LOCUS       NM_001366057            7741 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens OTU deubiquitinase 4 (OTUD4), transcript variant 4,
            mRNA.
ACCESSION   NM_001366057 XM_005263079
VERSION     NM_001366057.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7741)
  AUTHORS   Li,Z., Tian,Y., Zong,H., Wang,X., Li,D., Keranmu,A., Xin,S., Ye,B.,
            Bai,R., Chen,W., Yang,G., Ye,L. and Wang,S.
  TITLE     Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3
            transcription: a novel mechanism underlying the restrained
            malignant properties of ccRCC cells
  JOURNAL   Apoptosis 29 (7-8), 1051-1069 (2024)
   PUBMED   38553613
  REMARK    GeneRIF: Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce
            ATF3 transcription: a novel mechanism underlying the restrained
            malignant properties of ccRCC cells.
REFERENCE   2  (bases 1 to 7741)
  AUTHORS   Hu,S., Yuan,Y., Yan,R., Xie,H., Cai,R. and Xu,J.
  TITLE     NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
  JOURNAL   Biochem Biophys Res Commun 708, 149798 (2024)
   PUBMED   38518721
  REMARK    GeneRIF: NRF2 regulates EGF stability through OTUD4 in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 7741)
  AUTHORS   Ci,M., Zhao,G., Li,C., Liu,R., Hu,X., Pan,J., Shen,Y., Zhang,G.,
            Li,Y., Zhang,L., Liang,P. and Cui,H.
  TITLE     OTUD4 promotes the progression of glioblastoma by deubiquitinating
            CDK1 and activating MAPK signaling pathway
  JOURNAL   Cell Death Dis 15 (3), 179 (2024)
   PUBMED   38429268
  REMARK    GeneRIF: OTUD4 promotes the progression of glioblastoma by
            deubiquitinating CDK1 and activating MAPK signaling pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7741)
  AUTHORS   Ma,X., Wan,R., Wen,Y., Liu,T., Song,Y. and Zhu,Y.
  TITLE     Deubiquitinating enzyme OTUD4 regulates metastasis in
            triple-negative breast cancer by stabilizing Snail1
  JOURNAL   Exp Cell Res 434 (1), 113864 (2024)
   PUBMED   38040050
  REMARK    GeneRIF: Deubiquitinating enzyme OTUD4 regulates metastasis in
            triple-negative breast cancer by stabilizing Snail1.
REFERENCE   5  (bases 1 to 7741)
  AUTHORS   Gao,Y., Tang,J., Ma,X., Zhang,C., Huang,L., Che,J., Wen,Y.,
            Zhang,Y., Zhu,Y., Liu,T. and Zhang,H.
  TITLE     OTUD4 regulates metastasis and chemoresistance in melanoma by
            stabilizing Snail1
  JOURNAL   J Cell Physiol 238 (11), 2546-2555 (2023)
   PUBMED   37642406
  REMARK    GeneRIF: OTUD4 regulates metastasis and chemoresistance in melanoma
            by stabilizing Snail1.
REFERENCE   6  (bases 1 to 7741)
  AUTHORS   Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and
            Mosammaparast,N.
  TITLE     Noncanonical regulation of alkylation damage resistance by the
            OTUD4 deubiquitinase
  JOURNAL   EMBO J 34 (12), 1687-1703 (2015)
   PUBMED   25944111
  REMARK    GeneRIF: OTUD4 is a positive regulator of ALKBH2 and ALKBH3, two
            DNA demethylases critical for alkylation repair.
REFERENCE   7  (bases 1 to 7741)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   8  (bases 1 to 7741)
  AUTHORS   Margolin,D.H., Kousi,M., Chan,Y.M., Lim,E.T., Schmahmann,J.D.,
            Hadjivassiliou,M., Hall,J.E., Adam,I., Dwyer,A., Plummer,L.,
            Aldrin,S.V., O'Rourke,J., Kirby,A., Lage,K., Milunsky,A.,
            Milunsky,J.M., Chan,J., Hedley-Whyte,E.T., Daly,M.J., Katsanis,N.
            and Seminara,S.B.
