LOCUS       NM_001277204            2356 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens pyrimidinergic receptor P2Y6 (P2RY6), transcript
            variant 5, mRNA.
ACCESSION   NM_001277204
VERSION     NM_001277204.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2356)
  AUTHORS   Xu,X., Lu,Y., Cao,L., Miao,Y., Li,Y., Cui,Y. and Han,T.
  TITLE     Tumor-intrinsic P2RY6 drives immunosuppression by enhancing PGE2
            production
  JOURNAL   Cell Rep 43 (7), 114469 (2024)
   PUBMED   38996067
  REMARK    GeneRIF: Tumor-intrinsic P2RY6 drives immunosuppression by
            enhancing PGE2 production.
REFERENCE   2  (bases 1 to 2356)
  AUTHORS   Orimoto,A., Kitamura,C. and Ono,K.
  TITLE     Lipopolysaccharide-mediated ATP signaling regulates interleukin-6
            mRNA expression via the P2-purinoceptor in human dental pulp cells
  JOURNAL   Cell Biol Int 48 (3), 369-377 (2024)
   PUBMED   38225667
  REMARK    GeneRIF: Lipopolysaccharide-mediated ATP signaling regulates
            interleukin-6 mRNA expression via the P2-purinoceptor in human
            dental pulp cells.
REFERENCE   3  (bases 1 to 2356)
  AUTHORS   Nishiyama,K.
  TITLE     The role of P2Y6 receptor in the pathogenesis of cardiovascular and
            inflammatory diseases
  JOURNAL   J Pharmacol Sci 154 (2), 108-112 (2024)
   PUBMED   38246724
  REMARK    GeneRIF: The role of P2Y6 receptor in the pathogenesis of
            cardiovascular and inflammatory diseases.
            Review article
REFERENCE   4  (bases 1 to 2356)
  AUTHORS   Brinson,A.E. and Harden,T.K.
  TITLE     Differential regulation of the uridine nucleotide-activated P2Y4
            and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus
            are involved in agonist-dependent phosphorylation desensitization
            and internalization of the P2Y4 receptor
  JOURNAL   J Biol Chem 276 (15), 11939-11948 (2001)
   PUBMED   11114308
REFERENCE   5  (bases 1 to 2356)
  AUTHORS   Maier,R., Glatz,A., Mosbacher,J. and Bilbe,G.
  TITLE     Cloning of P2Y6 cDNAs and identification of a pseudogene:
            comparison of P2Y receptor subtype expression in bone and brain
            tissues
  JOURNAL   Biochem Biophys Res Commun 240 (2), 298-302 (1997)
   PUBMED   9412455
REFERENCE   6  (bases 1 to 2356)
  AUTHORS   Maier,R., Glatz,A., Mosbacher,J. and Bilbe,G.
  TITLE     Cloning of P2Y6 cDNAs and identification of a pseudogene:
            comparison of P2Y receptor subtype expression in bone and brain
            tissues
  JOURNAL   Biochem Biophys Res Commun 237 (2), 297-302 (1997)
   PUBMED   9268704
REFERENCE   7  (bases 1 to 2356)
  AUTHORS   Somers,G.R., Hammet,F., Woollatt,E., Richards,R.I., Southey,M.C.
            and Venter,D.J.
  TITLE     Chromosomal localization of the human P2y6 purinoceptor gene and
            phylogenetic analysis of the P2y purinoceptor family
  JOURNAL   Genomics 44 (1), 127-130 (1997)
   PUBMED   9286708
REFERENCE   8  (bases 1 to 2356)
  AUTHORS   Pidlaoan,L.V., Jin,J., Sandhu,A.K., Athwal,R.S. and Kunapuli,S.P.
  TITLE     Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome
            11q13.3-14.1
  JOURNAL   Somat Cell Mol Genet 23 (4), 291-296 (1997)
   PUBMED   9542531
REFERENCE   9  (bases 1 to 2356)
  AUTHORS   Nicholas,R.A., Watt,W.C., Lazarowski,E.R., Li,Q. and Harden,K.
