LOCUS       NM_001292063            8956 bp    mRNA    linear   PRI 01-JUL-2024
DEFINITION  Homo sapiens otogelin (OTOG), transcript variant 2, mRNA.
ACCESSION   NM_001292063
VERSION     NM_001292063.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8956)
  AUTHORS   Parra-Perez,A.M., Gallego-Martinez,A. and Lopez-Escamez,J.A.
  TITLE     An overload of missense variants in the OTOG gene may drive a
            higher prevalence of familial Meniere disease in the European
            population
  JOURNAL   Hum Genet 143 (3), 423-435 (2024)
   PUBMED   38519595
  REMARK    GeneRIF: An overload of missense variants in the OTOG gene may
            drive a higher prevalence of familial Meniere disease in the
            European population.
REFERENCE   2  (bases 1 to 8956)
  AUTHORS   Askari,M., Moradi,Z., Mohammadi,M., Lagzian,M. and Asgharzade,S.
  TITLE     Prediction and interpretation of rare missense variant in OTOG
            associated with hearing loss
  JOURNAL   Genomics 113 (4), 2793-2799 (2021)
   PUBMED   34118384
  REMARK    GeneRIF: Prediction and interpretation of rare missense variant in
            OTOG associated with hearing loss.
REFERENCE   3  (bases 1 to 8956)
  AUTHORS   Roman-Naranjo,P., Gallego-Martinez,A., Soto-Varela,A., Aran,I.,
            Moleon,M.D.C., Espinosa-Sanchez,J.M., Amor-Dorado,J.C.,
            Batuecas-Caletrio,A., Perez-Vazquez,P. and Lopez-Escamez,J.A.
  TITLE     Burden of Rare Variants in the OTOG Gene in Familial Meniere's
            Disease
  JOURNAL   Ear Hear 41 (6), 1598-1605 (2020)
   PUBMED   33136635
  REMARK    GeneRIF: Burden of Rare Variants in the OTOG Gene in Familial
            Meniere's Disease.
REFERENCE   4  (bases 1 to 8956)
  AUTHORS   Yu,S., Choi,H.J., Lee,J.S., Lee,H.J., Rim,J.H., Choi,J.Y., Gee,H.Y.
            and Jung,J.
  TITLE     A novel early truncation mutation in OTOG causes prelingual mild
            hearing loss without vestibular dysfunction
  JOURNAL   Eur J Med Genet 62 (1), 81-84 (2019)
   PUBMED   29800624
  REMARK    GeneRIF: A novel truncation mutation in OTOG gene is associated
            with prelingual mild hearing loss without vestibular dysfunction.
REFERENCE   5  (bases 1 to 8956)
  AUTHORS   Oonk,A.M., Leijendeckers,J.M., Huygen,P.L., Schraders,M., del
            Campo,M., del Castillo,I., Tekin,M., Feenstra,I., Beynon,A.J.,
            Kunst,H.P., Snik,A.F., Kremer,H., Admiraal,R.J. and Pennings,R.J.
  TITLE     Similar phenotypes caused by mutations in OTOG and OTOGL
  JOURNAL   Ear Hear 35 (3), e84-e91 (2014)
   PUBMED   24378291
  REMARK    GeneRIF: Patients with OTOG mutation show a flat to downsloping
            configuration of the audiogram with mild to moderate sensorineural
            hearing loss. Speech recognition scores remain good and vestibular
            hyporeflexia is present.
REFERENCE   6  (bases 1 to 8956)
  AUTHORS   Kirwan,J.D., Bekaert,M., Commins,J.M., Davies,K.T., Rossiter,S.J.
            and Teeling,E.C.
  TITLE     A phylomedicine approach to understanding the evolution of auditory
            sensory perception and disease in mammals
  JOURNAL   Evol Appl 6 (3), 412-422 (2013)
   PUBMED   23745134
REFERENCE   7  (bases 1 to 8956)
  AUTHORS   Schraders,M., Ruiz-Palmero,L., Kalay,E., Oostrik,J., del
            Castillo,F.J., Sezgin,O., Beynon,A.J., Strom,T.M., Pennings,R.J.,
            Zazo Seco,C., Oonk,A.M., Kunst,H.P., Dominguez-Ruiz,M.,
            Garcia-Arumi,A.M., del Campo,M., Villamar,M., Hoefsloot,L.H.,
            Moreno,F., Admiraal,R.J., del Castillo,I. and Kremer,H.
