LOCUS       NM_001198533            4691 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens oxidation resistance 1 (OXR1), transcript variant 4,
            mRNA.
ACCESSION   NM_001198533
VERSION     NM_001198533.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4691)
  AUTHORS   Wilson,K.A., Bar,S., Dammer,E.B., Carrera,E.M., Hodge,B.A.,
            Hilsabeck,T.A.U., Bons,J., Brownridge,G.W. 3rd, Beck,J.N., Rose,J.,
            Granath-Panelo,M., Nelson,C.S., Qi,G., Gerencser,A.A., Lan,J.,
            Afenjar,A., Chawla,G., Brem,R.B., Campeau,P.M., Bellen,H.J.,
            Schilling,B., Seyfried,N.T., Ellerby,L.M. and Kapahi,P.
  TITLE     OXR1 maintains the retromer to delay brain aging under dietary
            restriction
  JOURNAL   Nat Commun 15 (1), 467 (2024)
   PUBMED   38212606
  REMARK    GeneRIF: OXR1 maintains the retromer to delay brain aging under
            dietary restriction.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4691)
  AUTHORS   Lin,X., Wang,W., Yang,M., Damseh,N., de Sousa,M.M.L., Jacob,F.,
            Lang,A., Kristiansen,E., Pannone,M., Kissova,M., Almaas,R.,
            Kusnierczyk,A., Siller,R., Shahrour,M., Al-Ashhab,M.,
            Abu-Libdeh,B., Tang,W., Slupphaug,G., Elpeleg,O., Boe,S.O.,
            Eide,L., Sullivan,G.J., Rinholm,J.E., Song,H., Ming,G.L., van
            Loon,B., Edvardson,S., Ye,J. and Bjoras,M.
  TITLE     A loss-of-function mutation in human Oxidation Resistance 1
            disrupts the spatial-temporal regulation of histone arginine
            methylation in neurodevelopment
  JOURNAL   Genome Biol 24 (1), 216 (2023)
   PUBMED   37773136
  REMARK    GeneRIF: A loss-of-function mutation in human Oxidation Resistance
            1 disrupts the spatial-temporal regulation of histone arginine
            methylation in neurodevelopment.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4691)
  AUTHORS   Li,Y., Ning,G., Kang,B., Zhu,J., Wang,X.Y., Wang,Q. and Cai,T.
  TITLE     A novel recessive mutation in OXR1 is identified in patient with
            hearing loss recapitulated by the knockdown zebrafish
  JOURNAL   Hum Mol Genet 32 (5), 764-772 (2023)
   PUBMED   36130215
  REMARK    GeneRIF: A novel recessive mutation in OXR1 is identified in
            patient with hearing loss recapitulated by the knockdown zebrafish.
REFERENCE   4  (bases 1 to 4691)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 4691)
  AUTHORS   Matsui,A., Kobayashi,J., Kanno,S.I., Hashiguchi,K., Miyaji,M.,
            Yoshikawa,Y., Yasui,A. and Zhang-Akiyama,Q.M.
  TITLE     Oxidation resistance 1 prevents genome instability through
            maintenance of G2/M arrest in gamma-ray-irradiated cells
  JOURNAL   J Radiat Res 61 (1), 1-13 (2020)
   PUBMED   31845986
  REMARK    GeneRIF: Oxidation resistance 1 prevents genome instability through
            maintenance of G2/M arrest in gamma-ray-irradiated cells.
REFERENCE   6  (bases 1 to 4691)
  AUTHORS   Sirchia,R. and Luparello,C.
  TITLE     Mid-region parathyroid hormone-related protein (PTHrP) and gene
            expression of MDA-MB231 breast cancer cells
  JOURNAL   Biol Chem 388 (5), 457-465 (2007)
   PUBMED   17516841
REFERENCE   7  (bases 1 to 4691)
  AUTHORS   Durand,M., Kolpak,A., Farrell,T., Elliott,N.A., Shao,W., Brown,M.
            and Volkert,M.R.
