LOCUS       NM_002558               2662 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens purinergic receptor P2X 1 (P2RX1), mRNA.
ACCESSION   NM_002558
VERSION     NM_002558.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Oken,A.C., Lisi,N.E., Ditter,I.A., Shi,H., Nechiporuk,N.A. and
            Mansoor,S.E.
  TITLE     Cryo-EM structures of the human P2X1 receptor reveal
            subtype-specific architecture and antagonism by supramolecular
            ligand-binding
  JOURNAL   Nat Commun 15 (1), 8490 (2024)
   PUBMED   39353889
  REMARK    GeneRIF: Cryo-EM structures of the human P2X1 receptor reveal
            subtype-specific architecture and antagonism by supramolecular
            ligand-binding.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Yu,Y., Chang,L., Hu,Q., Zhu,J., Zhang,J., Xia,Q. and Zhao,J.
  TITLE     P2rx1 deficiency alleviates acetaminophen-induced acute liver
            failure by regulating the STING signaling pathway
  JOURNAL   Cell Biol Toxicol 39 (6), 2761-2774 (2023)
   PUBMED   37046119
  REMARK    GeneRIF: P2rx1 deficiency alleviates acetaminophen-induced acute
            liver failure by regulating the STING signaling pathway.
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   He,X., Xu,Y., Huang,D., Yu,Z., Yu,J., Xie,L., Liu,L., Yu,Y.,
            Chen,C., Wan,J., Zhang,Y. and Zheng,J.
  TITLE     P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways
  JOURNAL   Leukemia 37 (2), 265-275 (2023)
   PUBMED   36418376
  REMARK    GeneRIF: P2X1 enhances leukemogenesis through PBX3-BCAT1 pathways.
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Vargas-Martinez,E.M., Gomez-Coronado,K.S., Espinosa-Luna,R.,
            Valdez-Morales,E.E., Barrios-Garcia,T., Barajas-Espinosa,A.,
            Ochoa-Cortes,F., Montano,L.M., Barajas-Lopez,C. and
            Guerrero-Alba,R.
  TITLE     Functional expression of P2X1, P2X4 and P2X7 purinergic receptors
            in human monocyte-derived macrophages
  JOURNAL   Eur J Pharmacol 888, 173460 (2020)
   PUBMED   32805257
  REMARK    GeneRIF: Functional expression of P2X1, P2X4 and P2X7 purinergic
            receptors in human monocyte-derived macrophages.
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   Dhulipala,P.D., Lianos,E.A. and Kotlikoff,M.I.
  TITLE     Regulation of human P2X1 promoter activity by beta helix-loop-helix
            factors in smooth muscle cells
  JOURNAL   Gene 269 (1-2), 167-175 (2001)
   PUBMED   11376948
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Sun,B., Li,J., Okahara,K. and Kambayashi,J.
  TITLE     P2X1 purinoceptor in human platelets. Molecular cloning and
            functional characterization after heterologous expression
  JOURNAL   J Biol Chem 273 (19), 11544-11547 (1998)
   PUBMED   9565569
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Evans,R.J., Lewis,C., Virginio,C., Lundstrom,K., Buell,G.,
            Surprenant,A. and North,R.A.
  TITLE     Ionic permeability of, and divalent cation effects on, two
            ATP-gated cation channels (P2X receptors) expressed in mammalian
            cells
  JOURNAL   J Physiol 497 (Pt 2) (Pt 2), 413-422 (1996)
   PUBMED   8961184
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Longhurst,P.A., Schwegel,T., Folander,K. and Swanson,R.
  TITLE     The human P2x1 receptor: molecular cloning, tissue distribution,
            and localization to chromosome 17
  JOURNAL   Biochim Biophys Acta 1308 (3), 185-188 (1996)
   PUBMED   8809107
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Valera,S., Talabot,F., Evans,R.J., Gos,A., Antonarakis,S.E.,
            Morris,M.A. and Buell,G.N.
