LOCUS       NM_001302757             683 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens ovo like zinc finger 3 (OVOL3), mRNA.
ACCESSION   NM_001302757
VERSION     NM_001302757.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 683)
  AUTHORS   Kumar,A., Bhandari,A., Sinha,R., Sardar,P., Sushma,M., Goyal,P.,
            Goswami,C. and Grapputo,A.
  TITLE     Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc
            finger domain coupled by hypervariable unstructured regions
  JOURNAL   PLoS One 7 (6), e39399 (2012)
   PUBMED   22737237
  REMARK    GeneRIF: Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes
            illustrates a conserved C2H2 zinc finger domain coupled by
            hypervariable unstructured regions in humans and other species
REFERENCE   2  (bases 1 to 683)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
REFERENCE   3  (bases 1 to 683)
  AUTHORS   Li,B., Dai,Q., Li,L., Nair,M., Mackay,D.R. and Dai,X.
  TITLE     Ovol2, a mammalian homolog of Drosophila ovo: gene structure,
            chromosomal mapping, and aberrant expression in blind-sterile mice
  JOURNAL   Genomics 80 (3), 319-325 (2002)
   PUBMED   12213202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC004144.1 and AD001527.1.
            
            On May 1, 2021 this sequence version replaced NM_001302757.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.948653.1,
                                           SRR14038191.3138159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2158188, SAMEA2161674
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000633214.2/ ENSP00000487603.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AC004144.1         42459-42612
            155-219             AC004144.1         42685-42749
            220-424             AD001527.1         2754-2958
            425-683             AD001527.1         3447-3705
FEATURES             Location/Qualifiers
     source          1..683
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.12"
     gene            1..683
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /note="ovo like zinc finger 3"
                     /db_xref="GeneID:728361"
                     /db_xref="HGNC:HGNC:14186"
                     /db_xref="MIM:616442"
     exon            1..154
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..633
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /note="OVO homolog-like 3; ovo-like 3"
                     /codon_start=1
                     /product="putative transcription factor ovo-like protein
                     3"
                     /protein_id="NP_001289686.1"
                     /db_xref="CCDS:CCDS82333.1"
                     /db_xref="GeneID:728361"
                     /db_xref="HGNC:HGNC:14186"
                     /db_xref="MIM:616442"
                     /translation="MPRAFLVRSRRPQPPNWGHLPDQLRGDAYIPDCSSLGGPPAQQS
                     SSVRDPWTAQPTQGNLTSAPRGPGTLGCPLCPKAFPLQRMLTRHLKCHSPVRRHLCRC
                     CGKGFHDAFDLKRHMRTHTGIRPFRCSACGKAFTQRCSLEAHLAKVHGQPASYAYRER
                     REKLHVCEDCGFTSSRPDTYAQHRALHRAA"
     exon            155..219
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /inference="alignment:Splign:2.1.0"
     exon            220..424
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /inference="alignment:Splign:2.1.0"
     exon            425..683
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      665..670
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
     polyA_site      683
                     /gene="OVOL3"
                     /gene_synonym="HOVO3"
                     /note="major polyA site"
ORIGIN      
        1 gggctgaggt ctgacagcag gtggaagcag cccctgtgtg tggagagcct tccggagggc
       61 atgccccgcg ccttcctggt caggagtcgg cgtccacagc cccccaactg gggccatctg
      121 cctgaccagc tccggggaga tgcctatatc ccagactgca gcagcctggg ggggccaccg
      181 gcacaacagt cgtccagtgt cagggatccg tggacagcgc agcccacaca gggcaacctg
      241 acctctgctc ccaggggccc tgggacgctg ggctgcccgc tctgccctaa ggccttccct
      301 ctgcagcgca tgctgacaag gcacctcaag tgccacagcc ccgtgcgccg ccacctgtgc
      361 cgctgttgtg gcaagggctt tcatgacgcc ttcgatctca agcgccacat gaggactcac
      421 actgggatcc ggcccttccg ctgcagtgct tgcgggaaag cgtttacgca gcgctgctcc
      481 ctggaagctc accttgctaa ggtgcatgga cagccggcca gctacgctta ccgtgagcgc
      541 cgcgagaagc tgcacgtgtg cgaggactgc ggcttcacca gctcccggcc cgacacctac
      601 gcacagcacc gcgccctgca ccgcgcagcc tgatacggtg tgccagcgtc ctccccacga
      661 ggcaaataaa cacagaaaac tca
//
