LOCUS       NM_001378609            9982 bp    mRNA    linear   PRI 12-JUN-2024
DEFINITION  Homo sapiens otogelin like (OTOGL), transcript variant 3, mRNA.
ACCESSION   NM_001378609
VERSION     NM_001378609.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9982)
  AUTHORS   Feng,M.L., Huang,S.S., Tang,F.Z., Zhang,X., Li,X.H., Qiu,S.W. and
            Yuan,Y.Y.
  TITLE     [Phenotype and genotype analysis of recessive hereditary moderate
            sensorineural hearing loss caused by new mutations in OTOGL gene]
  JOURNAL   Zhonghua Yi Xue Za Zhi 101 (2), 115-121 (2021)
   PUBMED   33455126
  REMARK    GeneRIF: [Phenotype and genotype analysis of recessive hereditary
            moderate sensorineural hearing loss caused by new mutations in
            OTOGL gene].
REFERENCE   2  (bases 1 to 9982)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 9982)
  AUTHORS   Gu,X., Sun,S., Guo,L., Lu,X., Mei,H., Lai,C. and Li,H.
  TITLE     Novel biallelic OTOGL mutations in a Chinese family with moderate
            non-syndromic sensorineural hearing loss
  JOURNAL   Int J Pediatr Otorhinolaryngol 79 (6), 817-820 (2015)
   PUBMED   25829320
  REMARK    GeneRIF: We identified novel biallelic OTOGL mutations in a Chinese
            autosomal recessive non-syndromic hearing loss family.
REFERENCE   4  (bases 1 to 9982)
  AUTHORS   Oonk,A.M., Leijendeckers,J.M., Huygen,P.L., Schraders,M., del
            Campo,M., del Castillo,I., Tekin,M., Feenstra,I., Beynon,A.J.,
            Kunst,H.P., Snik,A.F., Kremer,H., Admiraal,R.J. and Pennings,R.J.
  TITLE     Similar phenotypes caused by mutations in OTOG and OTOGL
  JOURNAL   Ear Hear 35 (3), e84-e91 (2014)
   PUBMED   24378291
  REMARK    GeneRIF: Patients with OTOGL mutation show a flat to downsloping
            configuration of the audiogram with mild to moderate sensorineural
            hearing loss. Speech recognition scores remain good and vestibular
            hyporeflexia is present.
REFERENCE   5  (bases 1 to 9982)
  AUTHORS   Yariz,K.O., Duman,D., Zazo Seco,C., Dallman,J., Huang,M.,
            Peters,T.A., Sirmaci,A., Lu,N., Schraders,M., Skromne,I.,
            Oostrik,J., Diaz-Horta,O., Young,J.I., Tokgoz-Yilmaz,S.,
            Konukseven,O., Shahin,H., Hetterschijt,L., Kanaan,M., Oonk,A.M.,
            Edwards,Y.J., Li,H., Atalay,S., Blanton,S., Desmidt,A.A., Liu,X.Z.,
            Pennings,R.J., Lu,Z., Chen,Z.Y., Kremer,H. and Tekin,M.
  TITLE     Mutations in OTOGL, encoding the inner ear protein otogelin-like,
            cause moderate sensorineural hearing loss
  JOURNAL   Am J Hum Genet 91 (5), 872-882 (2012)
   PUBMED   23122586
  REMARK    GeneRIF: OTOGL mutations affect the production and/or function of
            acellular structures of the inner ear, which ultimately leads to
            sensorineural hearing loss.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC078817.18, AC092945.6 and
            AC083812.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Oct 20, 2020 this sequence version replaced NM_001378609.2.
            
            Summary: The protein encoded by this gene belongs to the otogelin
            family. This gene is expressed in the inner ear of vertebrates with
            the highest level of expression seen at the embryonic stage and
            lowest in adult. Knockdown studies in zebrafish suggest that this
            gene is essential for normal inner ear function. Mutations in this
            gene are associated with autosomal recessive deafness. [provided by
            RefSeq, Dec 2012].
