LOCUS       NM_207320               1723 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens OTU deubiquitinase 6A (OTUD6A), mRNA.
ACCESSION   NM_207320
VERSION     NM_207320.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Kim,H.J., Choi,Y., Lee,Y., Hwangbo,M. and Kim,J.
  TITLE     OTUD6A orchestrates complex modulation of TEAD4-mediated
            transcriptional programs
  JOURNAL   FEBS Lett 598 (9), 1045-1060 (2024)
   PUBMED   38594215
  REMARK    GeneRIF: OTUD6A orchestrates complex modulation of TEAD4-mediated
            transcriptional programs.
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Fang,Z., Han,J., Lin,L., Ye,B., Qu,X., Zhang,Y., Zhao,Y., Xu,D.,
            Lin,W., Shen,S., Min,J., Wu,G., Huang,Z. and Liang,G.
  TITLE     Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy
            by deubiquitination of STING
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (4), 167061 (2024)
   PUBMED   38342418
  REMARK    GeneRIF: Deubiquitinase OTUD6a drives cardiac inflammation and
            hypertrophy by deubiquitination of STING.
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Sun,X., Chen,S., Zhao,Y., Wu,T., Zhao,Z., Luo,W., Han,J., Fang,Z.,
            Ye,B., Cao,G., Huang,S. and Liang,G.
  TITLE     OTUD6A in tubular epithelial cells mediates angiotensin II-induced
            kidney injury by targeting STAT3
  JOURNAL   Am J Physiol Cell Physiol 326 (2), C400-C413 (2024)
   PUBMED   38105755
  REMARK    GeneRIF: OTUD6A in tubular epithelial cells mediates angiotensin
            II-induced kidney injury by targeting STAT3.
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Zhao,Y., Huang,X., Zhu,D., Wei,M., Luo,J., Yu,S., Tian,Y. and
            Zheng,X.
  TITLE     Deubiquitinase OTUD6A promotes breast cancer progression by
            increasing TopBP1 stability and rendering tumor cells resistant to
            DNA-damaging therapy
  JOURNAL   Cell Death Differ 29 (12), 2531-2544 (2022)
   PUBMED   35768646
  REMARK    GeneRIF: Deubiquitinase OTUD6A promotes breast cancer progression
            by increasing TopBP1 stability and rendering tumor cells resistant
            to DNA-damaging therapy.
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Kim,S.H. and Baek,K.H.
  TITLE     Ovarian tumor deubiquitinase 6A regulates cell proliferation via
            deubiquitination of nucleolin and caspase-7
  JOURNAL   Int J Oncol 61 (4) (2022)
   PUBMED   36082810
  REMARK    GeneRIF: Ovarian tumor deubiquitinase 6A regulates cell
            proliferation via deubiquitination of nucleolin and caspase7.
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Peng,Y., Liu,J., Wang,Z., Cui,C., Zhang,T., Zhang,S., Gao,P.,
            Hou,Z., Liu,H., Guo,J., Zhang,J., Wen,Y., Wei,W., Zhang,L., Liu,J.
            and Long,J.
  TITLE     Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis
            via deubiquitinating and stabilizing c-Myc
  JOURNAL   Cell Death Differ 29 (9), 1730-1743 (2022)
   PUBMED   35217790
  REMARK    GeneRIF: Prostate-specific oncogene OTUD6A promotes prostatic
            tumorigenesis via deubiquitinating and stabilizing c-Myc.
            Erratum:[Cell Death Differ. 2023 Jan;30(1):224-225. doi:
            10.1038/s41418-022-00978-1.. PMID: 35440730]
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Kim,H.J. and Kim,J.
  TITLE     OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase
  JOURNAL   Int J Mol Sci 22 (4), 1936 (2021)
   PUBMED   33669244
  REMARK    GeneRIF: OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Shi,L., Liu,J., Peng,Y., Zhang,J., Dai,X., Zhang,S., Wang,Y.,
            Liu,J. and Long,J.
  TITLE     Deubiquitinase OTUD6A promotes proliferation of cancer cells via
            regulating Drp1 stability and mitochondrial fission
  JOURNAL   Mol Oncol 14 (12), 3169-3183 (2020)
   PUBMED   33070427
  REMARK    GeneRIF: Deubiquitinase OTUD6A promotes proliferation of cancer
            cells via regulating Drp1 stability and mitochondrial fission.
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL158141.14 and AK098697.1.
            
            On May 17, 2019 this sequence version replaced NM_207320.2.
