LOCUS       NM_020205               8922 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens OTU deubiquitinase 7B (OTUD7B), mRNA.
ACCESSION   NM_020205
VERSION     NM_020205.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8922)
  AUTHORS   Sun,C., Bai,J., Sun,J., Sun,Y., Zhang,F., Li,H., Liu,Y., Meng,L.
            and Wang,X.
  TITLE     OTU deubiquitinase 7B facilitates the hyperthermia-induced
            inhibition of lung cancer progression through enhancing
            Smac-mediated mitochondrial dysfunction
  JOURNAL   Environ Toxicol 39 (4), 1989-2005 (2024)
   PUBMED   38088504
  REMARK    GeneRIF: OTU deubiquitinase 7B facilitates the hyperthermia-induced
            inhibition of lung cancer progression through enhancing
            Smac-mediated mitochondrial dysfunction.
REFERENCE   2  (bases 1 to 8922)
  AUTHORS   Guo,Z. and Guo,L.
  TITLE     OTUD7B deubiquitinates and stabilizes YAP1 to upregulate NUAK2
            expression, thus accelerating gastric cancer procession
  JOURNAL   Dig Liver Dis 56 (2), 352-362 (2024)
   PUBMED   37429790
  REMARK    GeneRIF: OTUD7B deubiquitinates and stabilizes YAP1 to upregulate
            NUAK2 expression, thus accelerating gastric cancer procession.
REFERENCE   3  (bases 1 to 8922)
  AUTHORS   Harit,K., Bhattacharjee,R., Matuschewski,K., Becker,J., Kalinke,U.,
            Schluter,D. and Nishanth,G.
  TITLE     The deubiquitinating enzyme OTUD7b protects dendritic cells from
            TNF-induced apoptosis by stabilizing the E3 ligase TRAF2
  JOURNAL   Cell Death Dis 14 (7), 480 (2023)
   PUBMED   37516734
  REMARK    GeneRIF: The deubiquitinating enzyme OTUD7b protects dendritic
            cells from TNF-induced apoptosis by stabilizing the E3 ligase
            TRAF2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8922)
  AUTHORS   Benz,C., Ali,M., Krystkowiak,I., Simonetti,L., Sayadi,A.,
            Mihalic,F., Kliche,J., Andersson,E., Jemth,P., Davey,N.E. and
            Ivarsson,Y.
  TITLE     Proteome-scale mapping of binding sites in the unstructured regions
            of the human proteome
  JOURNAL   Mol Syst Biol 18 (1), e10584 (2022)
   PUBMED   35044719
REFERENCE   5  (bases 1 to 8922)
  AUTHORS   Tang,J., Wu,Z., Tian,Z., Chen,W. and Wu,G.
  TITLE     OTUD7B stabilizes estrogen receptor alpha and promotes breast
            cancer cell proliferation
  JOURNAL   Cell Death Dis 12 (6), 534 (2021)
   PUBMED   34035221
  REMARK    GeneRIF: OTUD7B stabilizes estrogen receptor alpha and promotes
            breast cancer cell proliferation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8922)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 8922)
  AUTHORS   Evans,P.C., Ovaa,H., Hamon,M., Kilshaw,P.J., Hamm,S., Bauer,S.,
            Ploegh,H.L. and Smith,T.S.
  TITLE     Zinc-finger protein A20, a regulator of inflammation and cell
            survival, has de-ubiquitinating activity
  JOURNAL   Biochem J 378 (Pt 3), 727-734 (2004)
   PUBMED   14748687
REFERENCE   8  (bases 1 to 8922)
  AUTHORS   Evans,P.C., Smith,T.S., Lai,M.J., Williams,M.G., Burke,D.F.,
            Heyninck,K., Kreike,M.M., Beyaert,R., Blundell,T.L. and
            Kilshaw,P.J.
  TITLE     A novel type of deubiquitinating enzyme
  JOURNAL   J Biol Chem 278 (25), 23180-23186 (2003)
   PUBMED   12682062
  REMARK    GeneRIF: cleaves ubiquitin from proteins
REFERENCE   9  (bases 1 to 8922)
  AUTHORS   Evans,P.C., Taylor,E.R., Coadwell,J., Heyninck,K., Beyaert,R. and
            Kilshaw,P.J.
