LOCUS       NM_001353179            4154 bp    mRNA    linear   PRI 22-JAN-2025
DEFINITION  Homo sapiens ovochymase 1 (OVCH1), mRNA.
ACCESSION   NM_001353179 XM_011520639
VERSION     NM_001353179.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4154)
  AUTHORS   Scherer,S.E., Muzny,D.M., Buhay,C.J., Chen,R., Cree,A., Ding,Y.,
            Dugan-Rocha,S., Gill,R., Gunaratne,P., Harris,R.A., Hawes,A.C.,
            Hernandez,J., Hodgson,A.V., Hume,J., Jackson,A., Khan,Z.M.,
            Kovar-Smith,C., Lewis,L.R., Lozado,R.J., Metzker,M.L.,
            Milosavljevic,A., Miner,G.R., Montgomery,K.T., Morgan,M.B.,
            Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z., Steffen,D.,
            Lovering,R.C., Wheeler,D.A., Worley,K.C., Yuan,Y., Zhang,Z.,
            Adams,C.Q., Ansari-Lari,M.A., Ayele,M., Brown,M.J., Chen,G.,
            Chen,Z., Clerc-Blankenburg,K.P., Davis,C., Delgado,O., Dinh,H.H.,
            Draper,H., Gonzalez-Garay,M.L., Havlak,P., Jackson,L.R.,
            Jacob,L.S., Kelly,S.H., Li,L., Li,Z., Liu,J., Liu,W., Lu,J.,
            Maheshwari,M., Nguyen,B.V., Okwuonu,G.O., Pasternak,S., Perez,L.M.,
            Plopper,F.J., Santibanez,J., Shen,H., Tabor,P.E., Verduzco,D.,
            Waldron,L., Wang,Q., Williams,G.A., Zhang,J., Zhou,J., Allen,C.C.,
            Amin,A.G., Anyalebechi,V., Bailey,M., Barbaria,J.A., Bimage,K.E.,
            Bryant,N.P., Burch,P.E., Burkett,C.E., Burrell,K.L., Calderon,E.,
            Cardenas,V., Carter,K., Casias,K., Cavazos,I., Cavazos,S.R.,
            Ceasar,H., Chacko,J., Chan,S.N., Chavez,D., Christopoulos,C.,
            Chu,J., Cockrell,R., Cox,C.D., Dang,M., Dathorne,S.R., David,R.,
            Davis,C.M., Davy-Carroll,L., Deshazo,D.R., Donlin,J.E., D'Souza,L.,
            Eaves,K.A., Simons,R., Emery-Cohen,A.J., Escotto,M., Flagg,N.,
            Forbes,L.D., Gabisi,A.M., Garza,M., Hamilton,C., Henderson,N.,
            Hernandez,O., Hines,S., Hogues,M.E., Huang,M., Idlebird,D.G.,
            Johnson,R., Jolivet,A., Jones,S., Kagan,R., King,L.M., Leal,B.,
            Lebow,H., Lee,S., LeVan,J.M., Lewis,L.C., London,P.,
            Lorensuhewa,L.M., Loulseged,H., Lovett,D.A., Lucier,A.,
            Lucier,R.L., Ma,J., Madu,R.C., Mapua,P., Martindale,A.D.,
            Martinez,E., Massey,E., Mawhiney,S., Meador,M.G., Mendez,S.,
            Mercado,C., Mercado,I.C., Merritt,C.E., Miner,Z.L., Minja,E.,
            Mitchell,T., Mohabbat,F., Mohabbat,K., Montgomery,B., Moore,N.,
            Morris,S., Munidasa,M., Ngo,R.N., Nguyen,N.B., Nickerson,E.,
            Nwaokelemeh,O.O., Nwokenkwo,S., Obregon,M., Oguh,M., Oragunye,N.,
            Oviedo,R.J., Parish,B.J., Parker,D.N., Parrish,J., Parks,K.L.,
            Paul,H.A., Payton,B.A., Perez,A., Perrin,W., Pickens,A.,
            Primus,E.L., Pu,L.L., Puazo,M., Quiles,M.M., Quiroz,J.B.,
            Rabata,D., Reeves,K., Ruiz,S.J., Shao,H., Sisson,I., Sonaike,T.,
            Sorelle,R.P., Sutton,A.E., Svatek,A.F., Svetz,L.A., Tamerisa,K.S.,
            Taylor,T.R., Teague,B., Thomas,N., Thorn,R.D., Trejos,Z.Y.,
            Trevino,B.K., Ukegbu,O.N., Urban,J.B., Vasquez,L.I., Vera,V.A.,
            Villasana,D.M., Wang,L., Ward-Moore,S., Warren,J.T., Wei,X.,
            White,F., Williamson,A.L., Wleczyk,R., Wooden,H.S., Wooden,S.H.,
            Yen,J., Yoon,L., Yoon,V., Zorrilla,S.E., Nelson,D.,
            Kucherlapati,R., Weinstock,G. and Gibbs,R.A.