            
            Summary: Deubiquitinating enzymes (DUBs; see MIM 603478) are
            proteases that specifically cleave ubiquitin (MIM 191339) linkages,
            negating the action of ubiquitin ligases. DUBA2 belongs to a DUB
            subfamily characterized by an ovarian tumor (OTU) domain.[supplied
            by OMIM, May 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK098697.1, BC137355.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338352.3/ ENSP00000339389.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AL158141.14        88285-88318         c
            35-1679             AK098697.1         1-1645
            1680-1723           AL158141.14        86596-86639         c
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..1723
                     /gene="OTUD6A"
                     /gene_synonym="DUBA2; HSHIN6"
                     /note="OTU deubiquitinase 6A"
                     /db_xref="GeneID:139562"
                     /db_xref="HGNC:HGNC:32312"
                     /db_xref="MIM:300714"
     exon            1..1723
                     /gene="OTUD6A"
                     /gene_synonym="DUBA2; HSHIN6"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..935
                     /gene="OTUD6A"
                     /gene_synonym="DUBA2; HSHIN6"
                     /EC_number="3.4.19.12"
                     /note="HIN-6 protease"
                     /codon_start=1
                     /product="OTU domain-containing protein 6A"
                     /protein_id="NP_997203.1"
                     /db_xref="CCDS:CCDS14395.1"
                     /db_xref="GeneID:139562"
                     /db_xref="HGNC:HGNC:32312"
                     /db_xref="MIM:300714"
                     /translation="MDDPKSEQQRILRRHQRERQELQAQIRSLKNSVPKTDKTKRKQL
                     LQDVARMEAEMAQKHRQELEKFQDDSSIESVVEDLAKMNLENRPPRSSKAHRKRERME
                     SEERERQESIFQAEMSEHLAGFKREEEEKLAAILGARGLEMKAIPADGHCMYRAIQDQ
                     LVFSVSVEMLRCRTASYMKKHVDEFLPFFSNPETSDSFGYDDFMIYCDNIVRTTAWGG
                     QLELRALSHVLKTPIEVIQADSPTLIIGEEYVKKPIILVYLRYAYSLGEHYNSVTPLE
                     AGAAGGVLPRLL"
ORIGIN      
        1 gaggacttct ggtctgttcg gtacttgaac tgccagcaaa tttcaactcc cgcttgccat
       61 tcaacatcat ggatgatccg aagagtgaac agcagcgcat actgcgccgc caccaacgcg
      121 agaggcagga gctgcaggcc cagatccgga gcttaaaaaa ctcggtcccc aagaccgaca
      181 agacgaaaag aaagcagttg ctccaagacg tggcccgcat ggaggccgag atggctcaga
      241 agcaccggca ggagctggag aagttccaag acgacagtag cattgaatct gtcgtcgaag
      301 acctggccaa gatgaatctg gaaaaccggc ctccccgctc ctccaaagcc cacagaaaga
      361 gagaaagaat ggagtccgag gagagggagc gccaggagag catcttccag gctgagatgt
      421 cggagcacct ggccggcttc aagcgcgagg aggaggagaa gctcgccgcc atcctgggag
      481 ccaggggtct ggagatgaaa gcgatcccgg ccgacggcca ctgcatgtac cgcgccatcc
      541 aagaccagct ggtgttcagc gtgtctgtgg agatgctgcg ctgccgcacc gccagctaca
      601 tgaagaagca cgtcgacgag ttcctgccct tcttcagcaa ccccgagacc agcgactcct
      661 tcggctacga cgacttcatg atctactgcg acaacatcgt gcgcaccacg gcatggggag
      721 gccagctgga gctgagggcc ctgtcgcacg tcctgaagac ccccatcgag gtgatccagg
      781 ccgactcgcc caccttgatc atcggggagg agtacgtcaa gaagccgatc atcctggtct
      841 acctgcgcta tgcctacagc ctcggcgagc actacaactc cgtgacaccg ctcgaggccg
      901 gcgccgccgg gggcgtgctc ccgcgtctcc tgtaggcccc aaggcgctga gcagccccgg
      961 gaaactgtcg ccgtcgccgc atctcctcag taggctcagt ttattttccc cttttgcttt
     1021 tctctgtttt tcttttcctt ccttttaatc aaaactaccc gcccccgccc cgcccccgct
     1081 ttcctaacct tgctgctttc acagggtggg aaacgaaatt cgagggaaat tccccggaaa
     1141 tatgagggaa atctctgcat tgcaccacca gaggggcata aatttgaaag ttctaacctc
     1201 ttcttgccct taagggtctt ttacctccct caccaactaa gatttggtca tgttgcgtat
     1261 aacttcacca caaaaatgga aatattggcc gggcgcggtg gctcacgcct gtaatcccag
     1321 cactttggga ggccgaggcg ggcggatcac gaggtcagga gttcgagacc agcctggcca
     1381 acatggtgaa accccacctc tacaaaaaat acaaaaatta gccgggcgtg gtggcaggca
     1441 cctgtagtcc cagatactcg ggaggctaag gcaggagaat cgcttgacgg gaagcggagg
     1501 ttgcagtgag ccgagatcgt gcctttgcac tccagcgtgg aagacagtga gactccgtct
     1561 caaaaaaatg aaaaattagc caggcaggtt ggcgggggcc tgtaatccta gctacttggg
     1621 gtgctgaggc aggagaatca actgaacccg ggaggcggag gctgcagtgg gccgggatcg
     1681 tactactgca ctccagcatg gaagacagcg agactccgtc tcc
//
