LOCUS       NM_001136157            2888 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens OTU deubiquitinase 5 (OTUD5), transcript variant 2,
            mRNA.
ACCESSION   NM_001136157
VERSION     NM_001136157.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2888)
  AUTHORS   Lam,S.Y., van der Lugt,R., Cerutti,A., Yalcin,Z., Thouin,A.M.,
            Simonetta,M. and Jacobs,J.J.L.
  TITLE     OTUD5 promotes end-joining of deprotected telomeres by promoting
            ATM-dependent phosphorylation of KAP1S824
  JOURNAL   Nat Commun 15 (1), 8960 (2024)
   PUBMED   39420004
  REMARK    GeneRIF: OTUD5 promotes end-joining of deprotected telomeres by
            promoting ATM-dependent phosphorylation of KAP1[S824].
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2888)
  AUTHORS   Yang,Y., Jia,S., Zhu,N., Xiao,X., Ma,Y., Tu,K., Guo,Y. and Xu,Q.
  TITLE     OTUD5 promotes the growth of hepatocellular carcinoma by
            deubiquitinating and stabilizing SLC38A1
  JOURNAL   Biol Direct 19 (1), 31 (2024)
   PUBMED   38658981
  REMARK    GeneRIF: OTUD5 promotes the growth of hepatocellular carcinoma by
            deubiquitinating and stabilizing SLC38A1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2888)
  AUTHORS   Dai,J., Zhang,L., Zhang,R., Ge,J., Yao,F., Zhou,S., Xu,J., Yu,K.,
            Xu,J., Jiang,L., Jin,K., Dai,X., Li,J. and Li,Q.
  TITLE     Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key
            Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by
            Disturbing Mitochondrial Homeostasis
  JOURNAL   Cell Mol Gastroenterol Hepatol 17 (3), 399-421 (2024)
   PUBMED   38036082
  REMARK    GeneRIF: Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a
            Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis
            by Disturbing Mitochondrial Homeostasis.
REFERENCE   4  (bases 1 to 2888)
  AUTHORS   Chu,L.K., Cao,X., Wan,L., Diao,Q., Zhu,Y., Kan,Y., Ye,L.L.,
            Mao,Y.M., Dong,X.Q., Xiong,Q.W., Fu,M.C., Zhang,T., Zhou,H.T.,
            Cai,S.Z., Ma,Z.R., Hsu,S.W., Wu,R., Chen,C.H., Yan,X.M. and Liu,J.
  TITLE     Autophagy of OTUD5 destabilizes GPX4 to confer
            ferroptosis-dependent kidney injury
  JOURNAL   Nat Commun 14 (1), 8393 (2023)
   PUBMED   38110369
  REMARK    GeneRIF: Autophagy of OTUD5 destabilizes GPX4 to confer
            ferroptosis-dependent kidney injury.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2888)
  AUTHORS   Fu,L., Lu,K., Jiao,Q., Chen,X. and Jia,F.
  TITLE     The Regulation and Double-Edged Roles of the Deubiquitinase OTUD5
  JOURNAL   Cells 12 (8), 1161 (2023)
   PUBMED   37190070
  REMARK    GeneRIF: The Regulation and Double-Edged Roles of the
            Deubiquitinase OTUD5.
            Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2888)
  AUTHORS   Luo,J., Lu,Z., Lu,X., Chen,L., Cao,J., Zhang,S., Ling,Y. and
            Zhou,X.
  TITLE     OTUD5 regulates p53 stability by deubiquitinating p53
  JOURNAL   PLoS One 8 (10), e77682 (2013)
   PUBMED   24143256
  REMARK    GeneRIF: OTUD5 is required for the stabilization and the activation
            of a p53 response
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2888)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   8  (bases 1 to 2888)
  AUTHORS   Huang,O.W., Ma,X., Yin,J., Flinders,J., Maurer,T., Kayagaki,N.,
            Phung,Q., Bosanac,I., Arnott,D., Dixit,V.M., Hymowitz,S.G.,
            Starovasnik,M.A. and Cochran,A.G.
  TITLE     Phosphorylation-dependent activity of the deubiquitinase DUBA
  JOURNAL   Nat Struct Mol Biol 19 (2), 171-175 (2012)
   PUBMED   22245969
  REMARK    GeneRIF: Here the authors show that phosphorylation of the human
            deubiquitinase DUBA (OTUD5) at a single residue, Ser177, is both
            necessary and sufficient to activate the enzyme.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2888)
  AUTHORS   Kayagaki,N., Phung,Q., Chan,S., Chaudhari,R., Quan,C.,
            O'Rourke,K.M., Eby,M., Pietras,E., Cheng,G., Bazan,J.F., Zhang,Z.,
            Arnott,D. and Dixit,V.M.
