LOCUS       NM_001272005            2337 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens otopetrin 3 (OTOP3), transcript variant 2, mRNA.
ACCESSION   NM_001272005
VERSION     NM_001272005.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2337)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2337)
  AUTHORS   Oshikawa,M., Tsutsui,C., Ikegami,T., Fuchida,Y., Matsubara,M.,
            Toyama,S., Usami,R., Ohtoko,K. and Kato,S.
  TITLE     Full-length transcriptome analysis of human retina-derived cell
            lines ARPE-19 and Y79 using the vector-capping method
  JOURNAL   Invest Ophthalmol Vis Sci 52 (9), 6662-6670 (2011)
   PUBMED   21697133
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2337)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB593153.1, BK000568.2 and AC087651.19.
            
            On May 17, 2019 this sequence version replaced NM_001272005.1.
            
            Transcript Variant: This variant (2) uses alternate splice sites at
            the end of two exons compared to variant 1. The resulting isoform
            (2) has a shorter and distinct N-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB593153.1, SRR1660803.37083.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328801.6/ ENSP00000328090.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AB593153.1         17-176
            161-1761            BK000568.2         191-1791
            1762-2337           AC087651.19        96406-96981
FEATURES             Location/Qualifiers
     source          1..2337
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2337
                     /gene="OTOP3"
                     /note="otopetrin 3"
                     /db_xref="GeneID:347741"
                     /db_xref="HGNC:HGNC:19658"
                     /db_xref="MIM:607828"
     exon            1..43
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1761
                     /gene="OTOP3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     proton channel OTOP3"
                     /codon_start=1
                     /product="proton channel OTOP3 isoform 2"
                     /protein_id="NP_001258934.1"
                     /db_xref="CCDS:CCDS86637.1"
                     /db_xref="GeneID:347741"
                     /db_xref="HGNC:HGNC:19658"
                     /db_xref="MIM:607828"
                     /translation="MPLPASAPAEATPMPSSEAQETEAAPEKENRVDVGAEERAAATR
                     PRQKSWLVRHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVAVTLGD
                     VWILLATLKVLSLLWLLYYVASTTRRPHAVLYQDPHAGPLWVRGSLVLFGSCTFCLNI
                     FRVGYDVSHIRCKSQLDLVFSVIEMVFIGVQTWVLWKHCKDCVRVQTNFTRCGLMLTL
                     ATNLLLWVLAVTNDSMHREIEAELGILMEKSTGNETNTCLCLNATACEAFRRGFLMLY
                     PFSTEYCLICCAVLFVMWKNVGRHVAPHMGAHPATAPFHLHGAIFGPLLGLLVLLAGV
                     CVFVLFQIEASGPAIACQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTVKNP
                     TRSLDVVLLMGAALGQMGIAYFSIVAIVAKRPHELLNRLILAYSLLLILQHIAQNLFI
                     IEGLHRRPLWETVPEGLAGKQEAEPPRRGSLLELGQGLQRASLAYIHSYSHLNWKRRA
                     LKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYQIWFAIVNFGLPLGVFYRMH
                     SVGGLVEVYLGA"
     exon            44..460
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            461..597
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            598..656
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            657..775
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            776..1590
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..2337
                     /gene="OTOP3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtcggtg gttagcccac ggcgatgcct ctcccggcct cagcccctgc tgaggctaca
       61 cccatgcctt cttcagaagc acaggagact gaagcagccc cggagaagga gaaccgagtg
      121 gatgtggggg ccgaggagag agcggccgcc acccggcccc ggcagaagtc ctggctggtg
      181 aggcatttct ctctgctgct gcggcgggac cggcaggccc agaaggctgg acaactcttc
      241 tcggggctcc tggccctgaa tgtggtgttc ctgggtggcg ccttcatctg cagcatgatc
      301 ttcaacaagg tggccgtcac tctgggtgac gtgtggatcc tgctggccac gctgaaggtc
      361 ctctccctgc tttggcttct ctactatgtg gcaagcacca cccgccgacc acacgccgtg
      421 ctctaccaag atccccacgc ggggcccctc tgggtgcggg gttccctagt gctcttcggc
      481 agctgcacct tctgcctcaa catcttccga gtgggctacg atgtgagcca catccgctgc
      541 aagtcacagc tggaccttgt cttctctgtc atcgagatgg tcttcatcgg cgtccagacc
      601 tgggtgctct ggaaacactg caaagactgt gttcgggtcc agaccaactt cactaggtgt
      661 ggcctgatgc tgaccctggc cacaaacctg ctgctgtggg ttctggccgt taccaatgac
      721 tccatgcacc gagagatcga agctgagctt ggcatcctca tggaaaaatc cacaggcaat
      781 gagaccaaca cctgtctgtg cctcaatgcc accgcgtgtg aagctttccg gagaggcttc
      841 ctgatgctct accccttcag cactgagtac tgcctcatct gctgtgctgt gctgtttgtc
      901 atgtggaaga acgtgggccg ccacgtggca ccccacatgg gtgcccaccc tgccaccgca
      961 cccttccacc tgcacggggc catcttcggg ccgctgctgg gcctgctggt gctgctggca
     1021 ggtgtgtgcg tctttgtgct cttccaaatc gaggccagtg gccctgccat tgcttgccag
     1081 tacttcaccc tctactatgc cttctatgtg gctgtgctgc ccaccatgag tctggcgtgc
     1141 ctggcgggca cagccataca cgggctggag gagagagagc tggacacggt caagaaccct
     1201 acccgcagcc tggatgtggt gctgctaatg ggtgctgcac tgggccagat gggcatcgcc
     1261 tatttctcca tcgtggccat tgtggccaag cgcccgcatg agctgctcaa ccgcctcatc
     1321 ctggcctact cgctgctgct catcctgcag cacatcgctc agaacctctt catcatcgag
     1381 ggcctgcacc ggcgcccact ctgggagaca gttcccgagg gcctggcagg aaagcaggag
     1441 gctgagcctc cccgcagagg ctccttgctg gagctgggcc agggcctgca gcgggcctca
     1501 ctggcctaca tccactccta cagccacctc aactggaagc ggagggcact caaggagatc
     1561 tcactcttcc tcatcctctg caatatcaca ctgtggatga tgcctgcatt tggcatacac
     1621 ccggagtttg agaacgggct agaaaaggat ttctacggct accagatatg gttcgccatc
     1681 gtcaacttcg gcctgcctct gggggtcttc taccgcatgc actctgtggg aggcctggtg
     1741 gaggtctacc tgggggcctg aggctgccca cccccggcag aacctcgaag tgccaaggtg
     1801 gggaagatgg tagcccagag tctctgagca gatgcctcat tctgaggtgc cgagaccagc
     1861 ctgaggctct caaggcctcc tgctccccag agcctcactg aaggggaggg cactgcctag
     1921 agccagaggc caacagcagg ggcctggaca ctgagcttct gatgcccacg gccaggcctg
     1981 ggcacatgcc tgccccctgc cttcccacca cgatccgcaa gccaagggtg caccccagga
     2041 ggctggcagg ggccccctca cggctactct gtgggagggt cagacctaca tgaccgagtc
     2101 tggggagctt ggcgaggggc acccctctcc agccaggact cagaggtctg ccccctgctg
     2161 cgagaagagc acctggtcca agtgtggctc tggacatcct cagagctcag agctccgagc
     2221 taggaggcca gctcctctcc ccacacacct gtctcctaat gagctcattc attggctgcc
     2281 aggcagggtt caacagctct ctcctgccgc ataaacccta tttgtttaat ggattgc
//