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000547103.7/ ENSP00000447211.2
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AC078817.18        49705-49773
            70-167              AC078817.18        159581-159678
            168-207             AC078817.18        161015-161054
            208-256             AC078817.18        162117-162165
            257-323             AC078817.18        167766-167832
            324-422             AC078817.18        169982-170080
            423-577             AC078817.18        172259-172413
            578-699             AC092945.6         8627-8748
            700-905             AC092945.6         12262-12467
            906-1033            AC092945.6         18221-18348
            1034-1140           AC092945.6         18703-18809
            1141-1247           AC092945.6         31063-31169
            1248-1373           AC092945.6         31446-31571
            1374-1482           AC092945.6         32836-32944
            1483-1529           AC092945.6         33894-33940
            1530-1675           AC092945.6         34410-34555
            1676-1799           AC092945.6         35707-35830
            1800-1977           AC092945.6         37195-37372
            1978-2102           AC092945.6         41339-41463
            2103-2312           AC092945.6         44371-44580
            2313-2478           AC092945.6         45821-45986
            2479-2553           AC092945.6         46623-46697
            2554-2606           AC092945.6         49472-49524
            2607-2769           AC092945.6         51018-51180
            2770-2877           AC092945.6         57538-57645
            2878-3016           AC092945.6         58398-58536
            3017-3151           AC092945.6         76197-76331
            3152-3301           AC092945.6         82004-82153
            3302-3421           AC092945.6         84946-85065
            3422-3538           AC092945.6         89981-90097
            3539-3695           AC092945.6         92846-93002
            3696-3722           AC092945.6         93675-93701
            3723-3890           AC092945.6         97916-98083
            3891-4169           AC092945.6         99792-100070
            4170-4287           AC092945.6         103093-103210
            4288-4367           AC092945.6         108035-108114
            4368-4436           AC092945.6         108421-108489
            4437-4510           AC092945.6         112375-112448
            4511-4688           AC092945.6         115333-115510
            4689-4831           AC092945.6         115783-115925
            4832-4855           AC092945.6         116167-116190
            4856-4948           AC092945.6         116282-116374
            4949-5138           AC092945.6         118445-118634
            5139-5353           AC092945.6         121318-121532
            5354-5495           AC092945.6         131665-131806
            5496-5681           AC092945.6         132695-132880
            5682-5894           AC092945.6         135106-135318
            5895-5999           AC092945.6         135786-135890
            6000-6107           AC092945.6         136177-136284
            6108-6209           AC092945.6         137618-137719
            6210-6314           AC092945.6         138041-138145
            6315-6355           AC092945.6         138230-138270
            6356-6419           AC092945.6         145944-146007
            6420-6458           AC092945.6         146931-146969
            6459-6598           AC083812.24        160595-160734       c
