LOCUS       NM_002564               8619 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens purinergic receptor P2Y2 (P2RY2), transcript variant
            2, mRNA.
ACCESSION   NM_002564
VERSION     NM_002564.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8619)
  AUTHORS   Qian,S., Shi,Y., Senfeld,J., Peng,Q. and Shen,J.
  TITLE     The P2Y2 receptor mediates terminal adipocyte differentiation and
            insulin resistance: Evidence for a dual G-protein coupling mode
  JOURNAL   J Biol Chem 300 (2), 105589 (2024)
   PUBMED   38141758
  REMARK    GeneRIF: The P2Y2 receptor mediates terminal adipocyte
            differentiation and insulin resistance: Evidence for a dual
            G-protein coupling mode.
REFERENCE   2  (bases 1 to 8619)
  AUTHORS   Jin,H., Ko,Y.S., Yun,S.P., Park,S.W. and Kim,H.J.
  TITLE     P2Y2R-mediated transactivation of VEGFR2 through Src
            phosphorylation is associated with ESM-1 overexpression in
            radiotherapy-resistant-triple negative breast cancer cells
  JOURNAL   Int J Oncol 62 (6) (2023)
   PUBMED   37165911
  REMARK    GeneRIF: P2Y2R-mediated transactivation of VEGFR2 through Src
            phosphorylation is associated with ESM-1 overexpression in
            radiotherapy-resistant-triple negative breast cancer cells.
REFERENCE   3  (bases 1 to 8619)
  AUTHORS   Benzi,A., Baratto,S., Astigiano,C., Sturla,L., Panicucci,C.,
            Mamchaoui,K., Raffaghello,L., Bruzzone,S., Gazzerro,E. and Bruno,C.
  TITLE     Aberrant Adenosine Triphosphate Release and Impairment of
            P2Y2-Mediated Signaling in Sarcoglycanopathies
  JOURNAL   Lab Invest 103 (3), 100037 (2023)
   PUBMED   36925196
  REMARK    GeneRIF: Aberrant Adenosine Triphosphate Release and Impairment of
            P2Y2-Mediated Signaling in Sarcoglycanopathies.
REFERENCE   4  (bases 1 to 8619)
  AUTHORS   Hillmann,P., Ko,G.Y., Spinrath,A., Raulf,A., von Kugelgen,I.,
            Wolff,S.C., Nicholas,R.A., Kostenis,E., Holtje,H.D. and Muller,C.E.
  TITLE     Key determinants of nucleotide-activated G protein-coupled P2Y(2)
            receptor function revealed by chemical and pharmacological
            experiments, mutagenesis and homology modeling
  JOURNAL   J Med Chem 52 (9), 2762-2775 (2009)
   PUBMED   19419204
REFERENCE   5  (bases 1 to 8619)
  AUTHORS   Ivanov,A.A., Ko,H., Cosyn,L., Maddileti,S., Besada,P., Fricks,I.,
            Costanzi,S., Harden,T.K., Calenbergh,S.V. and Jacobson,K.A.
  TITLE     Molecular modeling of the human P2Y2 receptor and design of a
            selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate
  JOURNAL   J Med Chem 50 (6), 1166-1176 (2007)
   PUBMED   17302398
REFERENCE   6  (bases 1 to 8619)
  AUTHORS   Sullivan,D.M., Erb,L., Anglade,E., Weisman,G.A., Turner,J.T. and
            Csaky,K.G.
  TITLE     Identification and characterization of P2Y2 nucleotide receptors in
            human retinal pigment epithelial cells
  JOURNAL   J Neurosci Res 49 (1), 43-52 (1997)
   PUBMED   9211988
REFERENCE   7  (bases 1 to 8619)
  AUTHORS   Dasari,V.R., Sandhu,A.K., Mills,D.C., Athwal,R.S. and Kunapuli,S.P.
  TITLE     Mapping of the P2U purinergic receptor gene to human chromosome 11q
            13.5-14.1
  JOURNAL   Somat Cell Mol Genet 22 (1), 75-79 (1996)
   PUBMED   8643996
REFERENCE   8  (bases 1 to 8619)
  AUTHORS   Parr,C.E., Sullivan,D.M., Paradiso,A.M., Lazarowski,E.R.,
            Burch,L.H., Olsen,J.C., Erb,L., Weisman,G.A., Boucher,R.C. and
            Turner,J.T.