  TITLE     Isolation and characterization of two novel A20-like proteins
  JOURNAL   Biochem J 357 (Pt 3), 617-623 (2001)
   PUBMED   11463333
REFERENCE   10 (bases 1 to 8922)
  AUTHORS   Heyninck,K. and Beyaert,R.
  TITLE     The cytokine-inducible zinc finger protein A20 inhibits
            IL-1-induced NF-kappaB activation at the level of TRAF6
  JOURNAL   FEBS Lett 442 (2-3), 147-150 (1999)
   PUBMED   9928991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP321045.1, BC072681.1, BC015719.1, AC244033.1 and T51077.1.
            
            On Nov 22, 2018 this sequence version replaced NM_020205.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072681.1, SRR1163655.442727.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000581312.6/ ENSP00000462729.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                BP321045.1         12-63
            53-3553             BC072681.1         1-3501
            3554-4454           BC015719.1         309-1209
            4455-4455           AC244033.1         47347-47347         c
            4456-4901           BC015719.1         1211-1656
            4902-4906           AC244033.1         46896-46900         c
            4907-6402           BC015719.1         1662-3157
            6403-6404           T51077.1           3-4                 c
            6405-8922           AC244033.1         42880-45397         c
FEATURES             Location/Qualifiers
     source          1..8922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..8922
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="OTU deubiquitinase 7B"
                     /db_xref="GeneID:56957"
                     /db_xref="HGNC:HGNC:16683"
                     /db_xref="MIM:611748"
     exon            1..279
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            280..430
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     CDS             346..2877
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /EC_number="3.4.19.12"
                     /note="zinc finger protein Cezanne; cellular zinc finger
                     anti-NF-kappaB Cezanne; zinc finger, A20 domain containing
                     1; zinc finger A20 domain-containing protein 1; cellular
                     zinc finger anti-NF-kappa-B protein; OTU domain containing
                     7B"
                     /codon_start=1
                     /product="OTU domain-containing protein 7B"
                     /protein_id="NP_064590.2"
                     /db_xref="CCDS:CCDS72903.1"
                     /db_xref="GeneID:56957"
                     /db_xref="HGNC:HGNC:16683"
                     /db_xref="MIM:611748"
                     /translation="MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVNAALSDFEQL
                     RQVHAGNLPPSFSEGSGGSRTPEKGFSDREPTRPPRPILQRQDDIVQEKRLSRGISHA
                     SSSIVSLARSHVSSNGGGGGSNEHPLEMPICAFQLPDLTVYNEDFRSFIERDLIEQSM
                     LVALEQAGRLNWWVSVDPTSQRLLPLATTGDGNCLLHAASLGMWGFHDRDLMLRKALY
                     ALMEKGVEKEALKRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGTN
                     GANCGGVESSEEPVYESLEEFHVFVLAHVLRRPIVVVADTMLRDSGGEAFAPIPFGGI
                     YLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKENTKEQAVIPLTDSEYKLLPLHFA