  TITLE     Mutations of the gene encoding otogelin are a cause of
            autosomal-recessive nonsyndromic moderate hearing impairment
  JOURNAL   Am J Hum Genet 91 (5), 883-889 (2012)
   PUBMED   23122587
  REMARK    GeneRIF: study reports the identification of mutations in OTOG as a
            cause of moderate nonsyndromic hearing loss
REFERENCE   8  (bases 1 to 8956)
  AUTHORS   Simmler,M.C., Cohen-Salmon,M., El-Amraoui,A., Guillaud,L.,
            Benichou,J.C., Petit,C. and Panthier,J.J.
  TITLE     Targeted disruption of otog results in deafness and severe
            imbalance
  JOURNAL   Nat Genet 24 (2), 139-143 (2000)
   PUBMED   10655058
REFERENCE   9  (bases 1 to 8956)
  AUTHORS   Cohen-Salmon,M., Mattei,M.G. and Petit,C.
  TITLE     Mapping of the otogelin gene (OTGN) to mouse chromosome 7 and human
            chromosome 11p14.3: a candidate for human autosomal recessive
            nonsyndromic deafness DFNB18
  JOURNAL   Mamm Genome 10 (5), 520-522 (1999)
   PUBMED   10337628
REFERENCE   10 (bases 1 to 8956)
  AUTHORS   Cohen-Salmon,M., El-Amraoui,A., Leibovici,M. and Petit,C.
  TITLE     Otogelin: a glycoprotein specific to the acellular membranes of the
            inner ear
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14450-14455 (1997)
   PUBMED   9405633
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124799.5 and KC877393.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 3, 2019 this sequence version replaced NM_001292063.1.
            
            Summary: The protein encoded by this gene is a component of the
            acellular membranes of the inner ear. Disruption of the orthologous
            mouse gene shows that it plays a role in auditory and vestibular
            functions. It is involved in fibrillar network organization, the
            anchoring of otoconial membranes and cupulae to the neuroepithelia,
            and likely in sound stimulation resistance. Mutations in this gene
            cause autosomal recessive nonsyndromic deafness, type 18B.
            Alternative splicing of this gene results in multiple transcript
            variants. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (2) uses two alternate splice
            sites and includes an additional exon, which together result in an
            alternate in-frame segment in the 5' coding region, compared to
            variant 1. The encoded isoform (b) is shorter than isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            CCDS Note: This CCDS representation lacks full-length human
            transcript support. Its exon combination is therefore inferred, but
            it is supported by the full-length orthologous mouse transcript
            U96411.1, by partial human transcript alignments, and by data in
            PMID:23122587.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            inferred exon combination        :: based on alignments, homology
            MANE Ensembl match               :: ENST00000399397.6/
                                                ENSP00000382329.2
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-208               AC124799.5         58135-58342
            209-269             AC124799.5         58803-58863
            270-330             AC124799.5         59028-59088
            331-406             AC124799.5         62876-62951
            407-499             AC124799.5         63995-64087
            500-654             AC124799.5         64241-64395
            655-773             AC124799.5         66655-66773
            774-979             AC124799.5         67994-68199
            980-1110            AC124799.5         69061-69191
            1111-1217           AC124799.5         69414-69520
            1218-1327           AC124799.5         69928-70037
