LOCUS       NM_138381               3916 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens oxidoreductase NAD binding domain containing 1
            (OXNAD1), transcript variant 3, mRNA.
ACCESSION   NM_138381 NM_032754
VERSION     NM_138381.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3916)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3916)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3916)
  AUTHORS   Denisova,E., Heidenreich,B., Nagore,E., Rachakonda,P.S., Hosen,I.,
            Akrap,I., Traves,V., Garcia-Casado,Z., Lopez-Guerrero,J.A.,
            Requena,C., Sanmartin,O., Serra-Guillen,C., Llombart,B.,
            Guillen,C., Ferrando,J., Gimeno,E., Nordheim,A., Hemminki,K. and
            Kumar,R.
  TITLE     Frequent DPH3 promoter mutations in skin cancers
  JOURNAL   Oncotarget 6 (34), 35922-35930 (2015)
   PUBMED   26416425
REFERENCE   4  (bases 1 to 3916)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY044078.1, BC008322.1, AC090953.2 and BC007285.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138381.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.84498.1,
                                           SRR1803614.255140.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285083.10/ ENSP00000285083.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                HY044078.1         136-156
            22-1431             BC008322.1         1-1410
            1432-3915           AC090953.2         179642-182125
            3916-3916           BC007285.1         1165-1165
FEATURES             Location/Qualifiers
     source          1..3916
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.1-p24.3"
     gene            1..3916
                     /gene="OXNAD1"
                     /note="oxidoreductase NAD binding domain containing 1"
                     /db_xref="GeneID:92106"
                     /db_xref="HGNC:HGNC:25128"
                     /db_xref="MIM:620581"
     exon            1..294
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..444
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..571
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             453..1391
                     /gene="OXNAD1"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 3; oxidoreductase NAD-binding domain-containing
                     protein 1"
                     /codon_start=1
                     /product="oxidoreductase NAD-binding domain-containing
                     protein 1 isoform 2 precursor"
                     /protein_id="NP_612390.1"
                     /db_xref="CCDS:CCDS2630.1"
                     /db_xref="GeneID:92106"
                     /db_xref="HGNC:HGNC:25128"
                     /db_xref="MIM:620581"
                     /translation="MACAAVMIPGLLRCSVGAIRIEAASLRLTLSTLRHLTLTSIMKS
                     KRKTDHMERTASVLRREIVSAAKVCGAASESPSVKSLRLLVADQDFSFKAGQWVDFFI
                     PGVSVVGGFSICSSPRLLEQERVIELAVKYTNHPPALWVHNTCTLDCEVAVRVGGEFF
                     FDPQPADASRNLVLIAGGVGINPLLSILRHAADLLREQANKRNGYEIGTIKLFYSAKN
                     TSELLFKKNILDLVNEFPEKIACSLHVTKQTTQINAELKPYITEGRITEKEIRDHISK
                     ETLFYICGPPPMTDFFSKQLENNHVPKEHICFEKWW"
     exon            572..635
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..742
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            743..884
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            885..1127
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1236
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..3916
                     /gene="OXNAD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXNAD1"
                     /note="hexamer: AATAAT"
     polyA_site      1843
                     /gene="OXNAD1"
                     /note="major polyA site"
     regulatory      3896..3901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXNAD1"
                     /note="hexamer: ATTAAA"
     polyA_site      3916
                     /gene="OXNAD1"
                     /note="major polyA site"
ORIGIN      
        1 gtattccagg cgcctgcaac taaacgtggc cgggtctgca agctaggtgc cagcggggaa
       61 agtttccctg cttcttatcg tctgctttaa cgccttaaat agcccgctga aggctgcagc
      121 aggtgctagg tagcagcctc ccggccctcg ggaaaggcgg ggtggggagg cgagagcagc
      181 ttagcctcct cgacctccct tcctggtgac ggacgaacag ttcccgtaga atttcgcttc
      241 accgagtgac cttgagccca gggcgacggt cagcttgtta attcctggct gcaggaactt
      301 tgtgagaatt ttaatgcatg gaaaagctgt ccatgttcca actgctgtac atccaaaagt