                     VDPGKGWEWGKDDSDNVRLASVILSLEVKLHLLHSYMNVKWIPLSSDAQAPLAQPESP
                     TASAGDEPRSTPESGDSDKESVGSSSTSNEGGRRKEKSKRDREKDKKRADSVANKLGS
                     FGKTLGSKLKKNMGGLMHSKGSKPGGVGTGLGGSSGTETLEKKKKNSLKSWKGGKEEA
                     AGDGPVSEKPPAESVGNGGSKYSQEVMQSLSILRTAMQGEGKFIFVGTLKMGHRHQYQ
                     EEMIQRYLSDAEERFLAEQKQKEAERKIMNGGIGGGPPPAKKPEPDAREEQPTGPPAE
                     SRAMAFSTGYPGDFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPPYATFPRQCPPGRPY
                     PHQDSIPSLEPGSHSKDGLHRGALLPPPYRVADSYSNGYREPPEPDGWAGGLRGLPPT
                     QTKCKQPNCSFYGHPETNNFCSCCYREELRRREREPDGELLVHRF"
     exon            431..619
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..847
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            848..949
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1077
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1190
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1318
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1319..1468
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1583
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1668
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..8922
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5439..5444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="hexamer: AATAAA"
     polyA_site      5472
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="major polyA site"
     polyA_site      5553
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="major polyA site"
     regulatory      6382..6387
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="hexamer: AATAAA"
     polyA_site      6402
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="major polyA site"
     regulatory      8896..8901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="hexamer: AATAAA"
     polyA_site      8922
                     /gene="OTUD7B"
                     /gene_synonym="CEZANNE; ZA20D1"
                     /note="major polyA site"
ORIGIN      
        1 accgatcctg aaccagccgc cggagccgga gtggcgaccg ggtgcggagt gggcaaaaag
       61 ccactggggg aggccagtcc cgatcagtcc tttctggctc cagctccaga tcccgtgcgg
      121 agcaacagct gcggtcgcag tctccaccac cgcctccacc tccatcgccg tcgggggagg
      181 ggccggccgg accccggggt cactgccgag gaatgaagag aggcggccgg gccccgcgct
      241 ccgccccggc ctagggcctt gccccgggag cccgcgaggg tggaggcctg aattttgatc
      301 tatgttctac ctacatccag ctggctgaaa gtacttgagg atcacatgac cctggacatg
      361 gatgctgttc tgtcagattt tgtccgttcc acaggagcag agccagggct agcgcgagat
      421 ctcctagaag gaaagaattg ggatgtgaat gccgccctca gtgattttga acagctacgt
      481 caagtccatg ctggaaacct acccccatcc tttagtgagg ggagtggtgg ctccaggacc
      541 cctgaaaaag ggttttctga cagagagcct actcgccctc cccgacccat cctccagcgg
      601 caggatgaca tcgttcaaga aaaacgcctg tctaggggca tctcccacgc cagctccagc
      661 attgtttccc tggcccggtc ccatgtctcc tccaatggtg ggggtggggg gagcaatgag
      721 caccccctgg aaatgcccat ctgtgccttc cagcttccag atctcactgt atacaatgaa
      781 gacttccgca gcttcataga gagagacctc attgagcagt ccatgctggt tgccttggaa
      841 caggcagggc gtttgaactg gtgggtgagt gtggatccca cctctcagag gctgcttcct
      901 ttggcaacta ctggagatgg gaactgcctc ctgcatgcag cctcccttgg aatgtggggt
      961 ttccatgatc gggacttgat gctgcggaaa gctttgtatg cactgatgga gaagggagtt