  TITLE     Cloning and expression of a human P2U nucleotide receptor, a target
            for cystic fibrosis pharmacotherapy
  JOURNAL   Proc Natl Acad Sci U S A 91 (26), 13067 (1994)
   PUBMED   7809171
  REMARK    Correction to:[Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3275-9.
            doi: 10.1073/pnas.91.8.3275.. PMID: 8159738]
REFERENCE   9  (bases 1 to 8619)
  AUTHORS   Parr,C.E., Sullivan,D.M., Paradiso,A.M., Lazarowski,E.R.,
            Burch,L.H., Olsen,J.C., Erb,L., Weisman,G.A., Boucher,R.C. and
            Turner,J.T.
  TITLE     Cloning and expression of a human P2U nucleotide receptor, a target
            for cystic fibrosis pharmacotherapy
  JOURNAL   Proc Natl Acad Sci U S A 91 (8), 3275-3279 (1994)
   PUBMED   8159738
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13067. doi:
            10.1073/pnas.91.26.13067.. PMID: 7809171]
REFERENCE   10 (bases 1 to 8619)
  AUTHORS   Erb,L., Lustig,K.D., Sullivan,D.M., Turner,J.T. and Weisman,G.A.
  TITLE     Functional expression and photoaffinity labeling of a cloned P2U
            purinergic receptor
  JOURNAL   Proc Natl Acad Sci U S A 90 (22), 10449-10453 (1993)
   PUBMED   8248130
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP002761.3.
            
            On Jun 2, 2019 this sequence version replaced NM_002564.3.
            
            Summary: The product of this gene belongs to the family of P2
            receptors, which is activated by extracellular nucleotides and
            subdivided into P2X ligand-gated ion channels and P2Y G-protein
            coupled receptors. This family has several receptor subtypes with
            different pharmacological selectivity, which overlaps in some
            cases, for various adenosine and uridine nucleotides. This
            receptor, found on many cell types, is activated by ATP and UTP and
            is reported to be overexpressed on some cancer cell types. It is
            involved in many cellular functions, such as proliferation,
            apoptosis and inflammation. Three transcript variants encoding the
            same protein have been identified for this gene. [provided by
            RefSeq, Mar 2013].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Transcript variants 1, 2 and 3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138518.195828.1,
                                           SRR1803611.69753.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142348
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393597.7/ ENSP00000377222.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-152               AP002761.3         53983-54134
            153-347             AP002761.3         63683-63877
            348-8619            AP002761.3         69858-78129
FEATURES             Location/Qualifiers
     source          1..8619
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..8619
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="purinergic receptor P2Y2"
                     /db_xref="GeneID:5029"
                     /db_xref="HGNC:HGNC:8541"
                     /db_xref="MIM:600041"
     exon            1..152
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /inference="alignment:Splign:2.1.0"
