LOCUS       NP_060367                459 aa            linear   PRI 09-FEB-2025
DEFINITION  3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial isoform 1
            precursor [Homo sapiens].
ACCESSION   NP_060367
VERSION     NP_060367.1
DBSOURCE    REFSEQ: accession NM_017897.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 459)
  AUTHORS   Duan,Y., Yu,J., Chen,M., Lu,Q., Ning,F., Gan,X., Liu,H., Ye,Y.,
            Lu,S. and Lash,G.E.
  TITLE     Knockdown of heat shock protein family D member 1 (HSPD1) promotes
            proliferation and migration of ovarian cancer cells via disrupting
            the stability of mitochondrial 3-oxoacyl-ACP synthase (OXSM)
  JOURNAL   J Ovarian Res 16 (1), 81 (2023)
   PUBMED   37087461
  REMARK    GeneRIF: Knockdown of heat shock protein family D member 1 (HSPD1)
            promotes proliferation and migration of ovarian cancer cells via
            disrupting the stability of mitochondrial 3-oxoacyl-ACP synthase
            (OXSM).
            Erratum:[J Ovarian Res. 2023 May 11;16(1):91. doi:
            10.1186/s13048-023-01184-4.. PMID: 37170129]
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 459)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (residues 1 to 459)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 459)
  AUTHORS   Zhang,L., Joshi,A.K., Hofmann,J., Schweizer,E. and Smith,S.
  TITLE     Cloning, expression, and characterization of the human
            mitochondrial beta-ketoacyl synthase. Complementation of the yeast
            CEM1 knock-out strain
  JOURNAL   J Biol Chem 280 (13), 12422-12429 (2005)
   PUBMED   15668256
  REMARK    GeneRIF: characterization of the human mitochondrial beta-ketoacyl
            synthase
REFERENCE   5  (residues 1 to 459)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA916187.1 and AK000611.1.
            
            Summary: This gene encodes a beta-ketoacyl synthetase. The encoded
            enzyme is required for elongation of fatty acid chains in the
            mitochondria. Alternatively spliced transcript variants have been
            described.[provided by RefSeq, Feb 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.529504.1,
                                           SRR5189658.98217.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000280701.8/
                                                  ENSP00000280701.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..459
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p24.2"
     Protein         1..459
                     /product="3-oxoacyl-[acyl-carrier-protein] synthase,
                     mitochondrial isoform 1 precursor"
                     /EC_number="2.3.1.41"
                     /note="beta-ketoacyl synthase; type II mitochondrial
                     beta-ketoacyl synthase; 3-oxoacyl-acyl-carrier-protein
                     synthase; 3-ketoacyl-acyl carrier protein synthase;
                     acyl-malonyl acyl carrier protein-condensing enzyme;
                     3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial;
                     beta-ketoacyl-ACP synthase"
                     /calculated_mol_wt=48712
     Region          42..455
                     /region_name="fabF"
                     /note="beta-ketoacyl-acyl-carrier-protein synthase II;
                     TIGR03150"
                     /db_xref="CDD:274452"
     Site            109
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0000250|UniProtKB:Q9D404; propagated from
                     UniProtKB/Swiss-Prot (Q9NWU1.1)"
     Site            order(153,160..161,165,167..168,180,186,190,194,200,202,
                     204..206,218,221..222,225,246..247,250..251,308..312,326,
                     448,450)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:238430"
     Site            174
                     /site_type="acetylation"
                     /note="N6-acetyllysine, alternate.
                     /evidence=ECO:0007744|PubMed:19608861; propagated from
                     UniProtKB/Swiss-Prot (Q9NWU1.1)"
     Site            order(209,348,385)
                     /site_type="active"
                     /db_xref="CDD:238430"
     CDS             1..459
                     /gene="OXSM"
                     /gene_synonym="CEM1; FASN2D; KASI; KS"
                     /coded_by="NM_017897.3:90..1469"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS2643.1"
                     /db_xref="GeneID:54995"
                     /db_xref="HGNC:HGNC:26063"
                     /db_xref="MIM:610324"
ORIGIN      
        1 msnclqnflk itstrllcsr lcqqlrskrk ffgtvpisrl hrrvvitgig lvtplgvgth
       61 lvwdrligge sgivslvgee yksipcsvaa yvprgsdegq fneqnfvsks diksmsspti
      121 maigaaelam kdsgwhpqse adqvatgvai gmgmiplevv setalnfqtk gynkvspffv
      181 pkilvnmaag qvsiryklkg pnhavstact tgahavgdsf rfiahgdadv mvaggtdsci
      241 splslagfsr aralstnsdp klacrpfhpk rdgfvmgega avlvleeyeh avqrrariya
      301 evlgyglsgd aghitapdpe gegalrcmaa alkdagvqpe eisyinahat stplgdaaen
      361 kaikhlfkdh ayalavsstk gatghllgaa gaveaafttl acyyqklppt lnldcsepef
      421 dlnyvplkaq ewktekrfig ltnsfgfggt natlciagl
//