            6599-6703           AC083812.24        160025-160129       c
            6704-6823           AC083812.24        157645-157764       c
            6824-6869           AC083812.24        156270-156315       c
            6870-6949           AC083812.24        151132-151211       c
            6950-9982           AC083812.24        147454-150486       c
FEATURES             Location/Qualifiers
     source          1..9982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q21.31"
     gene            1..9982
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="otogelin like"
                     /db_xref="GeneID:283310"
                     /db_xref="HGNC:HGNC:26901"
                     /db_xref="MIM:614925"
     exon            1..69
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            70..167
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..7150
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 3; otogelin-like protein"
                     /codon_start=1
                     /product="otogelin-like protein isoform 1 precursor"
                     /protein_id="NP_001365538.2"
                     /db_xref="CCDS:CCDS91730.1"
                     /db_xref="GeneID:283310"
                     /db_xref="HGNC:HGNC:26901"
                     /db_xref="MIM:614925"
                     /translation="MNIVRKLNLMIPWSIFLLHVLLFSLQEYICASSILMGTSKNGFN
                     ENRQKRALLAAQFEATSPRYFFHDAINWGESKIKGSCPYECLNGAFCSKTGTCDCQIF
                     QALGTRCQIIPNMGNGRDGICKTWGQYHFETFDGIYYYFPGNCSYIFAKDCGDLEPRY
                     TVWVHNSPKCLGSVYSCYRSISLFFSNQEEIRIYGHEIKKNGISLTLPQTIGQIFIEK
                     LADYILVKTTFGFSLAWDGISGIYLKLSEDHKGKSCGLCGNYNDIQSDDFIILQEDYT
                     EDIAMFANSWSVQTPDDTKCVLTPSDFPNPCSSGMPAFEAIFFKCQILLQFPFLSCHE
                     YIDPYLYIASCVNDLCKTDDDETYCRAATEYARACSHAGYPIQDWRDDFPACTDKCDD
                     SFVHRDCISCCPPTCTFEKQCLGSNLHCLDGCYCPDGLVMDNGTCISLENCPCGFHGL
                     AYSVGSKIEQECTECVCVGGVWNCTEQDCPVQCSVVGDSHFTTFDGRHYSFIGMCQYI
                     LVKGTGKDKFTITLQKAPCEQNLGLVCLQSITLILEDDFNKQVTLGRGGQILTSPNQG
                     FNLNGIVEIQTLSSLFILLKTTFGLKILFAIDGERIYIQLTSAWKRRTLGLCGTFNGN
                     IRDDFLSPSGMIEGTPQLHANAWRVSSTCFAPVHVPVVDPCNINQQNIGYAAHCDVIH
                     QELFAPCHIYISPGLYYQLCRHDACKCGSSCLCNALAHYAYLCGQHGVPIDFRTQISF
                     CAVVCQKGMLYHHCSSFCLHSCISLSSPEQCSDDCAEGCNCPEGKFYEDTLNFCVPIF
                     HCRCHYRGSVYQPGELIPTPSGLCQCSNGTVKCDELATPSAVHICPEGKEYFDCRFPD
                     PELPAGGVNCETTCANLAMNFTCTPSSPCISGCVCAPGMAEHRGKCYVPESCPCIWKD
                     WEYLSGEVIATPCYTCVCRRGMFNCTYYPCPAVCTIYGDRHYYSFDGLEYDYISDCQV
                     FLIKSADDSDISVIAQNKKCFDNDIVCSKSVLISVGDTEIYLNDTPYKQKQSGFFLEN
                     KSTYQLWKAGYYIVVYFPEKDITILWDRKTTIHIKVGPQWKNKLSGLCGNFDKCTSND
                     MTTSNNLEVRNARVFGDSWALGQCESPDETIKPCEAHQNKFPYAKKECSILYSDIFAS
                     CRNVIDVTSFAKNCHEDTCNCNLGGDCECLCTSIAAYAYKCCQEGISIHWRSSTVCSL
                     DCEYYNEGLGEGPYMLASYGQSGLVLGANMTSRSVFCLPRSSVHTSLFFYFMITPGLF
                     KEKVSSLALVSLESAERPNYFLYVHDNDTLSLELWEANSAFHRRATFFHHQGLWIPGY
                     SAFELYSKKGFFIIFTDSSVKASKYDDSEEFKHSSSFSIEEIQAAVPYRKMCEWRYEP
                     CATPCFKTCSDPEALACKFLPPVEGCLPYCPKNMILDEVTLKCVYPRDCIPVIPTEPT
                     LMPPAKPTVPMFTVWEMITPSDITVFDMLTPTTGLECEPQKFDPVYDCSQYICLNMEW
                     QLYNWSLNCPKDVEMPDCGFRGRPVQVNSDICCPEWECPCRCSMLSELSIITFDGNNA
                     ALYSMASYILVRIPGEIIVAHIEKCSMNQNGNSLKKLAPSGRISGLCFKKLNVTTPIH
