LOCUS       NM_001382637           10964 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens OTU deubiquitinase 7A (OTUD7A), transcript variant 3,
            mRNA.
ACCESSION   NM_001382637
VERSION     NM_001382637.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10964)
  AUTHORS   Su,S., Chen,J., Jiang,Y., Wang,Y., Vital,T., Zhang,J., Laggner,C.,
            Nguyen,K.T., Zhu,Z., Prevatte,A.W., Barker,N.K., Herring,L.E.,
            Davis,I.J. and Liu,P.
  TITLE     SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing
            Sarcoma Growth
  JOURNAL   Adv Sci (Weinh) 8 (14), e2004846 (2021)
   PUBMED   34060252
  REMARK    GeneRIF: SPOP and OTUD7A Control EWS-FLI1 Protein Stability to
            Govern Ewing Sarcoma Growth.
REFERENCE   2  (bases 1 to 10964)
  AUTHORS   Liu,W., Lei,L., Liu,X. and Ye,S.
  TITLE     CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the
            progression of diffuse large B-cell lymphoma via acting as a sponge
            of miR-431-5p
  JOURNAL   Genes Genomics 43 (6), 653-667 (2021)
   PUBMED   33830472
  REMARK    GeneRIF: CircRNA_OTUD7A upregulates FOXP1 expression to facilitate
            the progression of diffuse large B-cell lymphoma via acting as a
            sponge of miR-431-5p.
REFERENCE   3  (bases 1 to 10964)
  AUTHORS   Suzuki,H., Inaba,M., Yamada,M., Uehara,T., Takenouchi,T.,
            Mizuno,S., Kosaki,K. and Doi,M.
  TITLE     Biallelic loss of OTUD7A causes severe muscular hypotonia,
            intellectual disability, and seizures
  JOURNAL   Am J Med Genet A 185 (4), 1182-1186 (2021)
   PUBMED   33381903
  REMARK    GeneRIF: Biallelic loss of OTUD7A causes severe muscular hypotonia,
            intellectual disability, and seizures.
REFERENCE   4  (bases 1 to 10964)
  AUTHORS   Garret,P., Ebstein,F., Delplancq,G., Dozieres-Puyravel,B.,
            Boughalem,A., Auvin,S., Duffourd,Y., Klafack,S., Zieba,B.A.,
            Mahmoudi,S., Singh,K.K., Duplomb,L., Thauvin-Robinet,C.,
            Costa,J.M., Kruger,E., Trost,D., Verloes,A., Faivre,L. and
            Vitobello,A.
  TITLE     Report of the first patient with a homozygous OTUD7A variant
            responsible for epileptic encephalopathy and related proteasome
            dysfunction
  JOURNAL   Clin Genet 97 (4), 567-575 (2020)
   PUBMED   31997314
  REMARK    GeneRIF: Report of the first patient with a homozygous OTUD7A
            variant responsible for epileptic encephalopathy and related
            proteasome dysfunction.
REFERENCE   5  (bases 1 to 10964)
  AUTHORS   Uddin,M., Unda,B.K., Kwan,V., Holzapfel,N.T., White,S.H.,
            Chalil,L., Woodbury-Smith,M., Ho,K.S., Harward,E., Murtaza,N.,
            Dave,B., Pellecchia,G., D'Abate,L., Nalpathamkalam,T.,
            Lamoureux,S., Wei,J., Speevak,M., Stavropoulos,J., Hope,K.J.,
            Doble,B.W., Nielsen,J., Wassman,E.R., Scherer,S.W. and Singh,K.K.
  TITLE     OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3
            Microdeletion Syndrome
  JOURNAL   Am J Hum Genet 102 (2), 278-295 (2018)
   PUBMED   29395074
  REMARK    GeneRIF: OTUD7A is a major regulatory gene for 15q13.3
            microdeletion syndrome phenotypes.
REFERENCE   6  (bases 1 to 10964)
  AUTHORS   Xu,Z., Pei,L., Wang,L., Zhang,F., Hu,X. and Gui,Y.