  TITLE     Uridine nucleotide selectivity of three phospholipase C-activating
            P2 receptors: identification of a UDP-selective, a UTP-selective,
            and an ATP- and UTP-specific receptor
  JOURNAL   Mol Pharmacol 50 (2), 224-229 (1996)
   PUBMED   8700127
  REMARK    GeneRIF: Using rat P2Y6 recombinant protein expressed in human
            astrocytoma cells, the authors found that the P2Y6 receptor is
            highly selective for UDP over UTP.
REFERENCE   10 (bases 1 to 2356)
  AUTHORS   Communi,D., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning, functional expression and tissue distribution of the human
            P2Y6 receptor
  JOURNAL   Biochem Biophys Res Commun 222 (2), 303-308 (1996)
   PUBMED   8670200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF218005.1, BC009391.2 and
            HY271000.1.
            
            On Feb 27, 2020 this sequence version replaced NM_001277204.1.
            
            Summary: The product of this gene belongs to the family of P2
            receptors, which is activated by extracellular nucleotides and
            subdivided into P2X ligand-gated ion channels and P2Y G-protein
            coupled receptors. This family has several receptor subtypes with
            different pharmacological selectivity, which overlaps in some
            cases, for various adenosine and uridine nucleotides. This
            receptor, which is a G-protein coupled receptor, is responsive to
            UDP, partially responsive to UTP and ADP, and not responsive to
            ATP. It is proposed that this receptor mediates inflammatory
            responses. Alternative splicing results in multiple transcript
            variants that encode different protein isoforms. [provided by
            RefSeq, Mar 2013].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 1. Variants 1,2,3,5,6,7, and 8 encode the same isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.2105872.1, AF007893.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000540124.6/ ENSP00000442551.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1529              AF218005.1         54-1582
            1530-2127           BC009391.2         1580-2177
            2128-2356           HY271000.1         1-229               c
FEATURES             Location/Qualifiers
     source          1..2356
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..2356
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /note="pyrimidinergic receptor P2Y6"
                     /db_xref="GeneID:5031"
                     /db_xref="HGNC:HGNC:8543"
                     /db_xref="MIM:602451"
     exon            1..129
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /inference="alignment:Splign:2.1.0"
     exon            130..215
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /inference="alignment:Splign:2.1.0"
     exon            216..2356
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1236
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /note="isoform 1 is encoded by transcript variant 5; P2Y6
                     receptor; G-coupled nucleotide receptor; P2 purinoceptor;
                     P2Y purinoceptor 6; pyrimidinergic receptor P2Y, G-protein
                     coupled, 6"
                     /codon_start=1
                     /product="P2Y purinoceptor 6 isoform 1"
                     /protein_id="NP_001264133.1"
                     /db_xref="CCDS:CCDS8220.1"
                     /db_xref="GeneID:5031"
                     /db_xref="HGNC:HGNC:8543"
                     /db_xref="MIM:602451"
                     /translation="MEWDNGTGQALGLPPTTCVYRENFKQLLLPPVYSAVLAAGLPLN
