca tcttcacagt aacgcacgga
     3721 cgatccctaa actgccttgt aaacaaaaat gagagcttga gtcagaggaa gccgagacaa
     3781 tatccttcct cgacaacgtg cgagaaccct gacgtccccc agcaaaggaa gacgttgcaa
     3841 gcaggcaaaa tgcgtcgatt tttttttttt gtcagtatga tgatttttgc agccacttgg
     3901 ctatggagag cagccgacac cccctcttac agccgtggat gtttcctgga agctgactca
     3961 gtctgttcac tggttgagct ttgagtgaaa agataacaca ggtctattga ctcacacaca
     4021 tgttttaaga tggaaaactt tacttctgtt cttggcagga catggagaga gggagggatt
     4081 ccaaaaagtc tcagcctcca tcaaggcgtg gcagctcatg ccggtaatct cagcactttg
     4141 ggaggctcag gcgggaggac tgattgagtc cgggtgttca agggccaacc taggcaacac
     4201 agtgagaact catctctgta aaaaataaaa ataaaacatt aaaaaaaaac atgagctttg
     4261 aagtgca
//