  TITLE     The OXR domain defines a conserved family of eukaryotic oxidation
            resistance proteins
  JOURNAL   BMC Cell Biol 8, 13 (2007)
   PUBMED   17391516
  REMARK    GeneRIF: human OXR1 is capable of reducing the DNA damaging effects
            of reactive oxygen species when expressed in bacteria, indicating
            the protein has an activity that can contribute to oxidation
            resistance.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4691)
  AUTHORS   Elliott,N.A. and Volkert,M.R.
  TITLE     Stress induction and mitochondrial localization of Oxr1 proteins in
            yeast and humans
  JOURNAL   Mol Cell Biol 24 (8), 3180-3187 (2004)
   PUBMED   15060142
  REMARK    GeneRIF: Data show that human and yeast oxidation resistance 1
            (OXR1) genes are induced by heat and oxidative stress and that
            their proteins localize to the mitochondria and function to protect
            against oxidative damage.
REFERENCE   9  (bases 1 to 4691)
  AUTHORS   Ohira,M., Morohashi,A., Nakamura,Y., Isogai,E., Furuya,K.,
            Hamano,S., Machida,T., Aoyama,M., Fukumura,M., Miyazaki,K.,
            Suzuki,Y., Sugano,S., Hirato,J. and Nakagawara,A.
  TITLE     Neuroblastoma oligo-capping cDNA project: toward the understanding
            of the genesis and biology of neuroblastoma
  JOURNAL   Cancer Lett 197 (1-2), 63-68 (2003)
   PUBMED   12880961
  REMARK    Review article
REFERENCE   10 (bases 1 to 4691)
  AUTHORS   Volkert,M.R., Elliott,N.A. and Housman,D.E.
  TITLE     Functional genomics reveals a family of eukaryotic oxidation
            protection genes
  JOURNAL   Proc Natl Acad Sci U S A 97 (26), 14530-14535 (2000)
   PUBMED   11114193
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC027031.5, AP000430.3, AP002090.2, AC090579.6 and AC023344.4.
            
            On Aug 10, 2020 this sequence version replaced NM_001198533.1.
            
            Transcript Variant: This variant (4) has an alternate 5' sequence,
            compared to variant 3. The resulting isoform (4) has a distinct and
            one aa shorter N-terminus, as compared to isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.3152637.1,
                                           SRR14038196.2880772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000517566.7/ ENSP00000429205.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-178               AC027031.5         84896-85073         c
            179-339             AP000430.3         93406-93566         c
            340-536             AP002090.2         119078-119274
            537-619             AC090579.6         126715-126797
            620-727             AC090579.6         130704-130811
            728-841             AC090579.6         131751-131864
            842-991             AC090579.6         140233-140382
            992-1176            AC090579.6         150411-150595
            1177-1940           AC090579.6         153887-154650
            1941-2109           AC090579.6         158127-158295
            2110-2272           AC090579.6         161328-161490
            2273-2353           AC090579.6         185025-185105
            2354-2479           AC023344.4         79496-79621