  TITLE     Snail1-dependent transcriptional repression of Cezanne2 in
            hepatocellular carcinoma
  JOURNAL   Oncogene 33 (22), 2836-2845 (2014)
   PUBMED   23792447
  REMARK    GeneRIF: Snail1-mediated suppression of Cezanne2 may have a key
            role in HCC malignancy.
REFERENCE   7  (bases 1 to 10964)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   8  (bases 1 to 10964)
  AUTHORS   Tang,W., Teichert,M., Chasman,D.I., Heit,J.A., Morange,P.E., Li,G.,
            Pankratz,N., Leebeek,F.W., Pare,G., de Andrade,M., Tzourio,C.,
            Psaty,B.M., Basu,S., Ruiter,R., Rose,L., Armasu,S.M., Lumley,T.,
            Heckbert,S.R., Uitterlinden,A.G., Lathrop,M., Rice,K.M.,
            Cushman,M., Hofman,A., Lambert,J.C., Glazer,N.L., Pankow,J.S.,
            Witteman,J.C., Amouyel,P., Bis,J.C., Bovill,E.G., Kong,X.,
            Tracy,R.P., Boerwinkle,E., Rotter,J.I., Tregouet,D.A., Loth,D.W.,
            Stricker,B.H.C., Ridker,P.M., Folsom,A.R. and Smith,N.L.
  TITLE     A genome-wide association study for venous thromboembolism: the
            extended cohorts for heart and aging research in genomic
            epidemiology (CHARGE) consortium
  JOURNAL   Genet Epidemiol 37 (5), 512-521 (2013)
   PUBMED   23650146
REFERENCE   9  (bases 1 to 10964)
  AUTHORS   Morrison,A.C., Felix,J.F., Cupples,L.A., Glazer,N.L., Loehr,L.R.,
            Dehghan,A., Demissie,S., Bis,J.C., Rosamond,W.D., Aulchenko,Y.S.,
            Wang,Y.A., Haritunians,T., Folsom,A.R., Rivadeneira,F.,
            Benjamin,E.J., Lumley,T., Couper,D., Stricker,B.H., O'Donnell,C.J.,
            Rice,K.M., Chang,P.P., Hofman,A., Levy,D., Rotter,J.I., Fox,E.R.,
            Uitterlinden,A.G., Wang,T.J., Psaty,B.M., Willerson,J.T., van
            Duijn,C.M., Boerwinkle,E., Witteman,J.C., Vasan,R.S. and Smith,N.L.
  TITLE     Genomic variation associated with mortality among adults of
            European and African ancestry with heart failure: the cohorts for
            heart and aging research in genomic epidemiology consortium
  JOURNAL   Circ Cardiovasc Genet 3 (3), 248-255 (2010)
   PUBMED   20400778
  REMARK    GeneRIF: Meta-analysis and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   10 (bases 1 to 10964)
  AUTHORS   van Bon,B.W.M., Mefford,H.C., de Vries,B.B.A. and Schaaf,C.P.
  TITLE     15q13.3 Recurrent Deletion
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   21290787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC079969.5, AC104266.7,
            AC021316.17 and AC104759.10.