  CONSRTM   Baylor College of Medicine Human Genome Sequencing Center Sequence
            Production Team
  TITLE     The finished DNA sequence of human chromosome 12
  JOURNAL   Nature 440 (7082), 346-351 (2006)
   PUBMED   16541075
REFERENCE   2  (bases 1 to 4154)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC012151.14.
            
            On Aug 27, 2021 this sequence version replaced NM_001353179.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2151119
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000537054.2/ ENSP00000445480.2
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-64                AC012151.14        73793-73856         c
            65-183              AC012151.14        72726-72844         c
            184-281             AC012151.14        72351-72448         c
            282-454             AC012151.14        71455-71627         c
            455-550             AC012151.14        67267-67362         c
            551-702             AC012151.14        65790-65941         c
            703-892             AC012151.14        63863-64052         c
            893-991             AC012151.14        62420-62518         c
            992-1079            AC012151.14        60883-60970         c
            1080-1213           AC012151.14        55005-55138         c
            1214-1351           AC012151.14        53511-53648         c
            1352-1482           AC012151.14        53272-53402         c
            1483-1576           AC012151.14        52376-52469         c
            1577-1705           AC012151.14        51231-51359         c
            1706-1780           AC012151.14        49199-49273         c
            1781-1961           AC012151.14        47972-48152         c
            1962-2034           AC012151.14        41317-41389         c
            2035-2230           AC012151.14        40677-40872         c
            2231-2385           AC012151.14        38024-38178         c
            2386-2542           AC012151.14        31419-31575         c
            2543-2635           AC012151.14        31011-31103         c
            2636-2860           AC012151.14        27515-27739         c
            2861-2986           AC012151.14        21448-21573         c
            2987-3122           AC012151.14        20315-20450         c
            3123-3262           AC012151.14        19531-19670         c
            3263-4154           AC012151.14        16023-16914         c
FEATURES             Location/Qualifiers
     source          1..4154
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p11.22"
     gene            1..4154
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /note="ovochymase 1"
                     /db_xref="GeneID:341350"
                     /db_xref="HGNC:HGNC:23080"
                     /db_xref="MIM:621069"
     CDS             1..3273
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /codon_start=1
                     /product="ovochymase-1 precursor"
                     /protein_id="NP_001340108.1"
                     /db_xref="CCDS:CCDS91669.1"
                     /db_xref="GeneID:341350"
                     /db_xref="HGNC:HGNC:23080"
                     /db_xref="MIM:621069"
                     /translation="MGLLASAGLLLLLVIGHPRSLGLKCGIRMVNMKSKEPAVGSRFF
                     SRISSWRNSTVTGHPWQVSLKSDEHHFCGGSLIQEDRVVTAAHCLDSLSEKQLKNITV
                     TSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSPDIALLYLKHKVKFGNAVQPICL
                     PDSDDKVEPGILCLSSGWGKISKTSEYSNVLQEMELPIMDDRACNTVLKSMNLPPLGR
                     TMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSWVAGCAGGSVPVRNNHVKA
                     SLGIFSKVSELMDFITQNLFTGLDRGQPLSKVGSRYITKALSSVQEVNGSQRGKDCKP
                     QGTVLFGESGKICYPHSKGDYYSHNCLYVWKIMVPEDKIILIKFTSLDMEKQVGCDHD
                     YVSLRSSSGVLFSKVCGKILPSPLLAETSEAMVPFVSDTEDSGSGFELTVTAVQKSEA
                     GSGCGSLAILVEEGTNHSAKYPDLYPSNTRCHWFICAPEKHIIKLTFEDFAVKFSPNC