      361 ctcagtgtaa tagcaggacc aaaatattct gtcaatcagc tgaccatata cttaatgact
      421 cctaaaatct cgtggacttc taagaaagcg ccatggcctg tgctgctgtt atgattcctg
      481 ggttgttgcg gtgctctgtt ggagccatcc gtattgaggc tgcgtcactg agattgacac
      541 tcagcacttt gcgccacctt actctaacca gcataatgaa atccaaaagg aaaactgatc
      601 acatggagag aactgcaagt gtccttcgac gggagattgt gtcagcagct aaggtgtgtg
      661 gagctgccag tgagtcaccg tcagtgaaga gcctccgctt gcttgttgct gatcaagact
      721 tttcctttaa agctggccag tgggttgatt tctttattcc aggagtctct gtggttggtg
      781 ggttttcaat atgctccagt cccagactgc tagaacaaga gagagtgata gaattggcag
      841 tgaaatatac gaaccaccct cctgccctct gggttcacaa tacgtgtaca cttgactgtg
      901 aagtggctgt gagagtgggt ggagagttct tctttgaccc tcagcctgcg gatgcctcta
      961 gaaacctcgt gttgattgca ggaggagtcg gaattaaccc tctgctttcc atcctgcggc
     1021 acgcagcaga tctcctcaga gagcaggcaa acaaaagaaa tggatatgag ataggaacaa
     1081 taaaactatt ctacagtgca aaaaatacca gcgaactcct gtttaagaaa aatatccttg
     1141 atttagtaaa tgaatttcct gagaagattg catgcagttt gcatgttaca aaacagacta
     1201 cacaaatcaa tgcggaactc aagccataca tcacggaagg aagaataacg gagaaggaga
     1261 taagagatca tatttcaaaa gagactttgt tctatatttg tggcccacct ccaatgacag
     1321 actttttctc caagcaactg gaaaacaacc atgtacccaa agaacacatt tgctttgaga
     1381 agtggtggta ggaggcagac aaaggcagaa aaaataaaga ggtgagatct actcaggaga
     1441 gctcctgtcc tttgtggcat gattaatttt ttttatctct acttgagttg tcttattttt
     1501 taaggctata aacttagtga ccagctggat aataaaagcc agctggcaga cttaaatgat
     1561 aaactttttg caaagacctc agtgatcaaa ctatttttta ctatactgat tttctgttat
     1621 taacaacgat ttaattgtct catgatgtac catgattggt cagtatagat ttttcttttg
     1681 tctttaggca aaaaaaagat atatacttat gtctaatcat aggaaaatgt gatttttgag
     1741 tataaaatgt gggctagctt taaattattt gacagccatc tatatatctt atgtttaatg
     1801 aaagtataat ttaaatacaa tcttaataat tttactttga aaattctttt tatttaatgc
     1861 ctttgtttac tgtaccatgg cctacagtct tatttggtcc atcaaagtta agtttggaca
     1921 tggaaaattg ttaggaaaac tgctttaggg agttaaatat ccagcatatt tgctttcttg
     1981 ttaatgaata tcctaagtgt gtatcctgac taattgttag tttcttctca aatgaaaccc
     2041 tttctgtgtc ttggctgtct gccttaacgc tgtaggaggc agcttcttgc ttgggacaaa
     2101 ggcattggtg atgtgttcca tgttgaatct gccttcagtg cctgggctgg cttgctatgg
     2161 aaatgtgctt agcattgatt agggggtaga gagctgtttc taaatcctgc ttttctactt
     2221 tttatttcac tcatttgcca gaattgttct tggcaccagc agctccttaa catatagttg
     2281 ttgaatgact gaaagaaagc aactaatgtt ttaactcctt gctaagtctg agattgggag
     2341 gcagtcccct agagtggata gaaagaatgg tggagcctca tcccaaagct gctctgatga
     2401 aactgctaga aagcagattg tagttctttg tttagatttt taaaaatcca aaagaagtcc
     2461 tgactgaggc caggccattc cttttatgac aagtagtcct gggcccaagg ttgcctgcat
     2521 agagatcaca ggagggtgaa gggagcctgg gaagaaggac agataagtgc tggagaccta
     2581 ggagctccag ttgagattct gttctggagc ggatgagaga agacaggtta ccctttctta
     2641 tctttgttgt tgcaggcctc ccagggactt gtgggcttga acagatatga ttcatgggac
     2701 ctgaaggtga ctctagcttc tgcccagttt tgagttttgt caagttttaa gcagagatca
     2761 tttgtcaact attttgatcc cagatttgaa tttggggagg aagggaggag ctactgacct
     2821 gatgggaata tcataatcca ttcaaggaaa tggtcattag tacctcagag gtgaagggaa
     2881 tatgtgaagc tctggatcac tacaaggagc cctgacttac cagttggccc caaagtgccc
     2941 aggctgaggg cataggagca tgatgagatg caaggatgtg ggattatcaa ggggcacgtc
     3001 tactaactgg tgaaggcagt ctgcggggga ggacacctaa aggtatgcgg aaagtaccta
     3061 acccagacct ctctgcatta ggagtggagg tgcaaagtga gcatctccag tgcagcatgg
     3121 gatgggaaga tagggaggtg tcgcccactg tctcggttta gccagcacca cggctggctg
     3181 tgtgcctgct actgtcagag agcaagggtc atctgtcctg cccagctatg cctgccaccc
     3241 tgttgctgac tcagtattgg cagaattgct gagatgggcc aggtcatcac ctttgcctgg
     3301 agtgttcatc ctttcagtgc cattattctg gtgctaagtg ctgaagaaca ttttcaggtc
     3361 tagccgagaa tgtcctcttg ctcttgcctg ccaggcctgt ccagatcttt ttggtactta
     3421 aattgagcta actccagcca gagtggcttg gaattcatag tgcggtggct cagagtatag
     3481 gctcgaaagc ccttgagcca gattgcctgg gttcagatct cacctatact acttactagg
     3541 tagatgacct tgagcaagtc acttaactgc tctatgcctc atttaaaatt acatacaact
     3601 acatgtaaaa gggagatgat actgctgcct acctacctac atgatagggc tgttacgggg
     3661 attgaaggtg atcatacatg taaagtgctt ggcagagcac tgcatgagtg tgttgtcgtt
     3721 attaatttgc tattccttgt cctattcaga aaggatttca agaggctgga tgccttagat
     3781 gtggtctaac ttgaaacctt catgtgggtg tgcgtctgtc ttgtttattg ctgtgccagg
     3841 cacaaaatag gtatttcata aatatttgtt aatatgctca gagttgataa gctggattaa
     3901 agtgacttct taagga
//