            
            Summary: The protein encoded by this gene is a deubiquitinizing
            enzyme and possible tumor suppressor. The encoded protein acts on
            TNF receptor associated factor 6 (TRAF6) to control nuclear factor
            kappa B expression. However, this gene is downregulated by SNAIL1
            in hepatocellular carcinoma cells, contributing to their
            progression and malignancy. [provided by RefSeq, Aug 2016].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307050.6/ ENSP00000305926.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-167               AC079969.5         174326-174492
            168-262             AC104266.7         63192-63286         c
            263-417             AC104266.7         61305-61459         c
            418-597             AC021316.17        42245-42424
            598-816             AC021316.17        53255-53473
            817-918             AC021316.17        81634-81735
            919-1046            AC021316.17        85134-85261
            1047-1159           AC021316.17        85981-86093
            1160-1287           AC104759.10        20050-20177
            1288-1437           AC104759.10        22029-22178
            1438-1552           AC104759.10        36302-36416
            1553-1637           AC104759.10        36590-36674
            1638-10964          AC104759.10        39144-48470
FEATURES             Location/Qualifiers
     source          1..10964
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q13.3"
     gene            1..10964
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /note="OTU deubiquitinase 7A"
                     /db_xref="GeneID:161725"
                     /db_xref="HGNC:HGNC:20718"
                     /db_xref="MIM:612024"
     exon            1..167
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            168..262
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            263..417
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..3068
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /EC_number="3.4.19.12"
                     /note="isoform 3 is encoded by transcript variant 3;
                     cezanne 2; OTU domain-containing protein 7A; zinc finger
                     protein Cezanne 2; OTU domain-containing 7A"
                     /codon_start=1
                     /product="OTU domain-containing protein 7A isoform 3"
                     /protein_id="NP_001369566.1"
                     /db_xref="CCDS:CCDS91972.1"
                     /db_xref="GeneID:161725"
                     /db_xref="HGNC:HGNC:20718"
                     /db_xref="MIM:612024"
                     /translation="MVSSVLPNPTSAECWAALLHDPMTLDMDAVLSDFVRSTGAEPGL
                     ARDLLEGKNWDLTAALSDYEQLRQVHTANLPHVFNEGRGPKQPEREPQPGHKVERPCL
                     QRQDDIAQEKRLSRGISHASSAIVSLARSHVASECNNEQFPLEMPIYTFQLPDLSVYS
                     EDFRSFIERDLIEQATMVALEQAGRLNWWSTVCTSCKRLLPLATTGDGNCLLHAASLG
                     MWGFHDRDLVLRKALYTMMRTGAEREALKRRWRWQQTQQNKESGLVYTEEEWEREWTE
                     LLKLASSEPRTHFSKNGGTGGGVDNSEDPVYESLEEFHVFVLAHILRRPIVVVADTML
