LOCUS       NM_002563               6309 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens purinergic receptor P2Y1 (P2RY1), mRNA.
ACCESSION   NM_002563
VERSION     NM_002563.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6309)
  AUTHORS   Pan,D., Ladds,G., Rahman,K.M. and Pitchford,S.C.
  TITLE     Exploring bias in platelet P2Y1 signalling: Host defence versus
            haemostasis
  JOURNAL   Br J Pharmacol 181 (4), 580-592 (2024)
   PUBMED   37442808
  REMARK    GeneRIF: Exploring bias in platelet P2Y1 signalling: Host defence
            versus haemostasis.
            Review article
REFERENCE   2  (bases 1 to 6309)
  AUTHORS   Dance,A., Fernandes,J., Toussaint,B., Vaillant,E., Boutry,R.,
            Baron,M., Loiselle,H., Balkau,B., Charpentier,G., Franc,S.,
            Ibberson,M., Marre,M., Gernay,M., Fadeur,M., Paquot,N.,
            Vaxillaire,M., Boissel,M., Amanzougarene,S., Derhourhi,M.,
            Khamis,A., Froguel,P. and Bonnefond,A.
  TITLE     Exploring the role of purinergic receptor P2RY1 in type 2 diabetes
            risk and pathophysiology: Insights from human functional genomics
  JOURNAL   Mol Metab 79, 101867 (2024)
   PUBMED   38159881
  REMARK    GeneRIF: Exploring the role of purinergic receptor P2RY1 in type 2
            diabetes risk and pathophysiology: Insights from human functional
            genomics.
REFERENCE   3  (bases 1 to 6309)
  AUTHORS   Su,C., Zhang,Z., Chen,J., Tian,M., Wu,C. and Zhang,T.
  TITLE     Association between P2Y1 and P2Y12 polymorphisms and acute
            myocardial infarction and ADP-induced platelet aggregation
  JOURNAL   BMC Cardiovasc Disord 23 (1), 41 (2023)
   PUBMED   36681816
  REMARK    GeneRIF: Association between P2Y1 and P2Y12 polymorphisms and acute
            myocardial infarction and ADP-induced platelet aggregation.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6309)
  AUTHORS   Gil-Redondo,J.C., Iturri,J., Ortega,F., Perez-Sen,R., Weber,A.,
            Miras-Portugal,M.T., Toca-Herrera,J.L. and Delicado,E.G.
  TITLE     Nucleotides-Induced Changes in the Mechanical Properties of Living
            Endothelial Cells and Astrocytes, Analyzed by Atomic Force
            Microscopy
  JOURNAL   Int J Mol Sci 22 (2), 624 (2021)
   PUBMED   33435130
  REMARK    GeneRIF: Nucleotides-Induced Changes in the Mechanical Properties
            of Living Endothelial Cells and Astrocytes, Analyzed by Atomic
            Force Microscopy.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6309)
  AUTHORS   Maier,R., Glatz,A., Mosbacher,J. and Bilbe,G.
  TITLE     Cloning of P2Y6 cDNAs and identification of a pseudogene:
            comparison of P2Y receptor subtype expression in bone and brain
            tissues
  JOURNAL   Biochem Biophys Res Commun 237 (2), 297-302 (1997)
   PUBMED   9268704
REFERENCE   6  (bases 1 to 6309)
  AUTHORS   Leon,C., Hechler,B., Vial,C., Leray,C., Cazenave,J.P. and Gachet,C.
  TITLE     The P2Y1 receptor is an ADP receptor antagonized by ATP and
            expressed in platelets and megakaryoblastic cells
  JOURNAL   FEBS Lett 403 (1), 26-30 (1997)
   PUBMED   9038354
REFERENCE   7  (bases 1 to 6309)
  AUTHORS   Ayyanathan,K., Naylor,S.L. and Kunapuli,S.P.
