LOCUS       NM_004561               2988 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ovo like transcriptional repressor 1 (OVOL1), mRNA.
ACCESSION   NM_004561 XM_938747
VERSION     NM_004561.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2988)
  AUTHORS   Hemida,A.S., Hammam,M.A., Swilam,A.A. and Shehata,W.A.
  TITLE     Evaluation of OVOL1 and Filaggrin immunohistochemical expression
            and clinical relevance in psoriasis
  JOURNAL   Diagn Pathol 19 (1), 84 (2024)
   PUBMED   38907248
  REMARK    GeneRIF: Evaluation of OVOL1 and Filaggrin immunohistochemical
            expression and clinical relevance in psoriasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2988)
  AUTHORS   Fan,C., Wang,Q., van der Zon,G., Ren,J., Agaser,C., Slieker,R.C.,
            Iyengar,P.V., Mei,H. and Ten Dijke,P.
  TITLE     OVOL1 inhibits breast cancer cell invasion by enhancing the
            degradation of TGF-beta type I receptor
  JOURNAL   Signal Transduct Target Ther 7 (1), 126 (2022)
   PUBMED   35484112
  REMARK    GeneRIF: OVOL1 inhibits breast cancer cell invasion by enhancing
            the degradation of TGF-beta type I receptor.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2988)
  AUTHORS   Kutsuwada,Y., Yokota,K., Yoshida,K., Tsuda,H., Watanabe,K.,
            Matsumoto,A. and Iwamoto,S.
  TITLE     Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with the
            axillary microbiome in a Japanese population
  JOURNAL   J Dermatol Sci 105 (2), 98-104 (2022)
   PUBMED   35078690
  REMARK    GeneRIF: Association of HLA-DPB1, NLRP10, OVOL1, and ABCC11 with
            the axillary microbiome in a Japanese population.
REFERENCE   4  (bases 1 to 2988)
  AUTHORS   Sun,P., Vu,R., Dragan,M., Haensel,D., Gutierrez,G., Nguyen,Q.,
            Greenberg,E., Chen,Z., Wu,J., Atwood,S., Pearlman,E., Shi,Y.,
            Han,W., Kessenbrock,K. and Dai,X.
  TITLE     OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal
            Hyperplasia
  JOURNAL   J Invest Dermatol 141 (6), 1542-1552 (2021)
   PUBMED   33333123
  REMARK    GeneRIF: OVOL1 Regulates Psoriasis-Like Skin Inflammation and
            Epidermal Hyperplasia.
REFERENCE   5  (bases 1 to 2988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 2988)
  AUTHORS   Kumar,A., Bhandari,A., Sinha,R., Sardar,P., Sushma,M., Goyal,P.,
            Goswami,C. and Grapputo,A.
  TITLE     Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc
            finger domain coupled by hypervariable unstructured regions
  JOURNAL   PLoS One 7 (6), e39399 (2012)
   PUBMED   22737237
  REMARK    GeneRIF: Molecular phylogeny of OVOL1, OVOL2 and OVOL3 genes
            illustrates a conserved C2H2 zinc finger domain coupled by
            hypervariable unstructured regions in humans and other species
REFERENCE   7  (bases 1 to 2988)
  AUTHORS   Paternoster,L., Standl,M., Chen,C.M., Ramasamy,A., Bonnelykke,K.,
            Duijts,L., Ferreira,M.A., Alves,A.C., Thyssen,J.P., Albrecht,E.,
            Baurecht,H., Feenstra,B., Sleiman,P.M., Hysi,P., Warrington,N.M.,
            Curjuric,I., Myhre,R., Curtin,J.A., Groen-Blokhuis,M.M.,
            Kerkhof,M., Saaf,A., Franke,A., Ellinghaus,D., Folster-Holst,R.,
            Dermitzakis,E., Montgomery,S.B., Prokisch,H., Heim,K.,
            Hartikainen,A.L., Pouta,A., Pekkanen,J., Blakemore,A.I.,
            Buxton,J.L., Kaakinen,M., Duffy,D.L., Madden,P.A., Heath,A.C.,
            Montgomery,G.W., Thompson,P.J., Matheson,M.C., Le Souef,P., St
            Pourcain,B., Smith,G.D., Henderson,J., Kemp,J.P., Timpson,N.J.,
            Deloukas,P., Ring,S.M., Wichmann,H.E., Muller-Nurasyid,M.,
            Novak,N., Klopp,N., Rodriguez,E., McArdle,W., Linneberg,A.,
            Menne,T., Nohr,E.A., Hofman,A., Uitterlinden,A.G., van Duijn,C.M.,
            Rivadeneira,F., de Jongste,J.C., van der Valk,R.J., Wjst,M.,
            Jogi,R., Geller,F., Boyd,H.A., Murray,J.C., Kim,C., Mentch,F.,
            March,M., Mangino,M., Spector,T.D., Bataille,V., Pennell,C.E.,
            Holt,P.G., Sly,P., Tiesler,C.M., Thiering,E., Illig,T., Imboden,M.,
            Nystad,W., Simpson,A., Hottenga,J.J., Postma,D., Koppelman,G.H.,
            Smit,H.A., Soderhall,C., Chawes,B., Kreiner-Moller,E., Bisgaard,H.,
            Melen,E., Boomsma,D.I., Custovic,A., Jacobsson,B.,
            Probst-Hensch,N.M., Palmer,L.J., Glass,D., Hakonarson,H.,
            Melbye,M., Jarvis,D.L., Jaddoe,V.W., Gieger,C., Strachan,D.P.,
            Martin,N.G., Jarvelin,M.R., Heinrich,J., Evans,D.M. and
            Weidinger,S.