  TITLE     Characterization and chromosomal localization of a human P2X
            receptor from the urinary bladder
  JOURNAL   Recept Channels 3 (4), 283-289 (1995)
   PUBMED   8834001
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Zschauer,A., van Breemen,C., Buhler,F.R. and Nelson,M.T.
  TITLE     Calcium channels in thrombin-activated human platelet membrane
  JOURNAL   Nature 334 (6184), 703-705 (1988)
   PUBMED   2457808
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX644575.1, BC044657.1 and
            AC005940.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002558.3.
            
            Summary: The protein encoded by this gene belongs to the P2X family
            of G-protein-coupled receptors. These proteins can form homo-and
            heterotimers and function as ATP-gated ion channels and mediate
            rapid and selective permeability to cations. This protein is
            primarily localized to smooth muscle where binds ATP and mediates
            synaptic transmission between neurons and from neurons to smooth
            muscle and may being responsible for sympathetic vasoconstriction
            in small arteries, arterioles and vas deferens. Mouse studies
            suggest that this receptor is essential for normal male
            reproductive function. This protein may also be involved in
            promoting apoptosis. [provided by RefSeq, Jun 2013].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044657.1, U45448.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147975, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000225538.4/ ENSP00000225538.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BX644575.1         116-139
            25-2629             BC044657.1         1-2605
            2630-2630           AC005940.3         83623-83623
            2631-2662           BC044657.1         2607-2638
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..2662
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="purinergic receptor P2X 1"
                     /db_xref="GeneID:5023"
                     /db_xref="HGNC:HGNC:8533"
                     /db_xref="MIM:600845"
     exon            1..377
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1440
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="P2X1 receptor; ATP receptor; P2X receptor, subunit
                     1; purinergic receptor P2X1; purinergic receptor P2X,
                     ligand gated ion channel, 1"
                     /codon_start=1
                     /product="P2X purinoceptor 1"
                     /protein_id="NP_002549.1"
                     /db_xref="CCDS:CCDS11040.1"
                     /db_xref="GeneID:5023"
                     /db_xref="HGNC:HGNC:8533"
                     /db_xref="MIM:600845"
                     /translation="MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYV
                     IGWVFLYEKGYQTSSGLISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVV
                     MTNFIVTPKQTQGYCAEHPEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCE
                     IFGWCPVEVDDDIPRPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCL
                     FHKTLHPLCPVFQLGYVVQESGQNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEF
                     HGLYEEKNLSPGFNFRFARHFVENGTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTT
                     IGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGAAERDLAATSSTLGL
                     QENMRTS"
     exon            378..525
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            526..597
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            598..667
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            668..764
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..845
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            846..987
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1115
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1206
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            1207..1272
