LOCUS       NM_015207               6515 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens OTU deubiquitinase 3 (OTUD3), mRNA.
ACCESSION   NM_015207 XM_375697 XM_939048
VERSION     NM_015207.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6515)
  AUTHORS   Li,J., Yang,D., Lin,Y., Xu,W., Zhao,S.M. and Wang,C.
  TITLE     OTUD3 suppresses the mTORC1 signaling by deubiquitinating KPTN
  JOURNAL   Front Pharmacol 14, 1337732 (2024)
   PUBMED   38288086
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6515)
  AUTHORS   Liu,J.P., Yang,A.P., Lei,G., Yu,M., Peng,Y. and Le,A.P.
  TITLE     Prevalence and clinical characteristics of T2DM patients with OTUD3
            gene rs78466831 SNP at a single academic center in China
  JOURNAL   Front Endocrinol (Lausanne) 13, 1059641 (2022)
   PUBMED   36531510
  REMARK    GeneRIF: Prevalence and clinical characteristics of T2DM patients
            with OTUD3 gene rs78466831 SNP at a single academic center in
            China.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6515)
  AUTHORS   Zhao,L., Liu,X., Ren,C., Zhang,H. and Gao,L.
  TITLE     Silencing of LncRNA SNHG6 protects trophoblast cells through
            regulating miR-101-3p/OTUD3 axis in unexplained recurrent
            spontaneous abortion
  JOURNAL   J Mol Histol 53 (6), 871-882 (2022)
   PUBMED   36173586
  REMARK    GeneRIF: Silencing of LncRNA SNHG6 protects trophoblast cells
            through regulating miR-101-3p/OTUD3 axis in unexplained recurrent
            spontaneous abortion.
REFERENCE   4  (bases 1 to 6515)
  AUTHORS   Zhou,N., Qi,H., Liu,J., Zhang,G., Liu,J., Liu,N., Zhu,M., Zhao,X.,
            Song,C., Zhou,Z., Gong,J., Li,R., Bai,X., Jin,Y., Song,Y. and
            Yin,Y.
  TITLE     Deubiquitinase OTUD3 regulates metabolism homeostasis in response
            to nutritional stresses
  JOURNAL   Cell Metab 34 (7), 1023-1041 (2022)
   PUBMED   35675826
REFERENCE   5  (bases 1 to 6515)
  AUTHORS   Wang,M., Li,Y., Xiao,Y., Yang,M., Chen,J., Jian,Y., Chen,X.,
            Shi,D., Chen,X., Ouyang,Y., Kong,L., Huang,X., Bai,J., Lin,C. and
            Song,L.
  TITLE     Nicotine-mediated OTUD3 downregulation inhibits VEGF-C mRNA decay
            to promote lymphatic metastasis of human esophageal cancer
  JOURNAL   Nat Commun 12 (1), 7006 (2021)
   PUBMED   34853315
  REMARK    GeneRIF: Nicotine-mediated OTUD3 downregulation inhibits VEGF-C
            mRNA decay to promote lymphatic metastasis of human esophageal
            cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6515)
  AUTHORS   Yang,S.K., Hong,M., Zhao,W., Jung,Y., Tayebi,N., Ye,B.D., Kim,K.J.,
            Park,S.H., Lee,I., Shin,H.D., Cheong,H.S., Kim,L.H., Kim,H.J.,
            Jung,S.A., Kang,D., Youn,H.S., Liu,J. and Song,K.
  TITLE     Genome-wide association study of ulcerative colitis in Koreans
            suggests extensive overlapping of genetic susceptibility with
            Caucasians
  JOURNAL   Inflamm Bowel Dis 19 (5), 954-966 (2013)
   PUBMED   23511034
  REMARK    GeneRIF: Single-nucleotide polymorphism in OTUD3 gene is associated
            with ulcerative colitis.
