LOCUS       NM_002565               2039 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens pyrimidinergic receptor P2Y4 (P2RY4), mRNA.
ACCESSION   NM_002565
VERSION     NM_002565.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2039)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2039)
  AUTHORS   Sukigara,S., Dai,H., Nabatame,S., Otsuki,T., Hanai,S., Honda,R.,
            Saito,T., Nakagawa,E., Kaido,T., Sato,N., Kaneko,Y., Takahashi,A.,
            Sugai,K., Saito,Y., Sasaki,M., Goto,Y., Koizumi,S. and Itoh,M.
  TITLE     Expression of astrocyte-related receptors in cortical dysplasia
            with intractable epilepsy
  JOURNAL   J Neuropathol Exp Neurol 73 (8), 798-806 (2014)
   PUBMED   25003238
  REMARK    GeneRIF: reflected in the immunoblotting data P2RY4 receptors were
            detected at higher levels of expression in patient with cortical
            dysplasia with intractable epilepsy.
REFERENCE   3  (bases 1 to 2039)
  AUTHORS   Tran,M.D., Furones-Alonso,O., Sanchez-Molano,J. and Bramlett,H.M.
  TITLE     Trauma-induced expression of astrocytic thrombospondin-1 is
            regulated by P2 receptors coupled to protein kinase cascades
  JOURNAL   Neuroreport 23 (12), 721-726 (2012)
   PUBMED   22776902
  REMARK    GeneRIF: show that P2 receptors and protein kinases are also
            involved in regulating injury-induced expression and the release of
            TSP-1 in injured astrocytes
REFERENCE   4  (bases 1 to 2039)
  AUTHORS   Borno,A., Ploug,T., Bune,L.T., Rosenmeier,J.B. and Thaning,P.
  TITLE     Purinergic receptors expressed in human skeletal muscle fibres
  JOURNAL   Purinergic Signal 8 (2), 255-264 (2012)
   PUBMED   22052557
  REMARK    GeneRIF: P2Y4 receptors are expressed in intracellular vesicles and
            sarcolemma of skeletal muscle fibers.
REFERENCE   5  (bases 1 to 2039)
  AUTHORS   Luo,W., Wang,Y. and Reiser,G.
  TITLE     Proteinase-activated receptors, nucleotide P2Y receptors, and
            mu-opioid receptor-1B are under the control of the type I
            transmembrane proteins p23 and p24A in post-Golgi trafficking
  JOURNAL   J Neurochem 117 (1), 71-81 (2011)
   PUBMED   21219331
  REMARK    GeneRIF: Nucleotide P2Y4 receptor binding is arrested in post-Golgi
            trafficking by type I transmembrane proteins p23 and p24A.
REFERENCE   6  (bases 1 to 2039)
  AUTHORS   Maier,R., Glatz,A., Mosbacher,J. and Bilbe,G.
  TITLE     Cloning of P2Y6 cDNAs and identification of a pseudogene:
            comparison of P2Y receptor subtype expression in bone and brain
            tissues
  JOURNAL   Biochem Biophys Res Commun 237 (2), 297-302 (1997)
   PUBMED   9268704
REFERENCE   7  (bases 1 to 2039)
  AUTHORS   Nicholas,R.A., Watt,W.C., Lazarowski,E.R., Li,Q. and Harden,K.
  TITLE     Uridine nucleotide selectivity of three phospholipase C-activating
            P2 receptors: identification of a UDP-selective, a UTP-selective,
            and an ATP- and UTP-specific receptor
  JOURNAL   Mol Pharmacol 50 (2), 224-229 (1996)
   PUBMED   8700127
REFERENCE   8  (bases 1 to 2039)
  AUTHORS   Stam,N.J., Klomp,J., Van de Heuvel,N. and Olijve,W.
  TITLE     Molecular cloning and characterization of a novel orphan receptor
            (P2P) expressed in human pancreas that shows high structural
            homology to the P2U purinoceptor
  JOURNAL   FEBS Lett 384 (3), 260-264 (1996)
   PUBMED   8617367
REFERENCE   9  (bases 1 to 2039)
  AUTHORS   Communi,D., Pirotton,S., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning and functional expression of a human uridine nucleotide
            receptor
  JOURNAL   J Biol Chem 270 (52), 30849-30852 (1995)
   PUBMED   8537336
REFERENCE   10 (bases 1 to 2039)
  AUTHORS   Nguyen,T., Erb,L., Weisman,G.A., Marchese,A., Heng,H.H.,
            Garrad,R.C., George,S.R., Turner,J.T. and O'Dowd,B.F.
  TITLE     Cloning, expression, and chromosomal localization of the human
            uridine nucleotide receptor gene
  JOURNAL   J Biol Chem 270 (52), 30845-30848 (1995)
   PUBMED   8537335
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL357752.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 25, 2020 this sequence version replaced NM_002565.3.
