LOCUS       NM_000916               4387 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens oxytocin receptor (OXTR), transcript variant 1, mRNA.
ACCESSION   NM_000916
VERSION     NM_000916.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4387)
  AUTHORS   Liu,H., Yang,G. and Wang,H.
  TITLE     Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal
            System: Mechanisms and Therapeutic Potential
  JOURNAL   Int J Mol Sci 25 (20), 10935 (2024)
   PUBMED   39456718
  REMARK    GeneRIF: Oxytocin/Oxytocin Receptor Signalling in the
            Gastrointestinal System: Mechanisms and Therapeutic Potential.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4387)
  AUTHORS   Lammers,S.M., Peczkowski,K.K., Patel,N., Abdelwahab,M.,
            Summerfield,T.L., Costantine,M.M., Janssen,P.M.L., Kniss,D.A. and
            Frey,H.A.
  TITLE     Maternal Body Mass Index, Myometrium Contractility and Uterotonic
            Receptor Expression in Pregnancy
  JOURNAL   Reprod Sci 31 (10), 3016-3025 (2024)
   PUBMED   39060750
  REMARK    GeneRIF: Maternal Body Mass Index, Myometrium Contractility and
            Uterotonic Receptor Expression in Pregnancy.
REFERENCE   3  (bases 1 to 4387)
  AUTHORS   Rilling,J.K., Lee,M., Zhou,C., Gonzalez,A. and Lindo,J.
  TITLE     Grandmotherhood is associated with reduced OXTR DNA methylation
  JOURNAL   Psychoneuroendocrinology 168, 107122 (2024)
   PUBMED   39002451
  REMARK    GeneRIF: Grandmotherhood is associated with reduced OXTR DNA
            methylation.
REFERENCE   4  (bases 1 to 4387)
  AUTHORS   Danoff,J.S., Lillard,T.S., Myatt,L., Connelly,J.J. and
            Erickson,E.N.
  TITLE     A Common OXTR Risk Variant Alters Regulation of Gene Expression by
            DNA Hydroxymethylation in Pregnant Human Myometrium
  JOURNAL   Reprod Sci 31 (10), 3132-3138 (2024)
   PUBMED   38862858
  REMARK    GeneRIF: A Common OXTR Risk Variant Alters Regulation of Gene
            Expression by DNA Hydroxymethylation in Pregnant Human Myometrium.
REFERENCE   5  (bases 1 to 4387)
  AUTHORS   Cuyvers,B., Ein-Dor,T., Houbrechts,M., Freson,K., Goossens,L., Van
            Den Noortgate,W., van Leeuwen,K., Bijttebier,P., Claes,S.,
            Turner,J., Chubar,V., Bakermans-Kranenburg,M.J. and Bosmans,G.
  TITLE     Exploring the role of OXTR gene methylation in attachment
            development: A longitudinal study
  JOURNAL   Dev Psychobiol 66 (5), e22496 (2024)
   PUBMED   38689124
  REMARK    GeneRIF: Exploring the role of OXTR gene methylation in attachment
            development: A longitudinal study.
REFERENCE   6  (bases 1 to 4387)
  AUTHORS   Simmons,C.F. Jr., Clancy,T.E., Quan,R. and Knoll,J.H.
  TITLE     The oxytocin receptor gene (OXTR) localizes to human chromosome
            3p25 by fluorescence in situ hybridization and PCR analysis of
            somatic cell hybrids
  JOURNAL   Genomics 26 (3), 623-625 (1995)
   PUBMED   7607693
REFERENCE   7  (bases 1 to 4387)
  AUTHORS   Inoue,T., Kimura,T., Azuma,C., Inazawa,J., Takemura,M., Kikuchi,T.,
            Kubota,Y., Ogita,K. and Saji,F.
  TITLE     Structural organization of the human oxytocin receptor gene
  JOURNAL   J Biol Chem 269 (51), 32451-32456 (1994)
   PUBMED   7798245
REFERENCE   8  (bases 1 to 4387)
  AUTHORS   Kjaer,A., Knigge,U. and Warberg,J.
