LOCUS       NM_001145373            3303 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens OTU deubiquitinase 1 (OTUD1), mRNA.
ACCESSION   NM_001145373 XR_040063 XR_040064 XR_040065
VERSION     NM_001145373.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3303)
  AUTHORS   Ming,T., Liu,H., Yuan,M., Tian,J., Fang,Q., Liu,Y., Kong,Q.,
            Wang,Q., Song,X., Xia,Z. and Wu,X.
  TITLE     The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling
  JOURNAL   Biochem Pharmacol 227, 116418 (2024)
   PUBMED   38996928
  REMARK    GeneRIF: The deubiquitinase OTUD1 deubiquitinates TIPE2 and plays a
            protective role in sepsis-induced lung injury by targeting
            TAK1-mediated MAPK and NF-kappaB signaling.
REFERENCE   2  (bases 1 to 3303)
  AUTHORS   Zheng,S., Li,Y., Song,X., Wu,M., Yu,L., Huang,G., Liu,T., Zhang,L.,
            Shang,M., Zhu,Q., Gao,C., Chen,L. and Liu,H.
  TITLE     OTUD1 ameliorates cerebral ischemic injury through inhibiting
            inflammation by disrupting K63-linked deubiquitination of RIP2
  JOURNAL   J Neuroinflammation 20 (1), 281 (2023)
   PUBMED   38012669
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3303)
  AUTHORS   Song,J., Zhang,Y., Bai,Y., Sun,X., Lu,Y., Guo,Y., He,Y., Gao,M.,
            Chi,X., Heng,B.C., Zhang,X., Li,W., Xu,M., Wei,Y., You,F.,
            Zhang,X., Lu,D. and Deng,X.
  TITLE     The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis
  JOURNAL   Adv Sci (Weinh) 10 (30), e2303207 (2023)
   PUBMED   37639212
  REMARK    GeneRIF: The Deubiquitinase OTUD1 Suppresses Secretory Neutrophil
            Polarization And Ameliorates Immunopathology of Periodontitis.
REFERENCE   4  (bases 1 to 3303)
  AUTHORS   Fan,G., Wang,F., Chen,Y., Zheng,Q., Xiong,J., Lv,Q., Wu,K.,
            Xiong,J., Wei,L., Li,D., Zhang,J., Zhang,W. and Li,F.
  TITLE     The deubiquitinase OTUD1 noncanonically suppresses Akt activation
            through its N-terminal intrinsically disordered region
  JOURNAL   Cell Rep 42 (1), 111916 (2023)
   PUBMED   36640312
  REMARK    GeneRIF: The deubiquitinase OTUD1 noncanonically suppresses Akt
            activation through its N-terminal intrinsically disordered region.
REFERENCE   5  (bases 1 to 3303)
  AUTHORS   Snaurova,R., Vdovin,A., Durech,M., Nezval,J., Zihala,D.,
            Jelinek,T., Hajek,R. and Simicek,M.
  TITLE     Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare
            Codon Rich mRNAs
  JOURNAL   Mol Cell Biol 42 (12), e0026522 (2022)
   PUBMED   36445135
REFERENCE   6  (bases 1 to 3303)
  AUTHORS   Mevissen,T.E., Hospenthal,M.K., Geurink,P.P., Elliott,P.R.,
            Akutsu,M., Arnaudo,N., Ekkebus,R., Kulathu,Y., Wauer,T., El
            Oualid,F., Freund,S.M., Ovaa,H. and Komander,D.
  TITLE     OTU deubiquitinases reveal mechanisms of linkage specificity and
            enable ubiquitin chain restriction analysis
  JOURNAL   Cell 154 (1), 169-184 (2013)
   PUBMED   23827681
REFERENCE   7  (bases 1 to 3303)
  AUTHORS   Wheeler,E., Huang,N., Bochukova,E.G., Keogh,J.M., Lindsay,S.,
            Garg,S., Henning,E., Blackburn,H., Loos,R.J., Wareham,N.J.,
            O'Rahilly,S., Hurles,M.E., Barroso,I. and Farooqi,I.S.
  TITLE     Genome-wide SNP and CNV analysis identifies common and
            low-frequency variants associated with severe early-onset obesity
  JOURNAL   Nat Genet 45 (5), 513-517 (2013)
   PUBMED   23563609
REFERENCE   8  (bases 1 to 3303)
  AUTHORS   Kayagaki,N., Phung,Q., Chan,S., Chaudhari,R., Quan,C.,
            O'Rourke,K.M., Eby,M., Pietras,E., Cheng,G., Bazan,J.F., Zhang,Z.,
            Arnott,D. and Dixit,V.M.