                     RDSGGEAFAPIPFGGIYLPLEVPPNRCHCSPLVLAYDQAHFSALVSMEQRDQQREQAV
                     IPLTDSEHKLLPLHFAVDPGKDWEWGKDDNDNARLAHLILSLEAKLNLLHSYMNVTWI
                     RIPSETRAPLAQPESPTASAGEDVQSLADSLDSDRDSVCSNSNSNNGKNGKDKEKEKQ
                     RKEKDKTRADSVANKLGSFSKTLGIKLKKNMGGLGGLVHGKMGRANSANGKNGDSAER
                     GKEKKAKSRKGSKEESGASASTSPSEKTTPSPTDKAAGASPAEKGGGPRGDAWKYSTD
                     VKLSLNILRAAMQGERKFIFAGLLLTSHRHQFHEEMIGYYLTSAQERFSAEQEQRRRD
                     AATAAAAAAAAAAATAKRPPRRPETEGVPVPERASPGPPTQLVLKLKERPSPGPAAGR
                     AARAAAGGTASPGGGARRASASGPVPGRSPPAPARQSVIHVQASGARDEACAPAVGAL
                     RPCATYPQQNRSLSSQSYSPARAAALRTVNTVESLARAVPGALPGAAGTAGAAEHKSQ
                     TYTNGFGALRDGLEFADADAPTARSNGECGRGGPGPVQRRCQRENCAFYGRAETEHYC
                     SYCYREELRRRREARGARP"
     exon            418..597
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            598..816
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            817..918
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1046
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1159
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1287
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1437
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1552
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1637
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     exon            1638..10964
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4655..4660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /note="hexamer: AATAAA"
     polyA_site      4681
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /note="major polyA site"
     regulatory      10939..10944
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /note="hexamer: AATAAA"
     polyA_site      10964
                     /gene="OTUD7A"
                     /gene_synonym="C15orf16; C16ORF15; CEZANNE2; NEDHS; OTUD7"
                     /note="major polyA site"
ORIGIN      
        1 aggagaggcc accgggaccg cgagcggcag ctggggaggg ggccgcggag cccgagcggg
       61 agcaaaacag ctgatctggt tttcctttaa agcgagagaa aatggaagtc gggtagcggc
      121 gactgcggcg ctgcgggctg gcggagcgga gcggcgcggc gcggcaggtg gcagtgacga
      181 aagaagagac tctcccggcc gaggccccag tgcatggaga gaaggaagaa atcaatttcc
      241 taattggtac catatacatc agatggatgg tttctagtgt gcttccaaac cccacctcgg
      301 ctgagtgttg ggcagcactt ctacatgatc ctatgactct tgatatggac gcagtcctgt
      361 cagactttgt tcggtccacg ggggcagaac ctggtctggc cagagacctg ctggaaggca
      421 aaaactggga cctgacagcc gctctgagcg actatgagca gctccgccag gtgcacacag
      481 ccaatctgcc acatgtgttc aatgaagggc ggggtcccaa gcagccagag cgagagccac
      541 agcccgggca caaggtggag cgaccctgcc tgcagaggca ggacgacatt gcccaagaaa
      601 agcggctttc ccgggggatt tcccacgcca gctcagccat cgtctccctg gcccggtccc
      661 acgtggcaag tgaatgcaac aacgagcagt tccccctgga gatgccaatc tacacattcc
      721 agttgccaga cctgagcgtg tacagcgagg atttcaggag cttcatcgag cgggacttga
      781 tcgagcaggc aacaatggtg gctttggagc aggcaggtcg cctgaactgg tggtccactg
      841 tgtgcacgag ctgtaaacgg cttcttcctc tggccacaac aggggatggg aactgccttt
      901 tacatgctgc ttcactggga atgtgggggt ttcacgaccg ggacctggtg ttacggaaag
