LOCUS       NM_016023               3148 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens OTU deubiquitinase 6B (OTUD6B), transcript variant 1,
            mRNA.
ACCESSION   NM_016023
VERSION     NM_016023.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3148)
  AUTHORS   Xing,G., Chen,H., Guo,Z., Cui,Y., Li,Y. and Shen,J.
  TITLE     OTUD6B promotes cholangiocarcinoma growth by regulating STAT3
            phosphorylation through deubiquitination of PTK2
  JOURNAL   Cell Biol Int 48 (11), 1766-1778 (2024)
   PUBMED   39192576
  REMARK    GeneRIF: OTUD6B promotes cholangiocarcinoma growth by regulating
            STAT3 phosphorylation through deubiquitination of PTK2.
REFERENCE   2  (bases 1 to 3148)
  AUTHORS   Yang,M., Wei,Y., He,X. and Xia,C.
  TITLE     The deubiquitinating protein OTUD6B promotes lung adenocarcinoma
            progression by stabilizing RIPK1
  JOURNAL   Biol Direct 19 (1), 46 (2024)
   PUBMED   38880876
  REMARK    GeneRIF: The deubiquitinating protein OTUD6B promotes lung
            adenocarcinoma progression by stabilizing RIPK1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3148)
  AUTHORS   Liu,Y., Tang,B., Wang,H. and Lu,M.
  TITLE     Otud6b induces pulmonary arterial hypertension by mediating the
            Calpain-1/HIF-1alpha signaling pathway
  JOURNAL   Cell Mol Life Sci 81 (1), 258 (2024)
   PUBMED   38878112
  REMARK    GeneRIF: Otud6b induces pulmonary arterial hypertension by
            mediating the Calpain-1/HIF-1alpha signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3148)
  AUTHORS   Wang,J., Zheng,H., Dong,C. and Xiong,S.
  TITLE     Human OTUD6B positively regulates type I IFN antiviral innate
            immune responses by deubiquitinating and stabilizing IRF3
  JOURNAL   mBio 14 (5), e0033223 (2023)
   PUBMED   37650650
  REMARK    GeneRIF: Human OTUD6B positively regulates type I IFN antiviral
            innate immune responses by deubiquitinating and stabilizing IRF3.
REFERENCE   5  (bases 1 to 3148)
  AUTHORS   Ma,B., Wei,X., Zhou,S. and Yang,M.
  TITLE     MCTS1 enhances the proliferation of laryngeal squamous cell
            carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination
  JOURNAL   Biochem Biophys Res Commun 678, 128-134 (2023)
   PUBMED   37634410
  REMARK    GeneRIF: MCTS1 enhances the proliferation of laryngeal squamous
            cell carcinoma via promoting OTUD6B-1 mediated LIN28B
            deubiquitination.
REFERENCE   6  (bases 1 to 3148)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 3148)
  AUTHORS   Santiago-Sim,T., Burrage,L.C., Ebstein,F., Tokita,M.J., Miller,M.,
            Bi,W., Braxton,A.A., Rosenfeld,J.A., Shahrour,M., Lehmann,A.,
            Cogne,B., Kury,S., Besnard,T., Isidor,B., Bezieau,S., Hazart,I.,
            Nagakura,H., Immken,L.L., Littlejohn,R.O., Roeder,E., Kara,B.,
            Hardies,K., Weckhuysen,S., May,P., Lemke,J.R., Elpeleg,O.,
            Abu-Libdeh,B., James,K.N., Silhavy,J.L., Issa,M.Y., Zaki,M.S.,
            Gleeson,J.G., Seavitt,J.R., Dickinson,M.E., Ljungberg,M.C.,
            Wells,S., Johnson,S.J., Teboul,L., Eng,C.M., Yang,Y.,
            Kloetzel,P.M., Heaney,J.D. and Walkiewicz,M.A.
  CONSRTM   EuroEPINOMICS RES Consortium Autosomal Recessive working group, S.
            Hande Caglayan
  TITLE     Biallelic Variants in OTUD6B Cause an Intellectual Disability
            Syndrome Associated with Seizures and Dysmorphic Features
  JOURNAL   Am J Hum Genet 100 (4), 676-688 (2017)
   PUBMED   28343629
  REMARK    GeneRIF: OTUD6B encodes a deubiquitinating enzyme; study reports
            biallelic pathogenic variants in OTUD6B in 12 individuals from 6
            families with intellectual disability syndrome associated with
            seizures & dysmorphic features; other features include
            developmental delay, microcephaly, absent speech, hypotonia, growth
            retardation, feeding difficulties, structural brain abnormalities,
            malformations of heart & musculoskeleton.
REFERENCE   8  (bases 1 to 3148)
  AUTHORS   Sobol,A., Askonas,C., Alani,S., Weber,M.J., Ananthanarayanan,V.,
            Osipo,C. and Bocchetta,M.