                     KIIVNRLARKVEVDSIVVPLPFSSQELSIEDSGSMYVITTPAGLIIKWSHLTGIIDIH
                     FGFRFNLSSYTEGLCGICNEDPDDDLRMQNGTIITNMEDIGLFIESWEIEKSFEVTMR
                     RPVRNCTEHDCSQCIDLLNRRIFIPCHDKVSPEDFCEKMWINYTYFWNYECDALSAYV
                     ALCNKFDICIQWRTPDYCSLSCPEGKEYQPCVRPCEARTCLNQWFYGHTSCLNLREDC
                     VCKVGTILHRPHSAQCIPEKECACTDSEDQPRTAGEIWNGGIDECTLYKCLENGSIIP
                     IEPDCDEEPTPVCEREAEVVMGIIDKWTCCSKEVCGCDTTLCETSIPTCTNSQKLIVG
                     HSPLSCCPQYKCECDPLKCPSISTPECREDQFMIQVRQEEPCCFSPFCVCESCTKPVP
                     LCHDGEFLTVDLNSTHFCCPQYYCVCEPNLCPMPLLNCAEDMNLVKENVSGQCCPTWH
                     CECNCENLIMPTCEVGEFTAIDHNFQSDCGCIQYLCEKDDVCVFQEVSVLNPGQSMIK
                     YLEEDFCYAIECLEEKDNHTGFHTLNFTLVNCSKKCDVHQVYTPSPSDYGCCGTCKNV
                     SCKFHMENGTSVVYAVGSTWHYNCTTYECVKTDEGAIILNYTMVCPPFNETECKMNEG
                     IVKLYNEGCCKICKREERICQKVIIKSVIRKQDCMSQSPINVASCDGKCPSATIYNIN
                     IESHLRFCKCCRENGVRNLSVPLYCSGNGTEIMYTLQEPIDCTCQWN"
     exon            168..207
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            208..256
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            257..323
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            324..422
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            423..577
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            578..699
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            700..905
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1033
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1140
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1247
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1373
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1482
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1529
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1675
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1799
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1800..1977
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..2102
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2103..2312
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2478
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2479..2553
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2554..2606
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2769
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..2877
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            2878..3016
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3017..3151
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3301
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3302..3421
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3422..3538
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3695
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3696..3722
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3723..3890
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            3891..4169
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4170..4287
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4288..4367
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4368..4436
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4437..4510
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4511..4688
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4689..4831
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4832..4855
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4856..4948
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            4949..5138
