LOCUS       NM_001346194            2503 bp    mRNA    linear   PRI 13-FEB-2025
DEFINITION  Homo sapiens oxoglutarate receptor 1 (OXGR1), transcript variant 1,
            mRNA.
ACCESSION   NM_001346194
VERSION     NM_001346194.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2503)
  AUTHORS   Majmundar,A.J., Widmeier,E., Heneghan,J.F., Daga,A., Wu,C.W.,
            Buerger,F., Hugo,H., Ullah,I., Amar,A., Ottlewski,I., Braun,D.A.,
            Jobst-Schwan,T., Lawson,J.A., Zahoor,M.Y., Rodig,N.M., Tasic,V.,
            Nelson,C.P., Khaliq,S., Schonauer,R., Halbritter,J., Sayer,J.A.,
            Fathy,H.M., Baum,M.A., Shril,S., Mane,S., Alper,S.L. and
            Hildebrandt,F.
  TITLE     OXGR1 is a candidate disease gene for human calcium oxalate
            nephrolithiasis
  JOURNAL   Genet Med 25 (3), 100351 (2023)
   PUBMED   36571463
  REMARK    GeneRIF: OXGR1 is a candidate disease gene for human calcium
            oxalate nephrolithiasis.
REFERENCE   2  (bases 1 to 2503)
  AUTHORS   Calderon-Zamora,L., Canizalez-Roman,A., Leon-Sicairos,N.,
            Aguilera-Mendez,A., Huang,F., Hong,E. and Villafana,S.
  TITLE     Changes in expression of orphan receptors GPR99 and GPR107 during
            the development and establishment of hypertension in spontaneously
            hypertensive rats
  JOURNAL   J Recept Signal Transduct Res 41 (6), 558-565 (2021)
   PUBMED   33121311
  REMARK    GeneRIF: Changes in expression of orphan receptors GPR99 and GPR107
            during the development and establishment of hypertension in
            spontaneously hypertensive rats.
REFERENCE   3  (bases 1 to 2503)
  AUTHORS   Yuan,Y., Xu,P., Jiang,Q., Cai,X., Wang,T., Peng,W., Sun,J., Zhu,C.,
            Zhang,C., Yue,D., He,Z., Yang,J., Zeng,Y., Du,M., Zhang,F.,
            Ibrahimi,L., Schaul,S., Jiang,Y., Wang,J., Sun,J., Wang,Q., Liu,L.,
            Wang,S., Wang,L., Zhu,X., Gao,P., Xi,Q., Yin,C., Li,F., Xu,G.,
            Zhang,Y. and Shu,G.
  TITLE     Exercise-induced alpha-ketoglutaric acid stimulates muscle
            hypertrophy and fat loss through OXGR1-dependent adrenal activation
  JOURNAL   EMBO J 39 (7), e103304 (2020)
   PUBMED   32104923
  REMARK    GeneRIF: Exercise-induced alpha-ketoglutaric acid stimulates muscle
            hypertrophy and fat loss through OXGR1-dependent adrenal
            activation.
            Erratum:[EMBO J. 2021 Jul 15;40(14):e108434. doi:
            10.15252/embj.2021108434.. PMID: 34263469]
REFERENCE   4  (bases 1 to 2503)
  AUTHORS   Shirasaki,H., Kanaizumi,E. and Himi,T.
  TITLE     Expression and localization of GPR99 in human nasal mucosa
  JOURNAL   Auris Nasus Larynx 44 (2), 162-167 (2017)
   PUBMED   27324180
  REMARK    GeneRIF: GPR99 was mostly expressed in vascular smooth muscle cells
            of the nasal mucosa. There was no difference in GPR99 protein
            levels between allergic and non-allergic nasal mucosa.
REFERENCE   5  (bases 1 to 2503)
  AUTHORS   Kerschner,J.E., Hong,W., Taylor,S.R., Kerschner,J.A., Khampang,P.,
            Wrege,K.C. and North,P.E.
  TITLE     A novel model of spontaneous otitis media with effusion (OME) in
            the Oxgr1 knock-out mouse
  JOURNAL   Int J Pediatr Otorhinolaryngol 77 (1), 79-84 (2013)
   PUBMED   23200873
REFERENCE   6  (bases 1 to 2503)
  AUTHORS   He,W., Miao,F.J., Lin,D.C., Schwandner,R.T., Wang,Z., Gao,J.,
            Chen,J.L., Tian,H. and Ling,L.