  TITLE     Deubiquitinase OTUD6B Isoforms Are Important Regulators of Growth
            and Proliferation
  JOURNAL   Mol Cancer Res 15 (2), 117-127 (2017)
   PUBMED   27864334
  REMARK    GeneRIF: The global OTUD6B expression level does not change
            significantly between nonneoplastic and malignant tissues,
            suggesting that modifications of splicing factors during the
            process of transformation are responsible for this isoform switch.
REFERENCE   9  (bases 1 to 3148)
  AUTHORS   Xu,Z., Zheng,Y., Zhu,Y., Kong,X. and Hu,L.
  TITLE     Evidence for OTUD-6B participation in B lymphocytes cell cycle
            after cytokine stimulation
  JOURNAL   PLoS One 6 (1), e14514 (2011)
   PUBMED   21267069
  REMARK    GeneRIF: down-regulation of Otud-6b expression after prolonged
            cytokine stimulation may be required for cell proliferation in B
            lymphocytes
            Publication Status: Online-Only
REFERENCE   10 (bases 1 to 3148)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA034027.1, BC029760.1, BI712470.1 and AA748163.1.
            
            On May 17, 2019 this sequence version replaced NM_016023.4.
            
            Summary: This gene encodes a member of the ovarian tumor domain
            (OTU)-containing subfamily of deubiquitinating enzymes.
            Deubiquitinating enzymes are primarily involved in removing
            ubiquitin from proteins targeted for degradation. This protein may
            function as a negative regulator of the cell cycle in B cells.
            [provided by RefSeq, Nov 2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029760.1, BX647772.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000404789.8/ ENSP00000384190.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               DA034027.1         32-306
            276-2649            BC029760.1         270-2643
            2650-2769           BI712470.1         383-502             c
            2770-3148           AA748163.1         11-389              c
FEATURES             Location/Qualifiers
     source          1..3148
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..3148
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /note="OTU deubiquitinase 6B"
                     /db_xref="GeneID:51633"
                     /db_xref="HGNC:HGNC:24281"
                     /db_xref="MIM:612021"
     exon            1..123
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     CDS             42..923
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /EC_number="3.4.19.12"
                     /note="isoform 1 is encoded by transcript variant 1; OTU
                     domain-containing protein 6B; deubiquitinase OTUD6B; OTU
                     domain containing 6B"
                     /codon_start=1
                     /product="deubiquitinase OTUD6B isoform 1"
                     /protein_id="NP_057107.4"
                     /db_xref="CCDS:CCDS6253.3"
                     /db_xref="GeneID:51633"
                     /db_xref="HGNC:HGNC:24281"
                     /db_xref="MIM:612021"
                     /translation="MEAVLTEELDEEEQLLRRHRKEKKELQAKIQGMKNAVPKNDKKR
                     RKQLTEDVAKLEKEMEQKHREELEQLKLTTKENKIDSVAVNISNLVLENQPPRISKAQ
                     KRREKKAALEKEREERIAEAEIENLTGARHMESEKLAQILAARQLEIKQIPSDGHCMY
                     KAIEDQLKEKDCALTVVALRSQTAEYMQSHVEDFLPFLTNPNTGDMYTPEEFQKYCED
                     IVNTAAWGGQLELRALSHILQTPIEIIQADSPPIIVGEEYSKKPLILVYMRHAYGLGE
                     HYNSVTRLVNIVTENCS"
     exon            124..275
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            276..356
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            357..669
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            670..731
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            732..838
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     exon            839..3148
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3134..3139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /note="hexamer: AATGAA"
     polyA_site      3148