  CONSRTM   Australian Asthma Genetics Consortium (AAGC); Genetics of
            Overweight Young Adults (GOYA) Consortium; EArly Genetics &
            Lifecourse Epidemiology (EAGLE) Consortium
  TITLE     Meta-analysis of genome-wide association studies identifies three
            new risk loci for atopic dermatitis
  JOURNAL   Nat Genet 44 (2), 187-192 (2011)
   PUBMED   22197932
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2988)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   9  (bases 1 to 2988)
  AUTHORS   Dai,X., Schonbaum,C., Degenstein,L., Bai,W., Mahowald,A. and
            Fuchs,E.
  TITLE     The ovo gene required for cuticle formation and oogenesis in flies
            is involved in hair formation and spermatogenesis in mice
  JOURNAL   Genes Dev 12 (21), 3452-3463 (1998)
   PUBMED   9808631
REFERENCE   10 (bases 1 to 2988)
  AUTHORS   Chidambaram,A., Allikmets,R., Chandrasekarappa,S., Guru,S.C.,
            Modi,W., Gerrard,B. and Dean,M.
  TITLE     Characterization of a human homolog (OVOL1) of the Drosophila ovo
            gene, which maps to chromosome 11q13
  JOURNAL   Mamm Genome 8 (12), 950-951 (1997)
   PUBMED   9383297
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA585109.1, CV572438.1,
            BX648725.1 and BC059408.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004561.3.
            
            Summary: This gene encodes a putative zinc finger containing
            transcription factor that is highly similar to homologous protein
            in Drosophila and mouse. Based on known functions in these species,
            this protein is likely involved in hair formation and
            spermatogenesis in human as well. [provided by RefSeq, Aug 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059408.1, SRR5189667.56500.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335987.8/ ENSP00000337862.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               DA585109.1         43-188
            147-455             CV572438.1         130-438
            456-2021            BX648725.1         365-1930
            2022-2337           BC059408.1         2027-2342
            2338-2988           BX648725.1         2247-2897
FEATURES             Location/Qualifiers
     source          1..2988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..2988
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /note="ovo like transcriptional repressor 1"
                     /db_xref="GeneID:5017"
                     /db_xref="HGNC:HGNC:8525"
                     /db_xref="MIM:602313"
     exon            1..411
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1115
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /note="ovo homolog-like 1; ovo-like 1(Drosophila); ovo
                     like zinc finger 1"
                     /codon_start=1
                     /product="putative transcription factor Ovo-like 1"
                     /protein_id="NP_004552.2"
                     /db_xref="CCDS:CCDS8112.1"
                     /db_xref="GeneID:5017"
                     /db_xref="HGNC:HGNC:8525"
                     /db_xref="MIM:602313"
                     /translation="MPRAFLVKKPCVSTCKRNWSELPDEERGEIYVPVSLGFCPPQPY
                     REPEPSVAEPPSCPLALNMSLRDSSYSMAPGPCVVAQLPSEDMGHLTDPQSRDHGFLR
                     TKMKVTLGDSPSGDLFTCRVCQKAFTYQRMLNRHMKCHNDVKRHLCTYCGKGFNDTFD
                     LKRHVRTHTGVRPYKCSLCDKAFTQRCSLESHLKKIHGVQQKYAYKERRAKLYVCEEC
                     GCTSESQEGHVLHLKEHHPDSPLLRKTSKKVAVALQNTVTSLLQGSPHL"
     exon            412..629
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /inference="alignment:Splign:2.1.0"
     exon            630..819
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..2988
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2970..2975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /note="hexamer: ATTAAA"
     polyA_site      2988
