LOCUS       NM_014499               3517 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens P2Y receptor family member 10 (P2RY10), transcript
            variant 1, mRNA.
ACCESSION   NM_014499
VERSION     NM_014499.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3517)
  AUTHORS   Shi,L., Luo,B., Deng,L., Zhang,Q., Li,Y., Sun,D., Zhang,H. and
            Zhuang,L.
  TITLE     The lncRNA TRG-AS1 promotes the growth of colorectal cancer cells
            through the regulation of P2RY10/GNA13
  JOURNAL   Scand J Gastroenterol 59 (6), 710-721 (2024)
   PUBMED   38357893
  REMARK    GeneRIF: The lncRNA TRG-AS1 promotes the growth of colorectal
            cancer cells through the regulation of P2RY10/GNA13.
REFERENCE   2  (bases 1 to 3517)
  AUTHORS   Gurusamy,M., Tischner,D., Shao,J., Klatt,S., Zukunft,S.,
            Bonnavion,R., Gunther,S., Siebenbrodt,K., Kestner,R.I.,
            Kuhlmann,T., Fleming,I., Offermanns,S. and Wettschureck,N.
  TITLE     G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4
            T cell migration through autocrine/paracrine mediators
  JOURNAL   Nat Commun 12 (1), 6798 (2021)
   PUBMED   34815397
  REMARK    GeneRIF: G-protein-coupled receptor P2Y10 facilitates
            chemokine-induced CD4 T cell migration through autocrine/paracrine
            mediators.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3517)
  AUTHORS   Hwang,S.M., Kim,H.J., Kim,S.M., Jung,Y., Park,S.W. and Chung,I.Y.
  TITLE     Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor
            that mediates eosinophil degranulation
  JOURNAL   Clin Exp Allergy 48 (8), 990-999 (2018)
   PUBMED   29700886
  REMARK    GeneRIF: Our data show that the LysoPS-induced eosinophil
            degranulation most likely occurs through P2Y10. These findings
            suggest that LysoPS plays a specific role in eosinophils and
            introduces the possibility of LysoPS/P2Y10-based therapeutics in
            the treatment of eosinophilic diseases.
REFERENCE   4  (bases 1 to 3517)
  AUTHORS   Makide,K., Uwamizu,A., Shinjo,Y., Ishiguro,J., Okutani,M., Inoue,A.
            and Aoki,J.
  TITLE     Novel lysophosphoplipid receptors: their structure and function
  JOURNAL   J Lipid Res 55 (10), 1986-1995 (2014)
   PUBMED   24891334
  REMARK    Review article
REFERENCE   5  (bases 1 to 3517)
  AUTHORS   Kihara,Y., Maceyka,M., Spiegel,S. and Chun,J.
  TITLE     Lysophospholipid receptor nomenclature review: IUPHAR Review 8
  JOURNAL   Br J Pharmacol 171 (15), 3575-3594 (2014)
   PUBMED   24602016
  REMARK    Review article
REFERENCE   6  (bases 1 to 3517)
  AUTHORS   Luttrell,L.M.
  TITLE     Reviews in molecular biology and biotechnology: transmembrane
            signaling by G protein-coupled receptors
  JOURNAL   Mol Biotechnol 39 (3), 239-264 (2008)
   PUBMED   18240029
  REMARK    Review article
REFERENCE   7  (bases 1 to 3517)
  AUTHORS   Dowal,L., Provitera,P. and Scarlata,S.
  TITLE     Stable association between G alpha(q) and phospholipase C beta 1 in
            living cells
  JOURNAL   J Biol Chem 281 (33), 23999-24014 (2006)
   PUBMED   16754659
REFERENCE   8  (bases 1 to 3517)
  AUTHORS   Adrian,K., Bernhard,M.K., Breitinger,H.G. and Ogilvie,A.
  TITLE     Expression of purinergic receptors (ionotropic P2X1-7 and
            metabotropic P2Y1-11) during myeloid differentiation of HL60 cells
  JOURNAL   Biochim Biophys Acta 1492 (1), 127-138 (2000)
   PUBMED   11004484
REFERENCE   9  (bases 1 to 3517)
  AUTHORS   Berchtold,S., Ogilvie,A.L., Bogdan,C., Muhl-Zurbes,P., Ogilvie,A.,
            Schuler,G. and Steinkasserer,A.
  TITLE     Human monocyte derived dendritic cells express functional P2X and
            P2Y receptors as well as ecto-nucleotidases
  JOURNAL   FEBS Lett 458 (3), 424-428 (1999)
   PUBMED   10570953
REFERENCE   10 (bases 1 to 3517)
  AUTHORS   Ralevic,V. and Burnstock,G.
  TITLE     Receptors for purines and pyrimidines
  JOURNAL   Pharmacol Rev 50 (3), 413-492 (1998)
   PUBMED   9755289
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW294346.1, BC051875.1,
            Z82200.1 and BX104083.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 24, 2018 this sequence version replaced NM_014499.3.
