LOCUS       NM_148962               1637 bp    mRNA    linear   PRI 13-MAY-2024
DEFINITION  Homo sapiens oxoeicosanoid receptor 1 (OXER1), mRNA.
ACCESSION   NM_148962
VERSION     NM_148962.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1637)
  AUTHORS   Lin,L., Dai,F., Wei,J. and Chen,Z.
  TITLE     Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid and the
            OXE Receptor in Allergic Diseases: Collegium Internationale
            Allergologicum Update 2024
  JOURNAL   Int Arch Allergy Immunol 185 (4), 301-310 (2024)
   PUBMED   38176394
  REMARK    GeneRIF: Biological Roles of 5-Oxo-6,8,11,14-Eicosatetraenoic Acid
            and the OXE Receptor in Allergic Diseases: Collegium Internationale
            Allergologicum Update 2024.
            Review article
REFERENCE   2  (bases 1 to 1637)
  AUTHORS   Panagiotopoulos,A.A., Kalyvianaki,K., Serifoglou,B.,
            Konstantinou,E., Notas,G., Castanas,E. and Kampa,M.
  TITLE     OXER1 mediates testosterone-induced calcium responses in prostate
            cancer cells
  JOURNAL   Mol Cell Endocrinol 539, 111487 (2022)
   PUBMED   34634385
  REMARK    GeneRIF: OXER1 mediates testosterone-induced calcium responses in
            prostate cancer cells.
REFERENCE   3  (bases 1 to 1637)
  AUTHORS   Kalyvianaki,K., Drosou,I., Notas,G., Castanas,E. and Kampa,M.
  TITLE     Enhanced OXER1 expression is indispensable for human cancer cell
            migration
  JOURNAL   Biochem Biophys Res Commun 584, 95-100 (2021)
   PUBMED   34775286
  REMARK    GeneRIF: Enhanced OXER1 expression is indispensable for human
            cancer cell migration.
REFERENCE   4  (bases 1 to 1637)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1637)
  AUTHORS   Kalyvianaki,K., Panagiotopoulos,A.A., Malamos,P., Moustou,E.,
            Tzardi,M., Stathopoulos,E.N., Ioannidis,G.S., Marias,K., Notas,G.,
            Theodoropoulos,P.A., Castanas,E. and Kampa,M.
  TITLE     Membrane androgen receptors (OXER1, GPRC6A AND ZIP9) in prostate
            and breast cancer: A comparative study of their expression
  JOURNAL   Steroids 142, 100-108 (2019)
   PUBMED   30707908
  REMARK    GeneRIF: The G protein coupled oxo-eicosanoid receptor 1 (OXER1) (a
            receptor of the arachidonic acid metabolite, 5-oxoeicosatetraenoic
            acid, 5-oxoETE) is as a novel mAR involved in the rapid effects of
            androgens.
REFERENCE   6  (bases 1 to 1637)
  AUTHORS   Brink,C., Dahlen,S.E., Drazen,J., Evans,J.F., Hay,D.W.,
            Rovati,G.E., Serhan,C.N., Shimizu,T. and Yokomizo,T.
  TITLE     International Union of Pharmacology XLIV. Nomenclature for the
            oxoeicosanoid receptor
  JOURNAL   Pharmacol Rev 56 (1), 149-157 (2004)
   PUBMED   15001665
  REMARK    Review article
REFERENCE   7  (bases 1 to 1637)
  AUTHORS   Jones,C.E., Holden,S., Tenaillon,L., Bhatia,U., Seuwen,K.,
            Tranter,P., Turner,J., Kettle,R., Bouhelal,R., Charlton,S.,
            Nirmala,N.R., Jarai,G. and Finan,P.
  TITLE     Expression and characterization of a
            5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed
            on human eosinophils and neutrophils
  JOURNAL   Mol Pharmacol 63 (3), 471-477 (2003)
   PUBMED   12606753
  REMARK    GeneRIF: identification and cloning of a novel GPCR, R527;
            5-oxo-ETE was identified as the ligand for R527; very high level of
            mRNA expression in eosinophils with high expression also detected
            in neutrophils and lung macrophages
REFERENCE   8  (bases 1 to 1637)
  AUTHORS   Hosoi,T., Koguchi,Y., Sugikawa,E., Chikada,A., Ogawa,K., Tsuda,N.,
            Suto,N., Tsunoda,S., Taniguchi,T. and Ohnuki,T.
  TITLE     Identification of a novel human eicosanoid receptor coupled to
            G(i/o)
  JOURNAL   J Biol Chem 277 (35), 31459-31465 (2002)
   PUBMED   12065583
  REMARK    GeneRIF: Identification of a novel human receptor coupled to
            G(i/o).
REFERENCE   9  (bases 1 to 1637)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 1637)
  AUTHORS   Itoh,H., Toyama,R., Kozasa,T., Tsukamoto,T., Matsuoka,M. and
            Kaziro,Y.
  TITLE     Presence of three distinct molecular species of Gi protein alpha
            subunit. Structure of rat cDNAs and human genomic DNAs
  JOURNAL   J Biol Chem 263 (14), 6656-6664 (1988)
   PUBMED   2834384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC098824.3.