  TITLE     Histamine- and stress-induced prolactin secretion: importance of
            vasopressin V1- and V2-receptors
  JOURNAL   Eur J Endocrinol 131 (4), 391-397 (1994)
   PUBMED   7921229
REFERENCE   9  (bases 1 to 4387)
  AUTHORS   Mayerhofer,A., Sterzik,K., Link,H., Wiemann,M. and Gratzl,M.
  TITLE     Effect of oxytocin on free intracellular Ca2+ levels and
            progesterone release by human granulosa-lutein cells
  JOURNAL   J Clin Endocrinol Metab 77 (5), 1209-1214 (1993)
   PUBMED   8077313
REFERENCE   10 (bases 1 to 4387)
  AUTHORS   Kimura,T., Tanizawa,O., Mori,K., Brownstein,M.J. and Okayama,H.
  TITLE     Structure and expression of a human oxytocin receptor
  JOURNAL   Nature 356 (6369), 526-529 (1992)
   PUBMED   1313946
  REMARK    Erratum:[Nature 1992 May 14;357(6374):176]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC068312.5.
            
            On Aug 11, 2020 this sequence version replaced NM_000916.3.
            
            Summary: The protein encoded by this gene belongs to the G-protein
            coupled receptor family and acts as a receptor for oxytocin. Its
            activity is mediated by G proteins which activate a
            phosphatidylinositol-calcium second messenger system. The
            oxytocin-oxytocin receptor system plays an important role in the
            uterus during parturition. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1-5 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.1392539.1, X64878.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316793.8/ ENSP00000324270.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 5' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               AC068312.5         98992-99374         c
            384-479             AC068312.5         98257-98352         c
            480-1543            AC068312.5         97027-98090         c
            1544-4387           AC068312.5         80142-82985         c
FEATURES             Location/Qualifiers
     source          1..4387
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..4387
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="oxytocin receptor"
                     /db_xref="GeneID:5021"
                     /db_xref="HGNC:HGNC:8529"
                     /db_xref="MIM:167055"
     exon            1..383
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /inference="alignment:Splign:2.1.0"
     exon            384..479
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /inference="alignment:Splign:2.1.0"
     exon            480..1543
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..1791
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /codon_start=1
                     /product="oxytocin receptor"
                     /protein_id="NP_000907.2"
                     /db_xref="CCDS:CCDS2570.1"
                     /db_xref="GeneID:5021"
                     /db_xref="HGNC:HGNC:8529"
                     /db_xref="MIM:167055"
                     /translation="MEGALAANWSAEAANASAAPPGAEGNRTAGPPRRNEALARVEVA
                     VLCLILLLALSGNACVLLALRTTRQKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDIT
                     FRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLAT
                     WLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYITWITLAVYIVPVIVLAA
