LOCUS       NM_176894               2765 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens purinergic receptor P2Y13 (P2RY13), mRNA.
ACCESSION   NM_176894
VERSION     NM_176894.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2765)
  AUTHORS   Duparc,T., Gore,E., Combes,G., Beuzelin,D., Pires Da Silva,J.,
            Bouguetoch,V., Marques,M.A., Velazquez,A., Viguerie,N.,
            Tavernier,G., Arner,P., Ryden,M., Langin,D., Sioufi,N., Nasser,M.,
            Cabou,C., Najib,S. and Martinez,L.O.
  TITLE     P2Y13 receptor deficiency favors adipose tissue lipolysis and
            worsens insulin resistance and fatty liver disease
  JOURNAL   JCI Insight 9 (8), e175623 (2024)
   PUBMED   38470490
  REMARK    GeneRIF: P2Y13 receptor deficiency favors adipose tissue lipolysis
            and worsens insulin resistance and fatty liver disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2765)
  AUTHORS   Jiao,T., Collado,A., Mahdi,A., Jurga,J., Tengbom,J., Saleh,N.,
            Verouhis,D., Bohm,F., Zhou,Z., Yang,J. and Pernow,J.
  TITLE     Erythrocytes from patients with ST-elevation myocardial infarction
            induce cardioprotection through the purinergic P2Y13 receptor and
            nitric oxide signaling
  JOURNAL   Basic Res Cardiol 117 (1), 46 (2022)
   PUBMED   36112326
  REMARK    GeneRIF: Erythrocytes from patients with ST-elevation myocardial
            infarction induce cardioprotection through the purinergic P2Y13
            receptor and nitric oxide signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2765)
  AUTHORS   Wu,X., Wei,S., Chen,M., Li,J., Wei,Y., Zhang,J. and Dong,W.
  TITLE     P2RY13 Exacerbates Intestinal Inflammation by Damaging the
            Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway
  JOURNAL   Int J Biol Sci 18 (13), 5056-5069 (2022)
   PUBMED   35982893
  REMARK    GeneRIF: P2RY13 Exacerbates Intestinal Inflammation by Damaging the
            Intestinal Mucosal Barrier via Activating IL-6/STAT3 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2765)
  AUTHORS   Werder,R.B., Ullah,M.A., Rahman,M.M., Simpson,J., Lynch,J.P.,
            Collinson,N., Rittchen,S., Rashid,R.B., Sikder,M.A.A.,
            Handoko,H.Y., Curren,B.F., Sebina,I., Hartel,G., Bissell,A.,
            Ngo,S., Yarlagadda,T., Hasnain,S.Z., Lu,W., Sohal,S.S., Martin,M.,
            Bowler,S., Burr,L.D., Martinez,L.O., Robaye,B., Spann,K.,
            Ferreira,M.A.R. and Phipps,S.
  TITLE     Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1 Release and
            Ameliorates Experimental Asthma
  JOURNAL   Am J Respir Crit Care Med 205 (3), 300-312 (2022)
   PUBMED   34860143
  REMARK    GeneRIF: Targeting the P2Y13 Receptor Suppresses IL-33 and HMGB1
            Release and Ameliorates Experimental Asthma.
REFERENCE   5  (bases 1 to 2765)
  AUTHORS   Wang,J., Shi,W., Miao,Y., Gan,J., Guan,Q. and Ran,J.
  TITLE     Evaluation of tumor microenvironmental immune regulation and
            prognostic in lung adenocarcinoma from the perspective of
            purinergic receptor P2Y13
  JOURNAL   Bioengineered 12 (1), 6286-6304 (2021)
   PUBMED   34494914
  REMARK    GeneRIF: Evaluation of tumor microenvironmental immune regulation
            and prognostic in lung adenocarcinoma from the perspective of
            purinergic receptor P2Y13.
REFERENCE   6  (bases 1 to 2765)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   7  (bases 1 to 2765)
  AUTHORS   Zhang,F.L., Luo,L., Gustafson,E., Palmer,K., Qiao,X., Fan,X.,
            Yang,S., Laz,T.M., Bayne,M. and Monsma,F. Jr.