     exon            153..347
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /inference="alignment:Splign:2.1.0"
     exon            348..8619
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /inference="alignment:Splign:2.1.0"
     CDS             352..1485
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="purinoceptor P2Y2; P2U nucleotide receptor; P2U
                     receptor 1; P2U purinoceptor 1; ATP receptor; purinergic
                     receptor P2Y, G-protein coupled, 2"
                     /codon_start=1
                     /product="P2Y purinoceptor 2"
                     /protein_id="NP_002555.4"
                     /db_xref="CCDS:CCDS8219.1"
                     /db_xref="GeneID:5029"
                     /db_xref="HGNC:HGNC:8541"
                     /db_xref="MIM:600041"
                     /translation="MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVC
                     VPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFS
                     TVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVL
                     VLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCY
                     VLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDL
                     SCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARR
                     RLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL"
     regulatory      2103..2108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="hexamer: ACTAAA"
     polyA_site      2126
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="major polyA site"
     regulatory      2515..2520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="hexamer: TATAAA"
     polyA_site      2544
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
     regulatory      8503..8508
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="hexamer: ATTAAA"
     polyA_site      8527
                     /gene="P2RY2"
                     /gene_synonym="HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R"
                     /note="major polyA site"
ORIGIN      
        1 cccggcttcg gggttgggga acagcgcagg gaggtgggta gccgggctcc caggcacgtg
       61 ggtctctgcg gctgcggcgg gacccgggca ctggcacccg ggagcggcgg cgacggcacc
      121 ctgagaggag aagcgcagcg cagtggcgag aggagcccct tgtggcagca gcactacctg
      181 cccagaaaaa tgctggaggc tgggcgtggc cccaggcctg gggacctgtt tttcctgttt
      241 cccgcagagt tccctgcagc ccggtccagg tccaggcgtg tgcattcatg agtgaggaac
      301 ccgtgcaggc gctgagcatc ctgacctgga gagcaggggc tggtcagggc gatggcagca
      361 gacctgggcc cctggaatga caccatcaat ggcacctggg atggggatga gctgggctac
      421 aggtgccgct tcaacgagga cttcaagtac gtgctgctgc ctgtgtccta cggcgtggtg
      481 tgcgtgcctg ggctgtgtct gaacgccgtg gcgctctaca tcttcttgtg ccgcctcaag
      541 acctggaatg cgtccaccac atatatgttc cacctggctg tgtctgatgc actgtatgcg
      601 gcctccctgc cgctgctggt ctattactac gcccgcggcg accactggcc cttcagcacg
      661 gtgctctgca agctggtgcg cttcctcttc tacaccaacc tttactgcag catcctcttc
      721 ctcacctgca tcagcgtgca ccggtgtctg ggcgtcttac gacctctgcg ctccctgcgc
      781 tggggccggg cccgctacgc tcgccgggtg gccggggccg tgtgggtgtt ggtgctggcc
      841 tgccaggccc ccgtgctcta ctttgtcacc accagcgcgc gcgggggccg cgtaacctgc