  TITLE     Ataxia, dementia, and hypogonadotropism caused by disordered
            ubiquitination
  JOURNAL   N Engl J Med 368 (21), 1992-2003 (2013)
   PUBMED   23656588
  REMARK    GeneRIF: The syndrome of hypogonadotropic hypogonadism, ataxia, and
            dementia can be caused by inactivating mutations in RNF216 or by
            the combination of mutations in RNF216 and OTUD4
REFERENCE   9  (bases 1 to 7741)
  AUTHORS   Li,S., Zheng,H., Mao,A.P., Zhong,B., Li,Y., Liu,Y., Gao,Y., Ran,Y.,
            Tien,P. and Shu,H.B.
  TITLE     Regulation of virus-triggered signaling by OTUB1- and
            OTUB2-mediated deubiquitination of TRAF3 and TRAF6
  JOURNAL   J Biol Chem 285 (7), 4291-4297 (2010)
   PUBMED   19996094
REFERENCE   10 (bases 1 to 7741)
  AUTHORS   Raineri,I. and Senn,H.P.
  TITLE     HIV-1 promotor insertion revealed by selective detection of
            chimeric provirus-host gene transcripts
  JOURNAL   Nucleic Acids Res 20 (23), 6261-6266 (1992)
   PUBMED   1475186
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096757.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 21, 2018 this sequence version replaced XM_005263079.4.
            
            Summary: Alternatively spliced transcript variants have been found
            for this gene. The smaller protein isoform encoded by the shorter
            transcript variant is found only in HIV-1 infected cells. [provided
            by RefSeq, Jul 2010].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.220827.1,
                                           SRR1803615.28899.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447906.8/ ENSP00000395487.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-775               AC096757.3         146791-147565       c
            776-859             AC096757.3         141637-141720       c
            860-910             AC096757.3         138646-138696       c
            911-957             AC096757.3         132127-132173       c
            958-1030            AC096757.3         131130-131202       c
            1031-1112           AC096757.3         129616-129697       c
            1113-1245           AC096757.3         126479-126611       c
            1246-1306           AC096757.3         122912-122972       c
            1307-1424           AC096757.3         122545-122662       c
            1425-1489           AC096757.3         122387-122451       c
            1490-1584           AC096757.3         119517-119611       c
            1585-1688           AC096757.3         117778-117881       c
            1689-1875           AC096757.3         117489-117675       c
            1876-2038           AC096757.3         113243-113405       c
            2039-2162           AC096757.3         111287-111410       c
            2163-2218           AC096757.3         110922-110977       c
            2219-2299           AC096757.3         110341-110421       c
            2300-2438           AC096757.3         109172-109310       c
            2439-2699           AC096757.3         108355-108615       c
            2700-2740           AC096757.3         106927-106967       c
            2741-7741           AC096757.3         100626-105626       c
FEATURES             Location/Qualifiers
     source          1..7741
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..7741
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /note="OTU deubiquitinase 4"