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            5139..5353
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            5354..5495
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            5496..5681
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            5682..5894
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            5895..5999
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6000..6107
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6108..6209
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6210..6314
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6315..6355
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6356..6419
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6420..6598
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6599..6703
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6704..6823
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6824..6869
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6870..6949
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     exon            6950..9982
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8162..8167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="hexamer: AATAAA"
     polyA_site      8196
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="major polyA site"
     regulatory      8826..8831
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="hexamer: ATTAAA"
     polyA_site      8851
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
     regulatory      9964..9969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
                     /note="hexamer: AATAAA"
     polyA_site      9982
                     /gene="OTOGL"
                     /gene_synonym="C12orf64; DFNB84B"
ORIGIN      
        1 agaccttcag ataaaggagc tctcgaaata caacccataa ggaataaagc catagccagt
       61 gcttccctgg gggaaaggct acactgaaat gaacattgta agaaaactca atttaatgat
      121 accttggagt atattcttgc ttcatgtact gctgttttca ttacaagaat atatttgtgc
      181 atcgtctata ttgatgggaa catcaaaaaa cgggtttaat gaaaatcgac agaaaagagc
      241 tcttttagca gcacagtttg aagctacttc tccgagatac tttttccatg atgctattaa
      301 ttggggtgag agcaaaataa aaggttcttg tccttatgaa tgccttaatg gagctttctg
      361 ttctaagact ggaacatgtg actgtcaaat atttcaggct cttgggacaa gatgccagat
      421 catcccaaac atgggcaacg gcagagatgg gatttgtaaa acctggggac agtatcattt
      481 tgaaacattc gatggcatct actattactt cccaggaaac tgttcttaca tttttgcaaa
      541 ggactgtggt gatttggagc ctcggtacac tgtatgggtt cataacagcc ctaaatgcct
      601 tggttcggtg tattcttgtt atcggtcaat cagcttgttc ttttcaaacc aagaggaaat
      661 tcgaatttat ggtcatgaaa taaaaaagaa tggaatcagt ttaacattgc ctcagacaat
      721 tggacagatt ttcattgaga aactagctga ctacattctt gtgaaaacaa cctttggctt
      781 ttcattggct tgggacggga tatctgggat ctacctcaag ctgtctgagg accataaggg
      841 gaaatcatgt ggcctatgtg gaaactacaa tgacattcaa tctgatgatt tcataattct
      901 gcaagaggac tatacagaag acatcgctat gtttgcaaat agttggtcgg tgcaaactcc
      961 agatgacacc aaatgtgtac tcacaccctc agattttcca aatccgtgct ccagtggaat
     1021 gccagcattt gaggcaatct tcttcaagtg tcagatactg ttgcagtttc cttttctgag
     1081 ctgccatgag tatatcgatc catacttata tattgccagc tgtgttaatg atctttgcaa
     1141 aactgatgat gatgaaacct attgccgagc agccactgag tatgctagag cctgctctca
     1201 tgctggctac cctattcaag actggagaga tgactttcca gcatgcactg ataaatgtga
     1261 tgatagcttt gtccatcggg actgtatcag ttgttgtcca ccaacctgca catttgagaa
     1321 gcaatgtctt gggagcaatc tccattgtct tgatggatgt tactgcccag atggcctcgt
     1381 aatggacaat gggacttgca tctccttgga aaattgccca tgcggttttc atggattagc