  TITLE     DUBA: a deubiquitinase that regulates type I interferon production
  JOURNAL   Science 318 (5856), 1628-1632 (2007)
   PUBMED   17991829
  REMARK    GeneRIF: data identify DUBA as a negative regulator of innate
            immune responses
REFERENCE   10 (bases 1 to 2888)
  AUTHORS   Makarova,K.S., Aravind,L. and Koonin,E.V.
  TITLE     A novel superfamily of predicted cysteine proteases from
            eukaryotes, viruses and Chlamydia pneumoniae
  JOURNAL   Trends Biochem Sci 25 (2), 50-52 (2000)
   PUBMED   10664582
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC009917.2, BC028225.1,
            AL137509.1 and CB243128.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001136157.1.
            
            Summary: This gene encodes a member of the OTU (ovarian tumor)
            domain-containing cysteine protease superfamily. The OTU domain
            confers deubiquitinase activity and the encoded protein has been
            shown to suppress the type I interferon-dependent innate immune
            response by cleaving the polyubiquitin chain from an essential type
            I interferon adaptor protein. Cleavage results in disassociation of
            the adaptor protein from a downstream signaling complex and
            disruption of the type I interferon signaling cascade.
            Alternatively spliced transcript variants encoding different
            isoforms have been described. [provided by RefSeq, Oct 2008].
            
            Transcript Variant: This variant (2) lacks an in-frame portion of
            an internal coding exon, compared to variant 1, resulting in a
            shorter protein (isoform b) compared to isoform a. Variants 2 and 3
            encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL137509.1, AK026260.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376488.8/ ENSP00000365671.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                BC009917.2         25-48
            25-454              BC028225.1         1-430
            455-2700            AL137509.1         1-2246
            2701-2888           CB243128.1         15-202              c
FEATURES             Location/Qualifiers
     source          1..2888
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.23"
     gene            1..2888
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /note="OTU deubiquitinase 5"
                     /db_xref="GeneID:55593"
                     /db_xref="HGNC:HGNC:25402"
                     /db_xref="MIM:300713"
     exon            1..631
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..1738
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /EC_number="3.4.19.12"
                     /note="isoform b is encoded by transcript variant 2;
                     deubiquinating enzyme A; OTU domain-containing protein 5;
                     deubiquitinating enzyme A; OTU domain containing 5;
                     deubiquitinase A"
                     /codon_start=1
                     /product="OTU domain-containing protein 5 isoform b"
                     /protein_id="NP_001129629.1"
                     /db_xref="CCDS:CCDS48104.1"
                     /db_xref="GeneID:55593"
                     /db_xref="HGNC:HGNC:25402"
                     /db_xref="MIM:300713"
                     /translation="MTILPKKKPPPPDADPANEPPPPGPMPPAPRRGGGVGVGGGGTG
                     VGGGDRDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPP
                     CGGPGGPGGGPGDALGAAAAGVGAAGVVVGVGGAVGVGGCCSGPGHSKRRRQAPGVGA
                     VGGGSPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQM
                     KEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKN
                     NCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVV
                     NPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEA
                     IEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQ
                     RSSASSPEHPELHAELGMKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSL
                     YPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHRDPPPDKS
                     "
     exon            632..725
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            726..790
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            791..947
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1096
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1300
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1502
