LOCUS       NM_014562               2828 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens orthodenticle homeobox 1 (OTX1), transcript variant 1,
            mRNA.
ACCESSION   NM_014562
VERSION     NM_014562.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2828)
  AUTHORS   Cao,B., Liu,K., Tian,C., He,H., He,S., Chen,H., Zhang,X., Liu,Y.,
            Wang,L., Liu,X., Li,M., Jia,Q. and Chai,J.
  TITLE     OTX1 regulates tumorigenesis and metastasis in glioma
  JOURNAL   Pathol Res Pract 254, 155116 (2024)
   PUBMED   38218040
  REMARK    GeneRIF: OTX1 regulates tumorigenesis and metastasis in glioma.
REFERENCE   2  (bases 1 to 2828)
  AUTHORS   Hu,S., Zhou,H., Zhao,X., Qian,F. and Jin,C.
  TITLE     MiR-195-5p suppresses gastric adenocarcinoma cell progression via
            targeting OTX1
  JOURNAL   Histol Histopathol 38 (6), 659-668 (2023)
   PUBMED   36093844
  REMARK    GeneRIF: MiR-195-5p suppresses gastric adenocarcinoma cell
            progression via targeting OTX1.
REFERENCE   3  (bases 1 to 2828)
  AUTHORS   Zhou,L., Li,H., Zhang,D., Chen,L., Dong,H., Yuan,Y. and Wang,T.
  TITLE     OTX1 promotes tumorigenesis and progression of cervical cancer by
            regulating the Wnt signaling pathway
  JOURNAL   Oncol Rep 48 (5) (2022)
   PUBMED   36177903
  REMARK    GeneRIF: OTX1 promotes tumorigenesis and progression of cervical
            cancer by regulating the Wnt signaling pathway.
REFERENCE   4  (bases 1 to 2828)
  AUTHORS   Li,S., Zhang,Y., He,Z., Xu,Q., Li,C. and Xu,B.
  TITLE     Knockdown of circMYOF inhibits cell growth, metastasis, and
            glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal
            squamous cell carcinoma
  JOURNAL   Funct Integr Genomics 22 (4), 1-13 (2022)
   PUBMED   35474406
  REMARK    GeneRIF: Knockdown of circMYOF inhibits cell growth, metastasis,
            and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal
            squamous cell carcinoma.
REFERENCE   5  (bases 1 to 2828)
  AUTHORS   Puelles,E., Annino,A., Tuorto,F., Usiello,A., Acampora,D.,
            Czerny,T., Brodski,C., Ang,S.L., Wurst,W. and Simeone,A.
  TITLE     Otx2 regulates the extent, identity and fate of neuronal progenitor
            domains in the ventral midbrain
  JOURNAL   Development 131 (9), 2037-2048 (2004)
   PUBMED   15105370
REFERENCE   6  (bases 1 to 2828)
  AUTHORS   Francks,C., Fisher,S.E., Olson,R.K., Pennington,B.F., Smith,S.D.,
            DeFries,J.C. and Monaco,A.P.
  TITLE     Fine mapping of the chromosome 2p12-16 dyslexia susceptibility
            locus: quantitative association analysis and positional candidate
            genes SEMA4F and OTX1
  JOURNAL   Psychiatr Genet 12 (1), 35-41 (2002)
   PUBMED   11901358
  REMARK    GeneRIF: Fine mapping of the chromosome 2p12-16 dyslexia
            susceptibility locus candidate gene
REFERENCE   7  (bases 1 to 2828)
  AUTHORS   Weimann,J.M., Zhang,Y.A., Levin,M.E., Devine,W.P., Brulet,P. and
            McConnell,S.K.
  TITLE     Cortical neurons require Otx1 for the refinement of exuberant
            axonal projections to subcortical targets
  JOURNAL   Neuron 24 (4), 819-831 (1999)
   PUBMED   10624946
REFERENCE   8  (bases 1 to 2828)
  AUTHORS   Nagao,T., Leuzinger,S., Acampora,D., Simeone,A., Finkelstein,R.,
            Reichert,H. and Furukubo-Tokunaga,K.