  TITLE     Citric acid cycle intermediates as ligands for orphan
            G-protein-coupled receptors
  JOURNAL   Nature 429 (6988), 188-193 (2004)
   PUBMED   15141213
REFERENCE   7  (bases 1 to 2503)
  AUTHORS   Inbe,H., Watanabe,S., Miyawaki,M., Tanabe,E. and Encinas,J.A.
  TITLE     Identification and characterization of a cell-surface receptor,
            P2Y15, for AMP and adenosine
  JOURNAL   J Biol Chem 279 (19), 19790-19799 (2004)
   PUBMED   15001573
  REMARK    GeneRIF: P2Y15 is a cell surface receptor for AMP and adenosine
REFERENCE   8  (bases 1 to 2503)
  AUTHORS   Wittenberger,T., Hellebrand,S., Munck,A., Kreienkamp,H.J.,
            Schaller,H.C. and Hampe,W.
  TITLE     GPR99, a new G protein-coupled receptor with homology to a new
            subgroup of nucleotide receptors
  JOURNAL   BMC Genomics 3, 17 (2002)
   PUBMED   12098360
REFERENCE   9  (bases 1 to 2503)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 2503)
  AUTHORS   Lee,D.K., Nguyen,T., Lynch,K.R., Cheng,R., Vanti,W.B., Arkhitko,O.,
            Lewis,T., Evans,J.F., George,S.R. and O'Dowd,B.F.
  TITLE     Discovery and mapping of ten novel G protein-coupled receptor genes
  JOURNAL   Gene 275 (1), 83-91 (2001)
   PUBMED   11574155
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DN993601.1, AK122639.1 and
            AL356486.12.
            
            On Aug 14, 2020 this sequence version replaced NM_001346194.1.
            
            Summary: This gene encodes a G protein-coupled receptor (GPCR) that
            belongs to the oxoglutarate receptor family within the GPCR
            superfamily. The encoded protein is activated by the citric acid
            intermediate, oxoglutarate, as well as several cysteinyl
            leukotrienes, including leukotrienes E4, C4 and D4, which are
            implicated in many inflammatory disorders. In mice, a knock-out of
            this gene leads to middle ear inflammation, changes in the mucosal
            epithelium, and an increase in fluid behind the eardrum, and is
            associated with hearing loss. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Oct 2016].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2, 3, 4, and 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DN993601.1, SRR18074967.300895.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541038.2/ ENSP00000437356.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               DN993601.1         7-132
            127-179             AK122639.1         1-53
            180-643             DN993601.1         186-649
            644-1055            AK122639.1         432-843
            1056-1192           AL356486.12        4356-4492           c
            1193-2497           AK122639.1         981-2285
            2498-2503           AL356486.12        3045-3050           c
FEATURES             Location/Qualifiers
     source          1..2503
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q32.1"
     gene            1..2503
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /note="oxoglutarate receptor 1"
                     /db_xref="GeneID:27199"
                     /db_xref="HGNC:HGNC:4531"
                     /db_xref="MIM:606922"
     exon            1..179
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            180..330
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            331..382
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     exon            383..2503
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /inference="alignment:Splign:2.1.0"
     CDS             457..1470
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /note="G protein-coupled receptor 80; oxoglutarate
                     (alpha-ketoglutarate) receptor 1; seven transmembrane
                     helix receptor; P2Y-like nucleotide receptor; P2Y-like
                     GPCR; P2Y purinoceptor 15; G-protein coupled receptor 99;
                     alpha-ketoglutarate receptor 1"
                     /codon_start=1
                     /product="2-oxoglutarate receptor 1"
                     /protein_id="NP_001333123.1"