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1616
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..2888
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2253..2258
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /note="hexamer: ATTAAA"
     polyA_site      2278
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
     regulatory      2680..2685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /note="hexamer: AATAAA"
     polyA_site      2706
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /note="major polyA site"
     regulatory      2853..2858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
                     /note="hexamer: ATTAAA"
     polyA_site      2888
                     /gene="OTUD5"
                     /gene_synonym="DUBA; MCAND"
ORIGIN      
        1 gcgccgggtt tgttgggggg tactcggcag tgcagccatg actatactcc ccaaaaagaa
       61 gccgccgcct cccgacgccg accccgccaa cgagccgccg ccgcccgggc cgatgccccc
      121 ggcgccgcgg cgcggcggag gtgtgggcgt gggcggcggc ggcacgggcg tgggcggcgg
      181 cgatcgcgac cgtgactccg gcgtcgtggg ggcccgtccg cgagcttcgc caccgcctca
      241 aggcccgcta ccaggaccgc cgggcgctct tcatcgctgg gcgctggccg tgccgcctgg
      301 tgcagtggcg ggtccccggc cacaacaggc ttctccacct ccttgcgggg gcccaggtgg
      361 tcccggcggc ggtcccggcg acgcgctggg cgcagcggcg gcgggtgtgg gtgccgcggg
      421 cgtggtggtg ggtgtgggtg gtgccgtagg cgtgggcggc tgctgctccg ggcctgggca
      481 cagcaagcgg cgacgtcaag ctcccggggt tggcgcggtt ggcgggggca gtcccgagcg
      541 tgaggaggtc ggcgcaggct acaacagtga ggacgagtat gaggcggctg cagcacgcat
      601 cgaggctatg gaccctgcca ctgtcgagca gcaggagcat tggtttgaaa aggccctacg
      661 agacaagaag ggcttcatca tcaagcagat gaaggaggat ggcgcctgtc tcttccgggc
      721 tgtagctgac caggtgtatg gagaccagga catgcatgag gttgtgcgaa agcattgcat
      781 ggactatctg atgaagaatg ccgactactt ctccaactat gtcacagagg actttaccac
      841 ctacattaac aggaagcgga aaaacaattg ccatggcaac cacattgaga tgcaggccat
      901 ggcagagatg tacaaccgtc ctgtggaggt gtaccagtac agcacagaac ccatcaacac
      961 attccatggg atacatcaaa acgaggacga acccattcgt gttagctacc atcggaatat
     1021 ccactataat tcagtggtga atcctaacaa ggccaccatt ggtgtggggc tgggcctgcc
     1081 atcattcaaa ccagggtttg cagagcagtc tctgatgaag aatgccataa aaacatcgga
     1141 ggagtcatgg attgaacagc agatgctaga agacaagaaa cgggccacag actgggaggc
     1201 cacaaatgaa gccatcgagg agcaggtggc tcgggaatcc tacctgcagt ggttgcggga
     1261 tcaggagaaa caggctcgcc aggtccgagg ccccagccag ccccggaaag ccagcgccac
     1321 atgcagttcg gccacagcag cagcctccag tggcctggag gagtggacta gccggtcccc
     1381 gcggcagcgg agttcagcct cgtcacctga gcaccctgag ctgcatgctg aattgggcat
     1441 gaagccccct tccccaggca ctgttttagc tcttgccaaa cctccttcgc cctgtgcgcc
     1501 aggtacaagc agtcagttct cggcaggggc cgaccgggca acttcccccc ttgtgtccct
     1561 ctaccctgct ttggagtgcc gggccctcat tcagcagatg tccccctctg cctttggtct
     1621 gaatgactgg gatgatgatg agatcctagc ttcggtgctg gcagtgtccc aacaggaata
     1681 cctagacagt atgaagaaaa acaaagtgca cagagacccg cccccagaca agagttgatg
     1741 gagacccagg gattggacac catctcccaa ccccagtact cctgctctcc ggtgccacct
     1801 caccttcttt ggcttcttcc ctcttgcctc cttctgttct ttctgctctc ccctcttttc
     1861 cctcctcctc acttccctct ggctagccca cccctgcact ctctctcatt gccgctgcca
     1921 ctatcacctg tctctctgcc agctgatgtg ccctgttgcc ccccacccca tcccgcacag
     1981 aaccatccct gcattccaca ggggactcgg gcaagggtgc cgaagataga caagaggcac
     2041 acagagacag accaactggc agccaggcag ccccagagga gagagacatt cagacagagg
     2101 aaagtctccc tgcccctcat tccttccaag atgagaaaaa cttgccgcca ccccccgaca
     2161 ctgatgccag ggaggtggga ggaagaagtg ggaaatttcc cttcccagta cccccaagaa
     2221 cgtctgagcc ttcaatgttg aattttttct ttattaaaat tacttttatc ttataaaatc
     2281 aactaatcaa aaatgatata gacgacagca ctggctctgt gaaggtggca tctttctggg
     2341 caggcaggcc atggggcatg gaggagggtg caaagatatg ggttgctgtc ttctggcctc
     2401 cagctgcatg gaggccggcc cagggtctag ggtgtgcact gggcaagggc agggcggcag
     2461 gtgtcaggcc ggcttggaca atgaaaccct gaccttgctg cattcctttt gcttccacca
     2521 ccactagctt ctttggaatc ttggggtggg ggtcatcttt ggggattatg gctgccaccc
     2581 gggatttgag tgtagggagt gtgggagcag ccttggcaga tggggcaccc gtgccctgca
     2641 ggtgttgaca agatccgcca tctgtaatgt ccttggcaca ataaaaccaa atgtcagttt
     2701 ccctgagcga ctctgttctg tgtggggcag gggttgggcg ggcctctggg cagaggatgc
     2761 aatggcacgg accttggctt gacctcagag gtgtgaatgc tctccagcag ggtctgtctg
     2821 ggggcctgga gtttgtattt gatttgctgc ttattaaacc tccttctgga cctattgcca
     2881 ctggaaaa
//