REFERENCE   7  (bases 1 to 6515)
  AUTHORS   McGovern,D.P., Gardet,A., Torkvist,L., Goyette,P., Essers,J.,
            Taylor,K.D., Neale,B.M., Ong,R.T., Lagace,C., Li,C., Green,T.,
            Stevens,C.R., Beauchamp,C., Fleshner,P.R., Carlson,M., D'Amato,M.,
            Halfvarson,J., Hibberd,M.L., Lordal,M., Padyukov,L., Andriulli,A.,
            Colombo,E., Latiano,A., Palmieri,O., Bernard,E.J., Deslandres,C.,
            Hommes,D.W., de Jong,D.J., Stokkers,P.C., Weersma,R.K., Sharma,Y.,
            Silverberg,M.S., Cho,J.H., Wu,J., Roeder,K., Brant,S.R.,
            Schumm,L.P., Duerr,R.H., Dubinsky,M.C., Glazer,N.L.,
            Haritunians,T., Ippoliti,A., Melmed,G.Y., Siscovick,D.S.,
            Vasiliauskas,E.A., Targan,S.R., Annese,V., Wijmenga,C.,
            Pettersson,S., Rotter,J.I., Xavier,R.J., Daly,M.J., Rioux,J.D. and
            Seielstad,M.
  CONSRTM   NIDDK IBD Genetics Consortium
  TITLE     Genome-wide association identifies multiple ulcerative colitis
            susceptibility loci
  JOURNAL   Nat Genet 42 (4), 332-337 (2010)
   PUBMED   20228799
  REMARK    Erratum:[Nat Genet. 2011 Apr;43(4):388]
REFERENCE   8  (bases 1 to 6515)
  AUTHORS   Franke,A., Balschun,T., Sina,C., Ellinghaus,D., Hasler,R., Mayr,G.,
            Albrecht,M., Wittig,M., Buchert,E., Nikolaus,S., Gieger,C.,
            Wichmann,H.E., Sventoraityte,J., Kupcinskas,L., Onnie,C.M.,
            Gazouli,M., Anagnou,N.P., Strachan,D., McArdle,W.L., Mathew,C.G.,
            Rutgeerts,P., Vermeire,S., Vatn,M.H., Krawczak,M., Rosenstiel,P.,
            Karlsen,T.H. and Schreiber,S.
  CONSRTM   IBSEN study group
  TITLE     Genome-wide association study for ulcerative colitis identifies
            risk loci at 7q22 and 22q13 (IL17REL)
  JOURNAL   Nat Genet 42 (4), 292-294 (2010)
   PUBMED   20228798
REFERENCE   9  (bases 1 to 6515)
  AUTHORS   Barrett,J.C., Lee,J.C., Lees,C.W., Prescott,N.J., Anderson,C.A.,
            Phillips,A., Wesley,E., Parnell,K., Zhang,H., Drummond,H.,
            Nimmo,E.R., Massey,D., Blaszczyk,K., Elliott,T., Cotterill,L.,
            Dallal,H., Lobo,A.J., Mowat,C., Sanderson,J.D., Jewell,D.P.,
            Newman,W.G., Edwards,C., Ahmad,T., Mansfield,J.C., Satsangi,J.,
            Parkes,M., Mathew,C.G., Donnelly,P., Peltonen,L., Blackwell,J.M.,
            Bramon,E., Brown,M.A., Casas,J.P., Corvin,A., Craddock,N.,
            Deloukas,P., Duncanson,A., Jankowski,J., Markus,H.S., Mathew,C.G.,
            McCarthy,M.I., Palmer,C.N., Plomin,R., Rautanen,A., Sawcer,S.J.,
            Samani,N., Trembath,R.C., Viswanathan,A.C., Wood,N., Spencer,C.C.,
            Barrett,J.C., Bellenguez,C., Davison,D., Freeman,C., Strange,A.,
            Donnelly,P., Langford,C., Hunt,S.E., Edkins,S., Gwilliam,R.,
            Blackburn,H., Bumpstead,S.J., Dronov,S., Gillman,M., Gray,E.,
            Hammond,N., Jayakumar,A., McCann,O.T., Liddle,J., Perez,M.L.,
            Potter,S.C., Ravindrarajah,R., Ricketts,M., Waller,M., Weston,P.,
            Widaa,S., Whittaker,P., Deloukas,P., Peltonen,L., Mathew,C.G.,
            Blackwell,J.M., Brown,M.A., Corvin,A., McCarthy,M.I., Spencer,C.C.,
            Attwood,A.P., Stephens,J., Sambrook,J., Ouwehand,W.H.,
            McArdle,W.L., Ring,S.M. and Strachan,D.P.