            2480-2632           AC023344.4         80381-80533
            2633-2728           AC023344.4         82260-82355
            2729-2802           AC023344.4         85827-85900
            2803-4691           AC023344.4         90844-92732
FEATURES             Location/Qualifiers
     source          1..4691
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..4691
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /note="oxidation resistance 1"
                     /db_xref="GeneID:55074"
                     /db_xref="HGNC:HGNC:15822"
                     /db_xref="MIM:605609"
     exon            1..178
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..339
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             317..2938
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /note="isoform 4 is encoded by transcript variant 4;
                     oxidation resistance protein 1; putative protein product
                     of Nbla00307; TBC/LysM-associated domain containing 3"
                     /codon_start=1
                     /product="oxidation resistance protein 1 isoform 4"
                     /protein_id="NP_001185462.1"
                     /db_xref="CCDS:CCDS56547.1"
                     /db_xref="GeneID:55074"
                     /db_xref="HGNC:HGNC:15822"
                     /db_xref="MIM:605609"
                     /translation="MSVSNLSWLKKKSQSVDINAPGFNPLAGAGKQTPQASKPPAPKT
                     PIIEEEQNNAANTQKHPSRRSELKRFYTIDTGQKKTLDKKDGRRMSFQKPKGTIEYTV
                     ESRDSLNSIALKFDTTPNELVQLNKLFSRAVVTGQVLYVPDPEYVSSVESSPSLSPVS
                     PLSPTSSEAEFDKTTNPDVHPTEATPSSTFTGIRPARVVSSTSEEEEAFTEKFLKINC
                     KYITSGKGTVSGVLLVTPNNIMFDPHKNDPLVQENGCEEYGIMCPMEEVMSAAMYKEI
                     LDSKIKESLPIDIDQLSGRDFCHSKKMTGSNTEEIDSRIRDAGNDSASTAPRSTEESL
                     SEDVFTESELSPIREELVSSDELRQDKSSGASSESVQTVNQAEVESLTVKSESTGTPG
                     HLRSDTEHSTNEVGTLCHKTDLNNLEMAIKEDQIADNFQGISGPKEDSTSIKGNSDQD
                     SFLHENSLHQEESQKENMPCGETAEFKQKQSVNKGKQGKEQNQDSQTEAEELRKLWKT
                     HTMQQTKQQRENIQQVSQKEAKHKITSADGHIESSALLKEKQRHRLHKFLCLRVGKPM
                     RKTFVSQASATMQQYAQRDKKHEYWFAVPQERTDHLYAFFIQWSPEIYAEDTGEYTRE
                     PGFIVVKKIEESETIEDSSNQAAAREWEVVSVAEYHRRIDALNTEELRTLCRRLQITT
                     REDINSKQVATVKADLESESFRPNLSDPSELLLPDQIEKLTKHLPPRTIGYPWTLVYG
                     TGKHGTSLKTLYRTMTGLDTPVLMVIKDSDGQVFGALASEPLKVSDGFYGTGETFVFT
                     FCPEFEVFKWTGDNMFFIKGDMDSLAFGGGGGEFALWLDGDLYHGRSHSCKTFGNRTL
                     SKKEDFFIQDIEIWAFE"
     exon            340..536
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            537..619
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            620..727
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            728..841
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            842..991
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1176
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1940
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2109
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2272
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2353
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..2479