            
            On May 5, 2021 this sequence version replaced NM_148962.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC063549.1, AB083055.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000378661.4/ ENSP00000367930.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1637              AC098824.3         70142-71778         c
FEATURES             Location/Qualifiers
     source          1..1637
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p21"
     gene            1..1637
                     /gene="OXER1"
                     /gene_synonym="GPCR; GPR170; TG1019"
                     /note="oxoeicosanoid receptor 1"
                     /db_xref="GeneID:165140"
                     /db_xref="HGNC:HGNC:24884"
                     /db_xref="MIM:620064"
     exon            1..1637
                     /gene="OXER1"
                     /gene_synonym="GPCR; GPR170; TG1019"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..1228
                     /gene="OXER1"
                     /gene_synonym="GPCR; GPR170; TG1019"
                     /note="G-protein coupled receptor TG1019; 5-oxo-ETE acid
                     G-protein-coupled receptor 1; G-protein coupled receptor
                     170; G-protein coupled receptor R527; oxoeicosanoid (OXE)
                     receptor 1; 5-oxo-ETE G-protein coupled receptor; OXE
                     receptor"
                     /codon_start=1
                     /product="oxoeicosanoid receptor 1"
                     /protein_id="NP_683765.2"
                     /db_xref="CCDS:CCDS1810.2"
                     /db_xref="GeneID:165140"
                     /db_xref="HGNC:HGNC:24884"
                     /db_xref="MIM:620064"
                     /translation="MELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPC
                     HPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLL
                     ISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHH
                     VLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALY
                     LLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFG
                     MASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLT
                     RGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG"
     regulatory      1615..1620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXER1"
                     /gene_synonym="GPCR; GPR170; TG1019"
                     /note="hexamer: AATAAA"
     polyA_site      1637
                     /gene="OXER1"
                     /gene_synonym="GPCR; GPR170; TG1019"
                     /note="major polyA site"
ORIGIN      
        1 actttgccct gagcactcct gcaggggtag aagactccag aaccttctct caggcccatg
       61 gcccaagcag cccatggaac ttcataacct gagctctcca tctccctctc tctcctcctc
      121 tgttctccct ccctccttct ctccctcacc ctcctctgct ccctctgcct ttaccactgt
      181 gggggggtcc tctggagggc cctgccaccc cacctcttcc tcgctggtgt ctgccttcct
      241 ggcaccaatc ctggccctgg agtttgtcct gggcctggtg gggaacagtt tggccctctt
      301 catcttctgc atccacacgc ggccctggac ctccaacacg gtgttcctgg tcagcctggt
      361 ggccgctgac ttcctcctga tcagcaacct gcccctccgc gtggactact acctcctcca
      421 tgagacctgg cgctttgggg ctgctgcctg caaagtcaac ctcttcatgc tgtccaccaa
      481 ccgcacggcc agcgttgtct tcctcacagc catcgcactc aaccgctacc tgaaggtggt
      541 gcagccccac cacgtgctga gccgtgcttc cgtgggggca gctgcccggg tggccggggg
      601 actctgggtg ggcatcctgc tcctcaacgg gcacctgctc ctgagcacct tctccggccc
      661 ctcctgcctc agctacaggg tgggcacgaa gccctcggcc tcgctccgct ggcaccaggc
      721 actgtacctg ctggagttct tcctgccact ggcgctcatc ctctttgcta ttgtgagcat
      781 tgggctcacc atccggaacc gtggtctggg cgggcaggca ggcccgcaga gggccatgcg
      841 tgtgctggcc atggtggtgg ccgtctacac catctgcttc ttgcccagca tcatctttgg
      901 catggcttcc atggtggctt tctggctgtc cgcctgccga tccctggacc tctgcacaca
      961 gctcttccat ggctccctgg ccttcaccta cctcaacagt gtcctggacc ccgtgctcta
     1021 ctgcttctct agccccaact tcctccacca gagccgggcc ttgctgggcc tcacgcgggg
     1081 ccggcagggc ccagtgagcg acgagagctc ctaccaaccc tccaggcagt ggcgctaccg
     1141 ggaggcctct aggaaggcgg aggccatagg gaagctgaaa gtgcagggcg aggtctctct
     1201 ggaaaaggaa ggctcctccc agggctgagg gccagctgca gggctgcagc gctgtggggg
     1261 taagggctgc cgcgctctgg cctggaggga caaggccagc acacggtgcc tcaaccaact
     1321 ggacaaggga tggcggcaga ccaggggcca ggccaaagca ctggcaggac tcaggtgggt
     1381 ggcagggaga gaaacccacc taggcctctc agtgtgtcca ggatggcatt cccagaatgc
     1441 aggggagagc aggatgccgg gtggaggaga caggcaaggt gccgttggca caccagctca
     1501 gacaggggcc tgcgcagctg caggggacag acgccaatca ctgtcacagc agagtcacct
     1561 tagaaattgg acagctgcat gttctgtgct ctccagtttg tcccttccaa tattaataaa
     1621 cttccctttt aaatata
//