                     IYDAVVIYGDSEEKHKLAKLCGMLTITSIFSSSNMTVIYFKSDGKNRLQGFKARFTIL
                     PSESLNKFEPKLPPQNNPVSTVKAILHDVCGIPPFSPQWLSRRIAGGEEACPHCWPWQ
                     VGLRFLGDYQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQVRRA
                     KHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEICAVTGWGS
                     ISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDS
                     GGPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSKINGPASLQTNN
                     KCKTLKQQLPPPTPSPDSASWPGCCSEAELEKPRGFFPTPRYLLDYRGRLECSWVLRV
                     SASSMAKFTIEYLSLLGSPVCQDSVLIIYEERHSKRKTAGGLHGRRLYSMTFMSPGPL
                     VRVTFHALVRGAFGISYIVLKVLGPKDSKITRLSQSSNREHLVPCEDVLLTKPEGIMQ
                     IPRNSHRTTMGCQWRLVAPLNHIIQLNIINFPMKPTTFVCHGHLRVYEGFGPGKKLIG
                     EC"
     exon            1..64
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            65..183
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            184..281
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            282..454
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            455..550
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            551..702
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            703..892
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            893..991
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1079
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1213
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1351
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1352..1482
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1576
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1705
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1780
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1961
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            1962..2034
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2035..2230
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2231..2385
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2542
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2543..2635
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2636..2860
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2861..2986
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3122
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3123..3262
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..4154
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4136..4141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /note="hexamer: AATAAA"
     polyA_site      4154
                     /gene="OVCH1"
                     /gene_synonym="OVCH"
                     /note="major polyA site"
ORIGIN      
        1 atgggcctgc tggccagtgc tggtttgttg ctgttgctgg tcatcggcca ccccagaagc
       61 ctaggactga agtgtggaat tcgcatggtc aacatgaaaa gtaaggaacc tgccgtggga
      121 tctagattct tctctagaat tagtagttgg agaaattcaa cagtgactgg acatccatgg
      181 caggtctccc taaaatcaga tgagcaccac ttctgtggag gaagcttgat tcaagaagat
      241 cgggttgtta cagcagcaca ctgcctggac agcctcagtg agaagcagct gaagaatata
      301 actgtgactt ctggggagta cagcctcttt cagaaggata agcaagaaca gaatattcct
      361 gtctcaaaaa ttattaccca tcctgaatac aacagccgtg aatatatgag tcctgatatt
      421 gcactgctgt atctaaaaca caaagtcaag tttggaaatg ctgttcagcc aatctgtctt
      481 cctgacagcg atgataaagt tgaaccagga attctttgct tatccagtgg atggggcaag
      541 atttccaaaa catcagaata ttcaaatgtc ctacaagaaa tggaacttcc catcatggat
      601 gacagagcgt gtaatactgt gctcaagagc atgaacctcc ctcccctggg aaggaccatg
      661 ctgtgtgctg gcttccctga ttggggaatg gacgcctgcc agggggactc tggaggacca
      721 ctggtttgta gaagaggtgg tggaatctgg attcttgctg ggataacttc ctgggtagct
      781 ggttgtgctg gaggttcagt tcccgtaaga aacaaccatg tgaaggcatc acttggcatt
      841 ttctccaaag tgtctgagtt gatggatttt atcactcaaa acctgttcac aggtttggat
      901 cggggccaac ccctctcaaa agtgggctca aggtatataa caaaggccct gagttctgtc