            
            Summary: The protein encoded by this gene belongs to the family of
            G-protein coupled receptors that are preferentially activated by
            adenosine and uridine nucleotides. There is a pseudogene for this
            gene nearby on chromosome X. Multiple alternatively spliced
            transcripts have been observed. [provided by RefSeq, Apr 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC051875.1, AK292138.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000171757.3/ ENSP00000171757.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AW294346.1         74-104
            32-1692             BC051875.1         2-1662
            1693-3054           Z82200.1           13723-15084         c
            3055-3517           BX104083.1         14-476              c
FEATURES             Location/Qualifiers
     source          1..3517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq21.1"
     gene            1..3517
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="P2Y receptor family member 10"
                     /db_xref="GeneID:27334"
                     /db_xref="HGNC:HGNC:19906"
                     /db_xref="MIM:300529"
     exon            1..105
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /inference="alignment:Splign:2.1.0"
     exon            106..154
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /inference="alignment:Splign:2.1.0"
     exon            155..297
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /inference="alignment:Splign:2.1.0"
     exon            298..3517
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /inference="alignment:Splign:2.1.0"
     CDS             311..1330
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="isoform a is encoded by transcript variant 1;
                     P2Y-like receptor; purinergic receptor P2Y, G-protein
                     coupled, 10; G-protein coupled purinergic receptor P2Y10;
                     putative P2Y purinoceptor 10; lysophosphatidylserine
                     receptor 2"
                     /codon_start=1
                     /product="putative P2Y purinoceptor 10 isoform a"
                     /protein_id="NP_055314.1"
                     /db_xref="CCDS:CCDS14442.1"
                     /db_xref="GeneID:27334"
                     /db_xref="HGNC:HGNC:19906"
                     /db_xref="MIM:300529"
                     /translation="MANLDKYTETFKMGSNSTSTAEIYCNVTNVKFQYSLYATTYILI
                     FIPGLLANSAALWVLCRFISKKNKAIIFMINLSVADLAHVLSLPLRIYYYISHHWPFQ
                     RALCLLCFYLKYLNMYASICFLTCISLQRCFFLLKPFRARDWKRRYDVGISAAIWIVV
                     GTACLPFPILRSTDLNNNKSCFADLGYKQMNAVALVGMITVAELAGFVIPVIIIAWCT
                     WKTTISLRQPPMAFQGISERQKALRMVFMCAAVFFICFTPYHINFIFYTMVKETIISS
                     CPVVRIALYFHPFCLCLASLCCLLDPILYYFMASEFRDQLSRHGSSVTRSRLMSKESG
                     SSMIG"
     regulatory      1602..1607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="hexamer: AATAAA"
     polyA_site      1628
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="major polyA site"
     regulatory      1711..1716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="hexamer: TATAAA"
     polyA_site      1731
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="major polyA site"
     regulatory      3493..3498
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="hexamer: AATATA"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="hexamer: TATAAA"
     polyA_site      3509
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="major polyA site"
     polyA_site      3517
                     /gene="P2RY10"
                     /gene_synonym="LPS2; LYPSR2; P2Y10"
                     /note="major polyA site"
ORIGIN      
        1 aacaaatgtg tcagttatca gcaggatcca tgccgccaga gtaaagcttt ctacccttta
       61 ctccctgcaa agaaacaaga gtgcttatcc cagctaagct ccagggtaat gttatcatga
      121 cagcttcaac ttttagacca caggcaaatg ctttgttaaa actctatgct ggtcattccc
      181 ttcaggattt ggcactcacc aacataccct tctttcaagt gaaaaggcat ctcttttaat
      241 ggtcctgacc tttggaatag gaagcatgta ccctggacag agcacttcaa actagaggaa
