LOCUS       NM_080822               1031 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens OVCA2 serine hydrolase domain containing (OVCA2),
            mRNA.
ACCESSION   NM_080822
VERSION     NM_080822.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1031)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1031)
  AUTHORS   Gowsalya,R., Ravi,C. and Nachiappan,V.
  TITLE     Human OVCA2 and its homolog FSH3-induced apoptosis in Saccharomyces
            cerevisiae
  JOURNAL   Curr Genet 67 (4), 631-640 (2021)
   PUBMED   33715035
  REMARK    GeneRIF: Human OVCA2 and its homolog FSH3-induced apoptosis in
            Saccharomyces cerevisiae.
REFERENCE   3  (bases 1 to 1031)
  AUTHORS   Bun,J.S., Slack,M.D., Schemenauer,D.E. and Johnson,R.J.
  TITLE     Comparative analysis of the human serine hydrolase OVCA2 to the
            model serine hydrolase homolog FSH1 from S. cerevisiae
  JOURNAL   PLoS One 15 (3), e0230166 (2020)
   PUBMED   32182256
  REMARK    GeneRIF: OVCA2 was confirmed as a serine hydrolase with a strong
            preference for long-chain alkyl ester substrates (>10-carbons) and
            high selectivity against a variety of short, branched, and
            substituted esters, homologous to FSH1 from S. cerevisiae
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1031)
  AUTHORS   Azizi,A.A., Gelpi,E., Yang,J.W., Rupp,B., Godwin,A.K., Slater,C.,
            Slavc,I. and Lubec,G.
  TITLE     Mass spectrometric identification of serine hydrolase OVCA2 in the
            medulloblastoma cell line DAOY
  JOURNAL   Cancer Lett 241 (2), 235-249 (2006)
   PUBMED   16368187
REFERENCE   5  (bases 1 to 1031)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   6  (bases 1 to 1031)
  AUTHORS   Baxter,S.M., Rosenblum,J.S., Knutson,S., Nelson,M.R.,
            Montimurro,J.S., Di Gennaro,J.A., Speir,J.A., Burbaum,J.J. and
            Fetrow,J.S.
  TITLE     Synergistic computational and experimental proteomics approaches
            for more accurate detection of active serine hydrolases in yeast
  JOURNAL   Mol Cell Proteomics 3 (3), 209-225 (2004)
   PUBMED   14645503
REFERENCE   7  (bases 1 to 1031)
  AUTHORS   Prowse,A.H., Vanderveer,L., Milling,S.W., Pan,Z.Z., Dunbrack,R.L.,
            Xu,X.X. and Godwin,A.K.
  TITLE     OVCA2 is downregulated and degraded during retinoid-induced
            apoptosis
  JOURNAL   Int J Cancer 99 (2), 185-192 (2002)
   PUBMED   11979432
  REMARK    GeneRIF: is downregulated and degraded during retinoid-induced
            apoptosis
REFERENCE   8  (bases 1 to 1031)
  AUTHORS   Schultz,D.C., Vanderveer,L., Berman,D.B., Hamilton,T.C., Wong,A.J.
            and Godwin,A.K.
  TITLE     Identification of two candidate tumor suppressor genes on
            chromosome 17p13.3
  JOURNAL   Cancer Res 56 (9), 1997-2002 (1996)
   PUBMED   8616839
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB137429.1 and BC041170.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080822.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.325048.1,
                                           SRR1660809.210881.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000572195.3/ ENSP00000461388.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CB137429.1         40-50
            12-1031             BC041170.1         1-1020
FEATURES             Location/Qualifiers
     source          1..1031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..1031
                     /gene="OVCA2"
                     /note="OVCA2 serine hydrolase domain containing"
                     /db_xref="GeneID:124641"
                     /db_xref="HGNC:HGNC:24203"
                     /db_xref="MIM:607896"
     exon            1..210
                     /gene="OVCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..710
                     /gene="OVCA2"
                     /EC_number="3.1.2.-"
                     /note="candidate tumor suppressor in ovarian cancer 2;
                     ovarian cancer-associated gene 2 protein; ovarian cancer
                     gene-2 protein; ovarian tumor suppressor candidate 2"
                     /codon_start=1
                     /product="esterase OVCA2"
                     /protein_id="NP_543012.1"
                     /db_xref="CCDS:CCDS11015.1"
                     /db_xref="GeneID:124641"
                     /db_xref="HGNC:HGNC:24203"
                     /db_xref="MIM:607896"
                     /translation="MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSG
                     PHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMV
                     AQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKE
                     SILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAY
                     LKFLDQFAE"
     exon            211..1031
                     /gene="OVCA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1013..1018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OVCA2"
                     /note="hexamer: AATAAA"
     polyA_site      1031
                     /gene="OVCA2"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgtcg ctccttgccg ggcataatgg ccgcgcagcg acccctgcgg gtcctgtgcc
       61 tggcgggctt ccggcagagc gagcggggct tccgtgagaa gaccggggcg ctgaggaagg
      121 cgctgcgggg tcgcgccgag ctcgtgtgcc tcagcggccc gcacccggtc cccgaccccc
      181 cgggccccga gggcgccaga tcagacttcg ggtcctgccc tccggaggag cagcctcgag
      241 gctggtggtt ttcagagcag gaggccgacg ttttctccgc attggaagag cccgccgtct
      301 gcaggggcct ggaggaatca ctggggatgg tggcacaggc actgaacagg ctggggcctt
      361 ttgacggcct tcttggtttc agccaagggg ctgcgctagc agcccttgtg tgtgccctgg
      421 gccaggcagg cgatccccgc ttccccttgc cacggtttat cctcttggtg tctggtttct
      481 gtccccgggg cattgggttc aaggaatcca tcctgcaaag gcccttgtca ttgccttcgc
      541 tccatgtttt tggggacact gacaaagtca tcccctctca ggagagtgtg caactggcca
      601 gccaatttcc cggagccatc accctcaccc actctggtgg ccacttcatt ccagcagctg
      661 caccccagcg tcaggcctac ctcaagttct tggaccagtt tgcagagtga aagatcaaga
      721 aatgtctctg ctcctacatc cagctcctct aggggcagcc tccgtcatcc atgccctccc
      781 aggaccctcc actcactgct gtgagtgcgc ctcaccagaa ccagttaaga gacaactatc
      841 aattcttgag acccaaatta taagggccct gccctgtact gaagaaaagg ggagcacaag
      901 gccttaatgg acattgactt gtgaaaacgc aaacatgaat atggttggag agccctggat
      961 taggagggtg acatggggaa ggcagaggct ggcaccatgg tgactgccac ataataaagt
     1021 ggtgatttgg a
//