                     ICVITQICTSRRALTRTAVYTLNLALADLLYACSLPLLIYNYAQGDHWPFGDFACRLV
                     RFLFYANLHGSILFLTCISFQRYLGICHPLAPWHKRGGRRAAWLVCVAVWLAVTTQCL
                     PTAIFAATGIQRNRTVCYDLSPPALATHYMPYGMALTVIGFLLPFAALLACYCLLACR
                     LCRQDGPAEPVAQERRGKAARMAVVVAAAFAISFLPFHITKTAYLAVRSTPGVPCTVL
                     EAFAAAYKGTRPFASANSVLDPILFYFTQKKFRRRPHELLQKLTAKWQRQGR"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /note="hexamer: AATACA"
     polyA_site      1536
                     /gene="P2RY6"
                     /gene_synonym="P2Y6"
                     /note="major polyA site"
ORIGIN      
        1 agacttctgc cagaacattg cacgcgacag tttcaggcac agaactgact ggcagcaggg
       61 gctgctccac gagtgggaat ttgctccagc acttcacgga ctgcaagcga ggcacttgct
      121 aactcttgga taacaagacc tctgccagaa gaaccatggc tttggaaggc ggagttcagg
      181 ctgaggagat gggtgcggtc ctcagtgagc ccctgcctcc ctgaacatag gaaacccacc
      241 tgggcagcca tggaatggga caatggcaca ggccaggctc tgggcttgcc acccaccacc
      301 tgtgtctacc gcgagaactt caagcaactg ctgctgccac ctgtgtattc ggcggtgctg
      361 gcggctggcc tgccgctgaa catctgtgtc attacccaga tctgcacgtc ccgccgggcc
      421 ctgacccgca cggccgtgta caccctaaac cttgctctgg ctgacctgct atatgcctgc
      481 tccctgcccc tgctcatcta caactatgcc caaggtgatc actggccctt tggcgacttc
      541 gcctgccgcc tggtccgctt cctcttctat gccaacctgc acggcagcat cctcttcctc
      601 acctgcatca gcttccagcg ctacctgggc atctgccacc cgctggcccc ctggcacaaa
      661 cgtgggggcc gccgggctgc ctggctagtg tgtgtagccg tgtggctggc cgtgacaacc
      721 cagtgcctgc ccacagccat cttcgctgcc acaggcatcc agcgtaaccg cactgtctgc
      781 tatgacctca gcccgcctgc cctggccacc cactatatgc cctatggcat ggctctcact
      841 gtcatcggct tcctgctgcc ctttgctgcc ctgctggcct gctactgtct cctggcctgc
      901 cgcctgtgcc gccaggatgg cccggcagag cctgtggccc aggagcggcg tggcaaggcg
      961 gcccgcatgg ccgtggtggt ggctgctgcc tttgccatca gcttcctgcc ttttcacatc
     1021 accaagacag cctacctggc agtgcgctcg acgccgggcg tcccctgcac tgtattggag
     1081 gcctttgcag cggcctacaa aggcacgcgg ccgtttgcca gtgccaacag cgtgctggac
     1141 cccatcctct tctacttcac ccagaagaag ttccgccggc gaccacatga gctcctacag
     1201 aaactcacag ccaaatggca gaggcagggt cgctgagtcc tccaggtcct gggcagcctt
     1261 catatttgcc attgtgtccg gggcaccagg agccccacca accccaaacc atgcggagaa
     1321 ttagagttca gctcagctgg gcatggagtt aagatccctc acaggaccca gaagctcacc
     1381 aaaaactatt tcttcagccc cttctctggc ccagaccctg tgggcatgga gatggacaga
     1441 cctgggcctg gctcttgaga ggtcccagtc agccatggag agctggggaa accacattaa
     1501 ggtgctcaca aaaatacagt gtgacgtgta ctgtcatcaa ggggtatgct ccatgctttg
     1561 agtcaccaat gaagcgggtg agggaagatg agagggggag gtgagagctt ctgggaaggg
     1621 gcatttgagc tgggttttga gggatgatta tgagctctct ggagaggagt gatattccat
     1681 ttatttagaa agcctttact gacaccttgt gctcaggcct gtgttggttc tggggcccta
     1741 gaagaaccag tcctagccct ggtccatacg ggctcccaac tgctggaagt acagactggc
     1801 acagcaacat cagggttgtg acagagggaa gcatggctgg ggggaggggg tacacagaca
     1861 gtgcccatga cccagtccaa ggagtcagga aagagctctc tgaggaggga gcatctgagc
     1921 cagatgttga gggctgagtg ggaacttggc aagcagaagt ggggagcact ttaatgcaac
     1981 ccaggtatgc tccatgcata tccagctggg ccagcctcgt gctgggctct gccctgggca
     2041 gacaggcaga gggccagagc agaggacaca tggccttgcg tgtgtgaaag ctgagaaaat
     2101 gggagctgtg cttcagctac cctccagaca agggcaagag ttagccagat gctccaggca
     2161 gtgggaagcc aatggaggga ttaagcggcg gaagcttctt agaagaggca gggggcgaag
     2221 tgcagtggct catgcctgta atctcagcaa tttgggaggc caaggaagga ggaatgcttg
     2281 agcccaagag ttttagacca gcctgggcaa cacagtaaga ccctgtttct acaaaaaaat
     2341 ataaaaaata gcctgg
//