      901 cacgacacct cggcacccga gctcttcagc cgcttcgtgg cctacagctc agtcatgctg
      961 ggcctgctct tcgcggtgcc ctttgccgtc atccttgtct gttacgtgct catggctcgg
     1021 cgactgctaa agccagccta cgggacctcg ggcggcctgc ctagggccaa gcgcaagtcc
     1081 gtgcgcacca tcgccgtggt gctggctgtc ttcgccctct gcttcctgcc attccacgtc
     1141 acccgcaccc tctactactc cttccgctcg ctggacctca gctgccacac cctcaacgcc
     1201 atcaacatgg cctacaaggt tacccggccg ctggccagtg ctaacagttg ccttgacccc
     1261 gtgctctact tcctggctgg gcagaggctc gtacgctttg cccgagatgc caagccaccc
     1321 actggcccca gccctgccac cccggctcgc cgcaggctgg gcctgcgcag atccgacaga
     1381 actgacatgc agaggataga agatgtgttg ggcagcagtg aggactctag gcggacagag
     1441 tccacgccgg ctggtagcga gaacactaag gacattcggc tgtaggagca gaacacttca
     1501 gcctgtgcag gtttatattg ggaagctgta gaggaccagg acttgtgcag acgccacagt
     1561 ctccccagat atggaccatc agtgactcat gctggatgac cccatgctcc gtcatttgac
     1621 aggggctcag gatattcact ctgtggtcca gagtcaactg ttcccataac ccctagtcat
     1681 cgtttgtgtg tataagttgg gggaattaag tttcaagaaa ggcaagagct caaggtcaat
     1741 gacacccctg gcctgactcc catgcaagta gctggctgta ctgccaaggt acctaggttg
     1801 gagtccagcc taatcaagtc aaatggagaa acaggcccag agaggaaggt ggcttaccaa
     1861 gatcacatac cagagtctgg agctgagcta cctggggtgg gggccaagtc acaggttggc
     1921 cagaaaaccc tggtaagtaa tgagggctga gtttgcacag tggtctggaa tggactgggt
     1981 gccacggtgg acttagctct gaggagtacc cccagcccaa gagatgaaca tctggggact
     2041 aatatcatag acccatctgg aggctcccat gggctaggag ccagtgtgag gctgtaactt
     2101 atactaaagg ttgtgttgcc tgctgagctg tgccctattg tgtggtcggg ggatgaggat
     2161 atggcaggga agctttcacc agccacacaa gggtcctttc tccaatccgt tcccttctgc
     2221 cacctgcctt ctcactagct gtctcaggag tagtctcata tcagggatcc tctctccagg
     2281 ccccaggtca tcccccactg taaagccagt tggcttctgt gcctgactct gtgctgagca
     2341 cagagaaaag tcaggtgcag tcccagtcct tgagatttcc cagtttaggt gatggccagt
     2401 catgtgctgg taaatgttaa gccatttaac tggagctccg atttaactgg gaaccccttc
     2461 tttgtagaac tgcccatttc catggtgcaa aaactcttat ggccaaattc aaactataaa
     2521 catgatgtca acttccttgt aaaattcctg aaaatttaac aattggttct tgcaagcagg
     2581 tacaagtcac tctagcacac cactggataa tgccgagtgg ctggggctgt gagccagggg
     2641 gtcagggaag ggttcctgga gtgggagact cctgagctgt agcttctgag aaaagcagct
     2701 caccggaaga acatccacac acaggatgca tcccaggcaa agacatgggg caagagggca
     2761 gggtgtgcat gagccataag caggctggac agctgactcc aggctcaagg cagggttggg
     2821 gctgggtcac aaggaggcca agttagggct ccctccttgc cctgaccctg aggcttcctt
     2881 tgcactgggg gtaaatatga aagagattca ctcctcctcc tgtccatcgt ctgccttctg
     2941 ggaaaatccc agaatggcag ggtggtgctc aggctgggtc aggacttagt atgggggaga
     3001 tgggtctcac ctatgatagg ttctgagtct agccaggacc actctgggct gacgtgtggc
     3061 gctcagctgg acagggcccc gccctagcct ttggaaaggg acagggcaaa gctgacaggc
     3121 ctcactcttg atctcaagga cagggactcc ctcctctccc tctgggagag ccctcgccct
     3181 gtggcccact ctgcctgccc cctctgacct ctccaccctt cccactctgc cttgtgaaag
     3241 gcaggacatc cccaaagctt gctgtatttg gagcctgact ccacagcgcc ctcatgtgac
     3301 agagacccat cacagaccat gacccaaatg attactctgt actgtgccag gtgggtgacc
     3361 tgcccagaat agtgtgagct attcacctct caccttctag gttctatact tctgttaatg
     3421 tagccgatgt ccttctgagt tttttttttc tttttgagac gaagtcttgt tctgtcaccc