  TITLE     Structural characterization and fine chromosomal mapping of the
            human P2Y1 purinergic receptor gene (P2RY1)
  JOURNAL   Somat Cell Mol Genet 22 (5), 419-424 (1996)
   PUBMED   9039850
REFERENCE   8  (bases 1 to 6309)
  AUTHORS   Leon,C., Vial,C., Cazenave,J.P. and Gachet,C.
  TITLE     Cloning and sequencing of a human cDNA encoding endothelial P2Y1
            purinoceptor
  JOURNAL   Gene 171 (2), 295-297 (1996)
   PUBMED   8666290
REFERENCE   9  (bases 1 to 6309)
  AUTHORS   Janssens,R., Communi,D., Pirotton,S., Samson,M., Parmentier,M. and
            Boeynaems,J.M.
  TITLE     Cloning and tissue distribution of the human P2Y1 receptor
  JOURNAL   Biochem Biophys Res Commun 221 (3), 588-593 (1996)
   PUBMED   8630005
REFERENCE   10 (bases 1 to 6309)
  AUTHORS   Ayyanathan,K., Webbs,T.E., Sandhu,A.K., Athwal,R.S., Barnard,E.A.
            and Kunapuli,S.P.
  TITLE     Cloning and chromosomal localization of the human P2Y1 purinoceptor
  JOURNAL   Biochem Biophys Res Commun 218 (3), 783-788 (1996)
   PUBMED   8579591
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA453416.1, DA396016.1,
            U42030.1, AC013251.19 and AK026659.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002563.4.
            
            Summary: The product of this gene belongs to the family of
            G-protein coupled receptors. This family has several receptor
            subtypes with different pharmacological selectivity, which overlaps
            in some cases, for various adenosine and uridine nucleotides. This
            receptor functions as a receptor for extracellular ATP and ADP. In
            platelets binding to ADP leads to mobilization of intracellular
            calcium ions via activation of phospholipase C, a change in
            platelet shape, and probably to platelet aggregation. [provided by
            RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: SRR1803615.19852.1, SRR1660805.223567.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000305097.6/ ENSP00000304767.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 DA453416.1         439-443
            6-142               DA396016.1         6-142
            143-580             DA396016.1         144-581
            581-2847            U42030.1           66-2332
            2848-4259           AC013251.19        63532-64943
            4260-5686           AK026659.1         1-1427
            5687-6309           AK026659.1         1429-2051
FEATURES             Location/Qualifiers
     source          1..6309
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.2"
     gene            1..6309
                     /gene="P2RY1"
                     /gene_synonym="P2Y1; SARCC"
                     /note="purinergic receptor P2Y1"
                     /db_xref="GeneID:5028"
                     /db_xref="HGNC:HGNC:8539"
                     /db_xref="MIM:601167"
     exon            1..6309
                     /gene="P2RY1"
                     /gene_synonym="P2Y1; SARCC"
                     /inference="alignment:Splign:2.1.0"
     CDS             653..1774
                     /gene="P2RY1"
                     /gene_synonym="P2Y1; SARCC"