            1328-1456           AC124799.5         70410-70538
            1457-1565           KC877393.1         385-493             c
            1566-1612           KC877393.1         65-111              c
            1613-1758           AC124799.5         72538-72683
            1759-1891           AC124799.5         80032-80164
            1892-2069           AC124799.5         81089-81266
            2070-2194           AC124799.5         82956-83080
            2195-2407           AC124799.5         83954-84166
            2408-2600           AC124799.5         85596-85788
            2601-2675           AC124799.5         87432-87506
            2676-2719           AC124799.5         87744-87787
            2720-2873           AC124799.5         89249-89402
            2874-2981           AC124799.5         97350-97457
            2982-3120           AC124799.5         102326-102464
            3121-3255           AC124799.5         104069-104203
            3256-3402           AC124799.5         104486-104632
            3403-3522           AC124799.5         104923-105042
            3523-3639           AC124799.5         106914-107030
            3640-3796           AC124799.5         107727-107883
            3797-3823           AC124799.5         110547-110573
            3824-3991           AC124799.5         113086-113253
            3992-4270           AC124799.5         116733-117011
            4271-4388           AC124799.5         119172-119289
            4389-4468           AC124799.5         120006-120085
            4469-6237           AC124799.5         120531-122299
            6238-6406           AC124799.5         123038-123206
            6407-6552           AC124799.5         123496-123641
            6553-6642           AC124799.5         124488-124577
            6643-6826           AC124799.5         140009-140192
            6827-7047           AC124799.5         142578-142798
            7048-7186           AC124799.5         142964-143102
            7187-7381           AC124799.5         144556-144750
            7382-7594           AC124799.5         144945-145157
            7595-7699           AC124799.5         145720-145824
            7700-7807           AC124799.5         145956-146063
            7808-7909           AC124799.5         146486-146587
            7910-8008           AC124799.5         149327-149425
            8009-8049           AC124799.5         150299-150339
            8050-8125           AC124799.5         151621-151696
            8126-8304           AC124799.5         151789-151967
            8305-8409           AC124799.5         152723-152827
            8410-8529           AC124799.5         153003-153122
            8530-8575           AC124799.5         154337-154382
            8576-8655           AC124799.5         156440-156519
            8656-8956           AC124799.5         156620-156920
FEATURES             Location/Qualifiers
     source          1..8956
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..8956
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /note="otogelin"
                     /db_xref="GeneID:340990"
                     /db_xref="HGNC:HGNC:8516"
                     /db_xref="MIM:604487"
     exon            1..208
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..8856
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /note="isoform b precursor is encoded by transcript
                     variant 2"
                     /codon_start=1
                     /product="otogelin isoform b precursor"
                     /protein_id="NP_001278992.1"
                     /db_xref="CCDS:CCDS59225.2"
                     /db_xref="GeneID:340990"
                     /db_xref="HGNC:HGNC:8516"
                     /db_xref="MIM:604487"
                     /translation="MGVLASALCWLLCVWLPWGEQAAESLRVQRLAAAPVLWGSAEPQ
