LOCUS       NM_002557               2196 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens oviductal glycoprotein 1 (OVGP1), mRNA.
ACCESSION   NM_002557
VERSION     NM_002557.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2196)
  AUTHORS   Zhao,Y. and Kan,F.W.K.
  TITLE     Human OVGP1 enhances tyrosine phosphorylation of proteins in the
            fibrous sheath involving AKAP3 and increases sperm-zona binding
  JOURNAL   J Assist Reprod Genet 36 (7), 1363-1377 (2019)
   PUBMED   31254143
  REMARK    GeneRIF: The present study revealed that one of the major
            rHuOVGP1-enhanced pY proteins could be AKAP3 of the FS and that
            rHuOVGP1 is capable of binding to human ZP and its presence in the
            medium results in an increase in sperm-zona binding. Supplement of
            rHuOVGP1 in in vitro fertilization media could be beneficial for
            enhancement of the fertilizing ability of human sperm.
REFERENCE   2  (bases 1 to 2196)
  AUTHORS   Laheri,S., Ashary,N., Bhatt,P. and Modi,D.
  TITLE     Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial
            epithelium that regulates receptivity and trophoblast adhesion
  JOURNAL   J Assist Reprod Genet 35 (8), 1419-1429 (2018)
   PUBMED   29968069
  REMARK    GeneRIF: OVGP1 is specifically induced in the luminal epithelium at
            the time of embryo implantation where it regulates
            receptivity-related genes and aids in trophoblast adhesion.
REFERENCE   3  (bases 1 to 2196)
  AUTHORS   Yamamoto-Furusho,J.K., Mendivil,E.J. and Fonseca-Camarillo,G.
  TITLE     Reduced expression of mucin 9 (MUC9) in patients with ulcerative
            colitis
  JOURNAL   Inflamm Bowel Dis 18 (3), E601 (2012)
   PUBMED   22028245
  REMARK    GeneRIF: Decreased gene expression of MUC9 was found from colonic
            biopsies in patients with active and remission ulcerative colitis.
            Erratum:[Inflamm Bowel Dis. 2015 Nov;21(11):2735. Mendivil-Rangel,
            Edgar J [corrected to Mendivil, Edgar J]]
REFERENCE   4  (bases 1 to 2196)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 2196)
  AUTHORS   Maines-Bandiera,S., Woo,M.M., Borugian,M., Molday,L.L., Hii,T.,
            Gilks,B., Leung,P.C., Molday,R.S. and Auersperg,N.
  TITLE     Oviductal glycoprotein (OVGP1, MUC9): a differentiation-based mucin
            present in serum of women with ovarian cancer
  JOURNAL   Int J Gynecol Cancer 20 (1), 16-22 (2010)
   PUBMED   20130498
  REMARK    GeneRIF: OVGP1 seems to detect a different spectrum of ovarian
            epithelial cancers than other markers and thus should be a useful
            adjunct for more accurate detection, particularly of early serous
            ovarian cancers and mucinous carcinomas.
REFERENCE   6  (bases 1 to 2196)
  AUTHORS   Lok,I.H., Briton-Jones,C.M., Yuen,P.M. and Haines,C.J.
  TITLE     Variable expression of oviductin mRNA at different stages of human
            reproductive cycle
  JOURNAL   J Assist Reprod Genet 19 (12), 569-576 (2002)
   PUBMED   12503889
  REMARK    GeneRIF: The production and function of oviductin at different
            stages of human reproductive cycle is not well known. Its highest
            expression at the time of ovulation is consistent with a supportive
            role in fertilization and early embryo development.
REFERENCE   7  (bases 1 to 2196)
  AUTHORS   Agarwal,A., Yeung,W.S. and Lee,K.F.
  TITLE     Cloning and characterization of the human oviduct-specific
            glycoprotein (HuOGP) gene promoter
  JOURNAL   Mol Hum Reprod 8 (2), 167-175 (2002)
   PUBMED   11818519
  REMARK    GeneRIF: cloning and characterization of the promoter and gene
            expression regulation in the oviduct (human oviduct-specific
            glycoprotein, HuOPG)
REFERENCE   8  (bases 1 to 2196)
  AUTHORS   Lapensee,L., Paquette,Y. and Bleau,G.