                     /db_xref="GeneID:54726"
                     /db_xref="HGNC:HGNC:24949"
                     /db_xref="MIM:611744"
     exon            1..775
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     CDS             617..3961
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /EC_number="3.4.19.12"
                     /note="isoform 4 is encoded by transcript variant 4; OTU
                     domain-containing protein 4; HIV-1 induced protein HIN-1"
                     /codon_start=1
                     /product="OTU domain-containing protein 4 isoform 4"
                     /protein_id="NP_001352986.1"
                     /db_xref="CCDS:CCDS93644.1"
                     /db_xref="GeneID:54726"
                     /db_xref="HGNC:HGNC:24949"
                     /db_xref="MIM:611744"
                     /translation="MEAAVGVPDGGDQGGAGPREDATPMDAYLRKLGLYRKLVAKDGS
                     CLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVG
                     QVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKES
                     SAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVADEDNSEISDSEDDSCKSKTAAAAA
                     DVNGFKPLSGNEQLKNNGNSTSLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDY
                     SIAAGLQYEVGDKCQVRLDHNGKFLNADVQGIHSENGPVLVEELGKKHTSKNLKAPPP
                     ESWNTVSGKKMKKPSTSGQNFHSDVDYRGPKNPSKPIKAPSALPPRLQHPSGVRQHAF
                     SSHSSGSQSQKFSSEHKNLSRTPSQIIRKPDRERVEDFDHTSRESNYFGLSPEERREK
                     QAIEESRLLYEIQNRDEQAFPALSSSSVNQSASQSSNPCVQRKSSHVGDRKGSRRRMD
                     TEERKDKDSIHGHSQLDKRPEPSTLENITDDKYATVSSPSKSKKLECPSPAEQKPAEH
                     VSLSNPAPLLVSPEVHLTPAVPSLPATVPAWPSEPTTFGPTGVPAPIPVLSVTQTLTT
                     GPDSAVSQAHLTPSPVPVSIQAVNQPLMPLPQTLSLYQDPLYPGFPCNEKGDRAIVPP
                     YSLCQTGEDLPKDKNILRFFFNLGVKAYSCPMWAPHSYLYPLHQAYLAACRMYPKVPV
                     PVYPHNPWFQEAPAAQNESDCTCTDAHFPMQTEASVNGQMPQPEIGPPTFSSPLVIPP
                     SQVSESHGQLSYQADLESETPGQLLHADYEESLSGKNMFPQPSFGPNPFLGPVPIAPP
                     FFPHVWYGYPFQGFIENPVMRQNIVLPSDEKGELDLSLENLDLSKDCGSVSTVDEFPE
                     ARGEHVHSLPEASVSSKPDEGRTEQSSQTRKADTALASIPPVAEGKAHPPTQILNRER
                     ETVPVELEPKRTIQSLKEKTEKVKDPKTAADVVSPGANSVDSRVQRPKEESSEDENEV
                     SNILRSGRSKQFYNQTYGSRKYKSDWGYSGRGGYQHVRSEESWKGQPSRSRDEGYQYH
                     RNVRGRPFRGDRRRSGMGDGHRGQHT"
     exon            776..859
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            860..910
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..957
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1030
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1112
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1245
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1306
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1424
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1489
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1490..1584
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1585..1688
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1875
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..2038
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2162
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2163..2218
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2299
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2438