                     /gene="OTUD6B"
                     /gene_synonym="CGI-77; DUBA-5; DUBA5; IDDFSDA"
                     /note="major polyA site"
ORIGIN      
        1 gcaggtttct tctagcgcgt gtgctggggt acctggtcgt catggaggcg gtattgaccg
       61 aagagcttga tgaggaagag cagctgctga gaaggcatcg caaagagaag aaggagttgc
      121 aagccaaaat tcagggcatg aagaatgctg ttcccaagaa tgacaagaag aggaggaagc
      181 aactcaccga agatgtggcc aagttggaaa aagaaatgga acagaaacat agagaggaac
      241 tggagcaatt gaagctgact actaaggaga ataagataga ttctgttgct gttaacattt
      301 caaacttggt gcttgagaat cagccacctc ggatatcaaa agcacaaaag agacgggaaa
      361 agaaagctgc attggaaaag gagcgagaag aacggatagc tgaagctgaa attgaaaact
      421 taacaggagc cagacatatg gaaagtgaga aacttgctca aatattggca gctagacagt
      481 tagaaattaa acagattcca tctgatggcc actgtatgta taaagccatt gaagatcaac
      541 tgaaagaaaa ggattgtgct ctgactgtgg ttgccttgag aagtcagacc gctgagtata
      601 tgcaaagcca tgtggaagac tttctgccat ttttaacaaa ccctaataca ggagatatgt
      661 atactccaga agaatttcag aagtactgtg aagatattgt aaacacagct gcatggggag
      721 gtcagcttga gctaagagct ctgtctcaca ttttacaaac accaatagag ataatacagg
      781 cagattctcc tcccattata gttggtgaag aatattcaaa aaaaccacta atacttgtat
      841 atatgagaca tgcatatggc ttaggagaac attataattc ggttacacgg ttggtaaaca
      901 tagttactga aaattgcagc taatttatac aatgttgtac aattatgttt taatacagtg
      961 tgctgaactg agtatttcta ccaagtgttg ggttgttcta aatgctactg aaaaacacaa
     1021 ctaccttata tcagttttat ggcaaagcta ctaacaggtg tttttagaaa tatgtcagag
     1081 ataaacttta accagtgtct tcttagtgga attttaaaaa tttgttaagt tcattgtaga
     1141 gaacaccatt catagaccaa gatggtcccc tattagctga tattttcatt tatgtaagat
     1201 cctggacatt ctgttttgtg ttggaacaaa ttttcaatgt ttttaattct cccttttctg
     1261 cctgttccta aaaactttca aaataaccat ttcaatgtaa tttgtcttga agaagtttac
     1321 ccaatatctt tgtcattgca ataatgtagt atggtgatgg tcaatttaat tattgcttat
     1381 aaaatgaact tgattgcagt aaccatggta tcgatgagac taatgcagtg aagctttatt
     1441 actaatatat atagccttat caaagcaagc taagaagctt gctttaataa ttaataattt
     1501 aaaaatattt atttagatgg gattcagttg tttaaagaag tgagataaat tcaaaggtaa
     1561 ataggtattc tctgtcaaat ttaaatctct aaagaattag agattagttt tttatttgtg
     1621 tataatttaa aaaagaccta ataggttact gtctttttaa tgcatttgtt attctttcgt
     1681 attttttaag catcggactg gagttagtac catcatctct tgagtctttc ataactacac
     1741 atttttatat ttccttttgt gttttctact ttgctttcct tgaaggaaca agcattttgt
     1801 ggcctttacc ttgtgcaatt ttagggagta gcagtgtaaa aggtccaaga ccacatttac
     1861 ttgaaattct tcctcttttc tgatttgtct taccagatat ttcccttctt gcctcattct
     1921 ctaggatttg aataaaacct ttgccactta ttttattagc cttattaatg tcacctttcc
     1981 ttcaactcaa atatttgaga aattttatgt tacatatatg aatgaagttg aaagctactg
     2041 tttggaagct aagacttgta tagagtagtt ttgtatatga atggttgttc tagctcagat
     2101 ttcaggttac tcacaacagt attctttcta agaggatata tacaaatgtc tctcataatt
     2161 tatgtaagga aatattatga aaatgagact tttttagttt gatgtgtgtt tcccaaacta
     2221 gagataaaac tagtaagatt tagtatcgtt tataacattt gaatttttgc tccatgagta
     2281 caactaattt ttataagtaa atattgggtt tatatgaaaa atggggtgtc agtcttttca
     2341 cacgcccagc aggtaacaat gtgggaagct ggcagggtca ttgatagcaa gtaagtactt
     2401 cctgaaggct ttccagttca aaagattaca agccattctg cctgccaaac aaattatatt
     2461 ctgaagatgc ctgttttgta acccttgatg tgaatttttt ggtgtctgaa atttacaaaa
     2521 gaatgaaatt gaaattgtaa aacactaaat gctttgggtt tattttgaag taatctgtta
     2581 ctttaaaatg tcaacattag gaagccataa aacaagatat tatgaaaccc agtattataa
     2641 atgttatcta catctaaagt attttaaaat aacttattgg cagctttatt ctttttttcc
     2701 ttacaagatt tagaatcttt ttggttatat gtctattttt caattttgtt atatttttaa
     2761 tttaagtggc caatgtggtt atgaacaaga tttgtatggt cagcttctgt tctttcctaa
     2821 aacttcagat aaatatcatt ttagctataa cctaaaaaag tgtttaaata aaatgacaga
     2881 tgttaattta aaagcagcat atgctaattt actttttcat atgatgatgg tctaatggaa
     2941 gttacatatg ctttcttttg tcctaactct gaaaagtata tgtcagagtt ctggaatatg
     3001 tctttagcca agaattttat tcacttaaat ttgtttacaa cttgtataaa gcaaaaaaga
     3061 atgtgtgtaa ctatagtgaa cgcatagttt tgcttatatt atgtgatgtt tgccaaaaaa
     3121 agaataaaaa atgaatgaat taaatcaa
//
