LOCUS       NM_000915                513 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens oxytocin/neurophysin I prepropeptide (OXT), mRNA.
ACCESSION   NM_000915
VERSION     NM_000915.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 513)
  AUTHORS   Liu,H., Yang,G. and Wang,H.
  TITLE     Oxytocin/Oxytocin Receptor Signalling in the Gastrointestinal
            System: Mechanisms and Therapeutic Potential
  JOURNAL   Int J Mol Sci 25 (20), 10935 (2024)
   PUBMED   39456718
  REMARK    GeneRIF: Oxytocin/Oxytocin Receptor Signalling in the
            Gastrointestinal System: Mechanisms and Therapeutic Potential.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 513)
  AUTHORS   Ding,S., Liu,Y., Tao,H., Zhao,Y., Zeng,H., Han,Y., Wang,S.,
            Chen,Z., Tang,Y. and Guo,W.
  TITLE     Chronic intranasal oxytocin alleviates cognitive impairment and
            reverses oxytocin signaling upregulation in MK801-induced mice
  JOURNAL   Psychoneuroendocrinology 168, 107138 (2024)
   PUBMED   39068687
  REMARK    GeneRIF: Chronic intranasal oxytocin alleviates cognitive
            impairment and reverses oxytocin signaling upregulation in
            MK801-induced mice.
REFERENCE   3  (bases 1 to 513)
  AUTHORS   Koyama,Y., Nawa,N., Ochi,M., Surkan,P.J. and Fujiwara,T.
  TITLE     Epistatic interactions between oxytocin- and dopamine-related genes
            and trust
  JOURNAL   PLoS One 19 (9), e0308728 (2024)
   PUBMED   39298414
  REMARK    GeneRIF: Epistatic interactions between oxytocin- and
            dopamine-related genes and trust.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 513)
  AUTHORS   Bie,P.
  TITLE     Plasma concentrations of peptide hormones: Unrealistic levels of
            vasopressin (AVP), oxytocin (OXT), and brain natriuretic peptide
            (BNP)
  JOURNAL   Acta Physiol (Oxf) 240 (9), e14200 (2024)
   PUBMED   39034759
  REMARK    GeneRIF: Plasma concentrations of peptide hormones: Unrealistic
            levels of vasopressin (AVP), oxytocin (OXT), and brain natriuretic
            peptide (BNP).
            Review article
REFERENCE   5  (bases 1 to 513)
  AUTHORS   Rao,V.V., Loffler,C., Battey,J. and Hansmann,I.
  TITLE     The human gene for oxytocin-neurophysin I (OXT) is physically
            mapped to chromosome 20p13 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 61 (4), 271-273 (1992)
   PUBMED   1486803
REFERENCE   6  (bases 1 to 513)
  AUTHORS   Ivell,R., Furuya,K., Brackmann,B., Dawood,Y. and Khan-Dawood,F.
  TITLE     Expression of the oxytocin and vasopressin genes in human and
            baboon gonadal tissues
  JOURNAL   Endocrinology 127 (6), 2990-2996 (1990)
   PUBMED   2249637
REFERENCE   7  (bases 1 to 513)
  AUTHORS   Rehbein,M., Hillers,M., Mohr,E., Ivell,R., Morley,S., Schmale,H.
            and Richter,D.
  TITLE     The neurohypophyseal hormones vasopressin and oxytocin. Precursor
            structure, synthesis and regulation
  JOURNAL   Biol Chem Hoppe Seyler 367 (8), 695-704 (1986)
   PUBMED   3768139
REFERENCE   8  (bases 1 to 513)
  AUTHORS   Wood,S.P., Tickle,I.J., Treharne,A.M., Pitts,J.E., Mascarenhas,Y.,
            Li,J.Y., Husain,J., Cooper,S., Blundell,T.L., Hruby,V.J. et al.
  TITLE     Crystal structure analysis of deamino-oxytocin: conformational
            flexibility and receptor binding
  JOURNAL   Science 232 (4750), 633-636 (1986)
   PUBMED   3008332
REFERENCE   9  (bases 1 to 513)
  AUTHORS   Sausville,E., Carney,D. and Battey,J.