     1441 ttattcagtt ggttcaaaaa ttgaacaaga atgtactgaa tgtgtgtgtg ttggtggagt
     1501 ttggaactgc actgagcaag actgtccagt tcaatgctca gttgtaggtg attctcactt
     1561 tacaactttt gatggtcgac attattcttt tattggcatg tgccaataca tcctcgtgaa
     1621 aggaactgga aaagataaat tcacgattac tttacagaaa gctccctgtg agcagaatct
     1681 tggcttggtc tgccttcagt ctataactct gattctggag gatgatttta acaaacaagt
     1741 gacccttggt aggggaggac aaattctcac tagtcctaac caaggcttca acctgaatgg
     1801 tattgttgaa attcaaactc tgtcatcctt atttatactt ctaaaaacca catttggttt
     1861 aaagattctg tttgctatag atggggaaag aatttatatt cagcttacta gcgcatggaa
     1921 aagaagaaca ttaggtctgt gtggcacttt taatggcaac ataagggatg attttctttc
     1981 tccatcaggc atgatagaag gtacaccaca acttcacgca aatgcgtgga gagtttcttc
     2041 tacctgtttt gcacctgttc atgtcccagt ggtggacccc tgtaacatca atcaacaaaa
     2101 cattgggtat gcagcacact gtgatgtcat ccaccaggag ctctttgctc cttgccacat
     2161 ctatattagc cctgggctgt actatcagct atgccgccac gatgcatgca agtgtggaag
     2221 ctcctgcctg tgcaatgctc ttgcccacta tgcctacctc tgcggccagc acggtgttcc
     2281 cattgatttc agaactcaga tttctttctg tgctgtggtg tgccagaagg gcatgctgta
     2341 ccatcactgt tcctcgttct gcctccattc ctgcatttct ctctcttccc cggagcagtg
     2401 cagtgatgac tgtgctgaag gctgtaattg tccggaaggc aaattctatg aagacactct
     2461 taacttttgt gtacccatat tccactgccg ttgtcattat aggggcagtg tttatcaacc
     2521 tggagagctc atccccacac cctcgggctt atgccagtgt tcaaatggga ctgtgaaatg
     2581 tgatgaatta gcaacgccct ctgctgttca catctgccca gagggaaaag agtatttcga
     2641 ctgcaggttt cctgaccctg aattaccagc tggtggtgtt aattgtgaga ctacatgtgc
     2701 aaacctagcc atgaacttca cctgcacccc atcctcaccc tgtataagtg gctgtgtttg
     2761 tgctccagga atggcagagc acagaggaaa gtgttatgtt cctgaaagct gcccatgtat
     2821 ttggaaagat tgggagtatc tctcaggaga agtgattgct acaccgtgtt acacctgcgt
     2881 ttgtcgacga ggaatgttca attgcacata ttatccatgc ccagcagtgt gcacaatata
     2941 cggggaccga cattattatt cttttgatgg actagaatat gactatatca gtgattgcca
     3001 ggtgtttttg ataaagagtg cagatgattc agatatatct gtcattgccc agaacaagaa
     3061 atgctttgac aacgatattg tttgttctaa aagtgttttg atttcagttg gggacactga
     3121 aatttacctg aatgatactc cttacaaaca gaaacaatca ggtttttttc tggaaaacaa
     3181 atctacctac cagctttgga aggctggtta ctatatagta gtatactttc cagagaaaga
     3241 tatcactatt ctttgggata ggaagacaac tattcatatc aaagttgggc cacagtggaa
     3301 gaacaagcta tcaggattgt gtggaaactt tgacaaatgc acttcaaatg atatgaccac
     3361 atctaataac ttggaagtga gaaatgctcg ggtatttgga gatagttggg cattaggaca
     3421 gtgtgaaagt ccagatgaaa caattaaacc ctgtgaggca catcaaaaca aatttcctta
     3481 tgccaagaaa gaatgctcca ttttgtacag tgatattttt gcttcttgtc gcaatgtgat
     3541 tgacgttact tcttttgcca aaaattgtca tgaagataca tgtaactgca atcttggtgg
     3601 cgactgtgag tgtttgtgca ctagtatagc tgcatatgca tacaagtgtt gtcaggaagg
     3661 aatatcaatt cattggagat catctactgt ttgttcactt gattgtgaat actacaatga
     3721 aggacttgga gaaggaccat atatgctggc aagctatggg cagagtggcc ttgttctggg
     3781 ggccaatatg accagcagaa gcgttttctg tttgccgaga agcagtgttc ataccagttt
     3841 atttttttat tttatgatca ctccaggcct tttcaaagag aaggtatcat cattagcact
     3901 tgtttccttg gaatctgctg aaaggccaaa ctactttctc tatgtccatg acaatgatac
     3961 tcttagcttg gagctgtggg aggcgaattc agcctttcat cggagagcaa catttttcca
     4021 ccatcagggc ctctggattc ctggttacag tgcatttgag ttatacagca agaaaggctt
     4081 tttcatcata ttcacagatt ctagtgtcaa agcatcaaaa tatgatgatt ctgaagaatt
     4141 taaacattca agtagcttca gcatagaaga aatccaggca gcagtgcctt acaggaagat
     4201 gtgtgaatgg agatatgaac cttgtgctac accctgtttt aaaacatgta gtgaccctga
     4261 agcactagca tgtaaatttc ttccaccggt tgaaggatgc ttgccctact gccctaaaaa