      961 ctctctatac catgatgagg acgggagctg agagggaagc cctgaagcgg aggtggaggt
     1021 ggcagcagac gcagcagaat aaggagtcag ggctggtgta cacagaggag gagtgggagc
     1081 gggagtggac ggagctgctg aagctggcct ccagcgagcc gcgcacacac ttcagcaaga
     1141 atggcggcac gggcgggggt gtggacaact ctgaggaccc cgtgtacgag agcctggaag
     1201 agttccacgt ttttgtccta gcccatatat taagaaggcc catcgttgtt gtggcagata
     1261 caatgttaag agactcaggt ggagaagcgt tcgcacccat cccattcgga gggatctacc
     1321 tgcccttgga ggtccctccc aacagatgcc actgctcgcc tctggttctg gcctatgatc
     1381 aagcccattt ctctgccctt gtgtccatgg aacagagaga ccagcaaaga gaacaagccg
     1441 tgatccccct gacggattct gagcacaagc tgctgcctct gcactttgca gtggaccctg
     1501 gcaaggactg ggagtggggg aaagacgaca acgataacgc ccggctggcc caccttatcc
     1561 tgtcgctaga agccaagctg aaccttctgc acagctacat gaacgtgacg tggatccgga
     1621 tcccctccga gacacgggcg cccctggcac agccggagtc tcccacggcc tcggcagggg
     1681 aggacgtgca gtccctggcc gactcgctgg actcggaccg cgattcggtg tgcagcaatt
     1741 ctaacagcaa taacggcaag aacggcaagg acaaggagaa ggagaagcag cgcaaggaga
     1801 aggacaagac gcgcgccgac tccgtggcca acaagctggg cagcttcagc aagacgctgg
     1861 gcatcaagct gaagaaaaac atgggcggcc tcggcggcct ggtgcacggc aagatgggcc
     1921 gcgccaactc cgccaatggc aagaacgggg actcggccga gcggggcaag gagaagaagg
     1981 ccaagtcgcg caagggcagc aaggaggagt ctggtgcgtc ggccagcacg tcgccgtcgg
     2041 aaaagaccac gccgtcgccc acagacaagg cagcgggcgc gtcgccggcg gagaagggcg
     2101 gtgggccgcg gggcgacgcc tggaagtaca gcacggatgt gaagctgagc ctcaacatcc
     2161 tgcgcgccgc catgcagggg gagcgcaagt tcatcttcgc cggcctgctg ctcaccagcc
     2221 accggcacca gttccacgag gagatgatcg gctactacct gacgagcgcg caggagcgct
     2281 tcagcgccga gcaggagcag cggcgccgcg acgccgctac tgcggccgcc gctgccgccg
     2341 ccgccgccgc cgccacggcc aagcggccgc cgcgcagacc ggagacggag ggcgtgccgg
     2401 tcccggagcg cgcctctccg ggcccaccca cgcagctggt gctcaagctc aaggagcggc
     2461 cgagccccgg gcccgcggca gggcgtgcgg cgcgggcggc ggcgggcggc acggcctccc
     2521 cggggggagg cgcgcggcgt gcgagcgcca gcggaccagt gcctggccgc agccccccgg
     2581 cgccagcgcg ccagagcgtc atccacgtgc aggcgtcggg cgcgcgggac gaggcgtgcg
     2641 cgccggccgt gggggcgctg cggccgtgcg ccacgtaccc gcagcagaac cgctcgctgt
     2701 cgtcgcagag ctacagcccg gcgcgcgccg ccgccctgcg caccgtcaac acggtcgagt
     2761 cgctggcgcg cgcggtgccc ggggccctac cgggcgcggc ggggacggcg ggggcggccg
     2821 agcacaagtc gcagacctac accaacggct tcggcgccct gcgcgacggc ctggagttcg
     2881 ccgacgccga cgcgccgacc gcgcgctcga acggtgagtg cggccgtggc ggcccggggc
     2941 cggtgcagcg gcgctgccag cgcgagaact gtgcgttcta cgggcgcgcc gagaccgagc
     3001 actactgctc ctactgctac cgcgaggagc tgcggcggcg gcgcgaggcg cgcggggccc
     3061 ggccctgagc ggcgcggcgc ggcgcgggcg gcgaggttct accttcgagg atttcttttc
     3121 cattgtgtcg gtgtcttttt tacatgccct ggtccaccgg aaggccggcg cctcctctgt
     3181 cagtgccgtg tacgtgtttg gtcaaacgtt cctaatggtg cctgaaccta cactgacgcc
     3241 actcaggtag tagacggata ggaaacaagt catactgttg gaagtgggtg tgctagccta
     3301 gcatctgcct cgtacctgtg gaaactcaat agccattgca agagtatttt tgttcctcag
     3361 taagagaaat aaagaaattc gcagcccttt gttttaagaa gggagtgttt tacatgcttt