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2699
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2700..2740
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..7741
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7723..7728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /note="hexamer: ATTAAA"
     polyA_site      7741
                     /gene="OTUD4"
                     /gene_synonym="DUBA6; HIN1; HSHIN1"
                     /note="major polyA site"
ORIGIN      
        1 gccgtcctct ccgctgtcgg gccgaaagcg aaaacaaatt ctgggctgcg aggtgctgtt
       61 ctctcccggg cgcccccacc cgctccctgc ccctccggcg ccctccagcg aggtggggaa
      121 acgaaaggcc gcgtctttct ttttggtttc ctcggctccc ggcgtgggga gtgcgcgggg
      181 gcgcaggccc cgcttcacct gagccggccc agcgtgcgcg ccaggggcgg gggttttctc
      241 gcttcacacc ggtacggagg aggaaacttg tgggggcggc gacccccggc ctgggtcctg
      301 agtcaggcag cgaggccgtc gggaagtgac tactcactct cggggttttc cttaatcccg
      361 ctccccccgt ttgtcgtggg cgcgtgttcg ctccgaggag gcggccgcgt gcggacagcc
      421 atgcattagg cagggcttcc ctatgcgccc ggagagcgcg gaccgctgcc tcgggccgcc
      481 gccgcctgcc gccgctcgcg gagcccgagc cccagcccga gccgccgcct gccccaggcc
      541 ggggcgtcga gcagccggcg gcctggccat gtggggctag ccctcgccgc gcctggcctg
      601 cagcaggacc agcaacatgg aggctgccgt cggcgtcccc gacggcgggg accagggcgg
      661 cgcggggccc cgcgaggacg cgacgcccat ggacgcctat ctgcggaaac tgggcttgta
      721 tcggaaactg gtcgccaagg acgggtcgtg cctgttccgg gccgtggcgg agcaggtatt
      781 gcactctcag tctcgccatg ttgaagtcag aatggcctgt attcactatc ttcgagagaa
      841 cagagagaaa tttgaagcgt ttatagaagg atcatttgaa gaatatttaa agcgtttgga
      901 aaatccacag gaatgggtag gacaagtgga aataagtgcc ctttctctta tgtacaggaa
      961 agattttata atttatcggg aaccaaatgt ttctccttca caagtaacag aaaataattt
     1021 tcctgaaaag gtgttactgt gtttttcaaa tggaaatcat tatgatattg tgtatcccat
     1081 aaagtataaa gaaagctctg ctatgtgtca gtctctcctt tatgaattgc tgtatgagaa
     1141 ggtatttaaa actgatgtta gtaaaattgt gatggaacta gacacgttgg aagtagctga
     1201 tgaagataac agtgaaatat cagattcaga ggatgacagt tgcaagagta agactgctgc
     1261 tgctgctgct gatgtgaatg gatttaaacc tttgtcaggc aatgagcagc tgaagaacaa
     1321 tgggaactct actagcctgc ctttgtctag aaaggttctt aagtcactca atcctgcagt
     1381 ctatagaaat gtggaatatg aaatttggct gaagtctaaa caagctcagc aaaaacgtga
     1441 ttattccatt gctgctggct tacaatatga agttggagac aaatgtcaag ttaggttgga
     1501 tcacaatgga aaatttttga atgcagatgt tcaaggaatt cattctgaga atggaccagt
     1561 tttggttgaa gaactgggaa agaagcacac atcaaagaac ctcaaggcac ctcccccaga
     1621 aagctggaac acagtgtcag ggaagaagat gaaaaaacct tccacttctg gacaaaattt
     1681 ccattctgat gtggattaca gagggccaaa gaatccaagc aagccaataa aagccccatc
     1741 agcactacct cctcgactgc agcatccttc aggagtaaga caacatgcgt tctctagtca
     1801 ttcttcaggg tcacagtctc agaaattctc cagtgagcac aaaaatctta gccggacacc
     1861 ttcacagatc ataagaaaac ctgatcgtga aagagttgag gattttgatc acacaagtcg
     1921 agaatctaac tatttcggcc tttccccaga agagcgcaga gagaagcaag ctatagaaga
     1981 atcccgttta ctctatgaga ttcagaacag agatgaacag gctttcccag ccctttccag
     2041 ctcatcagtc aatcagtcag cttctcagag tagcaatcca tgtgtccaga gaaaatcatc
     2101 acatgtaggt gatagaaaag gaagcaggcg gagaatggat acagaagaac gaaaagacaa
     2161 agactctatt catggacata gtcagttgga taaaagaccc gaaccaagca cattggagaa
     2221 tattactgat gataaatatg caacagtttc atcaccatca aagtcaaaga agttagagtg
     2281 cccttctcct gcggaacaaa agccagcaga acatgtgtct ttgtcaaatc cagctcccct
