LOCUS       NM_005109               4517 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens oxidative stress responsive kinase 1 (OXSR1), mRNA.
ACCESSION   NM_005109
VERSION     NM_005109.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4517)
  AUTHORS   Boyd-Shiwarski,C.R., Shiwarski,D.J., Griffiths,S.E., Beacham,R.T.,
            Norrell,L., Morrison,D.E., Wang,J., Mann,J., Tennant,W.,
            Anderson,E.N., Franks,J., Calderon,M., Connolly,K.A., Cheema,M.U.,
            Weaver,C.J., Nkashama,L.J., Weckerly,C.C., Querry,K.E.,
            Pandey,U.B., Donnelly,C.J., Sun,D., Rodan,A.R. and Subramanya,A.R.
  TITLE     WNK kinases sense molecular crowding and rescue cell volume via
            phase separation
  JOURNAL   Cell 185 (24), 4488-4506 (2022)
   PUBMED   36318922
REFERENCE   2  (bases 1 to 4517)
  AUTHORS   Salokas,K., Liu,X., Ohman,T., Chowdhury,I., Gawriyski,L.,
            Keskitalo,S. and Varjosalo,M.
  TITLE     Physical and functional interactome atlas of human receptor
            tyrosine kinases
  JOURNAL   EMBO Rep 23 (6), e54041 (2022)
   PUBMED   35384245
REFERENCE   3  (bases 1 to 4517)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 4517)
  AUTHORS   Kim,M.H., Chang,H.S., Lee,J.U., Shim,J.S., Park,J.S., Cho,Y.J. and
            Park,C.S.
  TITLE     Association of genetic variants of oxidative stress responsive
            kinase 1 (OXSR1) with asthma exacerbations in non-smoking
            asthmatics
  JOURNAL   BMC Pulm Med 22 (1), 3 (2022)
   PUBMED   34983467
  REMARK    GeneRIF: Association of genetic variants of oxidative stress
            responsive kinase 1 (OXSR1) with asthma exacerbations in
            non-smoking asthmatics.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4517)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   6  (bases 1 to 4517)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4517)
  AUTHORS   Chen,W., Yazicioglu,M. and Cobb,M.H.
  TITLE     Characterization of OSR1, a member of the mammalian Ste20p/germinal
            center kinase subfamily
  JOURNAL   J Biol Chem 279 (12), 11129-11136 (2004)
   PUBMED   14707132
  REMARK    GeneRIF: isolation and characterization of OSR1 (oxidative
            stress-responsive 1), one of two human Fray homologs. OSR1 is a
            58-kDa protein of 527 amino acids that is widely expressed in
            mammalian tissues and cell lines
REFERENCE   8  (bases 1 to 4517)
  AUTHORS   Piechotta,K., Lu,J. and Delpire,E.
  TITLE     Cation chloride cotransporters interact with the stress-related
            kinases Ste20-related proline-alanine-rich kinase (SPAK) and
            oxidative stress response 1 (OSR1)
  JOURNAL   J Biol Chem 277 (52), 50812-50819 (2002)
   PUBMED   12386165
  REMARK    GeneRIF: interacts with cation chloride cotransporters
REFERENCE   9  (bases 1 to 4517)
  AUTHORS   Daigo,Y., Isomura,M., Nishiwaki,T., Tamari,M., Ishikawa,S., Kai,M.,
            Murata,Y., Takeuchi,K., Yamane,Y., Hayashi,R., Minami,M.,
            Fujino,M.A., Hojo,Y., Uchiyama,I., Takagi,T. and Nakamura,Y.
  TITLE     Characterization of a 1200-kb genomic segment of chromosome
            3p22-p21.3
  JOURNAL   DNA Res 6 (1), 37-44 (1999)
   PUBMED   10231028
REFERENCE   10 (bases 1 to 4517)
  AUTHORS   Tamari,M., Daigo,Y. and Nakamura,Y.
  TITLE     Isolation and characterization of a novel serine threonine kinase
            gene on chromosome 3p22-21.3
  JOURNAL   J Hum Genet 44 (2), 116-120 (1999)
   PUBMED   10083736
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB017642.1 and BC008726.2.
            
            On Nov 23, 2018 this sequence version replaced NM_005109.2.