                     /note="purinergic receptor P2Y, G-protein coupled, 1; ATP
                     receptor; P2 purinoceptor subtype Y1; platelet ADP
                     receptor; suppressing androgen receptor in renal cell
                     carcinoma"
                     /codon_start=1
                     /product="P2Y purinoceptor 1"
                     /protein_id="NP_002554.1"
                     /db_xref="CCDS:CCDS3169.1"
                     /db_xref="GeneID:5028"
                     /db_xref="HGNC:HGNC:8539"
                     /db_xref="MIM:601167"
                     /translation="MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCAL
                     TKTGFQFYYLPAVYILVFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVL
                     TLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSL
                     GRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYS
                     MCTTVAMFCVPLVLILGCYGLIVRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPF
                     HVMKTMNLRARLDFQTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRR
                     LSRATRKASRRSEANLQSKSEDMTLNILPEFKQNGDTSL"
     regulatory      6290..6295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RY1"
                     /gene_synonym="P2Y1; SARCC"
                     /note="hexamer: AATAAA"
     polyA_site      6309
                     /gene="P2RY1"
                     /gene_synonym="P2Y1; SARCC"
                     /note="major polyA site"
ORIGIN      
        1 actccggaca gagctgggcc tggggaaggg gttcctgaac tacgcggacg ccgaacggga
       61 cgcgctgcag aagcgcacga gtctgcggcc acgcgcgctc cgatggctgc caggagctga
      121 gctcagggtg ggcggaggaa gcggttagac gccccgaaac tgagctgcac gtttctaagg
      181 tagggaggag gaagatgccc ccaattaagt tgatctttga gccaaggagg ctggggagca
      241 gcctccccaa gctagagccc tgcagagcga gtttcccttg acctcgctgc gcctctggcg
      301 cgctctgcag cgcggacccg cggcccctcg ggaaagcgca gtcggaaagt tatccgcggc
      361 ggttccctgc gcgccctgtt gtgtaagctc ggcgttgcca gcggacggag aagttgctgg
      421 cttgcccgat agcccagttc ggtggcggcc cggggcggat ttcatggccc gcggcgaacg
      481 cggggccaga gctggcgtgg gcgagcccct gcgcgccccc tcccgcgggg atccagttcg
      541 cctgctccct tccgctcgct ggcttttccg atgcttgctg cgcccctggc cgccgctgcc
      601 ctctcgccgc ctcctacccc tcggagccgc cgcctaagtc gaggaggaga gaatgaccga
      661 ggtgctgtgg ccggctgtcc ccaacgggac ggacgctgcc ttcctggccg gtccgggttc
      721 gtcctggggg aacagcacgg tcgcctccac tgccgccgtc tcctcgtcgt tcaaatgcgc
      781 cttgaccaag acgggcttcc agttttacta cctgccggct gtctacatct tggtattcat
      841 catcggcttc ctgggcaaca gcgtggccat ctggatgttc gtcttccaca tgaagccctg
      901 gagcggcatc tccgtgtaca tgttcaattt ggctctggcc gacttcttgt acgtgctgac
      961 tctgccagcc ctgatcttct actacttcaa taaaacagac tggatcttcg gggatgccat
     1021 gtgtaaactg cagaggttca tctttcatgt gaacctctat ggcagcatct tgtttctgac
     1081 atgcatcagt gcccaccggt acagcggtgt ggtgtacccc ctcaagtccc tgggccggct
     1141 caaaaagaag aatgcgatct gtatcagcgt gctggtgtgg ctcattgtgg tggtggcgat
     1201 ctcccccatc ctcttctact caggtaccgg ggtccgcaaa aacaaaacca tcacctgtta
     1261 cgacaccacc tcagacgagt acctgcgaag ttatttcatc tacagcatgt gcacgaccgt