     4321 tatgatcctt gatgaggtca ccctcaagtg tgtttatcca cgagactgta tacctgtgat
     4381 tcccacagaa ccaacattaa tgccaccagc taagccaact gtgcccatgt ttacagtttg
     4441 ggaaatgatt actccatcag acatcactgt gtttgatatg ctaacaccaa ctacaggctt
     4501 ggaatgtgag cctcagaaat ttgatcctgt ttatgattgt agccaataca tatgccttaa
     4561 tatggaatgg cagttataca actggtccct taattgccca aaggacgtgg aaatgcctga
     4621 ctgtggtttc cgaggaaggc cagttcaagt gaacagtgat atctgctgcc ctgagtggga
     4681 atgtccttgt cggtgttcca tgttgtcaga actgagcatt attacatttg atggaaacaa
     4741 cgcagcatta tatagcatgg cttcttatat cttagtaaga attcctggtg aaattatagt
     4801 tgctcatatc gaaaaatgtt ccatgaatca gaatggaaac tccttaaaaa agctagctcc
     4861 ctctggaaga atctctggac tttgttttaa gaagttaaat gtgacaacac ccatacataa
     4921 aataattgtc aatcggttgg caagaaaggt agaagtggat tccattgttg tgcctttgcc
     4981 cttttcaagt caggaactgt ccatagagga ttctggttca atgtatgtaa ttactactcc
     5041 agctggacta atcataaagt ggtctcatct tacaggaatc atagacattc attttggctt
     5101 ccgatttaac ttgtcatcct acacagaagg actctgtgga atttgcaatg aagatccgga
     5161 tgatgatcta aggatgcaaa atggcacaat tattacaaat atggaagaca taggattatt
     5221 tattgagagc tgggaaattg agaaatcatt tgaagtaaca atgagaagac ctgttaggaa
     5281 ttgtactgag catgattgca gccagtgcat tgatttatta aatagaagaa ttttcattcc
     5341 atgtcatgat aaagtttcac cggaagactt ttgtgaaaag atgtggatca attataccta
     5401 tttttggaac tatgaatgtg atgcactttc tgcatatgtg gctctgtgca acaagtttga
     5461 tatctgtatt cagtggagaa cacctgatta ctgctccctg agttgcccag aggggaagga
     5521 atatcaaccc tgtgtgcgac cttgtgaagc aagaacatgc ctgaaccaat ggttctatgg
     5581 acacacttcc tgtttgaatc taagagaaga ctgtgtgtgc aaagttggaa ctattcttca
     5641 caggccacat tcagcccagt gcattccaga gaaagagtgt gcatgcactg atagtgaaga
     5701 ccaaccccgc actgctgggg agatttggaa tgggggcatt gatgaatgca ctctatacaa
     5761 atgtttggag aatggaagca ttatccctat agaacctgac tgtgatgaag agcccacgcc
     5821 agtttgtgaa cgagaagctg aagttgtcat gggcatcatt gataaatgga cctgctgttc
     5881 aaaggaagtt tgtggatgtg acacgacttt gtgtgaaact agcattccaa catgtacaaa
     5941 tagtcaaaaa ttgattgttg gccacagtcc tctttcttgc tgtccacagt acaaatgtga
     6001 atgtgaccca ttgaaatgcc ccagtatttc aacaccagaa tgcagagaag atcaattcat
     6061 gattcaagtt cgacaggaag aaccttgttg tttttcccct ttttgtgttt gtgaatcttg
     6121 caccaaacct gttccactat gtcatgatgg ggaatttctc acagtagatc ttaatagcac
     6181 acacttctgt tgtcctcagt attactgtgt atgtgaacca aacctttgtc ctatgccatt
     6241 actcaactgt gcagaagata tgaatcttgt gaaagaaaat gtatctggtc aatgttgccc
     6301 aacatggcac tgtgaatgta actgtgaaaa ccttattatg ccaacttgtg aagtgggaga
     6361 atttactgca atagaccata acttccagag tgattgtgga tgcatacagt atctctgtga
     6421 aaaggatgat gtgtgtgtat ttcaagaagt atcagtattg aatcctggac aatccatgat
     6481 aaagtatttg gaagaagact tttgttatgc tatagagtgt ctggaagaaa aagataacca
     6541 tacgggcttt cacactctga attttacact ggtgaattgt tcaaaaaaat gtgatgttca
     6601 ccaggtatat actccatccc caagtgatta tggttgttgt ggtacctgca aaaatgtatc
     6661 ctgcaaattt cacatggaaa atggaacatc agttgtatac gcggtaggga gtacctggca
     6721 ctacaattgc accacatatg aatgtgttaa aactgatgaa ggagcaataa ttctgaacta
     6781 cacaatggtc tgtccccctt ttaatgagac tgaatgcaaa atgaatgaag ggattgtgaa
     6841 gctttataat gaaggctgtt gcaagatctg caaacgagaa gaaagaatat gccagaaagt
     6901 gatcattaaa tcggtcataa ggaaacagga ctgtatgagc caaagcccta taaatgttgc
     6961 atcttgtgac ggcaaatgcc catcagctac catatataac atcaatattg aaagtcacct
     7021 aagattctgc aagtgttgtc gtgaaaatgg agtacgaaac ttgtctgtgc ctctgtattg
     7081 ctcaggaaat ggcactgaaa ttatgtacac tctccaggaa cccatagact gtacgtgcca