            
            Summary: The product of this gene belongs to the Ser/Thr protein
            kinase family of proteins. It regulates downstream kinases in
            response to environmental stress, and may play a role in regulating
            the actin cytoskeleton. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB017642.1, SRR1660803.37988.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311806.8/ ENSP00000311713.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AB017642.1         3-17
            16-4358             BC008726.2         1-4343
            4359-4517           AB017642.1         4361-4519
FEATURES             Location/Qualifiers
     source          1..4517
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p22.2"
     gene            1..4517
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="oxidative stress responsive kinase 1"
                     /db_xref="GeneID:9943"
                     /db_xref="HGNC:HGNC:8508"
                     /db_xref="MIM:604046"
     exon            1..410
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1924
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /EC_number="2.7.11.1"
                     /note="oxidative stress-responsive 1 protein; oxidative
                     stress responsive 1"
                     /codon_start=1
                     /product="serine/threonine-protein kinase OSR1"
                     /protein_id="NP_005100.1"
                     /db_xref="CCDS:CCDS2675.1"
                     /db_xref="GeneID:9943"
                     /db_xref="HGNC:HGNC:8508"
                     /db_xref="MIM:604046"
                     /translation="MSEDSSALPWSINRDDYELQEVIGSGATAVVQAAYCAPKKEKVA
                     IKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDELWLVMKLLSGGSVLD
                     IIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLGEDGSV
                     QIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAI
                     ELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDP
                     EKRPTAAELLRHKFFQKAKNKEFLQEKTLQRAPTISERAKKVRRVPGSSGRLHKTEDG
                     GWEWSDDEFDEESEEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHL
                     PQPAGQIATQPTQVSLPPTAEPAKTAQALSSGSGSQETKIPISLVLRLRNSKKELNDI
                     RFEFTPGRDTAEGVSQELISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVE
                     GSDIPDDGKLIGFAQLSIS"
     exon            411..523
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            524..632
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..774
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            775..830
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            831..940
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1042
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1176
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1225
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1226..1291
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1414
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..1450
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1451..1597
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1662
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1715
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1784
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1849
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..4517
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4500..4505
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="hexamer: AATAAA"
     polyA_site      4517
                     /gene="OXSR1"
                     /gene_synonym="OSR1"
                     /note="major polyA site"
ORIGIN      
        1 ggcccgtgcg tggggctggg gtggagggcg ggacagaggg gctgggccca ggcaaagctt
       61 ctgtcgctgc tgctgcggag gccgaggaca ggacgtgggc tgggccgggc agtgccggac
      121 tcggaggagc aggaggcgag gtccgccgga gctctgagcc cccgctgctc tgccgcgcgg
      181 tgaccccgcg ccccggcgcc gtccgacccg tggctgttcc gagacgattg gtgggggcgc
      241 ggcggcggcg gcggcggctg ttgggggtgg ggagacgcgc ggcgaggaga cgagcgaggt
      301 cagcgagttt gagggaggac cgcgagccgc tgccgccgtc atgtccgagg actcgagcgc
      361 cctgccctgg tccatcaaca gggacgatta cgagctgcag gaggtgatcg ggagtggagc
      421 aactgctgta gtccaagcag cttattgtgc ccctaaaaag gagaaagtgg caatcaaacg
      481 gataaacctt gagaaatgtc aaactagcat ggatgaactc ctgaaagaaa ttcaagccat
      541 gagtcaatgc catcatccta atattgtatc ttactacaca tcttttgtgg taaaagatga
      601 gctgtggctt gtcatgaagc tgctaagtgg aggttctgtt ctggatatta ttaagcacat
      661 tgtggcaaaa ggggaacaca aaagtggagt cctagatgaa tctaccattg ctacgatact
      721 ccgagaagta ctggaagggc tggaatatct gcataaaaat ggacagatcc acagagatgt