     1021 gagaaggaag cgttgaaaag gcgctggagg tggcagcaga cacagcagaa taaagagtca
     1081 gggctggtat acacagaaga tgaatggcag aaggagtgga atgaactgat caagcttgcc
     1141 tcaagtgaac cccgaatgca tctaggtacc aatggagcca actgtggtgg ggtggagagt
     1201 tctgaggagc ctgtatatga gagccttgaa gagtttcacg tctttgtcct tgctcatgtg
     1261 cttaggaggc ccatagtcgt cgtggcagac accatgctga gggactccgg aggggaagca
     1321 tttgccccta ttccctttgg aggaatctat ctgcctttgg aggtcccagc cagccagtgt
     1381 caccgctccc ctctggtgct cgcctatgat caggcccact tttctgcact cgtgtccatg
     1441 gagcagaagg agaataccaa ggaacaagct gtgatcccac ttacagattc agagtataag
     1501 ctgctgccct tgcactttgc tgtggaccct ggaaagggct gggagtgggg caaagatgat
     1561 agtgacaatg tccgattggc cagtgtaatt ctgtccctag aggtcaaatt gcatctgctg
     1621 catagctaca tgaatgtgaa gtggatccca ctgtcctctg atgcacaggc tcctctggcc
     1681 cagcctgagt cccccaccgc ctcagctgga gatgagcccc ggtccactcc tgagtctgga
     1741 gactcagaca aggagtcagt tggcagcagt tccaccagca acgagggcgg ccggcggaag
     1801 gagaagtcaa agcgagatcg ggagaaggac aagaagagag cagattctgt ggctaacaaa
     1861 ctgggcagct ttggcaaaac cttgggcagc aagctcaaga agaacatggg gggcctgatg
     1921 cacagcaagg gttcaaagcc tggaggggtg gggacagggt tgggaggaag cagcggcact
     1981 gagacactgg agaagaagaa gaaaaactca ctgaagagct ggaagggtgg caaggaggag
     2041 gcagctgggg atgggcctgt gtctgagaag cccccagctg agtctgttgg taacggaggg
     2101 agcaagtata gccaggaggt gatgcagagc ctgagcattc tgaggactgc catgcaaggg
     2161 gaggggaagt ttatttttgt tggaaccctg aagatgggtc accgtcacca gtatcaggag
     2221 gaaatgatcc agcgctacct ttctgatgct gaggagagat tcctggcaga acagaagcag
     2281 aaggaggcag agaggaagat catgaatgga ggaatagggg gtggccctcc tccagccaaa
     2341 aagccagagc cagatgctag ggaagagcag ccgaccggtc ccccagcaga gtccagggca
     2401 atggcatttt ccactggcta ccctggggac tttactatcc ctcggccgtc tgggggcgga
     2461 gtccactgcc aggaaccccg gaggcagttg gcagggggtc catgtgtcgg gggcctacca
     2521 ccatatgcca ccttccccag acagtgccct cctgggcgac cctaccccca ccaggacagc
     2581 atcccttctc tggagccagg cagccactct aaggatggac ttcacagggg tgccttgtta
     2641 ccacccccct accgagtggc tgattcctat agcaatggct acagagagcc ccctgagcca
     2701 gatggatggg ctggaggtct ccggggcctt cccccaactc agaccaaatg caaacaaccg
     2761 aactgcagct tctatggaca ccctgagaca aacaacttct gttcctgttg ttacagggaa
     2821 gaactgagga ggagggagcg ggaaccggat ggggagctcc tggtgcacag gttctgaacg
     2881 ggtggaacac tgaagggcaa ggaggctaaa caaagttaag ctcaactaat tggctcatca
     2941 agaacacagt ccccatgttg agggggaaaa tgcagtaatg tttgtgggag cctggctgga
     3001 aacttttaag tgtgtgcaca caggagtgct gccaggctgg caagagcagg tcggggctgg
     3061 atggcacctc aggggctgta ctattcctct gcagagcttg acttgatgag gtttgaggta
     3121 caaggggaaa agatggcgat tctgtcttat aacctcctgg gtcccatcca gggacctaag
     3181 agaaagtagc aggggaaggt ttggtgtgtg ggggtgggag gtgggcagaa gtcttgggga
     3241 ggaatgggca aaggaggttc tcagtcaata aaaccaaagt tctttaggtt gggaaaaagc
     3301 acatggtgga gtgagaagtg tggaggggaa gtgggaaatt ggacacattt gctattgatt
     3361 tgaattaagc tagaaattaa ggttggataa attcttcccc ttgaaggatc tggaaagaca
     3421 aggcagtaat gtgtcctcat gggtgcctgt taggaggtgg gggtagttta aatccgtttg
     3481 tttagatggg aaagggagga acttaagagg gaaatccttt tcctcttaag gtttatttcc
     3541 ttccaagcag tcatatgtca tctgttacag tttgagaaga gattgctgat taccccctgt
     3601 cttttcctca tctaagtctt taattgtatt tgtttaaagg gaagagtgtg gtgagaacag