  TITLE     DUBA: a deubiquitinase that regulates type I interferon production
  JOURNAL   Science 318 (5856), 1628-1632 (2007)
   PUBMED   17991829
REFERENCE   9  (bases 1 to 3303)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 3303)
  AUTHORS   Makarova,K.S., Aravind,L. and Koonin,E.V.
  TITLE     A novel superfamily of predicted cysteine proteases from
            eukaryotes, viruses and Chlamydia pneumoniae
  JOURNAL   Trends Biochem Sci 25 (2), 50-52 (2000)
   PUBMED   10664582
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512603.26.
            
            On Jun 3, 2020 this sequence version replaced NM_001145373.2.
            
            Summary: Deubiquitinating enzymes (DUBs; see MIM 603478) are
            proteases that specifically cleave ubiquitin (MIM 191339) linkages,
            negating the action of ubiquitin ligases. DUBA7 belongs to a DUB
            subfamily characterized by an ovarian tumor (OTU) domain.[supplied
            by OMIM, May 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB188491.1, DRR138524.1051762.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376495.5/ ENSP00000365678.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3303              AL512603.26        6281-9583
FEATURES             Location/Qualifiers
     source          1..3303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.2"
     gene            1..3303
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /note="OTU deubiquitinase 1"
                     /db_xref="GeneID:220213"
                     /db_xref="HGNC:HGNC:27346"
                     /db_xref="MIM:612022"
     exon            1..3303
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1829
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /EC_number="3.4.19.12"
                     /note="DUBA-7; OTU domain containing 1"
                     /codon_start=1
                     /product="OTU domain-containing protein 1"
                     /protein_id="NP_001138845.1"
                     /db_xref="CCDS:CCDS44366.1"
                     /db_xref="GeneID:220213"
                     /db_xref="HGNC:HGNC:27346"
                     /db_xref="MIM:612022"
                     /translation="MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGA
                     APEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKP
                     PLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPR
                     RGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPD
                     PGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAE
                     PVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQS
                     LHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNI
                     HLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCK
                     QTQVQRKRDEELAKSMAISLSKMYIEQNACS"
     regulatory      3078..3083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3102
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /note="major polyA site"
     regulatory      3280..3285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
                     /note="hexamer: AATAAA"
     polyA_site      3303
                     /gene="OTUD1"
                     /gene_synonym="DUBA7; OTDC1"
ORIGIN      
        1 ctccgcgcgc accgcgctcc tcctcgccgg cgggacgcgc tccaacgggg cgggcggctt
       61 cctccgtgag tccccagcgg ccgccgcggg ccgaagcagc tgcagcgggc gcggcgcccc
      121 gggtctgcgg gccgagcgca ccggcagggg tcgagctcgc gtcccgtccc cgcccccctg
      181 cgctgtggcg cagcaggaat ttggccggga cccgggcgct attcgcggct gctgactcgc
      241 ggcggccggc tgcctttcgc tcatctctat tctggggccg ttgggtcacc gcgctccgcc
      301 ggccccctcc cccgggcccg gagggtgtgt cccccgctcc ggggctcgcc gcgcctataa
