LOCUS       NM_022120               1826 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens 3-oxoacid CoA-transferase 2 (OXCT2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_022120
VERSION     NM_022120.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1826)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1826)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1826)
  AUTHORS   Tanaka,H., Kohroki,J., Iguchi,N., Onishi,M. and Nishimune,Y.
  TITLE     Cloning and characterization of a human orthologue of
            testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t)
            cDNA
  JOURNAL   Mol Hum Reprod 8 (1), 16-23 (2002)
   PUBMED   11756565
REFERENCE   5  (bases 1 to 1826)
  AUTHORS   Lloyd,A.J. and Shoolingin-Jordan,P.M.
  TITLE     Dimeric pig heart succinate-coenzyme A transferase uses only one
            subunit to support catalysis
  JOURNAL   Biochemistry 40 (8), 2455-2467 (2001)
   PUBMED   11327867
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY013700.1 and AL033527.26.
            
            On May 17, 2019 this sequence version replaced NM_022120.1.
            
            Summary: The protein encoded by this gene catalyzes the transfer of
            a CoA group from succinate to acetoacetate and is an important
            enzyme in ketone body catabolism. The encoded protein localizes to
            the mitochondrion. This gene is intronless, and a pseudogene of
            this gene is located elsewhere on chromosome 1. [provided by
            RefSeq, Aug 2016].
            