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2632
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2633..2728
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2729..2802
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2803..4691
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4666..4671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /note="hexamer: AATAAA"
     polyA_site      4691
                     /gene="OXR1"
                     /gene_synonym="CHEGDD; Nbla00307; TLDC3"
                     /note="major polyA site"
ORIGIN      
        1 gctcagcggc gccggcagca gcggggctag agctgggctg cgtcaggctg agcccattca
       61 cctcgcggcc acaggagctc agcgccggcg ccgcgccgcc cagccccgcc gagaggggcg
      121 cactcgccgc cgcggggccc gccgccgctc accgcagccc cctcctggcg acccgcaagt
      181 cctctcaaac tgtgagtaac taagtggttt gtgcatcatt ccagaagcaa agctaaaatt
      241 tttagcggtg ttgtcgactt gacctgctaa tttcctgttc tggaatcgag agaagactcc
      301 tcaacaagtt gctgcaatgt ctgtgtctaa tctatcatgg ctgaagaaaa agtcccagtc
      361 ggtggatatt aatgctccag ggttcaaccc tttggctggt gcaggaaagc aaacaccaca
      421 agccagtaag cccccggcac ccaagacccc catcattgaa gaagagcaga acaatgcagc
      481 aaatactcag aaacatcctt ccagaaggag cgaactgaag aggttctaca caattgacac
      541 tggccaaaag aagaccctag acaagaaaga tggaagacga atgtcttttc agaaacctaa
      601 agggactatt gagtatactg ttgaatcaag ggattctttg aatagcatag ccctgaagtt
      661 tgatacaaca cctaacgaac ttgttcaatt aaataagtta ttctcccgag cagttgttac
      721 tggacaggtt ctgtatgttc ctgatcctga atatgtctcc agtgttgaga gctctccatc
      781 tctaagcccc gtaagtcctc tgtcaccaac atcatctgag gctgaatttg ataagaccac
      841 taatcctgat gtccatccaa cagaagcaac tccctcatct actttcactg gtattcgacc
      901 tgcacgagtt gtatcttcaa cttctgagga ggaggaagca tttactgaga aatttcttaa
      961 aattaattgc aaatatatta ccagtggcaa gggcacagtc agtggtgtgc tgctagttac
     1021 accaaataat ataatgtttg atccacataa aaatgaccct ttggttcaag agaatggctg
     1081 tgaggaatat ggcatcatgt gtccaatgga agaggtgatg tcagctgcaa tgtacaaaga
     1141 aattttggat agcaaaataa aggaatcttt acccatagat atagatcagc tatcaggaag
     1201 ggacttctgc cattcaaaga aaatgacagg aagtaacact gaggaaatag actcaagaat
     1261 ccgagatgca ggtaatgata gtgccagcac tgctcctagg agcactgagg agtctctttc
     1321 tgaagatgtg ttcacagaat cagaactttc ccctatacga gaggagcttg tatcttcaga
     1381 tgaactgcga caagataaat cttctggtgc gtcatcagaa tctgtgcaaa ctgtcaatca
     1441 ggctgaagta gaaagtctga cagtcaaatc agaatctact ggtactcctg gtcacttaag
     1501 atctgatact gaacattcta caaatgaagt tgggacttta tgtcataaaa ctgatttaaa
     1561 taatcttgaa atggccatta aggaagatca gattgcagat aactttcaag gaatatcagg
     1621 tcctaaagaa gacagcacaa gtataaaagg taattcagac caggattctt ttcttcatga
     1681 gaattcgtta caccaagaag agagtcaaaa agaaaatatg ccttgtgggg aaacagcaga
     1741 atttaaacaa aagcaaagtg ttaacaaagg aaaacaagga aaggagcaaa atcaggactc
     1801 acagacagag gcagaagagc tacgcaaact ttggaaaacc catactatgc aacaaactaa
     1861 acagcaaagg gaaaatattc aacaagtgtc acaaaaagaa gctaagcata aaattacatc
     1921 tgctgatgga cacatagaaa gttctgcact tttaaaagaa aagcaaaggc atcgattaca
     1981 taagttcttg tgtctcagag ttggaaaacc aatgaggaaa acgtttgtat ctcaagcaag
     2041 tgctacaatg caacagtatg cacagagaga taagaaacat gaatattggt ttgctgtgcc