     1321 ggccatgttc tgtgtcccct tggtgctgat tctgggctgt tacggattaa ttgtgagagc
     1381 tttgatttac aaagatctgg acaactctcc tctgaggaga aaatcgattt acctggtaat
     1441 cattgtactg actgtttttg ctgtgtctta catccctttc catgtgatga aaacgatgaa
     1501 cttgagggcc cggcttgatt ttcagacccc agcaatgtgt gctttcaatg acagggttta
     1561 tgccacgtat caggtgacaa gaggtctagc aagtctcaac agttgtgtgg accccattct
     1621 ctatttcttg gcgggagata ctttcagaag gagactctcc cgagccacaa ggaaagcttc
     1681 tagaagaagt gaggcaaatt tgcaatccaa gagtgaagac atgaccctca atattttacc
     1741 tgagttcaag cagaatggag atacaagcct gtgaaggcac aagaatctcc aaacacctct
     1801 ctgttgtaat atggtaggat gcttaacaga atcaagtact tttcccctct ttaactttct
     1861 agtttagaaa aaaatcaaac caagaaaata gtgagttaaa aaaataatag aagtagaaat
     1921 gcccacatcc acacttagct tgtttgggtt tgctttcaca gtctctcttc cttctgacta
     1981 gaagtatgta taataaaaca atactaccta gttaaacatt tactttctct tttgccttta
     2041 aaatgtgcag gcttttctgt ttaaagtgtg tgtgcacatg agtactgggg ctgtttttga
     2101 tattagtaat ttctctaaga aaactagccc cctgcaactt gagtttgtgg tttatctagc
     2161 ctttattgtt tttttaaaat ccacagtagg aataaaaaat ctatattctc agaaatatct
     2221 agcatggtat ataacaaaac actaaactca tcagttcatc cggcatcaga tcaatggatc
     2281 tctgagcggg gtgttttttt cagtgtctta taagcataga tgatagttga ctgagtttct
     2341 ttagggcatt gaatagacaa gtaaagctaa tgaatttaaa agcctgaaaa gtgattgttt
     2401 tccagttatt tctggaaaag gtctcattat atattgggtg ctaaatgttt gatggggaaa
     2461 gcctgcatat attatcgtac tggtaaaatg cattcaaaat aattaaagtg catgtatttt
     2521 ccttgtaaac accatgagct ctcttagaca tcttgtgata aagagcattt acttgcccca
     2581 ctgctgtgca atgccttagg actttgtttg tgttccagga caagtgttca ctcacatctg
     2641 taaaaacaat tttaagaatt gcaaataaat tacagaccaa agattgagta aagtcaaata
     2701 actgttagta agttgaagga tattggacag gaggacagta tttcagaaaa ggagaggttg
     2761 acagtcatcc acaaggcata gcctccaagt atactctcaa atgtatgaag caactggggt
     2821 gggcagaaga cattttagaa tgagggcttt agtttaaatt aaagtcatgg tggagaagac
     2881 tcttgcttcc tccaagtgtt tgaaaacaca aaatgcgata tgaaaagaag aaatagaatt
     2941 tgtataggtt gcattgatag aatgggaagc tataatcttt gaataaacct tacatctcaa
     3001 tatttaaaga aaaaacatat atatggaggg aaatatagag aattaaagta cctagatgcc
     3061 atagcactga aaagtaaagt actactcaaa ctactaatag aagactattg gtcagtgttt
     3121 tctattatat ttgttctctg ccaggtgtta atgaaaaatt tgtaaaatgc ttcaacagtg
     3181 ttaataattt taatgaatat tgaattgctg catgtctagt ccttgaaatg gtcaaattct
     3241 atataatgag aataacaagg tgagataatg caattgacaa tcccaaacaa atccagtgtc
     3301 aaaggaattt ttagttttgg aagctatccc tcataaagtc aacatcagag tttgcaactg
     3361 atggtggcat aacttgtttg aaagcacttt acaagtagag caacatgggg ctgtatgtta
     3421 aggcaagaaa gaaccttagt gccccgtgga ccataatgac aggaaatttt caggtcttga
     3481 tttcagttct tgcaatgcct atgtagattg aggatttgtg agaccttcag agtagcttca
     3541 ctttacccaa tctctggcca ctaagatcaa tgaagaaaag ctgtatttaa ccttccaaag
     3601 cagtgattct ttttacatgt tcagttttaa tgcataggat tatagaaacc aaatcaagaa
     3661 gaaacctact acacctcctt attttgagga aagagagggt tagcaaagtt ctcacttcat
     3721 caggctcaaa taacatccgt tttagattcc tacaagacaa aatctaaaat atgtcattac
     3781 tttattgacc ttgttaaaca agatcaatat cattaaactg accaagatgg aaattacagg