  TITLE     P2Y(13): identification and characterization of a novel
            Galphai-coupled ADP receptor from human and mouse
  JOURNAL   J Pharmacol Exp Ther 301 (2), 705-713 (2002)
   PUBMED   11961076
  REMARK    GeneRIF: (p2y13 purinoceptor)
REFERENCE   8  (bases 1 to 2765)
  AUTHORS   Communi,D., Gonzalez,N.S., Detheux,M., Brezillon,S., Lannoy,V.,
            Parmentier,M. and Boeynaems,J.M.
  TITLE     Identification of a novel human ADP receptor coupled to G(i)
  JOURNAL   J Biol Chem 276 (44), 41479-41485 (2001)
   PUBMED   11546776
REFERENCE   9  (bases 1 to 2765)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
REFERENCE   10 (bases 1 to 2765)
  AUTHORS   Wittenberger,T., Schaller,H.C. and Hellebrand,S.
  TITLE     An expressed sequence tag (EST) data mining strategy succeeding in
            the discovery of new G-protein coupled receptors
  JOURNAL   J Mol Biol 307 (3), 799-813 (2001)
   PUBMED   11273702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA676457.1 and AC024886.20.
            
            On Nov 22, 2018 this sequence version replaced NM_176894.2.
            
            Summary: The product of this gene belongs to the family of
            G-protein coupled receptors. This family has several receptor
            subtypes with different pharmacological selectivity, which overlaps
            in some cases, for various adenosine and uridine nucleotides. This
            receptor is activated by ADP. [provided by RefSeq, Sep 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because transcript sequence consistent with
            the reference genome assembly was not available for all regions of
            the RefSeq transcript. The extent of this transcript is supported
            by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041116.1, SRR3476690.845925.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000325602.6/ ENSP00000320376.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-508               DA676457.1         1-508
            509-2765            AC024886.20        137863-140119
FEATURES             Location/Qualifiers
     source          1..2765
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..2765
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /note="purinergic receptor P2Y13"
                     /db_xref="GeneID:53829"
                     /db_xref="HGNC:HGNC:4537"
                     /db_xref="MIM:606380"
     exon            1..69
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1086
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /note="G protein-coupled receptor 86; G-protein coupled
                     receptor 94; purinergic receptor P2Y, G-protein coupled,
                     13"
                     /codon_start=1
                     /product="P2Y purinoceptor 13"
                     /protein_id="NP_795713.2"
                     /db_xref="CCDS:CCDS3158.2"
                     /db_xref="GeneID:53829"
                     /db_xref="HGNC:HGNC:4537"
                     /db_xref="MIM:606380"
                     /translation="MTAAIRRQRELSILPKVTLEAMNTTVMQGFNRSERCPRDTRIVQ
                     LVFPALYTVVFLTGILLNTLALWVFVHIPSSSTFIIYLKNTLVADLIMTLMLPFKILS
                     DSHLAPWQLRAFVCRFSSVIFYETMYVGIVLLGLIAFDRFLKIIRPLRNIFLKKPVFA
                     KTVSIFIWFFLFFISLPNTILSNKEATPSSVKKCASLKGPLGLKWHQMVNNICQFIFW
                     TVFILMLVFYVVIAKKVYDSYRKSKSKDRKNNKKLEGKVFVVVAVFFVCFAPFHFARV
                     PYTHSQTNNKTDCRLQNQLFIAKETTLFLAATNICMDPLIYIFLCKKFTEKLPCMQGR
                     KTTASSQENHSSQTDNITLG"
     exon            70..2765
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2744..2749
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /note="hexamer: AATAAA"