     2101 acaagaaagg acagatcact tgtatgcctt cttcattcag tggagtccag aaatatatgc
     2161 agaagatact ggcgaatata ccagagaacc tggatttata gtagtaaaaa agattgagga
     2221 gtctgaaaca attgaggatt ctagtaatca agcagcagcc agagaatggg aggtagtgtc
     2281 agtggctgag tatcaccgca ggatcgatgc tctaaatact gaagaactgc gcacactctg
     2341 cagacgcctc cagattacta caagggaaga cataaattca aagcaggttg ctacagtgaa
     2401 agcagacctg gagtctgaat cttttcgacc aaacctaagt gatcccagtg aacttttact
     2461 gccagatcaa attgaaaagc ttaccaagca tcttccacca agaacaattg gctatccatg
     2521 gactcttgtt tatggtactg gaaaacatgg cacaagcttg aaaactcttt atcgaacaat
     2581 gacaggttta gacaccccag tgctgatggt gattaaagac agtgatggac aggtttttgg
     2641 tgcgttagca tctgagccac tgaaagtgag tgatggcttt tatggtactg gagagacctt
     2701 tgtttttaca ttctgtccgg agtttgaggt ctttaagtgg acaggagata atatgttttt
     2761 tatcaaagga gacatggatt cactagcttt cggtggtgga ggaggagaat ttgcgctttg
     2821 gcttgatgga gatctctacc atggaagaag ccattcttgt aaaacgtttg ggaatcgtac
     2881 actttctaag aaggaagatt tctttatcca agatattgaa atctgggctt ttgaataaat
     2941 aaaatgctct ctgtcttagc aggagaatgg cccaaacctg acatggacaa gcattgtttg
     3001 gaaagttcaa gaagcaatac agtgtaacat gtcacttgtg ctttaaaatt agtctgtatc
     3061 accatttatt acagttataa ttttggagtt tatttttcaa atcatgttct tgtcccagag
     3121 ttctttaggt taacactagg gactgcgtcc atgtactagt ataacagctt gggtttgtta
     3181 gaatttgggc aacattttga ttataatgac aacttcattt tcacatgtta ctcagttccc
     3241 taataggatg gtgctctttt gttgaacctg tattgatttt ttttttttta actatattga
     3301 ttcgtttact agaacagtct aattggggca ttgaggaaat gaagactgga tacttctgta
     3361 tctgtgaagt tggcacaggt aacatttgga catgttcatc ttattcttag gaaggaaaaa
     3421 atcacttgcc aaaataatac atacttcata gaccactgag ttctagtttt tattcacact
     3481 acaacattct ctttaacgat gttgcaggta ttctcaattt ccttttaaga aaaatgaaat
     3541 gtgaggagaa ttctggttgt aatagatgac agtacatatg atctgcaggt ttgggcatat
     3601 gctttcatca ttaaattatc tgataaagtt acaagtcaca aaggagaatg agaacttaat
     3661 gattctattg gatttaatat attagcaaga aaacatacta tttacatatg tgtagcttag
     3721 taaggcatta acataagtac aaaaactatg aaacagatgc atatttcctc aacatactgt
     3781 gtcaggtata ctgttttata atttggttgt tttagcctta ttgcacacca actcccaaaa
     3841 tataggttac tcttgttcaa aaggaaaaaa aaaattgtga ttttctttga gtggtatatg
     3901 ttattaatta ccattagcat ttgctcttat aaagggcaat gattatagta gacaatattg
     3961 taactcagta gacttgttga atatgcaaac ttactgtcaa gtgacctcaa aaaaaaaatg
     4021 aaaagataga atacactagt agttcttatc ctcttttgta ggaaaccaat aatagccatt
     4081 gtggcaataa ttcatcagtt gattttaaag cttcatgtta tgcaaaaaag aatcctgctg
     4141 ttatacatgt gacagtgact ttgtgctgaa atttcagcta ttccagataa acattgtata
     4201 tcttgtaaat taatgtttaa aggtgtagtt ttgttcttac agaaagtgtt gattgccagg
     4261 ttgcttatag cactttaagt tattctaaaa atgaaattat aagccaaata tttggcttaa
     4321 gtagatttag ttgtatagca cttacatatt tagttctttt gaaagtttag ataattattt
     4381 aaagaaagca taatgctaat ggaaaagaaa atctgatgtt ctattataat atgctattgc
     4441 tgaatatgaa tagaaataca gggcatcatt tccttgtctc attataagtt agtaacaata
     4501 tatagattaa atgtttacaa tatagggaat tgtaaataaa tatatcagtt tttttcccct
     4561 tcggtcttcc acagcagtat tattgtcttt gtggagttga ctaatgataa tttaaaaatc
     4621 ctgtaatgga tttctactaa aataaggtca tagtggcata taccaaataa aatcaaatac
     4681 agaaatacaa a
//