     3421 ttttgctttt ttttttttct cctaccctag cgatgacctc ttccaggtag cggtcccttg
     3481 tgcgcggttg gtagtaccca gggcttagag cgagcgcgca cccggggctg cggtggaggc
     3541 tcctctgtga gctctacctg cctcccatcc cgaggcctag gagaaggcgg gtacctggcc
     3601 gccagctgac gccctggtgg tcactgtggc cctttagaaa cacacagctc catttcataa
     3661 gcaaaacctc ctcccccagc cccggctcaa gcaccattca cactgccatc caagccgcgg
     3721 gcggccgtgg aaagggcact ggaccacccg tctcgcgggc gccgtgaggt acagcgatgg
     3781 ctcccagtgc cgggcagttc aggtgacagg agctttccaa agacacctag ggtccaaaaa
     3841 gcagggttcc catctcacaa tttggatttg ctcatagagg agcagatagg acaggctgct
     3901 cacatttctc ctttgaaggc acttccacag tggactgtcg ctggcgggcc cctgggcggt
     3961 gaccatcggt gccccgggag acagcgagga attgaccctt tggtcactgt gtaagccccc
     4021 actaggctgc tgctctttcc aaagggaagg ggctggggga accaggaagg aagcccaccc
     4081 ccacacctgc atctgtctgg gttcagccag gtaaagggac tcactgtgat cgtggcccct
     4141 ccacggggca ggacgaccct gcctccgtct cgtgacacaa tgagggagca gcccgatccc
     4201 tgagcggtct cttttttggt gcctcctaca tttcttgagg aaaaaaaaaa tgtgtcctta
     4261 gctaccctgt tttgagcagc aatatgcagc ctcttccttc caagattacc tccggagaac
     4321 accgttcttg gccaaggaca ctgaggagct aaatctgcct cactaaggaa cgagcttgtt
     4381 tccaagaaat gaggataaga tgggtaaaat cctcactaac aaagaatact ataaaacctg
     4441 tgagagcctt agaatagctt ctaataatcc taggacagga gaaagcgcct ggctttgctg
     4501 tgagtgtatc ctcagaaaaa gcaggaggtc gaccatctct tcactggagc cagcttctcc
     4561 tctagaaacg atgctttttt ccctaactaa agagcagcaa aaacaaaaaa aaaggggggg
     4621 cgaggggatt ttttttactt gtttgagaaa ttataataaa ataattgagt atctcctgtg
     4681 agtaatgcct ttttgttttt aattattcca cagcaggtgg agttttcagt aatttgttca
     4741 agttttgcat aagtggttcc ttaaatcaaa aattatttat taaataggat ctttaagaaa
     4801 ttttttgaaa gttttacttt tcctgctgaa caatattttc aatgtgtggt aattactgta
     4861 ctaacatcca tgtccctaat attactgggg tttcttttat tactcagaaa acaaaagtgg
     4921 ttttttaaaa atctcatgga gagggtctgt ggcagctttc tggactgatt cttcgtgtca
     4981 cgctgagcag ctgctttggc atccaaagct gtgggatcac agaaagtgtt gcttcaggtg
     5041 tggatgccag ccactcctca tgctcgtcac tcttaaaaga ttgagacacc caaccttaaa
     5101 aatgctccaa taatccattc agaaaccaaa ctcatatgca caagatgtca aggaggcata
     5161 aagtcaattc ttgcttgttt ttttcatttc ttaatgtaaa aacagccaac cagaaatttc
     5221 taaaactggc tatgctaatt cagatatttt ctttctcacg ctatctgcca ggtttgtcta
     5281 atttaaaaaa taaaaaaata aaacagaata aaaaccgtcc attgtaatag aggaaaacct
     5341 tccaaaccag gcagagtacg taattatcaa aacaccagga cctattctac ccttgcattt
     5401 ccaagttacc tccacccatc accatctgat gacagatgtg ccctaaataa gagcctgaga
     5461 taaagccact ggctgcatcc tgcaccccag cttctcaatg tggtaacgag gcgccagacg
     5521 cctgtagaca cctgctccag gctgatacat taccactcag tccacatgac ttaggaatag
     5581 ccatttcctt ttgtgagaga gctggatcca tccttcctct aaacagtatt aaaaatgcaa
     5641 aagggagaga gcggatggtc atattaaatg tgctagtccc gtgcaccgac agcatgctcc
     5701 ttgagaagag gcgtgtagac ctcgtccctg gccagagacc aacttcagca ggctggccag
     5761 aaactattaa aaactgtgtt gactgcatgt gggccaaggg cttccctcgt gttccatggc
     5821 gtgagggccc tttgtggagc agggagaaag ggaagaaggt gagtcctacc ggggtgcatg
     5881 gccctgctgc cctagctgac cctgcctgag agcagccttc cccacctgat ctggccacac