  CONSRTM   UK IBD Genetics Consortium; Wellcome Trust Case Control Consortium
            2
  TITLE     Genome-wide association study of ulcerative colitis identifies
            three new susceptibility loci, including the HNF4A region
  JOURNAL   Nat Genet 41 (12), 1330-1334 (2009)
   PUBMED   19915572
REFERENCE   10 (bases 1 to 6515)
  AUTHORS   Silverberg,M.S., Cho,J.H., Rioux,J.D., McGovern,D.P., Wu,J.,
            Annese,V., Achkar,J.P., Goyette,P., Scott,R., Xu,W., Barmada,M.M.,
            Klei,L., Daly,M.J., Abraham,C., Bayless,T.M., Bossa,F.,
            Griffiths,A.M., Ippoliti,A.F., Lahaie,R.G., Latiano,A., Pare,P.,
            Proctor,D.D., Regueiro,M.D., Steinhart,A.H., Targan,S.R.,
            Schumm,L.P., Kistner,E.O., Lee,A.T., Gregersen,P.K., Rotter,J.I.,
            Brant,S.R., Taylor,K.D., Roeder,K. and Duerr,R.H.
  TITLE     Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by
            genome-wide association study
  JOURNAL   Nat Genet 41 (2), 216-220 (2009)
   PUBMED   19122664
  REMARK    Erratum:[Nat Genet. 2009 Jun;41(6):762]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CV573628.1, AB007928.3 and AA829387.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015207.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB007928.3, SRR1803615.58407.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375120.4/ ENSP00000364261.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-23                CV573628.1         1-23
            24-6512             AB007928.3         1-6489
            6513-6515           AA829387.1         9-11                c
FEATURES             Location/Qualifiers
     source          1..6515
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.13"
     gene            1..6515
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /note="OTU deubiquitinase 3"
                     /db_xref="GeneID:23252"
                     /db_xref="HGNC:HGNC:29038"
                     /db_xref="MIM:611758"
     exon            1..340
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1316
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /EC_number="3.4.19.12"
                     /note="OTU domain containing 3"
                     /codon_start=1
                     /product="OTU domain-containing protein 3"
                     /protein_id="NP_056022.1"
                     /db_xref="CCDS:CCDS41279.1"
                     /db_xref="GeneID:23252"
                     /db_xref="HGNC:HGNC:29038"
                     /db_xref="MIM:611758"
                     /translation="MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESG
                     GGGGCEEEFVSFANQLQALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDY
                     MIKQREDFEPFVEDDIPFEKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLW
                     QIRGTEKSSVRELHIAYRYGEHYDSVRRINDNSEAPAHLQTDFQMLHQDESNKREKIK
                     TKGMDSEDDLRDEVEDAVQKVCNATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGK
                     RNNAEENLEPSGRVLKQCGPLWEEGGSGARIFGNQGLNEGRTENNKAQASPSEENKAN