                     PEPAGQPSSSHQEATLAMGDKATVVGGQQAEAPDSVAMSSWERRLHRAKCAPSYLFSC
                     FNGGECVHPAFCDCRRFNATGPRCQMVYNAGPERDSICRAWGQHHVETFDGLYYYLSG
                     KGSYTLVGRHEPEGQSFSIQVHNDPQCGSSPYTCSRAVSLFFVGEQEIHLAKEVTHGG
                     MRVQLPHVMGSARLQQLAGYVIVRHQSAFTLAWDGASAVYIKMSPELLGWTHGLCGNN
                     NADPKDDLVTSSGKLTDDVVEFVHSWQEQAPNQPPGPTTSSLPRPPCLQQNPGTMQGV
                     YEQCEALLRPPFDACHAYVSPLPFTASCTSDLCQSMGDVATWCRALAEYARACAQAGR
                     PLQGWRTQLRQCTVHCKEKAFTYNECIACCPASCHPRASCVDSEIACVDGCYCPNGLI
                     FEDGGCVAPAECPCEFHGTLYPPGSVVKEDCNTCTCTSGKWECSTAVCPAECSVTGDI
                     HFTTFDGRRYTFPATCQYILAKSRSSGTFTVTLQNAPCGLNQDGACVQSVSVILHQDP
                     RRQVTLTQAGDVLLFDQYKIIPPYTDDAFEIRRLSSVFLRVRTNVGVRVLYDREGLRL
                     YLQVDQRWVEDTVGLCGTFNGNTQDDFLSPVGVPESTPQLFGNSWKTLSACSPLVSGS
                     PLDPCDVHLQAASYSVQACSVLTGEMFAPCSAFLSPVPYFEQCRRDACRCGQPCLCAT
                     LAHYAHLCRRHGLPVDFRARLPACALSCEASKEYSPCVAPCGRTCQDLASPEACGVDG
                     GDDLSRDECVEGCACPPDTYLDTQADLCVPRNQCSCHFQGVDYPPGDSDIPSLGHCHC
                     KDGVMSCDSRAPAAACPAGQVFVNCSDLHTDLELSRERTCEQQLLNLSVSARGPCLSG
                     CACPQGLLRHGDACFLPEECPCTWKGKEYFPGDQVMSPCHTCVCQRGSFQCTLHPCAS
                     TCTAYGDRHYRTFDGLPFDFVGACKVHLVKSTSDVSFSVIVENVNCYSSGMICRKFIS
                     INVGNSLIVFDDDSGNPSPESFLDDKQEVHTWRVGFFTLVHFPQEHITLLWDQRTTVH
                     VQAGPQWQGQLAGLCGNFDLKTINEMRTPENLELTNPQEFGSSWAAVECPDTLDPRDM
                     CVLNPLREPFAKKECSILLSEVFEICHPVVDVTWFYSNCLTDTCGCSQGGDCECFCAS
                     VSAYAHQCCQHGVAVDWRTPRLCPYDCDFFNKVLGKGPYQLSSLAAGGALVGMKAVGD
                     DIVLVRTEDVAPADIVSFLLTAALYKAKAHDPDVVSLEAADRPNFFLHVTANGSLELA
                     KWQGRDTFQQHASFLLHRGTRQAGLVALESLAKPSSFLYVSGAVLALRLYEHTEVFRR
                     GTLFRLLDAKPSGAAYPICEWRYDACASPCFQTCRDPRAASCRDVPRVEGCVPVCPTP
                     QVLDEVTQRCVYLEDCVEPAVWVPTEALGNETLPPSQGLPTPSDEEPQLSQESPRTPT
                     HRPALTPAAPLTTALNPPVTATEEPVVSPGPTQTTLQQPLELTASQLPAGPTESPASK
                     GVTASLLAIPHTPESSSLPVALQTPTPGMVSGAMETTRVTVIFAGSPNITVSSRSPPA
                     PRFPLMTKAVTVRGHGSLPVRTTPPQPSLTASPSSRPVASPGAISRSPTSSGSHKAVL
                     TPAVTKVISRTGVPQPTQAQSASSPSTPLTVAGTAAEQVPVSPLATRSLEIVLSTEKG
                     EAGHSQPMGSPASPQPHPLPSAPPRPAQHTTMATRSPALPPETPAAASLSTATDGLAA
                     TPFMSLESTRPSQLLSGLPPDTSLPLAKVGTSAPVATPGPKASVITTPLQPQATTLPA
                     QTLSPVLPFTPAAMTQAHPPTHIAPPAAGTAPGLLLGATLPTSGVLPVAEGTASMVSV
                     VPRKSTTGKVAILSKQVSLPTSMYGSAEGGPTELTPATSHPLTPLVAEPEGAQAGTAL
                     PVPTSYALSRVSARTAPQDSMLVLLPQLAEAHGTSAGPHLAAEPVDEATTEPSGRSAP
                     ALSIVEGLAEALATTTEANTSTTCVPIAEQDCVRHICLEGQLIRVNQSQHCPQGAAPP
                     RCGILGLAVRVGGDRCCPLWECACRCSIFPDLSFVTFDGSHVALFKEAIYILSQSPDE
                     MLTVHVLDCKSANLGHLNWPPFCLVMLNMTHLAHQVTIDRFNRKVTVDLQPVWPPVSR
                     YGFRIEDTGHMYMILTPSDIQIQWLHSSGLMIVEASKTSKAQGHGLCGICDGDAANDL
                     TLKDGSVVGGAEDPAPFLDSWQVPSSLTSVGQTRFRPDSCATTDCSPCLRMVSNRTFS
                     ACHRFVPPESFCELWIRDTKYVQQPCVALTVYVAMCHKFHVCIEWRRSDYCPFLCSSD
                     STYQACVTACEPPKTCQDGILGPLDPEHCQVLGEGCVCSEGTILHRRHSALCIPEAKC
                     ACTDSMGVPRALGETWNSSLSGCCQHQCQAPDTIVPVDLGCPSPRPESCLRFGEVALL
                     LPTKDPCCLGTVCVCNQTLCEGLAPTCRPGHRLLTHFQEDSCCPSYSCECDPDLCEAE
                     LVPSCRQDQILITGRLGDSCCTSYFCACGDCPDSIPECQEGEALTVHRNTTELCCPLY
                     QCVCENFRCPQVQCGLGTALVEVWSPDRCCPYKSCECDCDTIPVPRCHLWEKSQLDEE
                     FMHSVENVCGCAKYECVKAPVCLSRELGVMQPGQTVVELSADGVCHTSRCTTVLDPLT
                     NFYQINTTSVLCDIHCEANQEYEHPRDLAACCGSCRNVSCLFTFPNGTTSLFLPGASW
                     IADCARHHCSSTPLGAVLVRSPISCPPLNETECAKVGGSVVPSLEGCCRTCKEDGRSC