                     /db_xref="CCDS:CCDS9482.1"
                     /db_xref="GeneID:27199"
                     /db_xref="HGNC:HGNC:4531"
                     /db_xref="MIM:606922"
                     /translation="MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIF
                     LVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFG
                     DFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWII
                     SLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCY
                     TTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSI
                     ENQIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYS
                     NNP"
     regulatory      2479..2484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /note="hexamer: AATAAA"
     polyA_site      2503
                     /gene="OXGR1"
                     /gene_synonym="aKGR; CAON2; GPR80; GPR99; P2RY15; P2Y15"
                     /note="major polyA site"
ORIGIN      
        1 ggatgctgct ggccaggctg ctcggggcga ggacccgaga acacgcactt gctcgctggg
       61 cctcggaggg gtgggagggg cggggcggtg cgcagcctcc ccgggacagg tctgcggtcc
      121 gggaccaact aggctgcaca ggcacgctgg gcgcatgtcc gcctcgccgg ggctgccaga
      181 atcttggaat cccaatccgt gaggttcctg ggtgtgctgg catcaggaca gcggtccacg
      241 aacggtgtgt tacccaaata ttgacatcct gcagctagcc tcaaacaatc acagctactt
      301 tccaatttca gagaaaaaaa ggctaaaatt ggtaatcctg atgaaaatca acaaaataca
      361 catgaagaga cagcactgag agcgagttac tgctcatttg attcatattg ccaaactgaa
      421 ctctcttgtt ttcttgcaag atgaaaggag acaaccatga atgagccact agactattta
      481 gcaaatgctt ctgatttccc cgattatgca gctgcttttg gaaattgcac tgatgaaaac
      541 atcccactca agatgcacta cctccctgtt atttatggca ttatcttcct cgtgggattt
      601 ccaggcaatg cagtagtgat atccacttac attttcaaaa tgagaccttg gaagagcagc
      661 accatcatta tgctgaacct ggcctgcaca gatctgctgt atctgaccag cctccccttc
      721 ctgattcact actatgccag tggcgaaaac tggatctttg gagatttcat gtgtaagttt
      781 atccgcttca gcttccattt caacctgtat agcagcatcc tcttcctcac ctgtttcagc
      841 atcttccgct actgtgtgat cattcaccca atgagctgct tttccattca caaaactcga
      901 tgtgcagttg tagcctgtgc tgtggtgtgg atcatttcac tggtagctgt cattccgatg
      961 accttcttga tcacatcaac caacaggacc aacagatcag cctgtctcga cctcaccagt
     1021 tcggatgaac tcaatactat taagtggtac aacctgattt tgactgcaac tactttctgc
     1081 ctccccttgg tgatagtgac actttgctat accacgatta tccacactct gacccatgga
     1141 ctgcaaactg acagctgcct taagcagaaa gcacgaaggc taaccattct gctactcctt
     1201 gcattttacg tatgtttttt acccttccat atcttgaggg tcattcggat cgaatctcgc
     1261 ctgctttcaa tcagttgttc cattgagaat cagatccatg aagcttacat cgtttctaga
     1321 ccattagctg ctctgaacac ctttggtaac ctgttactat atgtggtggt cagcgacaac
     1381 tttcagcagg ctgtctgctc aacagtgaga tgcaaagtaa gcgggaacct tgagcaagca
     1441 aagaaaatta gttactcaaa caacccttga aatatttcat ttacttaacc aaaaacaaat
     1501 acttgctgat actttaccta gcatcctaag atgttcagga tgtctccctc aatggaactc
     1561 ctggtaaata ctgtgtattc aagtaatcat gtgccaaagc cagggcagag cttctagttc
     1621 tttgcaatcc ctttattgag ctcctccact ggggagatat aagaatggga tgcatgtata
     1681 tcagcaaagt attcagacat agtattacaa gctattggaa ctcagaggca tcttagagaa
     1741 catctgttcc caccaactta ctatatatac acggaaacca atttcttacc cttgccctag
     1801 attgctcagt aaatttgtgc caagatagga gaaaaccaat cttttcactc atcatttcat
     1861 gcttctctgc actctgggcc tatttgtatt gaaccattag acaattcaaa ccactacttg
     1921 tatctttctt aatatttatt ttttacatct cagagctcta caatttgttt ccttcaagct
     1981 taactttgag attataaaac tgggtttagc cagttctgta tattacttca agccagtaag
     2041 atacccttga aataatccaa ggacgtccat gcaaatagtt gaaattagta cctgcaatat
     2101 atttggagta ttatgtcttt attgttgtta aaaagttttt attgaatgta tgaaaattat
     2161 caaattgtat tcatcattat taacatgtcc tggggaagga agggaaactt tctaggacag
     2221 aagtcacttt cagatgtcat gtatgtattg ggtgttcaat catatctaac actgttttga
     2281 tttttgtggg aaaatattcc aggaaacgct aattctcttt agactccttg ttcttttatg
     2341 actacaatga acatatgtct atgtgatagc taaagatatt tttgaattgt atgtgtgctt
     2401 aattatcggt aagtataaat atttgagaaa acacatggtc tggatattta aaaccctcat
     2461 aaacatgttg gtacagttaa taaacttatt tataattatg taa
//