                     KNQLAKVTNKQRREQQWMEKKKRQEERHRHKALESRGSHRDNNRSEAEANTQVTLVKT
                     FAALNI"
     exon            341..489
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            490..602
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            603..725
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            726..857
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            858..954
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            955..1139
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..6515
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6492..6497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /note="hexamer: AATAAA"
     polyA_site      6515
                     /gene="OTUD3"
                     /gene_synonym="DUBA4"
                     /note="major polyA site"
ORIGIN      
        1 gctgcgtagt cgtcgccggg ctccgttgcc cgcgctgttt taccttccca acgcttgagg
       61 cggacgctgg ggggtcctgc gcctttccct cctgccgctg gggactgcag gctaaggcca
      121 tgtcccgaaa gcaggcggcg aagagccggc cgggcagcgg cagccggaaa gccgaggccg
      181 agcgcaagcg ggacgagcgg gcggcgcgcc gggccctggc caaggagcgg cggaatcggc
      241 cggagtctgg cggcggcggc ggctgcgagg aggagttcgt cagcttcgcc aaccagctgc
      301 aggccctggg gctgaagctg cgggaggtgc cgggggacgg caattgcttg ttcagagctc
      361 ttggtgatca attggaggga cactcacgaa atcatctcaa gcacagacag gagacagtgg
      421 actacatgat aaagcagcgg gaagattttg aaccctttgt agaagatgac attccttttg
      481 agaagcatgt ggccagtttg gcaaagcctg gtacttttgc tggcaatgat gcaattgtag
      541 cctttgcaag aaatcatcag ttgaatgtag tgattcatca acttaatgcc cctttgtggc
      601 agattcgtgg tacagagaaa agcagcgtga gggagttaca catcgcatat cggtatggag
      661 agcactacga cagtgttcgg aggatcaatg acaactcaga ggcacctgca catctccaga
      721 cggattttca gatgcttcat caagatgaat caaataaaag agaaaagatc aagacaaagg
      781 gaatggactc tgaagacgac ctgagagatg aagtagagga tgctgtccag aaagtttgta
      841 atgcaactgg atgttcagat tttaatttaa tagtccagaa cctggaagct gaaaattata
      901 atattgaatc tgcaataatt gccgtgcttc ggatgaacca agggaagaga aataatgcag
      961 aagagaatct tgagcccagt ggtcgagtgc tgaagcagtg tggccctttg tgggaggagg
     1021 gtggcagtgg tgccagaatc tttggaaatc agggcttaaa tgaaggcagg accgaaaaca
     1081 ataaggcaca ggccagccct agtgaagaaa acaaagcaaa taaaaaccag ctcgcaaagg
     1141 tcacaaacaa acagaggcga gaacagcagt ggatggagaa gaagaagcgg caggaggaga
     1201 ggcaccgcca caaagccctg gagagcagag gtagccacag ggacaataac agaagcgaag
     1261 cagaggcgaa cacgcaggtc accttggtga agaccttcgc cgctctcaac atctgactct
     1321 ttggcctctt gggagttgta agaagcggct ggaaaaggat tgctgtgtgc tagactttcc
     1381 agtgaggccg tccttttata aaacgcaaca caaccaacga agcccacaca tgagctcaca
     1441 cactgagtta gtttcgttca agctgcctct ttttttgttc gaagttttat tagtgatatg
     1501 ttggtgtttt atgaaaatgc agtgaggcca ttcatattct gtaatacaaa attaaaatac
     1561 tgagttttag gggcagatag ttaggtcagg aaaaaccttt taagtggtgg ctttatttgc
     1621 cctgaaaatc agacttcagt gaccctagga tctttcctta acatttgggg tgagttttgc