     3481 aggctggaag tgcagtgctg cggtcttggc tcactgcaac tctctgcctc ccgggttcaa
     3541 gcaattctcc tgcctcagtt tcccaagtag ctgggattac aggtatgcgc caccacacct
     3601 ggctaatttt tgtattttta atagagacag ggtttcgcca tgttggccag gctggtctca
     3661 aactcctgac ctcaagtgat ccacctgcct cagcctccca aagtgctggg attacaggta
     3721 tgagccaccg cacccggccc ctcttgagct ttcttaatga ttgcctgtta caaaccaccc
     3781 ttgagccttt cccacaggcc cgagccactc cacaaggaca caggaggggc tcgttcacca
     3841 tctaatcctg tggcaggcac aggtgggggt ggatactgga gaccctgggt gaaccagggg
     3901 cacctctgga acccagttgg actgcctggc cccttggtat gcacgtccca ccttgctgct
     3961 cagtgcccag gccacttgcc ttgtgggtga agttcctgcc ctgatgcctc atgctatttt
     4021 cagcccaagt aagaccataa ttttccactc ctggccccag accattgtcc agcagtgacg
     4081 tgaggggatc tgcctgccct caaaatatct cctattaccc tccaatattc cctgccccct
     4141 tcacacctcc ctaacctgac atcacttcct gggctgttga ctcatgaagg ccactgtgaa
     4201 agggcacgtg agttgcccat ccactgagca gaccccaggg attatccagc ccagctgcag
     4261 actcaaggcc agagatgggc agggctgagc ccaaggtcat tcagcaggtc agcgtggcgc
     4321 ctggatgtaa gcaagtgcct tggtgacgat cctgctgtca ctcacactgc ccagctcttc
     4381 ctgcccaggg tgactgggat ggagccatag acctgaggcc agggacagga cagggatggg
     4441 aggaaaggga gggtagagag ttgagtgtca gggagtaaat gtctgctgat gtgcctgcag
     4501 cagctgttct caatgaactg catgacatca gggcagggtc cctggcacac aggggtctct
     4561 gccctgggtg gcaggtgtcc cagggtccag gagggatgga ggaaccccag ggtacattcc
     4621 cactttcacc ccctgaggtt agaagaggcc ctaagcaaca tgttatccac acatggttgc
     4681 tccaggtcaa gtcaccaaag ctacctctct gtcacccttg tcatggcaga tttgggctgc
     4741 tctgtttaga atcaggcaca tgagggaggg aagtcgtgta ttgacccatg tcccacgcac
     4801 cctctcatct atgttatatg gtggatgctt cacagaagcc ctgggaagta gatgctatga
     4861 tcctatttag cagatgagga aacaggagaa gggcgtgaga agtgaggact tgttccaggt
     4921 tatccaggct gtcagggtga gtcagagtga gtccaggttc acctgatggc cagaatcatg
     4981 ccctttatag tgccccacga cactcacagc cctgcagggc agaagggtct ataagtggcc
     5041 cctcgcatga ttcaagatga cagaggcagt gtagcaagga tgtgagaaca cagatgctcc
     5101 acccagacca cctcagtgtc aatattgtcc ccactttcct ggctggggtc tcttgggcaa
     5161 gttacctaat cttgcagcac ctcagttttc ccatttctaa agtgtgctgc taccttccat
     5221 gcagggcgtt gaggggcttc cctacgttat tacgcacaaa gtcctcctca cagtgcctgg
     5281 tgtgtggtca gcatttatat gcctggcacc aggccggggg ctatggaggc aaatcagctg
     5341 ggccctgccc tcacagagtt gacatcactt agtacgtaac cacattggga tacatgtttt
     5401 gaaggagagg acagtgtgtc tggccagtga gcaacagtgg gccatacgtc tccagggaac
     5461 ccccgtgggg tgtgggagga gggaagcagg tctgtcctgg gggaatgtgt gggaccacct
     5521 ctgccctgct tggcagtagg tggatttcag gaccatgggc ctgtgctgtt tacagaacct
     5581 tgtccaggtg cccagctgtg ggagggcagc atggagagga ggaagagggg gcccctagta
     5641 gcaagcttca gaaacttgcc acttcaggct agagagctcg caccctccca cggcagcagg
     5701 gtagccattt ctccctgact ggggtgtcca ccatggtgct ctgcagccac ctctcacttc
     5761 attaagagtc cacagatcta ggagcagagg actggtctgg agctgggcaa gggcaggcag
     5821 caaatgggga gtttttgctg tgtgacctga ggtcacttgc ctgccttctc tggactgcac
     5881 tgtagggcct ggagacctgt tcccctgttc caatttcccc acctcagtga aggcacaacc
     5941 aacagctgct ccccgggcat ttccaagacc ctccaggccc ccagctctga ggactagggt
     6001 ggaggcagtg tttctcccca gcatcaagtg accagagaag tgaagtgacc ccactgccgc