     3661 ccgtcatgtg tgttgcattt tctccaggtg aattggggca gagctgatct attttttaac
     3721 cacagcaata accatacgtt ggggtttgag tgcaccttgg gaggggtggg aggacagaca
     3781 ttttagccag aggctgtttc aaacaaaacc aaaaacctaa gtagagcatt acaggcctct
     3841 gtggctgctg cgtttctgta gaaagcaact tattttattg actttttttt ttaaggaaaa
     3901 gaaataaaaa gaccccagca agcaaaaaca tttaaaaaat gatttttttt cctcctactt
     3961 aagtggttct ttctcccttt gctctacttt tggagaatga acttaacatc ccggcttctt
     4021 ttgttaagcc atagctgacc ttaatctgtg gttagtttat taaaataatt aaaaatactt
     4081 tctaagaaga gatatttttg atattaggac tgatgttgaa acatataggg gcaatttata
     4141 aaaaggtagt tagagaaata tattttagtg aactataacc acagagcaca gatgactccc
     4201 aatgagctga tctgtcttta ggtttctccc tttccctgac ccttccctgt tctctagggg
     4261 ctgggagtgg ggatgcggac acagtagggg gagctccttc gcattttgca caaagcacaa
     4321 gtctgaacag cctatgctct ggccagagcc atttctaaga gctttaaacc ggaagaccta
     4381 tcctgggcca attttccttt ttctttatat ttttttccgg gaaaaaaagt caactatgca
     4441 attgtataca ctcccgggtg catgtgaaga aggggaataa gtgtacttat gtgtccagag
     4501 tattaactgg ggctgttttt ctgtgtttgg atttctcttt tgaggtatgt actcataacc
     4561 catcccttgg aacgtaatcc ccacatttga tctaaagcac ttgagcgtgc atgcatgtgc
     4621 gtgcgtgcat atgtgtgtgt gttttcctcc tcggtagcca gtcaagattg tccttgttgg
     4681 aaatgctcac ggtttataaa ggttattttc tcctcaacaa actcagaagt cacctatttt
     4741 ccaaatctga tttaataatt tcctatggct attaattctt agggttttct ttgaaaatag
     4801 atttgtgtta aggaagcagt gagattccaa aggaagggat gtgtatatgt ctaggcaggt
     4861 ctggaacctg gtatgagatg agcactcccc taagttgcaa aatttaaggg ttactataaa
     4921 actcattaat caagatacta taaaaaatgc agtatttaaa aaaattaatg caaaaaattt
     4981 atgttggata aaatagcgaa atcttacagg atctgacagg actgagatta ggaggaggga
     5041 agtgaggctg aattgaataa gtatggggat gaatccttct tatttaaatt tttgatacat
     5101 tgtccatcat agacttttta cattaattgt gattttttaa aaatgttgca ttaaaatagt
     5161 atttatcttg gttactgggt tttttggcac tccttaaatt ttgtgcccaa ggtgagtgct
     5221 ttgctcacct caccctagtt acgtccctgt ttctgtgatt tgaacactag cgagaacacc
     5281 actgtgtgcg cctccacccc catcacacac caaacaacag gtggctcaga caccctgaat
     5341 ttgcacagct cacctagctt tcctaattta ggccttcata tcatagaatg gtggcctgga
     5401 ccaataggaa tgaaaacaga ccaggggttt tcccagagaa taaagccgga aaagttttga
     5461 ttctccactg gactgctgtg tttggatttg atctgttgtt agattctagt taacactttt
     5521 gtttttaaaa actaaggaca aatgaacaaa aaaccttgta tcatgtttgt ttttatttat
     5581 aagttagcca atcccaattc cgtttgcttt attttcaaat aaaaaaagat ggaaattttg
     5641 aggggtggtc taggggtgaa tatggtaaaa tggggcttta ggccttatag ctttttatta
     5701 agaaataaat tatttttttt atttgggagg gtaactattt attgaggcat tgaaaaacct
     5761 ctccattcta aggatgagag accctgagac aatggatatt ttttatagga gatagtgaag
     5821 tttgttttgc ttcattcttt cggggagggt cttggtggga tggggggagg tgaaggaata
     5881 atgcctggga aattaatata gattcagctt ggtttgtggt attttgggaa gatgagggaa
     5941 tagaagaggc aagcccatgt cgttactggg ttggggagaa ggaaagaagg ggcatatggc
     6001 ctgcactcga aatgggcaga aaaattcctt agttaaggag gggtgtgtga gtgaaggggg
     6061 aaggtagacc ctttaacccc aagtgaggga tgatatcatc tctcaggctt aaatttaagt
     6121 gcacttagtt cctttaatcc agggcaactg gggtacctac tgaagttttt aatggagagg
     6181 ggagattttc agggttcttg tttttccctt tttgatgtta gacagtgcta ctccctccct
     6241 gctgtgctct ctgccccatc tccaatggag taagtattac tgtaggatag gcctccgctt