                     KKVTIRMTIRKNECRSSTPVNLVSCDGRCPSASIYNYNINTYARFCKCCREVGLQRRS
                     VQLFCATNATWVPYTVQEPTDCACQWS"
     exon            209..269
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            270..330
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            331..406
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            407..499
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            500..654
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            655..773
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            774..979
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1110
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1217
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1327
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1456
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1565
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1566..1612
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1758
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1891
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2069
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..2194
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2195..2407
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2600
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2601..2675
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2719
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2873
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2874..2981
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3120
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3121..3255
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3256..3402
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3522
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3523..3639
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3640..3796
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3797..3823
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3991
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            3992..4270
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            4271..4388
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4468
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            4469..6237
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            6238..6406
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            6407..6552
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            6553..6642
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            6643..6826
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            6827..7047
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7048..7186
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7187..7381
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7382..7594
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7595..7699
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7700..7807
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7808..7909
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            7910..8008
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8009..8049
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8050..8125
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8126..8304
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8305..8409
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8410..8529
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8530..8575
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8576..8655
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     exon            8656..8956
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8936..8941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /note="hexamer: ATTAAA"
     polyA_site      8956
                     /gene="OTOG"
                     /gene_synonym="DFNB18B; MLEMP; OTGN"
                     /note="major polyA site"
ORIGIN      
        1 atgagaacaa gagggacctc ggctgcggag tggaggtgtg accctgcctt agcccgggga
       61 ggcacctcgg gaggctggcc ctgcgctcaa gtcctccggt cccctcgtgt ccctatggga
      121 gtcctggcgt ctgcgctctg ctggctgctt tgtgtctggc tgccctgggg tgagcaggca
      181 gccgagtccc tgcgggtgca gcgcctcgcc gcagcacccg ttctgtgggg cagtgcagag
      241 ccacagccag agccagccgg gcaacccagc agcagccacc aggaggcgac ccttgccatg
      301 ggggacaagg ctacagtcgt gggaggccag caggctgaag ccccagactc cgtggccatg
      361 tcttcctggg aaaggcggct ccatcgggcc aagtgtgcac catcctactt gttctcctgc
      421 ttcaatggag gcgagtgtgt gcacccagcc ttctgtgact gcagacgctt caatgccact
      481 ggaccgcgct gccagatggt gtacaatgcc ggccctgaga gggacagcat ttgccgggcg
      541 tgggggcagc accacgtgga gacatttgat gggctctact actacctctc cggaaagggc
      601 agctacaccc tggtgggtcg ccatgagccc gagggacaga gcttctccat ccaggtacac
      661 aatgacccgc agtgtggctc ttcaccctac acctgctcca gggctgtcag cctcttcttt
      721 gtgggtgagc aggagatcca tctggccaag gaggtcaccc atggaggcat gagggtccaa
      781 ctgccacatg tcatggggag cgcgcgtctg cagcagcttg ccggctatgt catcgtgcgg
      841 catcagtcag ccttcacact ggcctgggat ggtgcctcgg ctgtctacat caagatgagt
      901 ccagagcttc tgggctggac ccatgggctg tgtgggaaca acaatgctga ccccaaggat
      961 gatctggtga ccagctctgg gaagctgact gacgacgtgg ttgagtttgt gcacagctgg
     1021 caggagcagg cccctaacca gcctccaggg cccacaactt cctccctgcc tcgcccaccg
     1081 tgcctacagc agaacccagg aaccatgcag ggcgtgtacg agcagtgtga ggctctactg
     1141 cggcccccct ttgacgcctg ccacgcctac gtcagccctc tgcccttcac agccagttgt
     1201 accagtgatc tctgccaatc aatgggtgat gtagccacct ggtgccgggc actggcggag
     1261 tatgcccggg cgtgtgccca ggcagggcgg cccttgcaag gctggaggac ccagctccgg
     1321 caatgcactg tgcactgcaa ggagaaggcc tttacctaca atgagtgcat cgcctgctgc
     1381 cctgcctcct gccatccccg ggcatcctgt gtggacagtg agatcgcctg tgtggacggc
     1441 tgctattgcc ccaatgggct catcttcgag gatgggggct gcgtggcacc agctgagtgt
     1501 ccctgtgagt ttcacgggac tctgtaccca cctggctctg tggtgaagga agactgcaat
     1561 acttgcacat gcacctcagg caagtgggag tgcagcacag ctgtctgccc agctgagtgc
     1621 tcagtgactg gtgacattca cttcacaacc tttgatggcc gccggtacac gttccccgcc
     1681 acatgtcagt acatcctggc caagagccgc tcttcgggca ccttcaccgt gacattgcag
     1741 aatgccccat gtggcctgaa ccaagatgga gcctgtgtcc agtcagtgtc agtgattctg
     1801 caccaggacc ctcggaggca ggtgaccctg acccaggcag gggatgtcct tctgtttgac
     1861 cagtacaaga tcatcccgcc atacacagat gatgcctttg agatccgtag gctgtcctcc
     1921 gtgttcctgc gggtgaggac gaacgtgggc gtgcgggtgc tctacgaccg tgaagggctc
     1981 cgactgtacc tgcaagtgga ccagcgatgg gtggaggata ccgtgggcct ctgcggcacc
     2041 ttcaatggca acacgcagga tgacttcctg tctccagtgg gtgtacctga gagcacccca
     2101 caactttttg gcaattcctg gaaaacactt tctgcttgct ccccgctggt ctctggctcc
     2161 cctctggacc cctgcgatgt gcacctgcaa gccgcctcct actcagtgca ggcctgcagc
     2221 gtgctcacgg gggagatgtt tgcgccctgc tctgcgttcc tgagccccgt gccctacttt
     2281 gagcagtgcc gcagggatgc ctgccgctgc gggcagccct gcctgtgcgc cacactggcc
     2341 cactacgccc acctgtgccg gcgccatggg ctccccgttg atttccgcgc ccgcctgcca
     2401 gcctgtgcac tgtcctgtga ggcctccaag gagtatagcc cctgcgtggc cccgtgtgga
     2461 cgtacctgcc aggacctggc cagccctgag gcctgtgggg ttgatggtgg cgatgacctg
     2521 agcagagacg agtgtgtgga gggctgtgcc tgcccaccgg acacctatct ggacacccag
     2581 gctgacctct gtgtcccccg gaaccagtgc tcctgccact tccagggagt ggactatccc
     2641 cccggagaca gtgacatccc atccctgggc cactgccact gcaaagatgg agtcatgagc
     2701 tgtgatagca gagccccagc tgctgcctgc ccagcaggcc aggtcttcgt gaactgcagc
     2761 gacctgcaca cggacctgga gctgagcagg gagaggacgt gtgagcagca actgctgaac
     2821 ctgagcgtgt cagcccgtgg cccctgcctc tcgggctgcg cctgtcccca gggtctgctc