      301 ccataaatcc atggctaacc ttgacaaata cactgaaaca ttcaagatgg gtagcaacag
      361 taccagcact gctgagattt actgtaatgt cactaatgtg aaatttcaat actccctcta
      421 tgcaaccacc tatatcctca tattcattcc tggtcttctg gctaacagtg cagccttgtg
      481 ggttctgtgc cgcttcatca gcaagaaaaa taaagccatc attttcatga tcaacctctc
      541 tgtggctgac cttgctcatg tattatcttt acccctccgg atttactatt acatcagcca
      601 ccactggcct ttccagagag ccctttgcct gctctgcttc tacctgaagt atctcaacat
      661 gtatgccagc atttgtttcc tgacgtgcat cagtcttcaa aggtgctttt ttctcctcaa
      721 gcccttcagg gccagagact ggaagcgtag gtacgatgtg ggcatcagtg ctgccatctg
      781 gatcgttgtg gggactgcct gtttgccatt tcccatcctg agaagcacag acttaaacaa
      841 caacaagtcc tgctttgctg atcttggata caagcaaatg aatgcagttg cgttggtcgg
      901 gatgattaca gttgctgagc ttgcaggatt tgtgatccca gtgatcatca tcgcatggtg
      961 tacctggaaa actactatat ccttgagaca gccaccaatg gctttccaag ggatcagtga
     1021 gaggcagaaa gcactgcgga tggtgttcat gtgtgctgca gtcttcttca tctgcttcac
     1081 tccctatcat attaacttta ttttttacac catggtaaag gaaaccatca ttagcagttg
     1141 tcccgttgtc cgaatcgcac tgtatttcca ccctttttgc ctgtgccttg caagtctctg
     1201 ctgccttttg gatccaattc tttattactt tatggcttca gagtttcgtg accaactatc
     1261 ccgccatggc agttctgtga cccgctcccg cctcatgagc aaggagagtg gttcatcaat
     1321 gattggctaa aattaagata tctctttaat tacgcctttg tttacctacg ttccttgtct
     1381 ttttccaaag gccagaattg tcaaccaatt tctttaattg aacattgtaa aaaacaggaa
     1441 taagtacttt tgtgtaatat tcacagtcaa caggggtgtg atggtgaagg cagagtgtga
     1501 aaaacgtgag agaggaagag aaaatagatt tacctgattc ctctttaaaa ttcaagccac
     1561 tttcttattt aagaaaccta gatcaagttt ttacagatgt aaataaaagt tgaatagttt
     1621 accttaaatt tttttcaata agtaagttat tgttaataat gcacagtaaa tatgtgaatt
     1681 tttcctagat gtaaaaaaaa aaatctttca tataaagacc ttaaattctg agtgagagta
     1741 aaaatgtcta atctttctaa caggtaaatt tttctaacag gcaagacagt gtgaagaatt
     1801 gaagcaatat gtgcataaat ttcaggacca caagcctgtt attaaagaaa aggcatggaa
     1861 attcattcat tccttgaaaa tgtgttgagt gcctattgtg ttcttggttg tcactttgtt
     1921 aggtactttc tttttttttc ataagttatt ggggtacagg tggtatttgg ttacatgagt
     1981 aagttcttta gtggtgattt gtgagatttt ggtgcagcca tcacccgagc agtatacact
     2041 gcaccacatt tgtagtcttc tatccctcgc ccccttccca ctcttccaca cataacatct
     2101 catcttgccc tcctaataaa cctgtggaag ttgccgatac aaatgaataa atggaacttc
     2161 agagaggtta agcaatttgc ctcaggatca acagtggtta gccaaaattg gtccagtata
     2221 atacaccata tatgcttatg ttattccctt gcttttgttg ttacatttat taggtctata
     2281 ctaaattagc cttcaatgat gaagacagac taaagctaag ccacatgaga tcaaggccat
     2341 ttcaacatgg tttgcctgga attctccaaa aaacctgtgg gttgtgggtt tggcatgtca
     2401 agcttcagac cacaaggtct taagtggtaa atagatgcgt tgtcctaata ctgttccaag
     2461 gtagagaatc ctgatgataa ggagtatagg aaactcaaat agttcattat ttctaaaaaa
     2521 tgtatatttt aaggcatgat acaagtccta caaacctcat aagtaggtga aaaaaaaaac
     2581 cctgtggagt gataaacatt ctataaaacc tggaaatttg tgtggagttc gcctaagctc
     2641 acttttccta aatatagcta tataatattg taaacaaatt tgttttttag aaacttttaa
     2701 gaagatttct gtgagcgtaa ttgacaatat ctgcattaga aacagaaagt attatccatc
     2761 ataaatatga gaaaagtgtg tgtcctcttt ctgacaatct ttttatctta tttttttcaa
     2821 acgttgtggt tgttgtttca gcaccatttt aaagaatttg aatacaaaca atccctcagc
     2881 ttatcaggtt gacatttatg aagctgacct catcactctt tatcttttat gtctgcagta
     2941 taaatagcat agacatttgg tgtgaaggga ggagaaagga agtagtagtt ctgagaatat
     3001 tcatttgaac agagtgacta tggaagaatg aatagcaaaa aaaggagaat ttttttaaaa
     3061 agatctctca ctgggaaaag aaaaagttat gcatttataa agtaattaaa ctggttttcc
     3121 ttgtacttta ttaatctgaa tctaatggca cttccttacg agggttttca gatgtgcttg
     3181 tagttaatgg caacattatc agaatgacta cacagacagt cctactctga ggagatgact
     3241 ttggaagaaa cccatttgga actacacacc ctgctatgtc tgtggagaaa tggaactgca
     3301 atcctcaaga gtcacacttc atattccttc ctttcaagtg gttgataaaa ggtagtgctt
     3361 caagcacagg atttatggaa tagttggcaa attaaacaac atgcttttta ttttgactac
     3421 catttaagtg gaatctttga actttttttt tgacatgtga atctctaatg tggtgagaga
     3481 gaaaaacata aaaatataaa aacattcaag caatcga
//