     6301 ctcccttaac ctatgctgca tttattgaaa gttacaagat ttaaccagaa gtttttcctc
     6361 catactggtt tttatcaaca aaataaaaag attatatcca aagatttttt aaagattcag
     6421 tctttttaag gagtggagat ggtgttaaac tcagtgctgt agagggcagt ggaagggaag
     6481 taccttccct ctattagctc agtttttttt tttctatcaa gcgaaactaa ggcccacaga
     6541 caaacaagaa ttagcagtga cttcgtgttg tatatctgcg gggtgatact gagcccaaaa
     6601 gaataaagct ggttttgaat gtgttctgag aacctagctt ttgccattct taactccttt
     6661 tagccatgtg tccaaggttc cagtcacatt tttttttctc aataaagagt atttcagaga
     6721 tgattgtctc tgaattactc agacacctct ggactctgag tcttctttct ttttcctttt
     6781 tctttctttc tttttttttt ggtttgagac ggagtctcgc tcagctgccc aggctggagt
     6841 gcagtggtgc aatctcggct cactccaacc accgtctcct gggttcaagt gattctcctg
     6901 tctcagcctc ccaggtggct gggattacag gcacccgcaa tcatgcccgg ctaatttttg
     6961 tattttagta gagatggggt ttcaccatgt tggccaggct gatcttgaac tcctgacctc
     7021 aggtgatccg ccagcctcgg cctcccaaag tgctgggatt acaggcatga gccaccgcga
     7081 ctggcctctg tgtcttcctt ctccaatgag tcagtgcccc agacatatag ccacaggtga
     7141 gaagacagaa ttagaagccc cttcccggcc tggaatcacc tgcactccag atttttctaa
     7201 tttccttctt tccctccagg cctttcaact atagatctgg atgagtcatg caggcattct
     7261 gtctcttcta ctttgcagac agccagtctg caaatcacag ggtattttgc caccatacat
     7321 cagttgggta acaaaatatt acgatgtccc catgtagact ttctctgtgc catctcttgc
     7381 attggccaag tgggtaaggg gcagtacaaa agagcaacgg aagctggctg gcagcagtta
     7441 agaggagtag gggtgggaag gaccttggcc tctttctgtg cttataactg gatctgtgac
     7501 tcatcttgtg agtcactcag ctccacctcc ctcctccggc tgcccctccc agcagccttt
     7561 actcctggca caaacctgca gccagaacag gattctgaaa atggaaaaat ctgatatagc
     7621 cccttgcctc tccacccttc ccttcatcta gtgcttctac tgggggtgtg tggggtggtg
     7681 agaggcagcc ttaaccctca gctcctgccc actccattcc tggttaagta ttgatccaaa
     7741 tcgcccaatt cttttctcct cctgatttcc ccccaccccg cttttttttt tttttttttt
     7801 tgagacagag tttcgctctt gtcgcccagg atggagtgca atggcgcgat cccggctcac
     7861 tgcaaccttc gtctcctggg ttcaagcgat tctcctgcct caggctcccg agtagctggg
     7921 attacaggag cctaccacca tgcctggctt aatttttttt tttttttttt tttttagtta
     7981 gagtcggggg tttcgccatg ttggccaggc tggtcttgaa ttcctaacct caggtgatcc
     8041 gtgatccacc cacctcagcc ttccaaagtg ctgggattac aggcatgagc caccacaccc
     8101 ctaccccccg attttttttc tccgtgttcc tccactgtct ccacacctca aagtgctaaa
     8161 gaatagaatg aggctcttga atgaaggatg gtggtgagaa ggaaagtgga taatgggatt
     8221 taaaagttat ggtacacacc tcttcctatg tctttttttt tttttttttt tttgcgatgg
     8281 agtcttgctc tgttgcccag gctggagcgt agtcattaga tcttggctca ctgcaacctc
     8341 tgcttcctgg gttcaagcga ttctcctgcc tcagcctccc aagtagctgg gattataggt
     8401 gtgagccacc acgcctggct aatttttgta ttttcagtag agatggggct tcatcatgtt
     8461 ggccaggtgg tcctgaactc ctgacctcaa gtaatctgcc tgccttggcc ttccaaaatg
     8521 cttgggatta caggcgtgag ccactgcgcc tggtccctat tttcttttta caacagacct
     8581 tgggaaatat tttcttcccc caagaggttg aggcccatgg aatgcattag gggcaggtgg
     8641 ggtggtggtg ctctgtagcc tttaggactt ctagaatcag gcttctgggc caccttctta
     8701 gcaggtgtat acctctttgt tccagactga ctttctgtct cacaatatct tcactatttc
     8761 cacagttgca gccaagacag gaaactgaaa gctgaggcca gaagggtggt gtactggggg
     8821 gaggggaaaa ttgagtgtca ctttggaaaa ctggggcccc catctaagga ttgctgcctc
     8881 tgtagattca aaagcaataa aacagcagct cattaactct ta
//