  TITLE     The human vasopressin gene is linked to the oxytocin gene and is
            selectively expressed in a cultured lung cancer cell line
  JOURNAL   J Biol Chem 260 (18), 10236-10241 (1985)
   PUBMED   2991279
REFERENCE   10 (bases 1 to 513)
  AUTHORS   Koida,M. and Walter,R.
  TITLE     Post-proline cleaving enzyme. Purification of this endopeptidase by
            affinity chromatography
  JOURNAL   J Biol Chem 251 (23), 7593-7599 (1976)
   PUBMED   12173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC069144.1 and AI185553.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000915.3.
            
            Summary: This gene encodes a precursor protein that is processed to
            produce oxytocin and neurophysin I. Oxytocin is a posterior
            pituitary hormone which is synthesized as an inactive precursor in
            the hypothalamus along with its carrier protein neurophysin I.
            Together with neurophysin, it is packaged into neurosecretory
            vesicles and transported axonally to the nerve endings in the
            neurohypophysis, where it is either stored or secreted into the
            bloodstream. The precursor seems to be activated while it is being
            transported along the axon to the posterior pituitary. This hormone
            contracts smooth muscle during parturition and lactation. It is
            also involved in cognition, tolerance, adaptation and complex
            sexual and maternal behaviour, as well as in the regulation of
            water excretion and cardiovascular functions. [provided by RefSeq,
            Dec 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069144.1, M25650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145774, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217386.2/ ENSP00000217386.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-509               BC069144.1         1-509
            510-513             AI185553.1         36-39               c
FEATURES             Location/Qualifiers
     source          1..513
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..513
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /note="oxytocin/neurophysin I prepropeptide"
                     /db_xref="GeneID:5020"
                     /db_xref="HGNC:HGNC:8528"
                     /db_xref="MIM:167050"
     exon            1..156
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..414
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /note="oxytocin, prepro- (neurophysin I);
                     oxytocin-neurophysin 1; oxytocin-neurophysin I,
                     preproprotein; oxytocin, prepropeptide"
                     /codon_start=1
                     /product="oxytocin-neurophysin 1 preproprotein"
                     /protein_id="NP_000906.1"
                     /db_xref="CCDS:CCDS13044.1"
                     /db_xref="GeneID:5020"
                     /db_xref="HGNC:HGNC:8528"
                     /db_xref="MIM:167050"
                     /translation="MAGPSLACCLLGLLALTSACYIQNCPLGGKRAAPDLDVRKCLPC
                     GPGGKGRCFGPNICCAEELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAVLG
                     LCCSPDGCHADPACDAEATFSQR"
     exon            157..358
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /inference="alignment:Splign:2.1.0"
     exon            359..513
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      490..495
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /note="hexamer: AATAAA"
     polyA_site      513
                     /gene="OXT"
                     /gene_synonym="OT; OT-NPI; OXT-NPI"
                     /note="major polyA site"
ORIGIN      
        1 accagtcacg gaccctggac ccagcgcacc cgcaccatgg ccggccccag cctcgcttgc
       61 tgtctgctcg gcctcctggc gctgacctcc gcctgctaca tccagaactg ccccctggga
      121 ggcaagaggg ccgcgccgga cctcgacgtg cgcaagtgcc tcccctgcgg ccccgggggc
      181 aaaggccgct gcttcgggcc caatatctgc tgcgcggaag agctgggctg cttcgtgggc
      241 accgccgaag cgctgcgctg ccaggaggag aactacctgc cgtcgccctg ccagtccggc
      301 cagaaggcgt gcgggagcgg gggccgctgc gcggtcttgg gcctctgctg cagcccggac
      361 ggctgccacg ccgaccctgc ctgcgacgcg gaagccacct tctcccagcg ctgaaacttg
      421 atggctccga acaccctcga agcgcgccac tcgcttcccc catagccacc ccagaaatgg
      481 tgaaaataaa ataaagcagg tttttctcct cta
//