     1681 tgtaattgtt catgagtagt ttagaataat tgttagaaat tcagaatgac aagtttcctt
     1741 agtttctctt tcattctcaa acagatatat agggtagctt ataaatgatc tccaactcag
     1801 gaatatgctt tgatttactt ctaatccaag ttactcagaa aataattcag gaattgtttt
     1861 cccaaagtta cgtgagggtt gtggcctgca gtcaggatgg aaattaaccg catttctctc
     1921 cttcctgatt ctgatgttat ttcagatggg atgcaggtgc tgttagttca tttgcactca
     1981 agccatatga taaatgcagc tgactgttaa ttaggcctgg ccttgttggg aagttgatag
     2041 tggtgttggg tttttggtat ttgtttcctg acagtgggga gatggcatgt tactgcttgt
     2101 gatacagttc tggaattctg atagtgtgta gagcagggtc tatagttgta acaggagacg
     2161 aactcctggg gttttgccta agaggagtct aaagaattat gtttttatag gagaagcctg
     2221 gaagaataag gtttttcatg ttcgcatttt aaataacgat tttcttccct tctgttgtag
     2281 acttagatgc cttcagagag atacgtggta acttgacctt ataggtcgct aaacttagta
     2341 ttgtggaaat taaatcttat aaaatgctac atttatttct ttttatttaa gccctgtttg
     2401 gcatttcaaa gttgggaaaa ctccagcatc tgctggaagt tgttggacca gcagggttgg
     2461 ttgacttagg ttggaccagc agagaagaga acatactttg gttgaggcct tcgaatcact
     2521 cttcagttct gaaatagaca gacttgagca gtggagagac gtctttccta aaactgagtt
     2581 aggtggatgt gaacttaaga actataacgt atgaggcagc ccatcttgga tcatctttgt
     2641 cttttgggac ctaatacttg ggcaaataat tgatgctgag ttgaaaggta aattattagt
     2701 tatcttcccc acccctcgca tttcagaatt ataaaaattc ggaggcaaat tgaaaactaa
     2761 aatgtttggt aggccctgga gtcgccagat tgtctttatc accaggcctt tggctttctt
     2821 cagtttcact ggtatctttt ggttttgttt ttgactttgg tggctttttg tagttggagc
     2881 atcagtagtc tcttggaatt gctcctagga cattgtggtt taggtttctt cctgggtaca
     2941 gtacattgta aaatttagca gattaaaaaa agtacacagc attttttttc tgtgcacgtc
     3001 gcagagtcct gagcttgagg ctgtgttact ctactcattc caaacgaatg aaagatctct
     3061 gttgccttac tctaaggaag tgggatcgag tgcgttagga tctatggttg tcttggtttt
     3121 caactctggg cagattcctg actggctgag tgtttctgaa tgaagatgtt ttcctgtctg
     3181 ttttgtactg cttgagtgca gaggccagat cctctcagaa agataagatt gtatgccaga
     3241 aattcagatt agcagtcagc ttaagagaga cttattgtca gaagtagtag aattgcttta
     3301 tttacttggt taatgaaggt ggccttgggc cctattgggt tttagaagtt ttagaagctg
     3361 ctaaaaagtt attaaagaat attgggaaca tttatttttt aaattaccta attctggtaa
     3421 taggcttcag catttctgga gtataataat ggtggtttaa aaaactaatc aaacggcttt
     3481 agtaatttta ctactggttt cacagctttt cagttacagt tggtctgttt agtgtgttaa
     3541 ttattaggaa tcgggtacat gcatccaact tcagtgatac cttctagcta atggtttcaa
     3601 tttagacttc actgcctcag tctcactggg tacatgagaa ggttggaatc aacatgctta
     3661 gttgcctcag tgggcacttg aaaattcctt cactggcagc ccgagtggag gcccagtatg
     3721 tctagtcctg ggatgactgt tgtcagcagc tgttactcta gtacaggtgc tcctgtgaac
     3781 tctttattag gaactgaatg tgtcttaacc tctgtgttac atcttggctg gcagagattt
     3841 atgttacatg agattgtctt ggtagcttgt agtgtggtca ggagaaaggg gatggagcag
     3901 tggtgcatag ctgcttactg ctcttataaa cggtatataa aggttttacg gattttgaaa
     3961 atattttttt ttagaggtca aaataaatac cattttagtg gcaacagctt tgaactagag
     4021 aggtagatgt attaaagcag catagaacca taacttctag ataatgtagt tgccactagg
     4081 agatattaga aagttagaat gtatgtgtgt atttagtttt tcaataataa tgaacataca