  TITLE     Allelic polymorphism and chromosomal localization of the human
            oviductin gene (MUC9)
  JOURNAL   Fertil Steril 68 (4), 702-708 (1997)
   PUBMED   9341614
REFERENCE   9  (bases 1 to 2196)
  AUTHORS   Arias,E.B., Verhage,H.G. and Jaffe,R.C.
  TITLE     Complementary deoxyribonucleic acid cloning and molecular
            characterization of an estrogen-dependent human oviductal
            glycoprotein
  JOURNAL   Biol Reprod 51 (4), 685-694 (1994)
   PUBMED   7819450
REFERENCE   10 (bases 1 to 2196)
  AUTHORS   Verhage,H.G., Fazleabas,A.T. and Donnelly,K.
  TITLE     The in vitro synthesis and release of proteins by the human oviduct
  JOURNAL   Endocrinology 122 (4), 1639-1645 (1988)
   PUBMED   3278893
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AY189737.1 and U09550.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002557.3.
            
            Summary: This gene encodes a large, carbohydrate-rich, epithelial
            glycoprotein with numerous O-glycosylation sites located within
            threonine, serine, and proline-rich tandem repeats. The gene is
            similar to members of the mucin and the glycosyl hydrolase 18 gene
            families. Regulation of expression may be estrogen-dependent. Gene
            expression and protein secretion occur during late follicular
            development through early cleavage-stage embryonic development. The
            protein is secreted from non-ciliated oviductal epithelial cells
            and associates with ovulated oocytes, blastomeres, and spermatozoan
            acrosomal regions. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314074.1, U09550.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369732.4/ ENSP00000358747.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-655               AY189737.1         44-698
            656-2196            U09550.1           654-2194
FEATURES             Location/Qualifiers
     source          1..2196
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p13.2"
     gene            1..2196
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /note="oviductal glycoprotein 1"
                     /db_xref="GeneID:5016"
                     /db_xref="HGNC:HGNC:8524"
                     /db_xref="MIM:603578"
     exon            1..39
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2051
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /note="mucin 9; estrogen-dependent oviduct protein;
                     oviductal glycoprotein 1, 120kDa; oviductin;
                     oviduct-specific glycoprotein; oviduct glycoprotein"
                     /codon_start=1
                     /product="oviduct-specific glycoprotein precursor"
                     /protein_id="NP_002548.3"
                     /db_xref="CCDS:CCDS834.1"
                     /db_xref="GeneID:5016"
                     /db_xref="HGNC:HGNC:8524"
                     /db_xref="MIM:603578"
                     /translation="MWKLLLWVGLVLVLKHHDGAAHKLVCYFTNWAHSRPGPASILPH
                     DLDPFLCTHLIFAFASMNNNQIVAKDLQDEKILYPEFNKLKERNRELKTLLSIGGWNF
                     GTSRFTTMLSTFANREKFIASVISLLRTHDFDGLDLFFLYPGLRGSPMHDRWTFLFLI
                     EELLFAFRKEALLTMRPRLLLSAAVSGVPHIVQTSYDVRFLGRLLDFINVLSYDLHGS
                     WERFTGHNSPLFSLPEDPKSSAYAMNYWRKLGAPSEKLIMGIPTYGRTFRLLKASKNG
                     LQARAIGPASPGKYTKQEGFLAYFEICSFVWGAKKHWIDYQYVPYANKGKEWVGYDNA
                     ISFSYKAWFIRREHFGGAMVWTLDMDDVRGTFCGTGPFPLVYVLNDILVRAEFSSTSL
                     PQFWLSSAVNSSSTDPERLAVTTAWTTDSKILPPGGEAGVTEIHGKCENMTITPRGTT
                     VTPTKETVSLGKHTVALGEKTEITGAMTMTSVGHQSMTPGEKALTPVGHQSVTTGQKT
                     LTSVGYQSVTPGEKTLTPVGHQSVTPVSHQSVSPGGTTMTPVHFQTETLRQNTVAPRR
                     KAVAREKVTVPSRNISVTPEGQTMPLRGENLTSEVGTHPRMGNLGLQMEAENRMMLSS