     7141 gtggaattaa acccttgggt tccaagagct ctatacaaca tcataacgtc agatagaatt
     7201 aacttttatt gctattactt aggcatgtgg cagatttatg ctgtttaaca atactgtatt
     7261 tttcagactt ggaatgtgga aatttagcaa tttgtacaaa atatatacag tttcaatagc
     7321 aaaattaaat ttattgcttt actctatttt agaaaatcaa atgactgtaa gttgttcagc
     7381 tgaaatgctg ttatgtattt aattacaact tggtgcagat acagtatatt ctcatcaact
     7441 ggaaggttat tttgcaaaat tccttcaatt tcactcagta gctctttttt tcttaatttg
     7501 caaagtctgc tatagctatc caaattaagg taccctttaa tatgtactcc ttaatctggt
     7561 aaatgtgatc agttaaaatt gtcatctaga tagcaataaa gagtgatatg cttagagata
     7621 gataatggat tatttaaaac ctgaatggtt tatagagaag tcattataaa ttcccctcat
     7681 tttgcaggtg taacagataa ccagagaagc tgtgtgactc gtacaaattt attcagtgta
     7741 ataatatagt aaattcatgt taacagttgg attaaatcct agctctctct tattccagta
     7801 ctatatcact tttaaaatcc tgagcagtat gtagtaagag tatatcacag aatctttcat
     7861 tcttaaagag tttgcattgg atagaattaa gtattttaag tttaacatat ttgaaaaatg
     7921 ccccccatac attgttattc caatagtaag gagcagggaa atatagcatc atttgctaaa
     7981 tagaggagat agatcttgaa ctgttatttt ttatataatt aaaactgcta ttaaatgtgt
     8041 tgtcagtatt taacatttag ttactgtctc attaatattt aattttgagg atgtacttgc
     8101 atactgttga agttgagtgc tgttttgctg ttaatgctgc tgctttgcca atgaagaatg
     8161 aaataaattt atctgaatgt atcaataact ttaaaatgga atgctgcact tttaaaatat
     8221 ggtagattat tgacatttgc aagaagaatg tattgaggtc tttggaaatg cccaaattct
     8281 ttgccaccta taattaaaaa ttgtctgaat tttctcctca gtataaagga gtgaatgccc
     8341 tacttagtgt aattgtatca agtgaagtca aacatcaaca aaagaacagt aaagtctcat
     8401 tgcaaagcag atactgggcc tcaagggtgg gcttaggctt aaactagatt atctgctttc
     8461 atatactaat gttttcattt caaaatcatg tgtccccaaa atattgcaac ttactgaata
     8521 ttttagatct cttgggttac ttaaatatgt gtgaaaaaat caacattgca tctgcaaatc
     8581 ccagtgttta ctgtatatgc aattgattta tcctgtttgt gcttaatata agtgttcctg
     8641 agatgttaac atttcaatat tctctgattc ctattaacat atagatatat aaaattaaat
     8701 gtttttggtt aaaatatatt aatatttcac ttaagagaaa atgttatgta tttcaaatag
     8761 aagtaactaa tgttgtatat tatctattgc ccatttttat ttccattttc tgtaaaatat
     8821 tcattattaa aaatattaag taatctttaa acctatttgt ggagaaatgg gaaacattct
     8881 cctagaactt tataaacatt caacaaatac agcaaataag catttagggc ctacatgtgc
     8941 caggcactat tataaactct tgggacacag gcaaaactaa acagacacag tcctaactcc
     9001 cttaattctt agagtctagc aagaaagcag gccttaaata gccatacata tgatatgaga
     9061 atgtccagaa agagatccca aaacttatta gaatgtggca tatcataaag atgactctga
     9121 aatcagtgga agagtgcaaa ttagctctta ataaatggtg ttgggacaac tgaatggtta
     9181 cgtagataaa gaaaaatttg aattcataca tccattgaca ttaggataac ctccaaatga
     9241 atcagagatt taaatgttaa aaaacaaaag aagataggag ttacaaaaga aaatagggaa
     9301 gaaatcttag attggggaga gccattctaa ttgtgactca gtatccagat accccaaata
     9361 aatgattcat agatttaaca gttagaaaac tgaaaacaga caaattctgc ttggtagaaa
     9421 aaagtcaaaa aaagataaaa gcaaagaaac aatatttgtg acatatcagt gacacagtct
     9481 aatcctcctg tatgtaaaga actcttgaaa aaaataacaa aaggaaaaaa ttaacaacct
     9541 gatagaaaaa tgagccaaag atataaactg atagttgaaa gaaaaataag taagactagt
     9601 ggatccttta acaaaaaaga taactgagca cacttctagc taataaaaaa tatttcacat
     9661 tcaatctaca gaaattcaat ttctcaccta ccagactggt aaaaaaccag aagtttaatg
     9721 atacttttat tttttaaggc tctgggaaga taagcactct cacatgtcat tgatggtaac
     9781 acaaaattgt agaaatccta gggaaaacct agaaatgtat actaatatta gaagtgattt
     9841 ttggtttgac caaactgcct agaatatata tgccgtacaa acgcctgtac aaatacaaag
     9901 tggtatttgt gaaggttatt aattgcagca ttgtttgtaa tagaaaaaaa ccaacaatag
     9961 ttgaataaac tacgttaatc ca
//