  TITLE     Developmental rescue of Drosophila cephalic defects by the human
            Otx genes
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3737-3742 (1998)
   PUBMED   9520436
REFERENCE   9  (bases 1 to 2828)
  AUTHORS   Kastury,K., Druck,T., Huebner,K., Barletta,C., Acampora,D.,
            Simeone,A., Faiella,A. and Boncinelli,E.
  TITLE     Chromosome locations of human EMX and OTX genes
  JOURNAL   Genomics 22 (1), 41-45 (1994)
   PUBMED   7959790
REFERENCE   10 (bases 1 to 2828)
  AUTHORS   Simeone,A., Acampora,D., Mallamaci,A., Stornaiuolo,A.,
            D'Apice,M.R., Nigro,V. and Boncinelli,E.
  TITLE     A vertebrate gene related to orthodenticle contains a homeodomain
            of the bicoid class and demarcates anterior neuroectoderm in the
            gastrulating mouse embryo
  JOURNAL   EMBO J 12 (7), 2735-2747 (1993)
   PUBMED   8101484
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK095680.1 and BU689444.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014562.3.
            
            Summary: This gene encodes a member of the bicoid sub-family of
            homeodomain-containing transcription factors. The encoded protein
            acts as a transcription factor and may play a role in brain and
            sensory organ development. A similar protein in mouse is required
            for proper brain and sensory organ development and can cause
            epilepsy. Alternative splicing results in multiple transcript
            variants. [provided by RefSeq, Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK095680.1, BC007621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893, SAMEA2151887
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000282549.7/ ENSP00000282549.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2165              AK095680.1         1-2165
            2166-2828           BU689444.1         17-679              c
FEATURES             Location/Qualifiers
     source          1..2828
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p15"
     gene            1..2828
                     /gene="OTX1"
                     /note="orthodenticle homeobox 1"
                     /db_xref="GeneID:5013"
                     /db_xref="HGNC:HGNC:8521"
                     /db_xref="MIM:600036"
     exon            1..68
                     /gene="OTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            69..137
                     /gene="OTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            138..345
                     /gene="OTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            346..497
                     /gene="OTX1"
                     /inference="alignment:Splign:2.1.0"
     exon            498..2828
                     /gene="OTX1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2809..2814
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTX1"
                     /note="hexamer: AATAAA"
     polyA_site      2828
                     /gene="OTX1"
                     /note="major polyA site"
ORIGIN      
        1 gatcaatctt catcaggcta catttccaat cacctaaaca accgagcaag acaagccact
       61 ccgacaaggt tggctgcccg gcgggtctct gtgagagatc caggtagatg gtgaacggcc
      121 ccggcagctg agggcaggcc aggcccccag acgcatcaga ccctgaagga ctgcgtggtg