     5941 ttccctttct aggaaggaca ggtgtctcca agggactgca ggtttccaga ggatcccaga
     6001 tacttctaaa cccctgcgaa ggttatttca gaaatttact ttacatttcc tgcacatttg
     6061 ttatctgggt aaatgatttt tttaaaatat tgttaaggga aggtgttttt cagtgtattc
     6121 tgttggtaga ctttatgctg tgttacgttg aaattttaca agccaagttt aaactgtact
     6181 ataaaaatta tttttgtatt attttcagaa catgccacag agcaatattt tgcacccgtt
     6241 attgccacag ggttgtccct tggaagggta actggaggtg ggaaggagct ccactgtggg
     6301 ctccgggggg ttaaacgctt tttgctgctt gttcaaatac cttctgaaag tgggaatgta
     6361 tcagtgtctt tttttattga aagcttgatt tccttttttc tgttcatgga ttttggtact
     6421 gcacctttcc tcttaaatga atactttgta ttcactaaat tactgtggac cttttcatac
     6481 ctattaccac ccagtggcat ttgaatctat ttacaaatcg aatgttttcc caaatgattt
     6541 aatttactac ttctcgtagc ttactgtcaa gaattggggg tgctgaagat aaaaggactc
     6601 tccatgcccc ccaggtgcac acctcagggt gtggacatcc tccatgcaga gcccgccctg
     6661 tctctgggga ggggtcatgg gcccatcacc cccccccccc acttagtgtc cacaaactta
     6721 ttttgcgaac tattctactt tgcaaaaata aacttaaaat atacttccca ttggttaaga
     6781 taaaagggct gtacttatca gtggtgggaa atttgtacaa gaaaaaacag acttttccaa
     6841 atccatgtgt gtaagttcca ttccatgtga gtcttttatt tacgaagaga cctggagtaa
     6901 aagctgaagg catctactgt atgtttgggg ctcctttctt tatggccatg attttttttc
     6961 tcctcatctt ggtgtggact ttaaaattaa gtacccccag tgttctgtcc tttttctttc
     7021 ctcagtgctt ctaatagata agaagaaatg tgtttctgtg gctgagcaag ccctgctggg
     7081 ccagacagac cttaccagcc ctggcttcat cctcgctggg ctgcagaggc ggcccctgct
     7141 ctagttgagt ccggttctgc tgccagctga ggacagacac accgtatgaa gggcctagag
     7201 gtggctggca tgccagggag caggtggccc cttccaaaac gccttaaagt ggtggctctc
     7261 tagagatctg aggcaccacc ttcccattta ctcctgactc taaactctag ctggcctgtt
     7321 ttagtgtggc tggccggggc agtgaccagc gctcagcttt gttcttgttt aattcaagtc
     7381 caccctgttg cccgtgtcct ctccacagct ctgggtctgt tggcccggag tgtatttctg
     7441 ccagtgctgc ctcactgact cgggagtggg tcctgggtag ttcacgatag agaggccagc
     7501 acacgccatg gggagagccc cccacgctca ccccaggagg ccctgcggca catccaggct
     7561 ggaccactct gcaagcttct gtcacaaaag acagctccgg gcactgtgca aattggcctg
     7621 ttagcagtta tgcaggtccc ttctttgcca aaagatctat tattcctccc cactgcaccc
     7681 ccagcagaaa agagcgaggg agatgccctg cagggacccc ttgggaacaa cagttatgtg
     7741 cagtctgtgc agtatgaaga acttggcccc accaggctga gccgaagaca cacgtagttg
     7801 cagagtagca ctgaagccat catctccaac catgctagta atgttactgt ttctatttat
     7861 tttgccaaat gatttgttga aaattgcatt tttgctattt taatcttgcc aaaaaagggg
     7921 gcctcactaa tcctaattat gtacatacag aatgatgcac attgcttgca tctttttatt
     7981 cctcccaaag agcatatcaa ggatatatat atacataatt tgttagttta acataaggcg
     8041 aagagtacca tttggtttta agagtaaata taggctgaat ttattcaaga ccaaagcaac
     8101 ctatttaatg aggacaaatg agtgaaacca gctgttttag aatttatctg cagacactgg
     8161 agtgctcctt taaacgaaga aacagcctcc catggcagag gaaaagccag gtccttacaa
     8221 aggcctctcc catcccagta cttcttctgc ctgctgctct gccctgggac gtaggccttc
     8281 ctgccgtttc tagtcacagg caccctcctg cctcagggcc tttgcacatg ccattccttc
     8341 tacctgaaca ttcttcccca gagagccaca tggttcaccc ctcactacct gccagtcttt
     8401 gctccaatgt cacctttcaa cgaggccttc cctgacttat ttaaaaggac aacacacccc
