LOCUS       NM_002566               1788 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens purinergic receptor P2Y11 (P2RY11), mRNA.
ACCESSION   NM_002566
VERSION     NM_002566.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1788)
  AUTHORS   Klaver,D., Gander,H., Frena,B., Amato,M. and Thurnher,M.
  TITLE     Crosstalk between purinergic receptor P2Y11 and chemokine receptor
            CXCR7 is regulated by CXCR4 in human macrophages
  JOURNAL   Cell Mol Life Sci 81 (1), 132 (2024)
   PUBMED   38472446
  REMARK    GeneRIF: Crosstalk between purinergic receptor P2Y11 and chemokine
            receptor CXCR7 is regulated by CXCR4 in human macrophages.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1788)
  AUTHORS   Andersen,L.L., Huang,Y., Urban,C., Oubraham,L., Winheim,E.,
            Stafford,C., Nagl,D., O'Duill,F., Ebert,T., Engleitner,T.,
            Paludan,S.R., Krug,A., Rad,R., Hornung,V. and Pichlmair,A.
  TITLE     Systematic P2Y receptor survey identifies P2Y11 as modulator of
            immune responses and virus replication in macrophages
  JOURNAL   EMBO J 42 (23), e113279 (2023)
   PUBMED   37881155
  REMARK    GeneRIF: Systematic P2Y receptor survey identifies P2Y11 as
            modulator of immune responses and virus replication in macrophages.
REFERENCE   3  (bases 1 to 1788)
  AUTHORS   Klaver,D. and Thurnher,M.
  TITLE     P2Y11/IL-1 receptor crosstalk controls macrophage inflammation: a
            novel target for anti-inflammatory strategies?
  JOURNAL   Purinergic Signal 19 (3), 501-511 (2023)
   PUBMED   37016172
  REMARK    GeneRIF: P2Y11/IL-1 receptor crosstalk controls macrophage
            inflammation: a novel target for anti-inflammatory strategies?
            Review article
REFERENCE   4  (bases 1 to 1788)
  AUTHORS   Klaver,D., Gander,H., Dobler,G., Rahm,A. and Thurnher,M.
  TITLE     The P2Y11 receptor of human M2 macrophages activates canonical and
            IL-1 receptor signaling to translate the extracellular danger
            signal ATP into anti-inflammatory and pro-angiogenic responses
  JOURNAL   Cell Mol Life Sci 79 (10), 519 (2022)
   PUBMED   36107259
  REMARK    GeneRIF: The P2Y11 receptor of human M2 macrophages activates
            canonical and IL-1 receptor signaling to translate the
            extracellular danger signal ATP into anti-inflammatory and
            pro-angiogenic responses.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1788)
  AUTHORS   Viste,R., Viken,M.K., Lie,B.A., Juvodden,H.T., Nordstrand,S.E.H.,
            Thorsby,P.M., Rootwelt,T., Kornum,B.R. and Knudsen-Heier,S.
  TITLE     High nocturnal sleep fragmentation is associated with low T
            lymphocyte P2Y11 protein levels in narcolepsy type 1
  JOURNAL   Sleep 44 (8) (2021)
   PUBMED   33710305
  REMARK    GeneRIF: High nocturnal sleep fragmentation is associated with low
            T lymphocyte P2Y11 protein levels in narcolepsy type 1.
REFERENCE   6  (bases 1 to 1788)
  AUTHORS   Moore,D.J., Chambers,J.K., Wahlin,J.P., Tan,K.B., Moore,G.B.,
            Jenkins,O., Emson,P.C. and Murdock,P.R.
  TITLE     Expression pattern of human P2Y receptor subtypes: a quantitative
            reverse transcription-polymerase chain reaction study
  JOURNAL   Biochim Biophys Acta 1521 (1-3), 107-119 (2001)
   PUBMED   11690642
  REMARK    GeneRIF: expression profile in human peripheral tissues and brain
            regions using PCR
REFERENCE   7  (bases 1 to 1788)
  AUTHORS   Communi,D., Suarez-Huerta,N., Dussossoy,D., Savi,P. and
            Boeynaems,J.M.
  TITLE     Cotranscription and intergenic splicing of human P2Y11 and SSF1
            genes
  JOURNAL   J Biol Chem 276 (19), 16561-16566 (2001)
   PUBMED   11278528
REFERENCE   8  (bases 1 to 1788)
  AUTHORS   van der Weyden,L., Conigrave,A.D. and Morris,M.B.
  TITLE     Signal transduction and white cell maturation via extracellular ATP
            and the P2Y11 receptor
  JOURNAL   Immunol Cell Biol 78 (4), 369-374 (2000)
   PUBMED   10947861
  REMARK    Review article
REFERENCE   9  (bases 1 to 1788)
  AUTHORS   Communi,D., Govaerts,C., Parmentier,M. and Boeynaems,J.M.
  TITLE     Cloning of a human purinergic P2Y receptor coupled to phospholipase
            C and adenylyl cyclase
  JOURNAL   J Biol Chem 272 (51), 31969-31973 (1997)
   PUBMED   9405388
REFERENCE   10 (bases 1 to 1788)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC073827.1 and BC009877.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002566.4.
            
            Summary: The product of this gene belongs to the family of
            G-protein coupled receptors. This family has several receptor
            subtypes with different pharmacological selectivity, which overlaps
            in some cases, for various adenosine and uridine nucleotides. This
            receptor is coupled to the stimulation of the phosphoinositide and
            adenylyl cyclase pathways and behaves as a selective purinoceptor.