      181 ggagccctgc accgctcctg gccccgggcc ccctggatcc gtcggggcgc ctccacccag
      241 ctgttagcat gatgtcttac ctcaaacaac ccccatacgg catgaacggg ctgggcctgg
      301 ccgggcccgc catggacctc ctgcacccat ccgtgggcta tccggccact ccgcggaagc
      361 agcggcggga gcgcaccacc ttcacgcgtt cacagctgga cgtgctcgag gcgctcttcg
      421 ccaagactcg ctaccctgac atcttcatgc gggaggaggt ggcgctcaag atcaacctgc
      481 cggagtctag agtccaggtc tggttcaaga accgccgcgc caaatgccgc cagcagcagc
      541 agagcgggag cggaaccaag agccgcccag ccaagaagaa gtcctctcca gtgcgggaga
      601 gctcgggctc cgaaagcagt ggccaattca cgccgccagc tgtgtccagc tctgcctcgt
      661 cctctagctc ggcgtccagc tcttccgcca acccagcggc tgcagcggct gcgggactag
      721 gtgggaaccc ggtggcggcc gcgtcgtcgc tgagtacacc agctgcctca tctatctgga
      781 gcccggcctc catctcgcca ggctcagcgc ccgcgtccgt gtcggtgccg gagccattgg
      841 ccgcgcctag caacacctcg tgtatgcagc gctccgtagc tgcaggcgcc gccaccgcag
      901 cagcctctta tcccatgtcc tacggccagg gcggcagcta cggccaaggc taccctacgc
      961 cctcctcttc ctactttggc ggcgtggact gcagctcata cctagcgccc atgcactcac
     1021 atcaccaccc gcaccagctc agccccatgg caccctcctc catggcgggc caccatcatc
     1081 accacccaca tgcgcaccac ccgttgagcc agtcctcagg ccaccaccac caccatcacc
     1141 accaccacca ccaaggctac ggtggctctg ggcttgcctt caactctgcc gactgcttgg
     1201 attacaagga gcctggcgcc gctgctgctt cctccgcctg gaaactcaac ttcaactccc
     1261 ccgactgtct ggactataag gaccaagcct catggcggtt ccaggtcttg tgagcccagg
     1321 aatgaaagag gagaagaaac gcaactacct gcgccctccg tggtcccgat cctgttgctg
     1381 ctgctgcacc gcccgccttt gcctcgtctt ctccaaaact gaattttcac cccccaaaaa
     1441 gatgtccatt gcctgcactg ccgcccccat ttttgtgcca cttgcttggg gggatgtgca
     1501 aacccaccct gccccttgga tggggggacc ggtgcttcgg cttggcctac acattctata
     1561 caggagagat gtattatttc cccccttcag cccctactaa actcttaagc ctccccttcc
     1621 agtctttctg gacagctatt aagcacttgc agccttcgga ggctctgcgc tctgatccgc
     1681 tgtttgagcc caacacttta atttattctt tctggacact ggagtcacta actggcgtgt
     1741 ttctgcccat tggagcaccc gcacactact ccaaatcaaa accactaaga gttcctcccg
     1801 cgcagactgc tgccccttca gctgccctcg attttgctcc acgcctgccg gccagagcct
     1861 cccggcgttt cttccgcccc agcggagtgc gctggggcgc gccagggcta ggcccgccgg
     1921 aggagcgcgt ccccagcctt ccgcgcacag agccgcatcc cgccccgccc tgcgctggac
     1981 tggttcaagc ttccgcctcg gcgggaacgc tgtacatagt caggtccgtt ccagggacca
     2041 cttaaacttt ttagttgctg ttggttggtt gaactgaaca tatcttgtct tagcacccag
     2101 gaaacagaac tttaagatat atacagcaca tatatatata tatacatata tatatacaca
     2161 tatataaaaa acaaaagcaa aaaatatttt ccctctgtcc gtcccccttc tgctcttcct
     2221 caatcaatgg cgctttttct ttttcagttg ttgcaaagct gccctgccct cttcacatct
     2281 tctccctctg tgtatttatt gaagagaacc gcttggtttc aggaagctgg gcgcgggata
     2341 tccgaagtgt ggaggaaaca gacaagtcag ggtacagagg tgggggttgg gcaggggcgc
     2401 agggctgacc ccctcacccg gtctaagcac agggtcgcag ttccagttta caaacctaaa
     2461 acaagaaaac caaaaccagg gaacaaaaca acaaaacaaa acaaaatccg taaaagtaca
     2521 gcattaggga aaaacaaaca aacccaggcc ccaaacccag ttccaactcc tctgtcggct
     2581 tctctctttc aacacccttg ttttgtctag tgagttttta gtgcaccttc gttctccgaa
     2641 atctgcggag agcccgcgcg cctgtgtatc aattttggct ttggccgctt cgtccagtag
     2701 gtgggaaagt aatttgtaaa tttgatttgt ctgatgtgaa gatcacaaat tacttgttga
     2761 aatgtaaggc agtccccctc ctcctcttta tctacattac ttcccgaaaa taaatgcaaa
     2821 ttaatgaa
//