     2881 agacacgggg atgcatgttt cctgccagag gagtgcccct gcacttggaa ggggaaggag
     2941 tatttccctg gggaccaggt gatgtctcct tgccatacct gtgtgtgcca gcggggctca
     3001 ttccagtgca ccctgcaccc ttgcgcctcc acctgcactg cctatgggga ccggcattac
     3061 cgcacgtttg atgggctccc gtttgacttc gtgggggcat gcaaagtgca cctggtcaag
     3121 agcacatcag atgtcagctt ctctgtgatt gtagagaatg tgaactgcta cagctctggc
     3181 atgatctgca ggaaatttat ttccatcaac gttgggaact cactcattgt ctttgatgat
     3241 gactccggaa atcctagtcc agagagcttc ctggatgaca agcaggaggt ccacacatgg
     3301 cgagtgggat ttttcacact ggtgcatttc ccacaggagc acatcaccct cttgtgggac
     3361 cagagaacca cagtgcacgt ccaggctggg cctcagtggc agggccagct ggcgggcctc
     3421 tgtgggaact ttgacttaaa aaccatcaat gagatgagga ccccggagaa cctagagcta
     3481 actaaccccc aggagtttgg cagcagttgg gctgcagttg agtgcccaga caccctcgat
     3541 cctcgggata tgtgtgtcct gaatcctctc cgagaaccat ttgccaagaa ggagtgcagc
     3601 atcctgctca gtgaggtgtt tgagatctgc caccctgtgg ttgatgtcac ttggttttac
     3661 tcaaactgcc tgacagacac atgtggctgc agccagggtg gtgactgtga gtgcttctgt
     3721 gccagcgtct ccgcttatgc ccaccagtgt tgccagcatg gggtggctgt tgactggcga
     3781 accccccgcc tctgcccgta tgactgtgac ttctttaaca aagtgctagg taagggcccc
     3841 tatcagctat ccagcttggc agccggtggt gctctggtgg gcatgaaggc ggtgggcgat
     3901 gacatagtcc tagtgaggac agaggatgtg gcgccagcag acattgtgag cttcctgctg
     3961 acagctgctc tgtacaaggc caaggcccat gacccagatg tggtgtccct ggaggcagca
     4021 gacagaccca acttcttcct tcacgtcaca gccaacgggt ctctggagct ggctaagtgg
     4081 cagggccgtg acaccttcca acagcatgcc tccttcttgc tgcaccgggg gacacggcag
     4141 gcaggcctgg tggccctgga gtccctggcc aagcccagct ccttcctcta tgtgtcgggc
     4201 gcggtgctgg ccctgcggct gtacgaacac acagaggtgt tccgccgggg cacactcttc
     4261 cgccttctgg atgccaagcc ctcgggggct gcctacccca tctgcgagtg gcgctacgat
     4321 gcctgtgcca gcccctgctt ccaaacctgc cgggacccac gggcagccag ctgccgggac
     4381 gtacccaggg tagaaggctg tgtccctgtg tgccccaccc cccaggtcct ggatgaagtc
     4441 acacagagat gtgtctactt ggaggactgt gtggagccag cagtttgggt tcccacagag
     4501 gcccttggca atgagaccct ccctcccagt caagggttgc ccactcccag tgatgaggag
     4561 ccacagctgt cacaggaaag ccccaggacc cccacccaca ggccagccct caccccagct
     4621 gccccactca ccacagccct gaacccacca gtgacagcca ctgaggagcc agtggtgtct
     4681 ccaggcccca cccagaccac cctgcagcag ccactggagc tcactgcatc tcaactcccc
     4741 gccggcccca cggagtcccc agccagcaag ggagtgactg ccagcctcct ggccatcccc
     4801 catacaccag agtcctcatc cctccctgtt gcactgcaga cacccacacc tggcatggtg
     4861 tcaggtgcca tggagacaac aagggtgact gtgatctttg caggaagccc taacatcaca
     4921 gtctcctccc ggtcgccccc tgcccctcgc ttcccgctca tgaccaaggc tgtgacagtc
     4981 cgaggccatg gctccttgcc tgttaggacg acacccccac agccctcctt gacagcaagt
     5041 ccctcctcca gacctgtggc ttcccctgga gccatctcca ggtcccccac ctcctcggga
     5101 tcccacaagg ctgtgctgac acctgcagta actaaggtca taagcaggac aggggtcccc
     5161 cagcccaccc aggcccagag tgcttcaagt cccagcaccc ctctaactgt ggctggaaca
     5221 gcagcagaac aggttcctgt cagtcccctt gcaaccagga gcttggagat agtgctatcc
     5281 acagagaagg gcgaagccgg gcacagccag cccatgggct cgcctgcctc cccacagcca
     5341 cacccactcc cctctgcacc accccgccca gcccagcata ccaccatggc caccaggtct
     5401 ccagctctgc ccccagagac cccagctgcc gccagcctgt caacagccac tgatgggctg
     5461 gcagccacac ccttcatgtc ccttgagtca actcgtccct cccagctcct ctctggcctg
     5521 cctcccgaca ccagcctgcc cctggccaag gtgggcacat ctgccccagt ggccacaccc
     5581 ggccccaaag cctctgtcat caccactcca ctccagccac aggccacgac tctgcctgct
     5641 cagacactta gcccagtact gcctttcact ccagcagcaa tgacccaggc gcacccaccc
     5701 actcacatag cacccccagc agcaggcaca gctccaggcc tgctgctggg agccacattg
     5761 ccaacctctg gagtcctgcc tgtggctgag ggcacggcct ccatggtatc tgttgtccca
     5821 cgaaagagca ccacagggaa ggtggccatc ctatccaagc aagtgtctct gcccacttcc
     5881 atgtatggtt ctgcagaggg tgggcccaca gagctcacgc ctgctacgag ccaccctctc