     2341 tctagtttct ccagaggtac atctaactcc tgcggtgcct tctttaccag ccactgtgcc
     2401 agcctggcca agtgaaccta caacttttgg accaacaggt gtccctgctc caattcccgt
     2461 tttgtcagtg acacagactt tgaccactgg acctgattca gctgtatccc aagctcattt
     2521 aacaccctct ccagttcctg tgtcaataca ggcagttaac cagcccttga tgcctttgcc
     2581 tcagacattg agcctttatc aagacccact ctatcctggg tttccttgta atgaaaaggg
     2641 agatcgagcc attgtaccac cttattcact gtgtcagact ggggaggacc tacctaaaga
     2701 taagaatatt cttcgattct tcttcaatct tggtgtgaag gcatacagtt gtcctatgtg
     2761 ggccccacat tcttacctgt accctctgca ccaggcctac ctggcagcct gcaggatgta
     2821 cccaaaggtc cctgtccctg tttatcctca taatccctgg ttccaagagg ctcctgctgc
     2881 tcagaatgaa agtgattgta cctgtactga tgcccacttt cctatgcaga ctgaggccag
     2941 tgttaatggt caaatgccac agccagagat tggaccgccg acattttctt cacctctggt
     3001 tatccctcca tctcaggtgt ctgaaagtca tggacaattg tcttaccagg ctgatcttga
     3061 atctgagacc cctgggcagc ttctgcatgc tgattatgaa gagtcactaa gtggcaagaa
     3121 tatgttcccc cagccatctt ttggacccaa tccattctta ggcccagttc ctattgcacc
     3181 tcctttcttt cctcatgttt ggtatgggta cccttttcag ggattcatag aaaatccagt
     3241 aatgaggcag aatattgtcc tgccctctga tgaaaaagga gaattggatc tgtctctgga
     3301 aaatctggat ctgtctaaag attgtggttc agtttcaaca gtagatgagt ttccagaagc
     3361 caggggtgaa catgtacatt ctctccctga agcaagtgtg agcagtaagc cggacgaagg
     3421 ccggacagag caatcttccc agacacgaaa ggcagatacg gcattggctt ccatccctcc
     3481 tgtagcagag ggaaaggctc atcctcccac tcagattcta aacagagaga gagaaactgt
     3541 gcctgttgaa cttgaaccta aaaggaccat tcaaagcctg aaagaaaaaa cagaaaaagt
     3601 aaaagatcct aagactgctg ctgatgtggt cagccctggg gccaactctg ttgatagcag
     3661 agtgcaaaga ccaaaagaag agagttcaga agatgaaaat gaagtgtcta atattttgag
     3721 aagtggtaga tccaagcagt tctataatca aacttatgga agcaggaagt acaaaagtga
     3781 ttggggctat tctggtaggg gtggatatca acatgtgaga agtgaggagt cctggaaagg
     3841 acagccaagc agaagtcggg atgaaggtta tcagtaccat cgaaatgtca gagggcgacc
     3901 atttagggga gataggagga gatcagggat gggagatggc cataggggac agcacacttg
     3961 atggttgttg ccgaagtatt ttctaacaga aactcttagg tggaatgttt ctgaaggctt
     4021 taaaaaaaat acaataaagt aaaaaccgca gttggaactc tttcctctcc ccagcccccc
     4081 ttaccttcac tcccatactg gacaagacat tttggacatg agttcaaggg ggcaggttaa
     4141 ttcctggcat tgccagtttt cttcattcag aatctgtttg ttgatcaagt gactgtcccc
     4201 gtaaaaagta gaagataagt ttgttaaagt attttttata aacagcttaa tataaaacat
     4261 tatagattta gtgtttggct tttttcctta taagtttata agtttgattt cagatgttgg
     4321 aaatgtgtgc tttatagtgt ttactaaagt gacaagaaaa tataccattt gacacactat
     4381 agattccaaa cataacgttg caccaaatag aaatgtatat tttattatgc aatgccttag
     4441 tcataaactg ggctcaaaca attctcagcc taaaacactg ttgtctttta aaatgcttcc
     4501 aacccaaagg cctttcatct caatatctgt caaacttgaa taatgtcttc tctttaatat
     4561 tcacataagg cagcctatta actgtgtctt agcaatgttg tatatagttc ttttaatatt
     4621 cataaggtat atttttgaat tttggtattt gttgagattg catagaagaa tagtaggaaa
     4681 tccaatgaaa tggctgtttc caccaagaat tcttagcact ggtgtaaata tcatggtgcc
     4741 tactcgaaag aaatgtagat gctatgcatt ttgaaaataa tctgcatcag ttagaactgc
     4801 agaagttttt ttaatgccac tttaacacta atgcactgac agattctaaa tattttgtga
     4861 gaagaaatgt taaaaatttt tagcttgaca ggtttctaga gttgttttct tcctcccccc
     4921 cccccccgca ccattggttg tgtatcactt tcactttaca cttgcatgtt ctacttgtca
     4981 gggctggaac tattgtatag aagataatat gattgtgact tctagttctt ttctagagga