     4141 ctttcaggag caaagtatgg ttgagaaatt gtggcagaaa gaattttaaa tgttagtcga
     4201 agttgtctgt agtttcttta ttaagctctg aaaacacttc caatgccagt ttgattctga
     4261 gggcttggga agtgggatct cccttgtgga gcagctggag ctggctggga gggagcctct
     4321 ccatgggtaa tttattatgc ctgccctgct tcccccaggg agctgcttca gtgtgaaatg
     4381 atgtgattgt cgggggtggg gtgggaggag ggccaccttc agtcggggag ttgctcacat
     4441 attacacagg tagcatcagg tggacttcag cgctgaactg tactagtagt gagtccctgt
     4501 agtcaatgtg caatttctct aattctgaga aactctgtag actctgcctg ggttttactg
     4561 ggtcagcata gaatgctatc agtttacctc tgtgaaatat tcagtcagtt gaaggaaact
     4621 tggattccta gtcagaggtg actaaaagtt accctgacca aaaggatctc tgcgggggga
     4681 agagaatgga gcttcctgat tttaatgtgt tgcgtcagtg gccctcttcg actcccgttt
     4741 tgggtagatg cgtagctctt cactttctta cctcaaggct ctgtctagcc atgttaaatc
     4801 tttagactca gtctgatgcc gtttttctgt tttgccattc tcattattca cagctttcag
     4861 aacaagtgtt gctaaaactc cggggccttt gacagttgtt ctgaggtgat ttaataatgg
     4921 actttttata agttatgttt tcctggctct aaagtaaatt tttttttttt tttttttgag
     4981 acagagtctt gctttgttgc ccaggctgga gtgtggtggg gcaatctcgg ctcactgcaa
     5041 cctccacctc ccgggttcaa gcgattctcc tgcctcagcc tcctgagtag ctgggattac
     5101 aggtgtgtgc caccatgctt ggctaatttt tgtattttta gtagagacgg ggtttcacca
     5161 tgttagccag gctggtctca aactcctgac cttgtgatct gcccgcctca gcctcccaaa
     5221 gtgctaggat tacgggtgtg agcaaccctg cccggccagt aaattgtatt tttttaatga
     5281 catcattgat ttgaagatct agatggcata aattacgacg tctgccatcg catattagaa
     5341 aggggacagt catatttgta acgtggagag aacacggagc accagtcacc acgtgcactt
     5401 aggatgcaga gcttaccgca caccgctgat ggggacctcc ggaaagagcg gtgccttgtg
     5461 gttggcctgg aagttctctc ccaaggtgaa attcctttaa aacctcaggc tctgacctat
     5521 gtctttgaag cagctgcttt gtagagtccc tctctttact gtcctcgtta ggactgtttt
     5581 gtggttccat gaaaatgttt agcatccttg cagaattact tgagaagggg ctggtaccag
     5641 tgtaaagaat ctatttctgt aaaactacga acttttgcat agggaattta ttctaagcag
     5701 gtcatagccg tgatccagag ctgctgctgc tcactgccag tccttgcggc tggcggcgat
     5761 tgccggacag actctctgtg gcctggctct catccttggc gtgtcagcct gcggcaggct
     5821 gccagccatc catgacaatc atgtgagctc agccacagac ctcagctggc ggtttgatcc
     5881 ctggcaggtc cctcgagcag tactggtaag aggcttcaca cattttccca ctcttacagt
     5941 tcatttttca tagtaggaag ggcccttggc ctccccagtg cctcttccag agcctccacc
     6001 agcactaagc tcagaggaaa gaagaaaagg gccaggagtc agacgtcaca cccgggggct
     6061 cccctttccc atgtagaagt gttggcatgc gtcagtctcc tttacagagg ggtggatgta
     6121 tccgtggagg aggggccttc tctctttcta attgcactat acttgttcta gcttcagtct
     6181 ggagatactt aagacctcca tggggtcgtg atccatagac ttagcaagtc ttgccttatc
     6241 tatggagctc gatggtgaga attgtgacca ttgtctgatg tccatagttc cttcccccta
     6301 gattgtttct ttccacggat tgtgttcatc tgaaccattt tattttttat ttaccaaagt
     6361 actgtacttg gctatttgca gtgttttcaa aaccaaatgt ttcttttttt gtgtttttaa
     6421 tcttcgatac ttggtgcaat agaagctgca aagatgtgcc actttatcta tgaaatggag
     6481 ttttgtatac caataaattc tagtttaaaa acaaa
//
