LOCUS       NM_017897               1506 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens 3-oxoacyl-ACP synthase, mitochondrial (OXSM),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_017897
VERSION     NM_017897.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1506)
  AUTHORS   Duan,Y., Yu,J., Chen,M., Lu,Q., Ning,F., Gan,X., Liu,H., Ye,Y.,
            Lu,S. and Lash,G.E.
  TITLE     Knockdown of heat shock protein family D member 1 (HSPD1) promotes
            proliferation and migration of ovarian cancer cells via disrupting
            the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM)
  JOURNAL   J Ovarian Res 16 (1), 81 (2023)
   PUBMED   37087461
  REMARK    GeneRIF: Knockdown of heat shock protein family D member 1 (HSPD1)
            promotes proliferation and migration of ovarian cancer cells via
            disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase
            (OXSM).
            Erratum:[J Ovarian Res. 2023 May 11;16(1):91. doi:
            10.1186/s13048-023-01184-4.. PMID: 37170129]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1506)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1506)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1506)
  AUTHORS   Zhang,L., Joshi,A.K., Hofmann,J., Schweizer,E. and Smith,S.
  TITLE     Cloning, expression, and characterization of the human
            mitochondrial beta-ketoacyl synthase. Complementation of the yeast
            CEM1 knock-out strain
  JOURNAL   J Biol Chem 280 (13), 12422-12429 (2005)
   PUBMED   15668256
  REMARK    GeneRIF: characterization of the human mitochondrial beta-ketoacyl
            synthase
REFERENCE   5  (bases 1 to 1506)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA916187.1 and AK000611.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017897.2.
            
            Summary: This gene encodes a beta-ketoacyl synthetase. The encoded
            enzyme is required for elongation of fatty acid chains in the
            mitochondria. Alternatively spliced transcript variants have been
            described.[provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.529504.1,
                                           SRR5189658.98217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000280701.8/
                                                  ENSP00000280701.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 DA916187.1         19-22
            5-1506              AK000611.1         15-1516
FEATURES             Location/Qualifiers
     source          1..1506
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     gene            1..1506
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /note="3-oxoacyl-ACP synthase, mitochondrial"
                     /db_xref="GeneID:54995"
                     /db_xref="HGNC:HGNC:26063"
                     /db_xref="MIM:610324"
     exon            1..58
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /inference="alignment:Splign:2.1.0"
     exon            59..1066
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1469
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /EC_number="2.3.1.41"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; beta-ketoacyl synthase; type II mitochondrial
                     beta-ketoacyl synthase; 3-oxoacyl-acyl-carrier-protein
                     synthase; 3-ketoacyl-acyl carrier protein synthase;
                     acyl-malonyl acyl carrier protein-condensing enzyme;
                     3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial;
                     beta-ketoacyl-ACP synthase"
                     /codon_start=1
                     /product="3-oxoacyl-[acyl-carrier-protein] synthase,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_060367.1"
                     /db_xref="CCDS:CCDS2643.1"
                     /db_xref="GeneID:54995"
                     /db_xref="HGNC:HGNC:26063"
                     /db_xref="MIM:610324"
                     /translation="MSNCLQNFLKITSTRLLCSRLCQQLRSKRKFFGTVPISRLHRRV
                     VITGIGLVTPLGVGTHLVWDRLIGGESGIVSLVGEEYKSIPCSVAAYVPRGSDEGQFN
                     EQNFVSKSDIKSMSSPTIMAIGAAELAMKDSGWHPQSEADQVATGVAIGMGMIPLEVV
                     SETALNFQTKGYNKVSPFFVPKILVNMAAGQVSIRYKLKGPNHAVSTACTTGAHAVGD
                     SFRFIAHGDADVMVAGGTDSCISPLSLAGFSRARALSTNSDPKLACRPFHPKRDGFVM
                     GEGAAVLVLEEYEHAVQRRARIYAEVLGYGLSGDAGHITAPDPEGEGALRCMAAALKD
                     AGVQPEEISYINAHATSTPLGDAAENKAIKHLFKDHAYALAVSSTKGATGHLLGAAGA
                     VEAAFTTLACYYQKLPPTLNLDCSEPEFDLNYVPLKAQEWKTEKRFIGLTNSFGFGGT
                     NATLCIAGL"
     exon            1067..1506
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /note="hexamer: ATTAAA"
     polyA_site      1506
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /note="major polyA site"
ORIGIN      
        1 gctcgagagc gtcatcgccc ccgactgtgg agaagtgtcc ggggtagccc cgttacagga
       61 atgtgtttct gatcatctga atcttaatca tgtccaactg cctgcaaaat ttcctgaaaa
      121 ttacaagcac tcgtcttcta tgttcaagat tatgccaaca gttaagaagt aaaaggaagt
      181 ttttcggaac tgtgccaata tccagattgc ataggcgagt tgtcattaca ggcattggct
      241 tagtgactcc tcttggtgtt ggaactcacc tggtttggga tcgtcttatc ggaggagaga
      301 gtggaattgt ttcactggtt ggtgaagagt ataagagtat cccttgcagt gttgctgctt
      361 atgtgccaag aggtagtgat gaaggtcagt tcaatgaaca aaactttgtg tccaaatcag
      421 atatcaagtc catgtcttct cccaccatca tggccattgg ggctgcagaa ttagccatga
      481 aggattctgg ctggcatcct cagtcagaag ctgatcaagt ggctactggt gttgcaattg
      541 gcatgggaat gattcctctt gaagttgttt ctgaaactgc tttgaatttt cagacaaaag
      601 gttacaataa agttagccca ttttttgtcc ctaagattct ggtcaatatg gcagcaggcc
      661 aggtcagcat tcgatataaa ctcaagggcc caaatcatgc agtatccaca gcctgtacca
      721 caggagctca tgctgtggga gactcattta gatttatagc ccatggtgat gctgatgtga
      781 tggtggctgg aggtacagat tcttgtatta gccctttatc tcttgctggg ttttccagag
      841 cccgggctct gagcacaaac tcagatccca agttggcatg tcgaccattt catccaaaga
      901 gagatggttt tgtaatggga gaaggtgcag ctgtgctggt gctggaagaa tatgaacatg
      961 ctgttcaaag aagagcccgg atctatgcag aagttttggg ctatggactc tcaggtgatg
     1021 ctggtcacat aactgcccct gatcctgaag gagaaggtgc cttaaggtgt atggctgctg
     1081 ctttaaaaga tgcaggtgtg cagcctgagg agatatccta tatcaatgca catgctactt
     1141 ccacaccatt gggagatgct gctgaaaaca aagctatcaa acatctcttc aaagaccatg
     1201 catatgccct tgcagtttcc tcaactaagg gagcaacagg acatctgctg ggagctgcag
     1261 gggcagtcga ggcagctttt accacattag cttgttatta tcaaaaacta ccacctactt
     1321 taaacctgga ttgttcggaa ccagaatttg atctcaacta tgttccacta aaggcacagg
     1381 aatggaaaac tgagaaaaga tttattggcc tcaccaattc ctttggtttt ggtggtacta
     1441 atgcaacact ttgtattgct ggactgtaga acatataatt tgtaattaaa tactgatttt
     1501 taaatg
//