            Naturally occuring read-through transcripts, resulting from
            intergenic splicing between this gene and an immediately upstream
            gene (PPAN, encoding peter pan homolog), have been found. The
            PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes
            a fusion protein that shares identity with each individual gene
            product. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DB009481.1, BC073827.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321826.5/ ENSP00000323872.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                BC073827.1         156-203
            49-266              BC009877.2         548-765
            267-1422            BC073827.1         422-1577
            1423-1788           BC009877.2         1922-2287
FEATURES             Location/Qualifiers
     source          1..1788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1788
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /note="purinergic receptor P2Y11"
                     /db_xref="GeneID:5032"
                     /db_xref="HGNC:HGNC:8540"
                     /db_xref="MIM:602697"
     exon            1..48
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1154
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /note="purinergic receptor P2Y, G-protein coupled, 11"
                     /codon_start=1
                     /product="P2Y purinoceptor 11"
                     /protein_id="NP_002557.2"
                     /db_xref="CCDS:CCDS12226.1"
                     /db_xref="GeneID:5032"
                     /db_xref="HGNC:HGNC:8540"
                     /db_xref="MIM:602697"
                     /translation="MAANVSGAKSCPANFLAAADDKLSGFQGDFLWPILVVEFLVAVA
                     SNGLALYRFSIRKQRPWHPAVVFSVQLAVSDLLCALTLPPLAAYLYPPKHWRYGEAAC
                     RLERFLFTCNLLGSVIFITCISLNRYLGIVHPFFARSHLRPKHAWAVSAAGWVLAALL
                     AMPTLSFSHLKRPQQGAGNCSVARPEACIKCLGTADHGLAAYRAYSLVLAGLGCGLPL
                     LLTLAAYGALGRAVLRSPGMTVAEKLRVAALVASGVALYASSYVPYHIMRVLNVDARR
                     RWSTRCPSFADIAQATAALELGPYVGYQVMRGLMPLAFCVHPLLYMAAVPSLGCCCRH
                     CPGYRDSWNPEDAKSTGQALPLNATAAPKPSEPQSRELSQ"
     exon            49..1788
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1763..1768
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /note="hexamer: AATAAA"
     polyA_site      1788
                     /gene="P2RY11"
                     /gene_synonym="P2Y11"
                     /note="major polyA site"
ORIGIN      
        1 agacacaggc tgaggatcgg cacgggagca tggcagccaa cgtctcgggt gccaagtcct
       61 gccctgccaa cttcttggca gctgccgacg acaaactcag tgggttccag ggggacttcc
      121 tgtggcccat actggtggtt gagttcctgg tggccgtggc cagcaatggc ctggccctgt
      181 accgcttcag catccggaag cagcgcccat ggcaccccgc cgtggtcttc tctgtccagc
      241 tggcagtcag cgacctgctc tgcgccctga cgctgccccc gctggccgcc tacctctatc
      301 cccccaagca ctggcgctat ggggaggccg cgtgccgcct ggagcgcttc ctcttcacct
      361 gcaacctgct gggcagcgtc atcttcatca cctgcatcag cctcaaccgc tacctgggca
      421 tcgtgcaccc cttcttcgcc cgaagccacc tgcgacccaa gcacgcctgg gccgtgagcg
      481 ctgccggctg ggtcctggcc gccctgctgg ccatgcccac actcagcttc tcccacctga
      541 agaggccgca gcagggggcg ggcaactgca gcgtggccag gcccgaggcc tgcatcaagt
      601 gtctggggac agcagaccac gggctggcgg cctacagagc gtatagcctg gtgctggcgg
      661 ggttgggctg cggcctgccg ctgctgctca cgctggcagc ctacggcgcc ctcgggcggg
      721 ccgtgctacg cagcccaggc atgactgtgg ccgagaagct gcgtgtggca gcgttggtgg
      781 ccagtggtgt ggccctctac gccagctcct atgtgcccta ccacatcatg cgggtgctca
      841 acgtggatgc tcggcggcgc tggagcaccc gctgcccgag ctttgcagac atagcccagg
      901 ccacagcagc cctggagctg gggccctacg tgggctacca ggtgatgcgg ggcctcatgc
      961 ccctggcctt ctgtgtccac cctctactct acatggccgc agtgcccagc ctgggctgct
     1021 gctgccgaca ctgccccggc tacagggaca gctggaaccc agaggacgcc aagagcactg
     1081 gccaagccct gcccctcaat gccacagccg cccctaaacc gtcagagccc cagtcccgtg
     1141 agctgagcca atgatgtggc ctagcggaag ctgcctcctc accctaggtg ttgctggaga
     1201 accctgaggg cagggcccga gccccgacac atcccttccc ccaaaaagca acacctgtgc
     1261 ttgcagccag gtcaggccca gctgcagccc aggcaggagc agtcgccttt cccacccaca
     1321 gcgctggcca cagggctccc tgcagggtca gggaccagac cacgcccaga ggaggggagg
     1381 cactggcccc cgccacagga ctggagacgc aagaacaaaa agaaccaagt agagagagtg
     1441 gagctgcttt attgcccttg gagcccgcgc tctcggaggc tgtcttctgt cgccaagggt
     1501 cccggaccga gtacacagtg gcagctggct tagttggtgg acggcctggg gtaggggagg
     1561 gtggcaggta taagacttct gggggcaccc caagacccca gacacccaag tggcatcttg
     1621 ggggtgggtg ggcagaggac ggggtaatgt gaggacgaag cgggcacgga gccagatggc
     1681 cagtctccag gcctggtcca cggactggca gggaccccag gcacaagagc tgccacccct
     1741 ctgcccggtt ttggaaaaaa acaataaagg actgtcccct caaaacca
//
