LOCUS       NM_198185               1978 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens ovochymase 2 (OVCH2), transcript variant 1, mRNA.
ACCESSION   NM_198185 XM_006718221 XM_291982
VERSION     NM_198185.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1978)
  AUTHORS   Kiyozumi,D., Noda,T., Yamaguchi,R., Tobita,T., Matsumura,T.,
            Shimada,K., Kodani,M., Kohda,T., Fujihara,Y., Ozawa,M., Yu,Z.,
            Miklossy,G., Bohren,K.M., Horie,M., Okabe,M., Matzuk,M.M. and
            Ikawa,M.
  TITLE     NELL2-mediated lumicrine signaling through OVCH2 is required for
            male fertility
  JOURNAL   Science 368 (6495), 1132-1135 (2020)
   PUBMED   32499443
REFERENCE   2  (bases 1 to 1978)
  AUTHORS   Heard-Costa,N.L., Zillikens,M.C., Monda,K.L., Johansson,A.,
            Harris,T.B., Fu,M., Haritunians,T., Feitosa,M.F., Aspelund,T.,
            Eiriksdottir,G., Garcia,M., Launer,L.J., Smith,A.V., Mitchell,B.D.,
            McArdle,P.F., Shuldiner,A.R., Bielinski,S.J., Boerwinkle,E.,
            Brancati,F., Demerath,E.W., Pankow,J.S., Arnold,A.M., Chen,Y.D.,
            Glazer,N.L., McKnight,B., Psaty,B.M., Rotter,J.I., Amin,N.,
            Campbell,H., Gyllensten,U., Pattaro,C., Pramstaller,P.P., Rudan,I.,
            Struchalin,M., Vitart,V., Gao,X., Kraja,A., Province,M.A.,
            Zhang,Q., Atwood,L.D., Dupuis,J., Hirschhorn,J.N., Jaquish,C.E.,
            O'Donnell,C.J., Vasan,R.S., White,C.C., Aulchenko,Y.S., Estrada,K.,
            Hofman,A., Rivadeneira,F., Uitterlinden,A.G., Witteman,J.C.,
            Oostra,B.A., Kaplan,R.C., Gudnason,V., O'Connell,J.R.,
            Borecki,I.B., van Duijn,C.M., Cupples,L.A., Fox,C.S. and North,K.E.
  TITLE     NRXN3 is a novel locus for waist circumference: a genome-wide
            association study from the CHARGE Consortium
  JOURNAL   PLoS Genet 5 (6), e1000539 (2009)
   PUBMED   19557197
REFERENCE   3  (bases 1 to 1978)
  AUTHORS   Taylor,T.D., Noguchi,H., Totoki,Y., Toyoda,A., Kuroki,Y., Dewar,K.,
            Lloyd,C., Itoh,T., Takeda,T., Kim,D.W., She,X., Barlow,K.F.,
            Bloom,T., Bruford,E., Chang,J.L., Cuomo,C.A., Eichler,E.,
            FitzGerald,M.G., Jaffe,D.B., LaButti,K., Nicol,R., Park,H.S.,
            Seaman,C., Sougnez,C., Yang,X., Zimmer,A.R., Zody,M.C.,
            Birren,B.W., Nusbaum,C., Fujiyama,A., Hattori,M., Rogers,J.,
            Lander,E.S. and Sakaki,Y.
  TITLE     Human chromosome 11 DNA sequence and analysis including novel gene
            identification
  JOURNAL   Nature 440 (7083), 497-500 (2006)
   PUBMED   16554811
REFERENCE   4  (bases 1 to 1978)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104237.2 and ABBA01028682.1.
            
            On Sep 28, 2020 this sequence version replaced NM_198185.6.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1968832
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000533663.6/
                                                ENSP00000484497.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AC104237.2         45304-45474
            172-281             AC104237.2         47107-47216
            282-373             AC104237.2         47992-48083
            374-546             AC104237.2         49452-49624
            547-642             AC104237.2         49970-50065
            643-794             AC104237.2         50306-50457
            795-984             AC104237.2         51296-51485
            985-1008            AC104237.2         53008-53031
            1009-1099           AC104237.2         54982-55072
            1100-1224           AC104237.2         55192-55316
            1225-1246           AC104237.2         56071-56092
            1247-1278           ABBA01028682.1     19961-19992         c
            1279-1365           AC104237.2         56441-56527
            1366-1496           AC104237.2         56909-57039
            1497-1590           AC104237.2         60102-60195
            1591-1722           AC104237.2         60697-60828
            1723-1812           AC104237.2         62084-62173
            1813-1978           AC104237.2         62495-62660
FEATURES             Location/Qualifiers
     source          1..1978
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..1978
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /note="ovochymase 2"
                     /db_xref="GeneID:341277"
                     /db_xref="HGNC:HGNC:29970"
                     /db_xref="MIM:618962"
     exon            1..171
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..1781
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /EC_number="3.4.21.120"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; oviductin protease"
                     /codon_start=1
                     /product="ovochymase-2 isoform 1 precursor"