            ##Evidence-Data-START##
            Transcript is intronless :: AY013700.1, AB050193.2 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327582.5/ ENSP00000361914.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1824              AY013700.1         1-1824
            1825-1826           AL033527.26        10053-10054         c
FEATURES             Location/Qualifiers
     source          1..1826
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..1826
                     /gene="OXCT2"
                     /gene_synonym="FKSG25; SCOTT"
                     /note="3-oxoacid CoA-transferase 2"
                     /db_xref="GeneID:64064"
                     /db_xref="HGNC:HGNC:18606"
                     /db_xref="MIM:610289"
     exon            1..1826
                     /gene="OXCT2"
                     /gene_synonym="FKSG25; SCOTT"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1647
                     /gene="OXCT2"
                     /gene_synonym="FKSG25; SCOTT"
                     /EC_number="2.8.3.5"
                     /note="testis-specific succinyl CoA:3-oxoacid
                     CoA-transferase; 3-oxoacid CoA-transferase 2A;
                     succinyl-CoA:3-ketoacid coenzyme A transferase 2,
                     mitochondrial"
                     /codon_start=1
                     /product="succinyl-CoA:3-ketoacid coenzyme A transferase
                     2, mitochondrial precursor"
                     /protein_id="NP_071403.1"
                     /db_xref="CCDS:CCDS445.1"
                     /db_xref="GeneID:64064"
                     /db_xref="HGNC:HGNC:18606"
                     /db_xref="MIM:610289"
                     /translation="MAALRLLASVLGRGVPAGGSGLALSQGCARCFATSPRLRAKFYA
                     DPVEMVKDISDGATVMIGGFGLCGIPENLIAALLRTRVKDLQVVSSNVGVEDFGLGLL
                     LAARQVRRIVCSYVGENTLCESQYLAGELELELTPQGTLAERIRAGGAGVPAFYTPTG
                     YGTLVQEGGAPIRYTPDGHLALMSQPREVREFNGDHFLLERAIRADFALVKGWKADRA
                     GNVVFRRSARNFNVPMCKAADVTAVEVEEIVEVGAFPPEDIHVPNIYVDRVIKGQKYE
                     KRIERLTILKEEDGDAGKEEDARTRIIRRAALEFEDGMYANLGIGIPLLASNFISPSM
                     TVHLHSENGILGLGPFPTEDEVDADLINAGKQTVTVLPGGCFFASDDSFAMIRGGHIQ
                     LTMLGAMQVSKYGDLANWMIPGKKVKGMGGAMDLVSSQKTRVVVTMQHCTKDNTPKIM
                     EKCTMPLTGKRCVDRIITEKAVFDVHRKKELTLRELWEGLTVDDIKKSTGCAFAVSPN
                     LRPMQQVAP"
     regulatory      1804..1809
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OXCT2"
                     /gene_synonym="FKSG25; SCOTT"
                     /note="hexamer: ATTAAA"
     polyA_site      1826
                     /gene="OXCT2"
                     /gene_synonym="FKSG25; SCOTT"
                     /note="major polyA site"
ORIGIN      
        1 cagggcgcgg gcgcccgccc tgctctgtga cgcgcggccc gaggcgcacg cagggctcac
       61 accacctgtc ctggcctccg acccgggccg actatggcgg cgctgcggct cctggcgtca
      121 gtgctcgggc gcggggtccc cgccggcggc tcagggctcg cgctgtccca gggctgcgcc
      181 cgctgctttg ccaccagtcc ccggctccgt gccaagttct acgcggaccc ggtggagatg
      241 gtgaaggaca tctctgacgg ggcgaccgtc atgatcgggg gcttcgggct ctgcgggatc
      301 cccgagaacc tgatcgccgc gctgctcagg acccgcgtga aagacctgca ggtggtcagc
      361 agcaacgtgg gcgtggagga cttcggcctg ggcctcctgc tggccgccag gcaggtccgt
      421 cgcatcgtct gttcctacgt gggcgagaac accctgtgcg agagccagta cctggcagga
      481 gagctggagc tggagctcac gccccagggc accctggccg agcgcatccg cgcggggggc
      541 gccggggtgc ccgccttcta cacccccacg ggctacggga ccctggtcca ggaagggggc
      601 gcccccatcc gctacacccc ggacggccac ctggcgctca tgagccagcc ccgagaggtg
      661 agggagttca acggcgacca cttccttttg gagcgcgcca tccgggcaga cttcgccctg
      721 gtgaaagggt ggaaggccga ccgggcagga aacgtggtct tcaggagaag cgcccgcaat
      781 ttcaacgtgc ccatgtgcaa agctgcagac gtcacggcgg tggaggtgga agagatcgtg
      841 gaggtggggg ctttcccccc agaagacatc cacgttccta acatttatgt agatcgcgtg
      901 ataaaggggc agaaatacga gaaacgaatt gagcgcttaa cgatcctgaa agaggaagat
      961 ggagacgctg gaaaggaaga ggacgccagg acgcgcatca tcagacgcgc agctctggaa
     1021 tttgaggacg gcatgtacgc caatctgggc ataggcatcc ccctgctggc cagcaacttc
     1081 atcagtccca gcatgactgt ccatcttcac agtgagaacg ggatcctggg cctgggcccg
     1141 tttcccacgg aagatgaggt ggatgccgac ctcatcaatg caggcaagca gacggtcacg
     1201 gtgcttcccg ggggctgctt cttcgccagc gacgactcct tcgccatgat ccgaggggga
     1261 cacatccaac taaccatgct tggagccatg caggtttcca aatacggcga cctggcgaac
     1321 tggatgatcc ctggcaagaa ggtgaaaggc atgggcggtg ccatggactt ggtgtccagt
     1381 cagaagacca gagtggtggt caccatgcag cactgcacaa aggacaacac ccccaagatc
     1441 atggagaaat gcaccatgcc gctgaccggg aagcggtgcg tggaccgcat catcaccgag
     1501 aaggccgtgt ttgacgtgca caggaagaaa gagctgacgc tgagggagct ctgggagggc
     1561 ctgacggtgg acgacatcaa aaagagcacg gggtgtgcct ttgctgtgtc cccgaacctc
     1621 aggcccatgc agcaggtggc accctgacgg gacctggatc tgggcggggt ggtgcgctcc
     1681 tcagggcggg tgccaccggg ttccccaggg gaatacatgt ccccagctct gggaggggtt
     1741 tgctactggc ctcctacttt cctccctagg tggacagtgc tcctctagag agctgcgact
     1801 ttaattaaaa acaacaggaa aacaga
//