     3841 acttgtacca gacttgaact tgtagcctaa tgatacacat ttttacaata tttcttcacc
     3901 atttagtttt ctttctttta ggtctcagga tgctcagctt aatttagagt atgtgttaag
     3961 tacattgttt cagcgtccag agaattttgt gagtgtggat ccagtgagga ggtgaacagt
     4021 aactagaaat gcttgtttac tacttggcat gttttttcca aagtgtttct tctttagctt
     4081 catacatcac atatggacac tgatgacatg tgaatgcatg ccacatagta acaagaatga
     4141 tcttgccaac tccttccaag ccaaaagaag cctctgggaa ggtgtgccaa tggtgaaaac
     4201 gtacagaggg tcagggtgaa gcagtgatct ctattggctg aaaaactgat caggtcatat
     4261 gatgattgaa gtatgtttat tgtaagggca gaaatgtgtt ggcatttgga taaaaaactg
     4321 ctaacattat agaacttatt acctaacaaa atttcacacc acaaaaaata ttttaatggc
     4381 aaattcaagg tgttttattg cttacaaatc agcatctttg actctttgaa catcaatttg
     4441 tgtttacatt gaaatgacaa aaagacaaac taagaagaaa tacagcatgc aagttggaat
     4501 tcagagttaa aaccatgatg ttgccgctca gccagctatg tgactgttga ccctttcaag
     4561 aacacacatg gatttaaaag ttggatgaca tccattgttg gggccttggg ggatatggta
     4621 aagcatgaaa actaaacagc caggagcctg tgaaatctgc tactgtattt tccaggactt
     4681 cattccactc cttggctaaa aaaatcttgg aagtttcaca gattatgatg tggacctgtc
     4741 acctgtaaat tgtctcaatc tactcagaca agacactaaa ctgtctttgg atactataga
     4801 tgtcagtgct tatagcagct ggaatttggc tagtgacaat gtttaaagat gtaatactag
     4861 ttagtatcta ttgaagctta aactttgctg gtcaggttgt agctattgta aaagtattta
     4921 ttgaagaagc tcacagtcct tcagttgtac agactgaaaa actttcatga aagatccaac
     4981 atactaatgt aaattatatt tattacaatg tatgatatta atgtgtcaaa ctggtgtatt
     5041 ttacaaaata tataatgcat acataaataa gagttgtata ttacagtgct tttcaaatat
     5101 cagtgtcttg gaatatttaa gtcttcacat tttttggtct aaaatatgaa aatgtttcat
     5161 gatacaagtg attaattttc cctagtagtg cttttgcatg tttgcctttt tatttaagtt
     5221 tttttctata tagacacaat ttggtgtcag actatcataa gatcgatagt gaatataaaa
     5281 tatcttagcc aaatggggtc tgtattgtct acattttata tattaaataa aagtttttgt
     5341 tgtcttttca ggaggtttag agtattgtca ctaaatatga tcaaagcttc cctttccaaa
     5401 tgcaaaagtc ttgtcctaca tttaaagttg atctgtcatg ttttagcagt caagtgggat
     5461 gggcattata taaacaacgt tacaatgtaa ggaaaatctt taaggagatg gggagagaaa
     5521 aaggcagctg gtataatcgg ttactgctgc ttagttctac ttaatttttt gtgttgcttc
     5581 ttcttaaggt gagatagcat aatcttaact gttttgagat ggaattttaa agtaacacac
     5641 taccagcgag ttcaacactg ctattgattt taatctgttt ttttttgttt agttgataac
     5701 ttaaattcca agtttcatag tgataattgt atattatttg gctgctgaat tctgttagag
     5761 ttttttattc tgttgtacat tgtattatac acataatcac aaattaatat gaaggtgaat
     5821 atatgttaca tatcaaaatt tgtgaatttg aattatagta tgttttagtg ctattgcaaa
     5881 aaatgtttat ttttatatta tctgtgattt taatatagat gattgaacta gatttctttt
     5941 tgagtgatag tgccattgaa tgagcagtat ggaaacagtg ttacttgata ttttgagctt
     6001 tctcaggttt atctaaatca gtggtagctt aacaaaaccc agactaattg tgtgtaattg
     6061 tatttttaat aaaaggaaag tacatttcct ataatagcat agtactgttt gcatgtaaga
     6121 gtatgcaaaa ccttgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtct tagtgtgtgt
     6181 aaggcatggc agccaacttt gtatctgcta tttttagtac gagcagagct tcataattgt
     6241 ggtcactaga actgtactta ccatggacag ttaaaactga aaaagactca ataaaactat
     6301 gaaacatgg
//