                     /protein_id="NP_937828.3"
                     /db_xref="CCDS:CCDS73251.1"
                     /db_xref="GeneID:341277"
                     /db_xref="HGNC:HGNC:29970"
                     /db_xref="MIM:618962"
                     /translation="MLISRNKLILLLGIVFFERGKSATLSLPKAPSCGQSLVKVQPWN
                     YFNIFSRILGGSQVEKGSYPWQVSLKQRQKHICGGSIVSPQWVITAAHCIANRNIVST
                     LNVTAGEYDLSQTDPGEQTLTIETVIIHPHFSTKKPMDYDIALLKMAGAFQFGHFVGP
                     ICLPELREQFEAGFICTTAGWGRLTEGGVLSQVLQEVNLPILTWEECVAALLTLKRPI
                     SGKTFLCTGFPDGGRDACQGDSGGSLMCRNKKGAWTLAGVTSWGLGCGRGWRNNVRKS
                     DQGSPGIFTDISKVLPWIHEHIQTGNRRKSSRAWCSEQDVIVSGAEGKLHFPESLHLY
                     YESKQRCVWTLLVPEEMHVLLSFSHLDVESCHHSYLSMYSLEDRPIGKFCGESLPSSI
                     LIGSNSLRLKFVSDATDNAAGFNLTYKALKPNYIPDSGCSYLTVLFEEGLIQSLNYPE
                     NYSDKANCDWIFQASKHHLIKLSFQSLEIEESGDCTSDYVTVHSDVERKKEIARLCGY
                     DVPTPVLSPSSIMLISFQSDENGTCRGFQATVSFIPKAVYPDLNISISEDESMFLET"
     exon            172..281
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            282..373
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            374..546
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            547..642
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            643..794
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            795..984
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1008
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1099
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1224
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1365
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1496
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1590
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1722
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1812
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1978
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1954..1959
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /note="hexamer: AATAAA"
     polyA_site      1978
                     /gene="OVCH2"
                     /gene_synonym="OVTN"
                     /note="major polyA site"
ORIGIN      
        1 gcttattgct ggtctctcaa ggcttcctat ttttgtttgc tttagtctct ctaaaatttc
       61 agggaaaaac tatgagtctc aaaatgctta taagcaggaa caagctgatt ttactactag
      121 gaatagtctt ttttgaacga ggtaaatctg caactctttc gctccccaaa gctcccagtt
      181 gtgggcagag tctggttaag gtacagcctt ggaattattt taacattttc agtcgcattc
      241 ttggaggaag ccaagtggag aagggttcct atccctggca ggtatctctg aaacaaaggc
      301 agaagcatat ttgtggagga agcatcgtct caccacagtg ggtgatcacg gcggctcact
      361 gcattgcaaa cagaaacatt gtgtctactt tgaatgttac tgctggagag tatgacttaa
      421 gccagacaga cccaggagag caaactctca ctattgaaac tgtcatcata catccacatt
      481 tctccaccaa gaaaccaatg gactatgata ttgccctttt gaagatggct ggagccttcc
      541 aatttggcca ctttgtgggg cccatatgtc ttccagagct gcgggagcaa tttgaggctg
      601 gttttatttg tacaactgca ggctggggcc gcttaactga aggtggcgtc ctctcacaag
      661 tcttgcagga agtgaatctg cctattttga cctgggaaga gtgtgtggca gctctgttaa
      721 cactaaagag gcccatcagt gggaagacct ttctttgcac aggttttcct gatggaggga
      781 gagacgcatg tcagggagat tcaggaggtt cactcatgtg ccggaataag aaaggggcct
      841 ggactctggc tggtgtgact tcctggggtt tgggctgtgg tcgaggctgg agaaacaatg
      901 tgaggaaaag tgatcaagga tcccctggga tcttcacaga cattagtaaa gtgcttccct
      961 ggatccacga acacatccaa actggtaatc ggagaaagag ctccagagcc tggtgcagtg
     1021 agcaggatgt catagtcagc ggggctgagg ggaagctgca cttcccagaa agcctccacc
     1081 tatattatga gagcaagcaa cggtgtgtct ggaccctgct ggtaccagag gaaatgcatg
     1141 tgttgctcag tttttcccac ctagatgttg agtcttgtca ccacagttac ctgtcaatgt
     1201 attctttaga agacagaccc attggaaaat tttgtggaga aagcctccct tcatccattc
     1261 ttattggctc taattctcta aggctgaaat tcgtctctga tgccacagat aatgcagctg
     1321 ggtttaatct tacctataaa gctcttaaac caaactacat tcctgattca ggttgcagtt
     1381 acttaactgt cctttttgaa gaaggtctca tacagagtct aaactatcct gaaaactaca
     1441 gtgacaaggc taactgtgac tggatttttc aagcctccaa acatcaccta attaagcttt
     1501 catttcagag tctggaaata gaagaaagtg gagactgcac ttccgactat gtgacagtgc
     1561 acagcgatgt agaaaggaag aaggaaatag ctcggctgtg tggctatgat gtccccaccc
     1621 ctgtgctgag cccctccagc atcatgctca tcagcttcca atcagatgaa aacgggacct
     1681 gcaggggctt tcaggctaca gtctccttca ttcctaaagc agtataccca gatttaaaca
     1741 tctccatatc agaggatgaa tcaatgtttc tggagacatg agatgtgcca aatggagaaa
     1801 ccaatgtttc tggccaaggg gcaccagtga ctgtcagtaa accaccagaa gctagaggag
     1861 aggcttgggg cagactcctc gtcacagccc tcagacagag ccatccctgc tgacacgttg
     1921 atcttggact tctagcctcc agaactatga gacaataaat ttctgttgtt ctaagcca
//