                     CYGLISFKIWQNLRLKTAAAAAAEAPEGAAAGDGGRVALARVSSVKLISKAKIRTVKM
                     TFIIVLAFIVCWTPFFFVQMWSVWDANAPKEASAFIIVMLLASLNSCCNPWIYMLFTG
                     HLFHELVQRFLCCSASYLKGRRLGETSASKKSNSSSFVLSHRSSSQRSCSQPSTA"
     exon            1544..4387
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2700..2705
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="hexamer: AACAAG"
     polyA_site      2734
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="major polyA site"
     regulatory      4351..4356
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="hexamer: AATAAA"
     regulatory      4355..4360
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="hexamer: AACAAA"
     polyA_site      4374
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="major polyA site"
     polyA_site      4387
                     /gene="OXTR"
                     /gene_synonym="OT-R; OTR"
                     /note="major polyA site"
ORIGIN      
        1 gttaaggctc tgggaccaac gctgggcgaa ccagctccgc tccggagggg tctgcgcggc
       61 tggcctcgcc cgccccctag cggacccgtg cgatagtgca gcctcagccc cagcgcacag
      121 cgccgcatcc agacgctgtc cgcgcgcgca gcctgggagg cgctcctcgc tcgcctcctg
      181 tacccatcca gcgaccagcc aggctgcggc gaggggattc caaccgaggc tccagtgaga
      241 gacctcagct tagcatcaca ttaggtgcag ccggcaggcc atcccaactc gggccgggag
      301 cgcacgcgtc actggggccg tcagtcgccg tgcaacttcc ccggggggag tcaactttag
      361 gttcgcctgc ggactcggtg cagtggaagc cgctgaacat cccgaggaac tggcacgctg
      421 ggggctctgg gcttgtggcc ggtagaggat tcccgctcat ttgcagtggc tcagaggagg
      481 gtggacccag cagatccgtc cgtggagtct ccaggagtgg agccccgggc gcccctacac
      541 cctccgacac gccggatccg gcccagccgc gccaagccgt aaagggctcg aaggccgggg
      601 cgcaccgctg ccgccagggt catggagggc gcgctcgcag ccaactggag cgccgaggca
      661 gccaacgcca gcgccgcgcc gccgggggcc gagggcaacc gcaccgccgg acccccgcgg
      721 cgcaacgagg ccctggcgcg cgtggaggtg gcggtgctgt gtctcatcct gctcctggcg
      781 ctgagcggga acgcgtgtgt gctgctggcg ctgcgcacca cacgccagaa gcactcgcgc
      841 ctcttcttct tcatgaagca cctaagcatc gccgacctgg tggtggcagt gtttcaggtg
      901 ctgccgcagt tgctgtggga catcaccttc cgcttctacg ggcccgacct gctgtgccgc
      961 ctggtcaagt acttgcaggt ggtgggcatg ttcgcctcca cctacctgct gctgctcatg
     1021 tccctggacc gctgcctggc catctgccag ccgctgcgct cgctgcgccg ccgcaccgac
     1081 cgcctggcag tgctcgccac gtggctcggc tgcctggtgg ccagcgcgcc gcaggtgcac
     1141 atcttctctc tgcgcgaggt ggctgacggc gtcttcgact gctgggccgt cttcatccag
     1201 ccctggggac ccaaggccta catcacatgg atcacgctag ctgtctacat cgtgccggtc
     1261 atcgtgctcg ctgcctgcta cggccttatc agcttcaaga tctggcagaa cttgcggctc
     1321 aagaccgctg cagcggcggc ggccgaggcg ccagagggcg cggcggctgg cgatgggggg
     1381 cgcgtggccc tggcgcgtgt cagcagcgtc aagctcatct ccaaggccaa gatccgcacg
     1441 gtcaagatga ctttcatcat cgtgctggcc ttcatcgtgt gctggacgcc tttcttcttc
     1501 gtgcagatgt ggagcgtctg ggatgccaac gcgcccaagg aagcctcggc cttcatcatc
     1561 gtcatgctcc tggccagcct caacagctgc tgcaacccct ggatctacat gctgttcacg
     1621 ggccacctct tccacgaact cgtgcagcgc ttcctgtgct gctccgccag ctacctgaag
     1681 ggcagacgcc tgggagagac gagtgccagc aaaaagagca actcgtcctc ctttgtcctg
     1741 agccatcgca gctccagcca gaggagctgc tcccagccat ccacggcgtg acccaccagc