      961 caagaagtga atggaagcca gagaggaaag gattgtaaac ctcaggggac agtgttattt
     1021 ggagaaagtg ggaagatttg ttacccccat tccaaaggag actactattc tcataattgc
     1081 ttatatgttt ggaaaataat ggtaccagaa gataaaataa tcctgataaa atttacaagt
     1141 ttagacatgg aaaagcaagt tggatgtgat catgactatg tatctttacg atcaagcagt
     1201 ggagtgcttt ttagtaaggt ctgtggaaaa atattgcctt caccattgct ggcagagacc
     1261 agtgaggcca tggttccatt tgtttctgat acagaagaca gtggcagtgg ctttgagctt
     1321 accgttactg ctgtacagaa gtcagaagca gggtcaggtt gtgggagtct ggctatattg
     1381 gtagaagaag ggacaaatca ctctgccaag tatcctgatt tgtatcccag taacacaagg
     1441 tgtcattggt tcatttgtgc tccagagaag cacattataa agttgacatt tgaggacttt
     1501 gctgtcaaat ttagtccaaa ctgtatttat gatgctgttg tgatttacgg tgattctgaa
     1561 gaaaagcaca agttagctaa actttgtgga atgttgacca tcacttcaat attcagttct
     1621 agtaacatga cggtgatata ctttaaaagt gatggtaaaa atcgtttaca aggcttcaag
     1681 gccagattta ccattttgcc ctcagagtct ttaaacaaat ttgaaccaaa gttacctccc
     1741 caaaacaatc ctgtatctac cgtaaaagct attctgcatg atgtctgtgg catccctcca
     1801 tttagtcccc agtggctttc cagaagaatc gcaggagggg aagaagcctg cccccactgt
     1861 tggccatggc aggtgggtct gaggtttcta ggcgattacc aatgtggagg tgccatcatc
     1921 aacccagtgt ggattctgac cgcagcccac tgtgtgcaat tgaagaataa tccactctcc
     1981 tggactatta ttgctgggga ccatgacaga aacctgaagg aatcaacaga gcaggtgaga
     2041 agggccaaac acataatagt gcatgaagac tttaacacac taagttatga ctctgacatt
     2101 gccctaatac aactaagctc tcctctggag tacaactcgg tggtgaggcc agtatgtctc
     2161 ccacacagcg cagagcctct attttcctcg gagatctgtg ctgtgaccgg atggggaagc
     2221 atcagtgcag atggtggcct agcaagtcgc ctacagcaga ttcaagtgca tgtgttagaa
     2281 agagaggtct gtgaacacac ttactattct gcccatccag gagggatcac agagaagatg
     2341 atctgtgctg gctttgcagc atctggagag aaagatttct gccagggaga ctctggtggg
     2401 ccactagtat gtagacatga aaatggtccc tttgtcctct atggcattgt cagctgggga
     2461 gctggctgtg tccagccatg gaagccgggt gtatttgcca gagtgatgat cttcttggac
     2521 tggatccaat caaaaatcaa tggtcctgct tcacttcaga caaataataa atgcaaaacc
     2581 ttaaaacaac aattgccacc acccacacct tcaccagaca gtgcatcttg gccaggttgt
     2641 tgctctgaag cagagctaga aaagcctaga ggcttttttc ccacaccacg gtatctactg
     2701 gattatagag gaagactgga atgttcttgg gtgctcagag tttcagcaag cagtatggca
     2761 aaatttacca ttgagtatct gtcactcctg gggtctcctg tgtgtcaaga ctcagttcta
     2821 attatttatg aagaaagaca cagtaagaga aagacggcag gtggattaca tggaagaaga
     2881 ctttactcaa tgactttcat gagtcctgga ccgctggtga gggtgacatt ccatgccctt
     2941 gtacgaggtg catttggtat aagctatatt gtcttgaaag tcctaggtcc aaaggacagt
     3001 aaaataacca gactttccca aagttcaaac agagagcact tggtcccttg tgaggatgtt
     3061 cttctgacca agccagaagg gatcatgcag atcccaagaa attctcacag aactactatg
     3121 ggttgccaat ggagattagt agccccttta aatcacatca ttcagcttaa tattattaac
     3181 ttcccgatga agccaacaac ttttgtctgt catggtcatc tgcgtgttta cgaaggattt
     3241 ggaccaggaa aaaaattaat aggagaatgt tgatgagcac tgagctttct tggttcctaa
     3301 gccaattcag caccaagaag accacagctt cttgtgggga gactgcagta tctatgaaaa
     3361 tgatgtatac ttctatcttt cttgccctac agaacacctg ttaccatgca ctgcctcatg
     3421 aggttgtttt gagaattaaa taagagaagg catgttaatc aatactaaga aaccaagctt
     3481 gcattttatt tggattagaa atatctatta tgattcctat tcttaaaatt gtgctgcttg
     3541 gaggagttta gactgtcacc ctattgcctc ttctatgggt gaaagggcac acaaagattg
     3601 gaaaaacaaa gaaataaaga aggggacaga gaaggaagag tacattagca atatcaatta
     3661 ttacttataa tgttaatcaa ctgtatatct gttctttact tagaattaat tcataaaacc
     3721 tactgttttc tatttccttc tccccaaaag ttttatgact ctatttcaat ttctctaaat
     3781 aaggtttaca agctctgggg tataggaaag gtaaaaaaat atttctcttc tacccatcta
     3841 tccagaggaa caaatcctgt gatcagaagt ttagaactta tagcccaacc tctgggtagg
     3901 ggagagggac tggaaattga cttaatcagc aattgccaat gatgtgattg atcatgtcta
     3961 tgtaatgaag ccctcataaa accccaaaag gagagttcat aaagttgggt tggtgaacac
     4021 acggagggtg ctgggaggat ggtgtaccca gaaagaacat tgaagctctg tgcccagtct
     4081 ccatatcttg ccctatacat ctttcattgg actgttcctg aattatatcc tttgtaataa
     4141 ataggtaaac acaa
//