      361 ggggccgagc ggcgggcagg gacatgcagc tctacagcag cgtctgcacc cactaccccg
      421 ccggggcccc gggtcccacg gccgccgccc ccgcgccacc cgccgccgct acccccttca
      481 aggtctcgct gcagcccccg ggagccgccg gcgccgcgcc cgagcccgag accggtgagt
      541 gccagcccgc cgcggccgcc gagcaccggg aagccgccgc tgtccccgcc gccaagatgc
      601 ccgccttctc ctcctgcttc gaggtggtgt ccggggccgc cgcgcccgcc tccgccgccg
      661 ccggcccgcc cggcgcgtcc tgcaagccgc cgctgccgcc gcactacacg tccaccgcac
      721 agatcaccgt gcgggccctg ggcgccgaca ggctcctgct gcacgggccc gatcccgttc
      781 ccggcgccgc gggctccgcc gctgccccgc gcggccgctg cctcctgctc gccccggcgc
      841 ccgcagcccc ggtcccgccg cggcggggct cctcggcctg gctcctggag gagctgctgc
      901 ggcccgactg ccccgagccc gcgggcttgg acgcgacacg ggaggggccc gatcggaact
      961 tccgactgag cgagcaccgc caggccctgg ccgccgccaa gcaccgaggc cccgcggcga
     1021 ccccggggag ccccgatccc ggccccggtc cgtggggcga agagcacttg gcggagaggg
     1081 gccccagggg ctgggagagg ggcggcgatc gctgcgacgc gcccggtggg gacgcggcgc
     1141 ggaggcccga cccagaggcc gaggcacccc ccgccgggag catcgaggcc gccccgagta
     1201 gtgcggcgga gccggtgatc gtctccaggt cggatcccag agacgagaag ctggccctat
     1261 acctggccga ggtggagaag caggacaagt atctgcggca gaggaataag taccgattcc
     1321 acatcattcc agacggcaac tgcctctacc gagctgtcag caagacggtg tatggggacc
     1381 agagcctgca ccgggagttg agggagcaga cggtgcacta catcgccgac catctcgacc
     1441 acttcagccc cctgattgag ggcgacgtgg gggagtttat catcgctgct gcccaagacg
     1501 gggcatgggc cgggtacccg gagttgctgg ccatggggca gatgctgaat gtgaatatcc
     1561 atttaactac tggagggagg ctggagagtc ccacggtgtc taccatgatt cattatttgg
     1621 gcccagagga ttccctgagg cctagtattt ggctcagttg gctcagtaac ggacactatg
     1681 atgctgtatt tgatcactcc tatcctaacc cagagtacga caactggtgc aaacaaactc
     1741 aagtgcaaag gaaacgcgac gaagaacttg ccaaatctat ggccatatcc ttgtctaaaa
     1801 tgtatattga acaaaatgca tgctcttgaa atgtctcaaa accttacacc ctgggaataa
     1861 ttgcatatat aacttgtgtt tggagaatca catgaacttt aatcagggta atagcacttt
     1921 caaacttgct agtagatttt actgtaggtg taatgcctta atcatctttt tgaatgtttt
     1981 ctcagagctg gaggttgctg ggcacctaaa tgatgtttca tgatagcttt gggtgatttt
     2041 actgctattt ataatttgct gtataaagtg agcattactt aatttgcaag ctgatttctc
     2101 acagtgtaaa tttgttcatt cctggtagtc tattttctat aaaaatgtat ttttgcacaa
     2161 catttttaaa aactggtgta ccttcatcta tgacgtgttc cattttgaca aacagctttc
     2221 aggcgtaaat ccagagaagt gctttatatg aaatgtatta ttttgaacag agtttgtgat
     2281 ttggtagtta ttttatgttg ttgaaatttg aatttcacaa ttcttagata attatttcaa
     2341 atggatattg atgcattctt gttaccagat gtttggccca ttccattttg atgaaacaga
     2401 gctgttgttt tggaagtcat tatttttcta gaaatggcga atcttttaaa gaaaattact
     2461 taatggaagg ttgtgggaag gtgttttttt gtgttttttt tttggttttt gttttgtttt
     2521 tcctctttta agggatagta gcaggtctta cttgaatgaa agtctgatat ttgctgatgg
     2581 cagaatgatt attctgtacc ctggttgatg tgtagagtag attgtctggt gctctcagtt
     2641 gtttttattt acatttgtca cgttgttgta agagaatgtt aacatggtat aaaactctgt
     2701 gacaagataa gcctcctgct ttatataact tcttgaatcc agctaagaga tttataaact
     2761 aatggcataa atgtctggag ccaaccttgg cagttatagc aggagaacac tgtcttaata
     2821 tttctttaca ttctttcaaa aggcaaaata ggattgccct gtattgatgt agaaatgtct
     2881 gtaaacagag cttgtatggt ttgctgggtc aaacaatgtt tccaacttaa aatcaatctc
     2941 attgccactt taactacttt tagtcatatt tattaagtaa tgcagtttgt acttttttta
     3001 ttttgtaaca ttttgtgatt tttttgtaca aaactgtatt tgtacaatag agcaattccc
     3061 agctgatgga atgaatgaat aaaatgcaaa attatacttt tacaatgcct ttttggatag
     3121 agtggttttt aaattgtgat gtttgtagga aactttcttg catgtatgca tgtacacaat
     3181 tttttttttc cataaagatg ccacagcaat agagaggttt cctaaattat cacatgaaga
     3241 ggataggcta atcatgagta atttcaaagg ataagtctga ataaaatata atttaaaagt
     3301 gga
//