     polyA_site      2765
                     /gene="P2RY13"
                     /gene_synonym="FKSG77; GPCR1; GPR86; GPR94; P2Y13; SP174"
                     /note="major polyA site"
ORIGIN      
        1 gctcatttgt aggctgaact aatgactgcc gccataagaa gacagagaga actgagtatc
       61 ctcccaaagg tgacactgga agcaatgaac accacagtga tgcaaggctt caacagatct
      121 gagcggtgcc ccagagacac tcggatagta cagctggtat tcccagccct ctacacagtg
      181 gttttcttga ccggcatcct gctgaatact ttggctctgt gggtgtttgt tcacatcccc
      241 agctcctcca ccttcatcat ctacctcaaa aacactttgg tggccgactt gataatgaca
      301 ctcatgcttc ctttcaaaat cctctctgac tcacacctgg caccctggca gctcagagct
      361 tttgtgtgtc gtttttcttc ggtgatattt tatgagacca tgtatgtggg catcgtgctg
      421 ttagggctca tagcctttga cagattcctc aagatcatca gacctttgag aaatattttt
      481 ctaaaaaaac ctgtttttgc aaaaacggtc tcaatcttca tctggttctt tttgttcttc
      541 atctccctgc caaatacgat cttgagcaac aaggaagcaa caccatcgtc tgtgaaaaag
      601 tgtgcttcct taaaggggcc tctggggctg aaatggcatc aaatggtaaa taacatatgc
      661 cagtttattt tctggactgt ttttatccta atgcttgtgt tttatgtggt tattgcaaaa
      721 aaagtatatg attcttatag aaagtccaaa agtaaggaca gaaaaaacaa caaaaagctg
      781 gaaggcaaag tatttgttgt cgtggctgtc ttctttgtgt gttttgctcc atttcatttt
      841 gccagagttc catatactca cagtcaaacc aacaataaga ctgactgtag actgcaaaat
      901 caactgttta ttgctaaaga aacaactctc tttttggcag caactaacat ttgtatggat
      961 cccttaatat acatattctt atgtaaaaaa ttcacagaaa agctaccatg tatgcaaggg
     1021 agaaagacca cagcatcaag ccaagaaaat catagcagtc agacagacaa cataacctta
     1081 ggctgacaac tgtacatagg gttaacttct atttattgat gagacttccg tagataatgt
     1141 ggaaatcaaa tttaaccaag aaaaaaagat tggaacaaat gctctcttac attttattat
     1201 cctcgtgtac agaaaagatt atataaaatt taaatccaca tagatctatt cataagctga
     1261 atgaaccatt actaagagaa tgcaacagga tacaaatggc cactagaggt cattatttct
     1321 ttctttcttt tttttttttt ttaatttcaa gagcatttca ctttaacatt ttggaaaaga
     1381 ctaaggagaa acgtatatcc ctacaaacct cccctccaaa caccttctca cattcttttc
     1441 cacaattcac ataacactac tgcttttgtg ccccttaaat gtagatatgt gctgaaagaa
     1501 aaaaaaaacg cccaactctt gaagtccatt gctgaaaact gcagccaggg gttgaaaggg
     1561 atgcagactt gaagagtctg aggaactgaa gtgggtcagc aagacctctg aaatcctggg
     1621 taaaggattt tctccttaca attacaaaca gcctctttca cattacaata atataccata
     1681 ggaggcacaa gcaccattat taagccactt tgcttacacc ttaagtgtgt acaattcaag
     1741 tgtgagaatg ctgtgttaac tattctttgg aattctcctt ctgtccagca aatactctaa
     1801 tgatggttaa acatggcacc tactcagcaa tgccttcctg gaccacaacc cctatccccc
     1861 tgccccaccc tcctcattaa aaacaaatac ttctactgtt tgggtgtgtg atagggttct
     1921 caatgcagat ctcccttttc tagttagcta tattcttgac tgcatccgct aaaaatgtta
     1981 aagcttcttg agagacagac atgccagatt ttcttggtat ctcccataat acgacctaca
     2041 gtccatggtc tacagatgtt ttaaatagaa ttgctattct cgatacatac aaagacgtaa
     2101 ttgctgaccc acaatcagta acatccatat tgagagattt ttcaaaggat ggtgaccctg
     2161 cttgtattta tttaccttgg tattttttct tgcatccttc tgtgattcaa aaaagtaaaa
     2221 tgtggctttc tgaaatgatg gataagagtc tacatcttct agaaaaaata cataaaggag
     2281 tagttaagct ctgtaaatgt gccacgagct ccaacacgac catcgtaggg tgaagcccac
     2341 gttttcttcc atggcctcaa aggccctaga acttgcctac ctttctggcc ttacctccta
     2401 gctacttatc catctcttga actttatact cttgtataaa tttctaactt tcagaaaatg
     2461 ccatactctg ttttggcacc acacatgtat atttccccct ggtacacttg gaagactctt
     2521 atccatctgt gaaaccctat gttgtcatca cttggtccat gaaatattac ctggccaata
     2581 tcccaccatc acctcaaacc caatcacccc ctcctctgta tgctgtcaca cctatattat
     2641 taaacttatc acattgcatt gtaattactt cctgaccttt gtatctactc ttttagtaac
     2701 tgatgtatat atctgaaagg agagattgtt tcattgtgca atcaataaat gtttgataaa
     2761 ataaa
//