            
            Summary: The product of this gene belongs to the family of
            G-protein coupled receptors. This family has several receptor
            subtypes with different pharmacological selectivity, which overlaps
            in some cases, for various adenosine and uridine nucleotides. This
            receptor is responsive to uridine nucleotides, partially responsive
            to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095503.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374519.4/ ENSP00000363643.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2039              AL357752.19        119385-121423
FEATURES             Location/Qualifiers
     source          1..2039
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..2039
                     /gene="P2RY4"
                     /gene_synonym="NRU; P2P; P2Y4; UNR"
                     /note="pyrimidinergic receptor P2Y4"
                     /db_xref="GeneID:5030"
                     /db_xref="HGNC:HGNC:8542"
                     /db_xref="MIM:300038"
     exon            1..2039
                     /gene="P2RY4"
                     /gene_synonym="NRU; P2P; P2Y4; UNR"
                     /inference="alignment:Splign:2.1.0"
     CDS             581..1678
                     /gene="P2RY4"
                     /gene_synonym="NRU; P2P; P2Y4; UNR"
                     /note="uridine nucleotide receptor; pyrimidinergic
                     receptor P2Y, G-protein coupled, 4"
                     /codon_start=1
                     /product="P2Y purinoceptor 4"
                     /protein_id="NP_002556.1"
                     /db_xref="CCDS:CCDS14398.1"
                     /db_xref="GeneID:5030"
                     /db_xref="HGNC:HGNC:8542"
                     /db_xref="MIM:300038"
                     /translation="MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAV
                     VFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWP
                     FGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVW
                     LVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLV
                     CYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEA
                     DCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASS
                     LALVSLPEDSSCRWAATPQDSSCSTPRADRL"
ORIGIN      
        1 gacagagtca gctgagctca gcttcaaggg gaccaggtag gagatgtgcc aacgttcttg
       61 ggcaagggtg gcaatggggc tcctgggctg taggcaggca gtggggaagg tgtcataggt
      121 aaatgtcatc tggagacact gtgaccaggg cactaggaga ggcgaaggca ctgtggggag
      181 agacactcct cttccaggga tatagctgtg atgacgagtc agaagacact ttgggtctgg
      241 gtatcttccc actttggata gtgctgggag gcctccaccc tcttcagcca gccaggctct
      301 tagggacaga gtgagctgca gagtgagtac aacccaaata cacgggctgc ctgcctgagc
      361 cccagcactg cctgctgccc accacttccc aagctggacc aagggagctt gggtaggggc
      421 caggctagcc tgagtgcacc cagatgcgct tctgtcagct ctccctagtg cttcaaccac
      481 tgctctccct gctctacttt ttttgctcca gctcagggat gggggtgggc agggaaatcc
      541 tgccaccctc acttctcccc ttcccatctc caggggggcc atggccagta cagagtcctc
      601 cctgttgaga tccctaggcc tcagcccagg tcctggcagc agtgaggtgg agctggactg
      661 ttggtttgat gaggatttca agttcatcct gctgcctgtg agctatgcag ttgtctttgt
      721 gctgggcttg ggccttaacg ccccaaccct atggctcttc atcttccgcc tccgaccctg
      781 ggatgcaacg gccacctaca tgttccacct ggcattgtca gacaccttgt atgtgctgtc
      841 gctgcccacc ctcatctact attatgcagc ccacaaccac tggccctttg gcactgagat
      901 ctgcaagttc gtccgctttc ttttctattg gaacctctac tgcagtgtcc ttttcctcac
      961 ctgcatcagc gtgcaccgct acctgggcat ctgccaccca cttcgggcac tacgctgggg
     1021 ccgccctcgc ctcgcaggcc ttctctgcct ggcagtttgg ttggtcgtag ccggctgcct
     1081 cgtgcccaac ctgttctttg tcacaaccag caacaaaggg accaccgtcc tgtgccatga
     1141 caccactcgg cctgaagagt ttgaccacta tgtgcacttc agctcggcgg tcatggggct
     1201 gctctttggc gtgccctgcc tggtcactct tgtttgctat ggactcatgg ctcgtcgcct
     1261 gtatcagccc ttgccaggct ctgcacagtc gtcttctcgc ctccgctctc tccgcaccat
     1321 agctgtggtg ctgactgtct ttgctgtctg cttcgtgcct ttccacatca cccgcaccat
     1381 ttactacctg gccaggctgt tggaagctga ctgccgagta ctgaacattg tcaacgtggt
     1441 ctataaagtg actcggcccc tggccagtgc caacagctgc ctggatcctg tgctctactt
     1501 gctcactggg gacaaatatc gacgtcagct ccgtcagctc tgtggtggtg gcaagcccca
     1561 gccccgcacg gctgcctctt ccctggcact agtgtccctg cctgaggata gcagctgcag
     1621 gtgggcggcc accccccagg acagtagctg ctctactcct agggcagata gattgtaaca
     1681 cgggaagccg ggaagtgaga gaaaagggga tgagtgcagg gcagaggtga gggaacccaa
     1741 tagtgatacc tggtaaggtg cttcttcctc ttttccaggc tctggagaga agccctcacc
     1801 ctgagggttg cagggaggca gggatatcat gggtgacctc atctctcata accccttcag
     1861 ttgccgactc tttttagcca atgccaatct tctactcctt tctcgttgtt tctgttcctt
     1921 cctggggcca ttggtcctac aatcttcctg aaaatcttcc ccagtcctct ttccctgtcc
     1981 catttccccc acagcctcct atagcatgtg tttctctacc cagaccagag cattcagct
//