                     /gene="OVOL1"
                     /gene_synonym="HOVO1"
                     /note="major polyA site"
ORIGIN      
        1 gcactttaag acttcccgag cggcggcggg gacgccagtc gagccgggag acgcttacct
       61 gccgcttccc cgcgccgccc ggtgcacctg gccgcaaggg acctcgttct cagggaagac
      121 ggcgacattc cgcggaggtg gaaccgccgc gcgccgtccg ggctcggacc ttccccggaa
      181 cgtgggggcg ccttagcgac tccttccctg ttgtgccccc gttcccggcg ttcagcccgg
      241 ccccgcaaag gtgggacggc tcccggcttc agttacggaa gcggcccgtg tccagcgacg
      301 agggttcgaa aatgccccgc gcgttcctgg tgaagaagcc gtgcgtctcc acgtgcaaga
      361 ggaactggag cgagctcccc gacgaggagc gcggcgagat ctacgtgcca gtcagcctgg
      421 gcttctgccc accacagccc taccgggagc cggaaccctc tgtggccgaa cccccttcct
      481 gcccgctggc tttgaacatg agccttcgag actctagcta cagcatggcc cccgggccct
      541 gtgtggtggc ccagctgccc tctgaagaca tgggccactt gacagacccc cagagcagag
      601 accatggctt cctgcgcacc aagatgaagg tgacccttgg ggacagtccc agtggagacc
      661 tgttcacctg ccgtgtctgc cagaaggcct tcacctacca gcgcatgctg aaccgccaca
      721 tgaagtgtca caacgacgtc aagaggcacc tctgcacgta ctgcgggaag ggcttcaatg
      781 acaccttcga cctcaagaga cacgtccgaa ctcacactgg cgtgcggccc tacaagtgca
      841 gcctgtgtga caaggccttc acgcagcgct gctctctgga gtctcacctc aagaagatcc
      901 atggtgtgca gcagaagtac gcgtacaagg agcggcgggc caagctgtac gtgtgtgagg
      961 agtgcggctg cacatctgag agccaggagg gccacgtcct gcacctgaag gagcaccacc
     1021 ctgacagccc gctgctgcgc aagacctcca agaaggtggc cgtggcacta cagaacactg
     1081 tcacttccct gctgcagggc agcccccacc tgtgagtggc tcgagccctg ggggtgctcc
     1141 tggaagcccc aagagcatcc aggattgcct cccagctgcc tggccagccc accctcctgc
     1201 aacctctcac ccgaacacca gtgatcagga ctggagcccc cgtgccttgg tctcccccct
     1261 gggcacacgt gctcactcag gcccagcaat gacctctgct catttttgca tttttgactt
     1321 atgggccgag gctgttctga gcctgggaag atgtacctat gtcaagagaa gggatgaggc
     1381 caaggctgcc ttcaattaga agcagccgcc cacagagaca ggcactgtgt gcctggcagc
     1441 aggacttcct acccagagga ggttcgagct aggatcccac tgcccccgcc tctcagcaca
     1501 gggcaggggc tgcaggtccc cagtggacat cagagtcaaa agcactggca aagggtaccc
     1561 ctgcaaacaa ctgtggtggg ggctggcagc agacccccca cctggcaggg cttctaatgc
     1621 tcagggttct ggagggctct gtccttccgg caaggagagg cacacatgtg tgcccagccg
     1681 tgtgtgtgcg tgtgcttgtg tgtgtgcact gctgtgtgtg tgtgcacgca caggaagcct
     1741 ttccacatat cacctcattt ctaagaaata aactacaagg tgccaagaag gttttatttc
     1801 cttttatttt ttaaagatga caaatgtaca gatgttaata tatttttggt gccaatggcg
     1861 atgtttttaa gagtgggatg gagctggctt ttctccattc ccgtgcgctt ctatttatcc
     1921 tggacatttc aaacctcctc tgtgccttgg ctctgggcgg gggctgcccc aacccacccc
     1981 cgttctttgt acgtgctgag acagccacta gaagatcttc ctccagcggc gccctggacg
     2041 gctgctcctg cgaacagccc atggcatctt ctgctcttcc ctcccggctc tgccctgcac
     2101 atcctgttga gccaagcccc agtgacccgg agagctggcc tgatgctgag agtgtgtcct
     2161 cctggggctt tagggggcag gaaggtggga cgaatgacga tgcccatcca ctacctgaag
     2221 cactaggaca ctcttgcagg gccaggctgg aagaccggcc cttttcttgg ttgagtcaaa
     2281 agccttagca cagtggcaaa aaatgggaca gaatgatgac cagcacctca gaaacttcca
     2341 gagggaggag aggatttgat ggctaccaaa ttgtatctgt tgcctttttt ctgacttttt
     2401 cacctgacca ggctggggtt tggagtggct gtggggagac ccgtcctggc tggctggctg
     2461 gctcccttgc tcccttgctg cagctgggaa aggggttctg ggtgtaaaga ggtgtgcgtc
     2521 ttgtgggcca aagggaaaaa caggcagggg tcagagccag cctgccagag gcaaatgcaa
     2581 aagaggtccc cagaacacag ccagctgggc agccccttaa agccaaaccc cacctgaagc
     2641 agaaccactt tggcctcccc tgcccaaaat gggtagtgtc tacacgtccc cgggctcagg
     2701 ctcaggccca gccctgggct gacctgagag gaaggctcct tcctggactg ccctctgaaa
     2761 tgtgtataga ttgattctaa aatctcttgt ttcacttgac tttagagtgt ctgggacgct
     2821 gctgtattct gaaagtcaca tagcacacag taatgttatc tggaagctct gtttttgttt
     2881 acatttctgt atccctgggt tgactgccaa tccgaggccg tcatgaagct ctgtgttgtc
     2941 tgttttattt tataaccttc ctctcaacta ttaaaattag agatctaa
//