     5041 tgctgctaga aaatggtttt gctttgtatt ttatagcttg ttacccttag gtaggtaaca
     5101 tcttacattc tgttttcttc cagtctttgc agtattcact agaggttccc tttgcatgtt
     5161 gcactctgtt ctcatttgga gattgaactc tgaattaaca cagtattcat tcatctgtgt
     5221 tattttgtaa aaataactgt agcttatatt ctttatttgt gcataccaat gtgaaaatcc
     5281 actcttttat tatgttgaga ttatcttctg atcaggaagt ttgagtgcta tgcaaataac
     5341 atagtagtaa tttctctttg catgccatgt gtaatatacc tagccaaaac cagatgcggt
     5401 gactttcttt ttttgtaaag caaattactt aagaaaatac aattcacttg aatttgacaa
     5461 actgaaacag atgggttttc tgggttctct gataacctat gggaatgttt ggatgccagt
     5521 tgggctagtg aatcgccact gtactgtaat aatggttatt tacctctgtg ctgttttaat
     5581 tacctaacgt ctgtgtaact gctgatttga gtagtgatta gcatttagat aatgtaacag
     5641 gattttagag agcactttga aagataacat tttattatga tggtgctagg taaaaaattg
     5701 taaagactgg gatggttgtg tggaaaactt ttcttgagag aacctattga aaggaatttg
     5761 ttgtcacctt cttaactaga atagttgttg aaggtaccgc ttaagccatt tttttcttaa
     5821 catcggtggc tcagttaagg aatgagaaga tagagggtcc tccactttca gctcatgctt
     5881 ttttatgtag gactagctta cctgatttta atgaaaatca cattttgata caaacaccag
     5941 atttgaaagt tcaatgtgtt tgatctcagg agtccaaaat aagttgttgc ttctagtgtc
     6001 ctgcatttta ttgactgggg tttgatctca gcttctgaaa atgtttaaaa attggaagga
     6061 aatactactc atatcttcat tgtcactttg tcttacctca attgagtaac agaatatagc
     6121 tcctgaagga aacactgatt tgctttctgt ttcccatatc tcacctctag gatatgatgg
     6181 aagaagtgct tgaaagagaa ttttagcaga tggtactttt ctcagtgacc tctggaataa
     6241 aagaactgac ttttgatagt tttaaaatta atctttgcat gaaggttggt ttcgcttttt
     6301 ttcctttaag tttgttttta aatgtattag tccaggggat tttgccttat gctgaggtca
     6361 aactaaggat aagcaagctt ttgtccttca ttttaactgt tatgtcatac tgttatgttg
     6421 acatatttct ttataagaga atagaggcaa aagtatagaa ctgaggatca tttgtatttt
     6481 tgagttggaa attatgaaac ttcaccatat tatgatcata catattttga agaacagact
     6541 gaccaaagct cacctgtttt ttgtgttagg tgctttggct gaacttgatt ccagccccct
     6601 tttccctttg gtgttgtgta tgtctcttca tttcctctca aatcttcaac tcttgcccca
     6661 tgtctccttg gcagcaggat gctggcatct gtgtagtcct catactgttt actgataacc
     6721 cacaaattca ttttcatggc agacctaagc tcagaccctg ccttgtcctg gcaagcatag
     6781 gttttcccag accacaatgc tgatatatct tatttaatgc agactgtatt cttgcagcgt
     6841 gttgtttcct ttgtgactca aggttgaatt aaaatgcctg tgaactgcaa acttgcttat
     6901 gattgacttg gtgcaataaa gttcctttct aaccatttct ggtttagaaa acattcagcc
     6961 atcctagaaa ctagcaatat ttatttttgc ctctttcgtt ttaccttcat ttttagatga
     7021 ggtaaatgtt ttgtctttta cttaagggta ctaagcaagg tccactctag tgtagctgaa
     7081 gagaatgcat atttggctac actatttctg tttactgtat tttgcttcct actttatgtc
     7141 taaatgctat tgtttgttta aaatcctaat aatgtctcat ttccaatatg ttattttcag
     7201 ataactaagg ttttgctact aatgtcagcc atttactctc ccactaattg ggattatttt
     7261 ttaaaagagg tctttctccc cgaaatacaa gttttagaaa atcttagaag aggggtgggt
     7321 gcatgtctta atgctgggaa gcggcaactt tggggttgaa cttacttgaa tggattaaaa
     7381 attgcattgt gttacagagc tagaaaattt tatgtatgaa aaacgataat agccttacac
     7441 tgagtacaaa taatacttta agagcatgtg aagatgtgat catttgtgat gttacttgta
     7501 aaaaaaagta tatatacata tcttttgaag tgttaaaagg aaactagtac tttatattct
     7561 ttatcatatc actttttgta agtgttgaat atattcctgt ttatttttct atgttctgtt
     7621 ttgtagcctt aagaagtgtt tcaaacatat ctgaatgtat aaaataagag taaatgccct
     7681 acatggtgtg atgctgcatt atatataaaa ctgtgtgcat atattaaatt ttgtctcttg
     7741 a
//