     8461 accctccctc cctacccacc tctctgcatc ttcttcttgt gcacctatca ccatctgagt
     8521 gctgcagatg ttaatcattc atccatttat ttgattctcg cctccccatc tcccatagac
     8581 tgtaagctcc atgtgggcag gaacttttat atgtcttgct cattgctgta tcctggtgcc
     8641 tacaacagtg cctgacacat attaggcact ggataagtat ttattgaaaa aaggaaatta
     8701 aatcagtaaa ttgaaaacta ttaagaggcc agaaaatgtc aatttcagct ttcatcaaat
     8761 ctaggttcta ttattgtgag aactttagct gacccagtga cctggctcct atgggtacaa
     8821 gatggttaga tacaccgggc agcagcggtg gcttctgttc acagacaagt gaatgcctgc
     8881 cctgccgcta gccccacctc acaaatatga ggctcactgt tcgcagggga gcattttgga
     8941 accagctggg atgaagacag ttttctgcag gtagcttttg tagccagatg cacagtagtg
     9001 ggttcccatc actccatgag gtcactgtag acctggacca ttccagagaa tcctttgtaa
     9061 tcagtcttta ggtgtctccc agtccttccc agttcaacac gggtggcagc agatggccca
     9121 gcccagggaa agtccacctg accattagaa ggactcatcc tccagccacc aaagcaaggc
     9181 tgcagaggaa gaggagcttg tcacaaacat taaccggctc agggctgggt aactgcattg
     9241 acaaatttgg aagcagcagg gccagagagc caaggccccc gggtatcccc attggccact
     9301 ggtggaggtg cactggaagg tcagggcctt gacaccacag agccaagcaa cacacacctc
     9361 cttgggccca ggccccagca cggtggccct ccagtgctgg caggtggcct cacccacagc
     9421 aggggaggcg tgggtcctcc aatgaccttc ctgcccctgc cagatgattt tcacaactac
     9481 ctaactttgg tgtttacttc taggtccttt ggccaaatgc gttttcttct aagagttgtt
     9541 ggcaaaatac tgttacaagc ttcttatggg acttttgtcc tactgtggcc tggttaaagg
     9601 ctttgtcctc ctgtttaatc cacttccgtg gttttgctgt catttctctt gatgccatat
     9661 tttcaggtcc ctcgtgggag ggggcataag gtctccatcg tgatgccctc tctgcagctg
     9721 tccagccagc agtgagtggg cccacacatg tgcattcctg tgcttgaatt gccaaataaa
     9781 cagtgtccct ttcattgctg cccaaacaga ctggaagcct gctcctgcca gcactcaggg
     9841 agggagtgtg tgcttcccaa gagcctgccc ccttggccca tgcaaacttt ctccatggca
     9901 ggtgtccgtg aaggtctccc aggccctatg ggctgtccag ctctttgcac acattcttcc
     9961 cgcttgcagg aatggaatcc aaacacctga tacggaatga tgacttggca gtggggagtg
    10021 gggcagcttg tctccgctaa cttaggacca aaactaggaa actcaccatg agcatgtgtt
    10081 ggagatcagc tgtggcctcc agcccctgta cacacagagg caagccccac ctctgacaga
    10141 gccagtcacc gttcagtagg agcttgtctt ccctgggccc ccaggtggga aaggctgggc
    10201 tcttagtcct acaagtaaag gcgctgttag gagcaaggag caggcttagc tgggtccaca
    10261 gagggactaa gctccttagt gacctgttac tgcctcatct acggagtttg aactccattc
    10321 accatcacct ttgagaattt ggccttgttt taactaagga ttgttgaagt taattataac
    10381 aagggaccat cctcaccctg tgtttgcttt gttccattaa acgtgcgttt ggcctaatga
    10441 agtcagtgaa tgttcctctt ttttcttttt tggtttcttt gactgatttt tggatgatat
    10501 atgttgcttt atttctccca ttttctttga ttactgtgga caaaggaaaa cactgaggca
    10561 aaagtaggtc gtcaatcaca ttactttgac ccagttgtgc agaacccctt tctacctgca
    10621 ggtgttaatt ccaattcaat gcaaatatcc ttttcaatcc ggtccattct tggagaagaa
    10681 acccattgta agagctgtct tctgtggttg ggatattact ttgtaaagta ttaaagcact
    10741 aaaccagttt ttgcaatatg tagtaaatct tgctttcatt ttggaaaact tccagtaatg
    10801 actactgcac tttttataga agaattgtat ttaatttctt tcttttatga aagattattt
    10861 caagtaaaaa tagctctgta atctgtgtga catggcttct ccattacctg acacagagag
    10921 aagctttgat gcctactcaa taaaattaac atgtttgtaa agta
//