      781 gaaagctgga aacattcttc ttggagaaga tggctcagta cagattgcag actttggggt
      841 tagtgctttt ttagcaactg gtggtgatat tacccgaaat aaagtgagaa agacctttgt
      901 tggcacccct tgttggatgg cacctgaagt tatggaacag gtccgtggtt atgatttcaa
      961 agctgatatt tggagttttg gaattacagc aattgaattg gctacagggg cggctcctta
     1021 tcataaatat ccaccaatga aggttttaat gctgacactg cagaacgatc ctccttcttt
     1081 ggaaactggt gttcaagata aagaaatgct gaaaaaatat ggaaaatcat ttagaaaaat
     1141 gatttcattg tgccttcaaa aagatccaga aaaaagacca acagcagcag aactattaag
     1201 gcacaaattt ttccagaaag caaagaataa agaatttctt caagaaaaaa cattgcagag
     1261 agcaccaacc atttctgaaa gagcaaaaaa ggttcggaga gtaccaggtt ccagtgggcg
     1321 tcttcataag acagaggatg gaggctggga gtggagtgat gatgaatttg atgaagaaag
     1381 tgaggaaggg aaagcagcaa tttcacaact caggtctccc cgagtgaaag aatcaatatc
     1441 aaattctgag ctctttccaa caactgatcc tgtgggtact ttgctccaag ttccagaaca
     1501 gatctctgct catctacctc agccagctgg gcagattgct acacagccaa ctcaagtctc
     1561 tctcccaccc accgcagagc cagcaaaaac agctcaggct ttgtcttcag gatcaggttc
     1621 acaagaaacc aagatcccaa tcagtctagt actaagatta aggaattcca aaaaagaact
     1681 aaatgatatt cgatttgaat ttactcctgg gagagataca gcagagggtg tctctcagga
     1741 actcatttct gctggcctgg tcgacggaag ggatttagta atagtggcag ctaatttgca
     1801 gaaaattgtg gaagaacctc agtcaaatcg atctgtcact ttcaaactgg catctggtgt
     1861 cgaaggctca gatattcctg atgatggtaa actgatagga tttgcccagc tcagcatcag
     1921 ctaaaccaca accctggaag aggcggccta aggagattcc acacatgcgt atctctgttg
     1981 cttctattgg cctaaaccca ctactgccaa agaacccagc aacaaacctc ccggctagga
     2041 gctttagaag tctttatgtt cttcctgcca tcattcctcc ttttcccaca gggaaagaaa
     2101 agttggatca ctagtggcca gcatccccag agttccgtta gtaaacttac ttcatatgtc
     2161 ccctgtcttc ctccatctga gaagtggccc atgtgcttca aggcccagga gggagatctg
     2221 tcagctcatt cttgccttac tccaatgatg gcccaggtgg aaaagtagca gctgtatcgg
     2281 gcttcctcat cctgcctgtt cccccacacc tgccaggata tggacatctt gggatatctc
     2341 tttaccactg aagtagaatt gattgttcag ctggagccca gagaatttaa tttaatgttt
     2401 tttctttgta cctgatgtga attctagcaa cctttgttag gaaaaagcac agcctcagat
     2461 ggaggcagcc taaactgtgt tcttgttttg ttcatggtgt ttctaagcgt tttgctgaag
     2521 ctgctctcag gcaccccctt cttcattgct ctctccagaa agggttgcta gccttaactt
     2581 cagctggtgc aaaacatctg actgtagccg aacttcagcc atcagatcct tcaaagtgga
     2641 actttggatt gtttttacag acaacatcga gtaatggctt gtaaatgtga attttgccag
     2701 aggtggtttt tgaacaggaa aatcataatt catatcattg gagaagtatt tattttcaaa
     2761 tatcaaattg aagaaaaact caatcctccc atgaaaatca gttcgcctgg cctccaagtc
     2821 gtgaggaaat gggtatgcaa ggctgagatt tctacagcaa taaaggagac acacactggg
     2881 ccagagaggc ctgccttctg cctgctctcc tgcactgacc ctttggaggg ggtctctgtg
     2941 tgctgaagct aactcaagat ggaaagtgaa accacatgtg ccgtgacctt taggttttat
     3001 gagtagacag tgttcatttg attttctaca gaaataatat aaattattct ttaggtttaa
     3061 aaaagagcac tcataatgca atatgtgaat aatcagtgag gttgattttt cttttttcct
     3121 accgtttcat agtctttgtc taactgctag taaccctacc gagttttata tatgagtggg
     3181 atactcaatc tggccttaaa aagatacaca aagatgggct gtgggtccct ggaaaggggg
     3241 agagttgccc tttacagaat cactcgagcc ctttccagca ctgttggtct gatgaacaag
     3301 gttgttttac cttattttct cttggaacat atctgaaaac cttccccaca aataacttgt
     3361 cacacctttt gtttcattct gagtctttag ttttagtcat gggctttctt cacctgctct
     3421 aggtgcaaag gcatgttggg aaagagatgg atgttgggga ggaagagagg agatggattt
     3481 cagttgggag ttaggaggag agtaggtgag atgatcagac accggagttc aacgtcccag
     3541 cagtcttggt aaaaggaggg agcctgctga gccaggaggg agaaaagaag attgaccagc
     3601 ttgctagaaa aatacttagc ttttcttttt ctttttttgt ggagggggga cggagaggaa
     3661 caaggatggg gaggtaggaa tgaggtatag aaaagagata gcatcttctt tggcacaaga
     3721 ctagtggctt accgcttacc ttagagtttt gttttttttt tttcaaaccc atcaaaatct
     3781 acttatttat gaatccaagg ggtggcagca tcactctgtt ctagcattct ttgtggagat
     3841 ggtctggtgc ctagctggga gtgagcagca gcccatcccc tgttcacttt ctctagccca
     3901 tcattacctg tgaactgcag tggggcagtc atggcaaata gaattgggct ggggtttctc
     3961 cttcttttca gttcattgtt tgccctgcta ggaattagaa gacagacacc atgtcccagg
     4021 acagtgttac ttcttctgca tgatgtgtgg tagactccct ttgctggctt gtgcagtgat
     4081 actgagaaaa tacatgaaca gaaactgccc aggtggaaca gcacgtaacc tagtgagtga
     4141 ctgtactcct ttctaggaat gctgattcag agtgcacctc tttgactagg tcccaggatc
     4201 cccttgtccc tggagtaggg actaactata gcacaaagta atatgtgcca atgctatttg
     4261 tgaaatgttt ggtctttcta aacgactaaa ggatttgttg ggtttttgct taagttttga
     4321 accaaatcct agagccagct gataatattt aataatctgg aggagagaat aatgatgtac
     4381 caataagtgg agattcctcc ttatgatgta tgctaggtta tggaagatgt aaaatattca
     4441 actttttcct cctttttttg gactttgtat tttactgcat gttttcttca tttttaatca
     4501 ataaagagta aattgtc
//