     1801 cagggccagg gctgcagcct gaggctcagg ctgtgctggc ataagtgctc tgctcctagg
     1861 tgatggcgta tgtttgtgta taaggtacct atcagtttgt atccctcccc tccttggggt
     1921 ggcttcagtg gggtggagag tggcctccat gatggaagat gataggggac tcagccatca
     1981 gacaacaccc tggcctccta cacgtacttc taccaccctg aacccactgc tgccctgggc
     2041 agtgagtggc ttgttttttc tcctggactt gtaatttcac tccagtatat ttttacttct
     2101 tcattctggg atattgtgaa aagcggtaaa tataggattg gtgaccaatt gggtcaggaa
     2161 gtccagtgtt ctggacttgg ggtaagcagt ggggttggga cctcagatgg gaagggtggt
     2221 gctaagatcc tcctgacctc aaagtgtatt tgcctttaag cgaacaaatg ctggggtcct
     2281 tggggaccag cttgtcagag ggtagcccta agagaagggg attaccttgt aagaccatct
     2341 ggcgcagtgg acctattaga acttgggtta aaaatgttta agaagctaat gtttaagaag
     2401 catttgggaa agaaaaagaa ataaatgtat ccagatagga aaagaagaag taaaactatt
     2461 tgcagatgac acagttttgt atatagaaaa tcctaaggaa ctcacacaca cacacacaca
     2521 cacacacgca cacagctatt agaactaata agcaagttcc gcaaggtttc aagatacaag
     2581 atcaatatac aaaaatgaat tgtatttctt tatactagca acaaacaata tgaaaacgaa
     2641 gttaaataat tccatttata ataccatcag aaagaataaa ataggaatca acttaacaaa
     2701 acaagtgcaa gactgaaaac tacaaaattg gaaagaaatt aaagaaggct taaataaatg
     2761 gaaagacatc ctgtgttcat ggatcagact tagtattgtt aagatggcaa tactatccta
     2821 actgacatgc agattcagtg caatccttat gaaaatcata gctggcttct ttacagaaat
     2881 tgataagcta gtcccaaaat tcataaagaa atgcaaggga cccagaatat ccaaataagc
     2941 cttgaaaaag aacaaagttg gtggattcac acttcctgat ttcataattt acgataaagg
     3001 taatcagctc agtgtgttac tggtttaagg atagacatac ggagcagaat aaagagtaca
     3061 gatatgaaca cttatactta cggtcaattg atttttgaca aggttcccaa gacaattcaa
     3121 tagagaaagg agagtctttt caacaaatgg caccgagaca atgatatgca agtgcaaaag
     3181 aatgaggttg gacctttact cacactatgt gcaaaaatca actcaaaacg catccaagat
     3241 ctaaatataa gagctgaaac tataaaatct tagaaagaaa cataggcata gatctttgta
     3301 accttgaatt aggcagtggt ttcttagata tgataccaaa gacacaagca accaatggaa
     3361 aaataggtaa attggactta atcaagattt gaagcttttg tgattgaaaa gaccctatca
     3421 agaaggtgaa aagataacct gcagaatggg agaaaatatt tgcgagtcat atatatgata
     3481 aggggcttgt atctggaata tataaataac tcttataaca caacaataag gagaaaaata
     3541 aatcaattta aaaaatgggc taacggtttg aatagacatt tctccaaaga agatatgcaa
     3601 atggctacta agcacatgaa aaaatactca acattattat tcattaggga aatgcaagtc
     3661 aaaatcacaa tgagattcca gtttacaatc actaggatgg ctacaataaa aagatggaca
     3721 agaacgagtg tcggtgagga tgtagagaaa ctggtagaaa tttaaattgt tggtgggaat
     3781 gtaaatggtg cacctgcttt gaaaaacagt ttggcagtac ctcaaaaagt taaacgtaga
     3841 gtgaccatat gacccaggaa tgccactcct aggtatttac ccaagagaaa tgaaaacgta
     3901 catacacaca aaaacttgta caccaatgtt catagcaaca ttatttgtaa tagccaaaaa
     3961 gtggaaacaa cccaaatgtc taccaactga tgaatgggaa ataaaatgtg gtctgtccac
     4021 gcaatggaac attattagac tctaaaaaga aatgaagtac tcacacatgc cacaacatgg
     4081 atgagccttg aaaacttgct aagtgaaaga agccaggtgc aaaagcccac atattgtctg
     4141 actgcattga aatgcaatgt ctaaaatgga cgaatctata tagagtgaat atagattagc
     4201 gtttgccagg gcctggaggc tgtgagagat gaggcatgac tactaagggt ttggggtttc
     4261 tttttcgggt gatgaaaatg ttctgaaatt agtggtgatt gtgcacgatt ttgagaatgt
     4321 actaaaaacc aatgaacttt aaaaaataaa aataaacaaa aaaaattcaa cagatgaatt
     4381 cagagaa
//