                     SPVIQLPEQTPLAFDNRFVPIYGNHSSVNSVTPQTSPLSLKKEIPENSAVDEEA"
     exon            40..69
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            70..274
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            275..331
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            332..497
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            498..622
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            623..731
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            732..917
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1034
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1170
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..2196
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2176..2181
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /note="hexamer: AATAAA"
     polyA_site      2196
                     /gene="OVGP1"
                     /gene_synonym="CHIT5; EGP; MUC9; OGP"
                     /note="major polyA site"
ORIGIN      
        1 atcagaccat tgagatgtgg aagctgttgc tgtgggttgg gctggttctt gtgctgaaac
       61 accacgatgg tgctgcccat aaactcgtgt gttatttcac caactgggca cacagtcggc
      121 caggccctgc ctcgatcttg ccccatgacc tggacccctt tctctgcacc cacctgatat
      181 ttgcctttgc ctcaatgaac aacaatcaga ttgttgctaa ggatctccag gatgagaaaa
      241 ttctctaccc agagttcaac aaactaaagg agaggaacag agagctgaaa acactactgt
      301 ccatcggcgg gtggaacttt ggcacctcaa gattcaccac tatgttgtcc acatttgcca
      361 accgtgaaaa gtttattgct tcagttatat cccttctgag gacacatgac tttgatggtc
      421 ttgacctttt cttcttatat cctggactaa gaggcagccc catgcatgac cggtggactt
      481 ttctcttctt aattgaagag ctcctgtttg ccttccggaa ggaggcactg ctcaccatgc
      541 gcccgaggct gctgctgtct gctgctgttt ctggggtccc acacatcgtc caaacatcct
      601 atgatgtgcg ctttctagga agactcctgg atttcatcaa tgtcttgtct tatgacttac
      661 atggaagttg ggaaaggttc acaggacata atagccccct cttctctctg cctgaagacc
      721 ccaaatcttc ggcatatgct atgaattatt ggagaaagct tggggcaccc tcagagaagc
      781 tcatcatggg gatccccacc tatggacgta cctttcgcct cctcaaagcc tctaagaatg
      841 ggttgcaggc cagagcgatc ggaccagcat ctccagggaa gtacaccaag caagaaggct
      901 tcttggctta ttttgagatt tgttcctttg tctggggagc gaagaagcac tggattgatt
      961 accagtatgt cccgtatgcc aacaagggga aagagtgggt tggctatgac aatgccatca
     1021 gcttcagtta caaggcatgg tttataaggc gagagcattt tgggggggcc atggtgtgga
     1081 cattggacat ggatgacgtc aggggcacgt tctgtggcac tggccctttc ccccttgtct
     1141 acgtattgaa tgatatcctg gtgcgggctg agttcagttc aacttcttta ccacaatttt
     1201 ggctgtcatc tgctgtgaat tcttcaagca ctgaccctga aaggctggct gtgaccacgg
     1261 catggaccac tgatagtaag attttgcccc caggaggaga ggctggggtc actgagatcc
     1321 acggaaagtg tgaaaatatg actataaccc ctagaggtac aactgtgacc cctacaaagg
     1381 aaactgtatc ccttggaaag cacactgtag ctctaggaga gaagactgag atcactgggg
     1441 caatgaccat gacttctgtg ggtcatcagt ccatgacccc tggagagaag gccctgaccc
     1501 ctgtgggtca tcaatctgtg accactggac agaagaccct gacctctgtg ggttatcagt
     1561 ctgtgacccc tggggaaaag accctgaccc ctgtgggtca tcagtctgtg acccctgtga
     1621 gtcatcagtc tgtgagccct ggaggaacga ctatgacccc tgtccatttt cagactgaga
     1681 cccttagaca gaatacagtg gcccctagaa ggaaggctgt ggcccgtgaa aaggtgactg
     1741 tcccctccag aaacatatca gtcacccctg aagggcagac tatgccttta agaggggaga
     1801 atttgacttc tgaggtgggc actcacccca ggatgggtaa cttgggtctt cagatggaag
     1861 ctgaaaacag gatgatgctg tcctccagcc ccgtcatcca gctcccggaa caaactcctc
     1921 tagcttttga caaccgcttt gttcccatct atggaaacca ttcctctgtc aactcagtaa
     1981 cccctcaaac aagtcctctt tctctaaaaa aagaaatccc agaaaactct gctgtggatg
     2041 aagaagccta agcccctctg gtgtcagaaa ccagggaaaa cccttgtctt ttcttctaag
     2101 tgacatgttg gaagccttct catcccgggg caaagcaggc atcaaaacca gaataggcca
     2161 atctcttttc cattaaataa actgtaaaca caagaa
//