     5941 acgcccttgg tggctgagcc cgagggagcc caggcaggca cagctctgcc agtgcccaca
     6001 tcctatgccc tgagccgtgt ctcagccagg acggcccccc aagacagcat gctggttctg
     6061 ttgcctcagc tggctgaggc ccatggaacc tcggcagggc ctcacctggc agcagagccg
     6121 gtggacgagg ccaccacaga accatctggg cgctcagccc cagccctgag catcgtagag
     6181 ggtttggcgg aggctttggc aactaccact gaggccaata catccaccac ctgtgttcca
     6241 atcgccgagc aggactgcgt ccgccacatc tgcctggagg gccagctgat tcgcgtgaat
     6301 cagtcccagc actgtcccca gggtgctgct ccccctcgct gtgggatcct gggcctcgcc
     6361 gtgcgggtgg gtggggaccg ctgctgccca ctctgggagt gtgcctgccg gtgctcaatc
     6421 ttccctgacc tgagcttcgt gaccttcgat gggagccacg tagctctgtt caaggaggcc
     6481 atctacatcc tcagccagag cccagatgaa atgctcaccg tccatgtact ggactgcaaa
     6541 agtgccaacc tggggcacct gaactggccc ccgttctgtc tggtgatgtt gaacatgact
     6601 cacttggccc atcaggtcac tattgatcgc ttcaaccgaa aggtgactgt ggacttgcag
     6661 cctgtgtggc caccggtgag caggtatgga ttcagaattg aggacacagg ccacatgtac
     6721 atgatcctga ctccctcaga catccagatc cagtggctcc acagctcagg actcatgatc
     6781 gtggaggcca gcaaaaccag caaggcccag ggccatggcc tgtgcggtat ctgtgatgga
     6841 gatgcagcca atgaccttac cctgaaggat ggctcagtgg tgggtggggc tgaggaccct
     6901 gctccctttc tggacagctg gcaggtgccc agctccctga cctcagtggg ccagacccgc
     6961 ttccgcccag acagctgcgc cacaactgac tgctcgccct gccttcgcat ggtgtccaac
     7021 cgcaccttca gtgcctgcca ccgctttgtg cctccggagt cattctgtga gctgtggatc
     7081 cgggacacca agtacgtgca gcagccctgc gtggccctga ctgtgtacgt ggccatgtgc
     7141 cacaaatttc atgtgtgcat cgagtggcgg cgctctgact actgcccctt cctgtgctcc
     7201 agcgactcca cataccaggc atgtgtgaca gcctgtgagc cacccaagac atgccaggat
     7261 gggatactag ggcctctgga cccagagcac tgccaggtgc tgggcgaggg ctgcgtctgc
     7321 tccgagggca ccatcttaca ccggcgccac tctgcactct gcatcccgga ggccaagtgc
     7381 gcctgcactg acagcatggg ggtgccgagg gccctggggg agacctggaa cagctccctc
     7441 agcggctgct gccagcacca gtgccaagcc ccagacacca ttgtcccggt ggatctgggc
     7501 tgccccagtc cccgccctga gagctgcctg cgattcgggg aggtggcctt gctcctaccc
     7561 accaaggacc cctgctgcct ggggactgtc tgtgtgtgta accagactct gtgtgagggt
     7621 ctcgccccca catgccgccc aggccaccgc ctcctcaccc acttccagga ggactcctgc
     7681 tgccccagct acagctgtga gtgtgaccca gatctctgtg aggcagagct ggtccccagc
     7741 tgccgacagg accagatcct gatcacgggc cgcctggggg actcctgctg cacctcctac
     7801 ttctgcgcct gtggtgactg tccagactcc atccccgaat gtcaagaagg ggaggcgctc
     7861 actgtgcaca ggaataccac ggaactctgc tgccctctgt accagtgtgt gtgtgagaac
     7921 ttccgctgtc cccaagtgca gtgtggcctg ggcactgccc tggtggaggt gtggagcccc
     7981 gaccgctgct gcccctacaa atcctgtgaa tgtgactgtg acacaatccc ggtgccccgg
     8041 tgccatctgt gggagaaatc ccagctggat gaggagttca tgcacagcgt ggagaatgtg
     8101 tgtggctgcg ccaagtacga gtgtgtgaag gccccggtgt gtctgagccg cgagctgggt
     8161 gtgatgcagc ccggccagac agtggtggag ctctcagcag atggcgtgtg ccacacctcc
     8221 cgctgcacca ccgtgctcga ccctctcacc aacttctacc agatcaacac cacctccgtg
     8281 ctctgtgaca tccactgtga ggcgaaccag gagtacgagc acccgcggga cctcgctgcc
     8341 tgctgcggct cctgcaggaa cgtgtcctgt ctcttcacct tccccaatgg caccacctcc
     8401 ctgttcttgc ccggggcatc ctggatcgca gactgcgccc gccaccactg cagcagcacg
     8461 cccctgggtg ccgtgctggt ccgctctccc ataagctgcc caccgctcaa tgagactgag
     8521 tgtgccaagg ttgggggttc cgtggtacct tccttggaag gatgctgcag gacctgtaag
     8581 gaggatgggc gctcctgcaa gaaggtgacc atccgcatga ccatccgcaa gaatgaatgc
     8641 aggagcagca cccctgtgaa cctagtgtcc tgcgatggga ggtgcccatc cgccagcatc
     8701 tacaactaca acatcaacac ctatgcccga ttctgcaagt gctgccgtga ggtgggcctg
     8761 cagcggcgct ctgtgcagct cttctgtgcc accaatgcca cctgggtgcc ctatacagtg
     8821 caggagccca ccgactgtgc ctgccagtgg tcctgaggcc tgggggcccg ggctagctgg
     8881 accacctctg ccagccccac tttctgtttc cagctggccc aatgtgaatg ggggtattaa
     8941 aggtggtaga aatctg
//