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1374
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..2662
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1841..1846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="hexamer: AATAGA"
     polyA_site      1859
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="major polyA site"
     regulatory      2642..2647
                     /regulatory_class="polyA_signal_sequence"
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="hexamer: AATAAA"
     polyA_site      2662
                     /gene="P2RX1"
                     /gene_synonym="P2X1"
                     /note="major polyA site"
ORIGIN      
        1 agtctgttgc cttccagggg ccaagagctg ctctgatcac ccagggattc tctctccaac
       61 ccaagtgcct ccagctgacc tctggctcct gtcctctggc tccacctgca ccgccctgct
      121 cttcctaagg ggccaggaag cccccagaag ctctaccatc gacgtgggtg gtggcacccg
      181 gctcaccctg agagcagagg ccgtgcaggg ggctcagttc tgagccccag ccggcccacc
      241 atggcacggc ggttccagga ggagctggcc gccttcctct tcgagtatga caccccccgc
      301 atggtgctgg tgcgtaataa gaaggtgggc gttatcttcc gactgatcca gctggtggtc
      361 ctggtctacg tcatcgggtg ggtgtttctc tatgagaagg gctaccagac ctcgagcggc
      421 ctcatcagca gtgtctctgt gaaactcaag ggcctggccg tgacccagct ccctggcctc
      481 ggcccccagg tctgggatgt ggctgactac gtcttcccag cccaggggga caactccttc
      541 gtggtcatga ccaatttcat cgtgaccccg aagcagactc aaggctactg cgcagagcac
      601 ccagaagggg gcatatgcaa ggaagacagt ggctgtaccc ctgggaaggc caagaggaag
      661 gcccaaggca tccgcacggg caagtgtgtg gccttcaacg acactgtgaa gacgtgtgag
      721 atctttggct ggtgccccgt ggaggtggat gacgacatcc cgcgccctgc ccttctccga
      781 gaggccgaga acttcactct tttcatcaag aacagcatca gctttccacg cttcaaggtc
      841 aacaggcgca acctggtgga ggaggtgaat gctgcccaca tgaagacctg cctctttcac
      901 aagaccctgc accccctgtg cccagtcttc cagcttggct acgtggtgca agagtcaggc
      961 cagaacttca gcaccctggc tgagaagggt ggagtggttg gcatcaccat cgactggcac
     1021 tgtgacctgg actggcacgt acggcactgc agacccatct atgagttcca tgggctgtac
     1081 gaagagaaaa atctctcccc aggcttcaac ttcaggtttg ccaggcactt tgtggagaac
     1141 gggaccaact accgtcacct cttcaaggtg tttgggattc gctttgacat cctggtggac
     1201 ggcaaggccg ggaagtttga catcatccct acaatgacca ccatcggctc tggaattggc
     1261 atctttgggg tggccacagt tctctgtgac ctgctgctgc ttcacatcct gcctaagagg
     1321 cactactaca agcagaagaa gttcaaatac gctgaggaca tggggccagg ggcggctgag
     1381 cgtgacctcg cagctaccag ctccaccctg ggcctgcagg agaacatgag gacatcctga
     1441 tgctcgggcc ccaactcctg actgggtgca gcgtgaggct tcagcctgga gccctggtgg
     1501 gtcccagcca gggcagaggg gcctccccag gaagtctcct accctctcag ccaggcagag
     1561 agcagtttgc cagaagctca gggtgcatag taggagagac ctgtgcaaat ctgagctccg
     1621 gctccgaccc cacacaccct gagggagccc taccctagcc tcagccgctc ctggtgggga
     1681 atggctgggg ctgggcagga ccctcccaca cacctgcacc ctagcttcgt gcttctctct
     1741 ccggactctc attatccaac ccgctgcctc catttctcta gatctgtgct ctccgatgtg
     1801 gcagtcagta accataggtg actaaattaa actaaaataa aatagaatga aacacaaaat
     1861 tcaattcctc ggctgaacta gccacatttc aactgctcag tagatacgtg tggttagtgg
     1921 ctgccatact ggacagctcg gggcattttc actgtcaaag aaagttctat tagacagccc
     1981 tgcttgagcc ctgtttcttc ctggccttcg gtttccctgg ggaacttatc gacaatgcaa
     2041 gctcctgggc ccacccccag acctcctgaa ccaaaagctc cagggctggc cgtatgatct
     2101 gtgtggatgg caaactcccc aggccattct gggacctaag tttaagaagt gccgtcctcg
     2161 aactttctga ctctaagctc ctgagcggga gtcagactta gccctgagcc tgcacttcct
     2221 gttcaggtgc agacactgaa cagggtctca aacaccttca gcatgtgtgt tgtgtgctca
     2281 cgtgccacac agtgtctcat gcacacaacc cagtgtacac accacctacg tgcacacagc
     2341 atccttccac actgtgtatg tgaacagctt gggccctgca aacacaacca tctacacaca
     2401 tctacacccc caagcacaca cacatggtcc gtgccatgtc acctccatag ggaaaggctt
     2461 ctctccaagt gtgccaggcc aggacagccc tcccagccat gaatccttac tcagctacct
     2521 cgggttgggg tgggagcccc agccaaatcc tgggctccct gcctgtggct cagccccagc
     2581 tcccaaggcc tgcctggctc tgtctgaaca gaaggtctgg gggaagcgac gggtggagta
     2641 caataaaggg aatgaggaca aa
//