     6061 cacacagagc cacacagtgc gatgtctgga gctcctgcct cctgcaaggt ggagggtggg
     6121 gcttggccag gagtgaccag actacagagt gaggggtgtg cttgtggggg tgaagggttg
     6181 gggtgagaac tgagcccgag tcgaactcat cctcctctgc cctgatgcac tgtgcaactt
     6241 gggggagtca ctgtccctct ctgggcctcg ctttccccat cttcgatagg acttggctct
     6301 gcctggccac tcctcctcca atgggggaat tcctgggctt gcctctgtct tggctccagc
     6361 tcaggtgtca gtctcagccc tgtcccagcc aggaacaatg ggccaggcag ggccagtcac
     6421 cccctgtccc tgggggctcc acccacggcc ctggactatt ttcagccctt gcagatggag
     6481 tcagaagagg attttccact cccagtacaa tgactgccct ggaccattgt ccagcagtga
     6541 cgcgggggac ctgcctgccc caaaatatct cctgccccta gtttccaagc ctctttgccc
     6601 tgctcctcac ctcctggccc tgctccttac ctccccaccc tgatgtcatt tcctggggct
     6661 cttaactcct gaaggccatt gtgaaacatc acgtgagact cctgggagac acaaccagtt
     6721 ggaatgagtt ttccctcctg gcagggaccc cagggattgt ttggctgctt agtgggactg
     6781 gtggcccaga gagggctgtg ccttacccag tcacacagca gtcagtgtga agcttaggtg
     6841 taagcccagg gctctttggc tgctcccact gcctcagcca acttcattag ctccagtctg
     6901 tggctcctgg actggagcta cagtggtgag agctcaccac tgagcttcct gggatgggca
     6961 cctgggatag cagcccaagt ggtgtgggtg gagaggtgca gctcatgctc tgaccttgga
     7021 gtgagcccag tgcaggggcc tgaccttaaa ccctttctcc ccactgagtc ccatttttac
     7081 caaatgtggc tgttaggaac tgaatgtttg tgtcccccgc cccacaaatc catatgtcaa
     7141 aatcccaact gccaaggtga tggtattaga aggtggggcc tttgggaagt aaccaggtcc
     7201 taagggtgca gccctcatga atgggtttag tgcccttaca gaatggaccc cagagagctc
     7261 ctcaccctct ttccaccatg tgaggatata atgagaagtt ggcagtctgc aacctggaag
     7321 aggtccctca ccagatccca accatgctgg caccccgatc ttagacttcc agtcttcaga
     7381 atggtgagaa ataaatgtct cttgtttcta atccacccag tcggtggcat tttgttatag
     7441 cagcccacgc tgactgtgac tgaactcagg gtgacagagc agcagctctg gggcaaaggg
     7501 gagggtgggg gccacagggc agctgatgca ggagcagggc tctggcacag ttcagccatc
     7561 accaattctg ggactgcaaa ttcagtttct tcatctggaa aattgaactg gtaataccaa
     7621 tacctctttt cccggtttac tagacagaga caatgcagtg aggcacaaac atgcaactgt
     7681 ttgattttcc tcccacccat gctccctgct cagtgacgtg tgattttcct ttcccatcca
     7741 taaactgcgc atttggcaaa ctccaaactt ttgagtcact tttgggtaac aaagtcaggt
     7801 ttaagatttc catcgcctgc ttaattgaat gctcacctgt cctcttcccc catgctgtga
     7861 ggaccttcat cactcctctt ctgggtccct ctctcctcta ggtgttgggg cagggtgggg
     7921 aggaaaggga ccaatgtgtc tttcctggtg atgctacagc cctctcttgc tgaccttgct
     7981 tcctgggcca tcagtgcccc ctgcacagaa ctctccaaac atcagtccac acctttgtaa
     8041 aaacagtctc tccgctaagc tatcccaaaa tgacctgatt agagtgtgca acgtctttcc
     8101 tgctgggact ctgactgata ccctggtctc cctgagtgat tttcctgcac accctgctgg
     8161 ggatgtggaa gcctgtcccc ctcccacccc acaccccaca cttggctgag atctcacagt
     8221 ggcaaagatg tctttgaatc catggtgccc agggttcagc gtgtagagtg aggtggggtg
     8281 tgtagagagc tggggcaagg aaccctgaga agatgtctta ccccagttgt ttccaggttt
     8341 ctttagaaag cgggctattt taccccatgt gtcctcagat ttatgtcctg gaaccaaatt
     8401 ccaaatcagc agccacatga aaagtcccct cctctctggc gtggaattaa actgttagac
     8461 ctgcctttgt gaccaaagca attgtaaaac gtgggggagg aaattaaaag cctgccacct
     8521 tagtccacac agtgtgtgct gtctctgtgt gtgtgcacgt gtgtttatgt gtgtgttgaa
     8581 tgatcacatg ttccagggag gatggtgagg ggcgagggg
//
