LOCUS       NM_178160               2150 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens otopetrin 2 (OTOP2), mRNA.
ACCESSION   NM_178160
VERSION     NM_178160.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2150)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2150)
  AUTHORS   Qu,H., Su,Y., Yu,L., Zhao,H. and Xin,C.
  TITLE     Wild-type p53 regulates OTOP2 transcription through DNA loop
            alteration of the promoter in colorectal cancer
  JOURNAL   FEBS Open Bio 9 (1), 26-34 (2018)
   PUBMED   30652071
  REMARK    GeneRIF: The OTOP2 is down-regulated in cancerous tissues and that
            elevated OTOP2 effectively suppresses tumor proliferation in vitro.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2150)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC087651.19.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 6, 2019 this sequence version replaced NM_178160.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968540,
                              SAMEA1968968 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331427.9/ ENSP00000332528.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AC087651.19        71262-71322
            62-407              AC087651.19        71589-71934
            408-544             AC087651.19        72545-72681
            545-603             AC087651.19        74212-74270
            604-737             AC087651.19        74654-74787
            738-1612            AC087651.19        77268-78142
            1613-2150           AC087651.19        80364-80901
FEATURES             Location/Qualifiers
     source          1..2150
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..2150
                     /gene="OTOP2"
                     /note="otopetrin 2"
                     /db_xref="GeneID:92736"
                     /db_xref="HGNC:HGNC:19657"
                     /db_xref="MIM:607827"
     exon            1..61
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            62..407
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1783
                     /gene="OTOP2"
                     /codon_start=1
                     /product="proton channel OTOP2"
                     /protein_id="NP_835454.1"
                     /db_xref="CCDS:CCDS11708.1"
                     /db_xref="GeneID:92736"
                     /db_xref="HGNC:HGNC:19657"
                     /db_xref="MIM:607827"
                     /translation="MSEELAQGPKESPPAPRAGPREVWKKGGRLLSVLLAVNVLLLAC
                     TLISGGAFNKVAVYDTDVFALLTAMMLLATLWILFYLLRTVRCPCAVPYRDAHAGPIW
                     LRGGLVLFGICTLIMDVFKTGYYSSFFECQSAIKILHPLIQAVFVIIQTYFLWVSAKD
                     CVHVHLDLTWCGLMFTLTTNLAIWMAAVVDESVHQSHSYSSSHSNASHARLISDQHAD
                     NPVGGDSCLCSTAVCQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRFLASTPGHS
                     HTPTPVSLFRETFFAGPVLGLLLFVVGLAVFIIYEVQVSGDGSRTRQALVIYYSFNIV
                     CLGLTTLVSLSGSIIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVA
                     GTPQDLLAGLNLTHALLMIAQHTFQNMFIIESLHRGPPGAEPHSTHPKEPCQDLTFTN
                     LDALHTLSACPPNPGLVSPSPSDQREAVAIVSTPRSQWRRQCLKDISLFLLLCNVILW
                     IMPAFGARPHFSNTVEVDFYGYSLWAVIVNICLPFGIFYRMHAVSSLLEVYVLS"
     exon            408..544
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            545..603
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            604..737
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1612
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..2150
                     /gene="OTOP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2128..2133
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTOP2"
                     /note="hexamer: AATAAA"
     polyA_site      2150
                     /gene="OTOP2"
                     /note="major polyA site"
ORIGIN      
        1 agagaggaga cgctcgccgt cccctgaccc ccagctcagc gccggctcca agcccagcca
       61 gtgatccctc tagccttctc cagtcgcctc cgccatgtcc gaggagctgg cccagggccc
      121 caaggagagc cccccggcgc cgcgtgcggg ccccagggag gtgtggaaga agggtggccg
      181 cctgctgtcg gtgctgctgg cggtgaacgt gctgctcctc gcctgcacgc tcatcagcgg
      241 cggagccttc aacaaggtgg ccgtgtacga caccgacgtg ttcgcgctgc tcactgcgat
      301 gatgctgctg gcaacgctct ggatcctctt ctacctcctc cgaaccgtgc gctgcccctg
      361 cgcggtaccc taccgggacg cgcacgctgg ccccatctgg ctccgaggtg ggctggtgct
      421 gtttggaatc tgcaccctca tcatggatgt cttcaagacc ggctactact ccagtttctt
      481 tgagtgccag tcagccatca agatcctgca ccccctcatc caggctgtgt ttgtcatcat
      541 ccagacctac tttctctggg tctctgctaa agactgcgtt cacgtccacc tggatctgac
      601 ctggtgtggt ctcatgttca cactcaccac caacctggcc atctggatgg cggccgtggt
      661 ggatgaatct gtgcaccaat cccactccta cagcagttct cacagcaacg ccagccacgc
      721 ccgtctcatc tctgaccagc atgcagacaa cccggtcgga ggagactcct gcctctgcag
      781 cacggccgtc tgccagatct tccagcaggg gtacttctac ctatatccct tcaacatcga
      841 gtacagcctc ttcgcctcca ccatgctgta tgtcatgtgg aagaatgtgg gtagattcct
      901 ggcctccacc cctggccaca gccacacccc aacccctgtc agcctcttcc gggagacctt
      961 ttttgctggc ccggttctgg gcctgctgct cttcgtggtg gggctggctg tcttcatcat
     1021 ctacgaggtt caagtgagcg gggacgggag ccgcaccagg caggccctgg tcatctacta
     1081 cagcttcaac attgtctgct tgggactcac caccttggtc agcctgagcg gctccatcat
     1141 ctaccgtttt gaccgccggg ccatggacca ccataagaac cccacgcgca ctctggacgt
     1201 ggccctgctg atgggtgccg ccctgggtca gtacgccatc tcttactact ccatcgtggc
     1261 tgtggtggcg ggcacacccc aggacctgct ggcagggctc aacctcaccc atgcactgct
     1321 catgatcgcc cagcacacct tccagaacat gtttatcatc gagagccttc accgaggacc
     1381 gcccggggct gagcctcaca gtacccaccc caaggagccc tgccaagacc tcaccttcac
     1441 caacctggat gccctccaca cgttgtccgc ctgcccaccc aaccccgggc tggttagccc
     1501 cagcccttca gaccagcggg aagcagtggc catcgtctca acccccagaa gccagtggag
     1561 acgccagtgc ctaaaagaca tttctctgtt tctcctactc tgcaatgtca ttctgtggat
     1621 catgcctgcc ttcggggccc gccctcattt cagcaacaca gtggaggtgg atttctacgg
     1681 ctactccctc tgggcggtca tcgtcaacat ctgcctccct ttcggcatct tctaccgcat
     1741 gcacgctgtg tccagcctgc tggaggtcta cgtgctgtcc tgaggcctcc aacagaggca
     1801 tggggggcag gaagaggggg ctcagctcat gtgcccactc agacaccctc tgggaatgaa
     1861 tcccagctgg tgccatatga cagcccattt ccttctggtc ccagagtgga attttcacaa
     1921 aagttatttt tccaggttca atttttaaat cacagtcagg acaggcccat ccaccccagt
     1981 atgaccgtgg ggcatgaggt gactggggaa gggagacctc tcctggcagc atttctagga
     2041 cccaacaaga tctggaggtg ccggctctgg ttccatctct aatcccctgc tgtggcctgg
     2101 ccagtgtact gcccggagct ggaaaccaat aaacctgtga tttgccccca
//
