LOCUS       NM_198184               3231 bp    mRNA    linear   PRI 31-JUL-2024
DEFINITION  Homo sapiens osteocrin (OSTN), mRNA.
ACCESSION   NM_198184 XM_005247428
VERSION     NM_198184.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Zhang,J., Shi,J., Cheng,Z. and Hu,W.
  TITLE     The correlation of serum musclin with diabetic nephropathy
  JOURNAL   Cytokine 167, 156211 (2023)
   PUBMED   37137178
  REMARK    GeneRIF: The correlation of serum musclin with diabetic
            nephropathy.
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Cho,W., Choi,S.W., Oh,H., Baygutalp,F., Abd El-Aty,A.M.,
            Jeong,J.H., Song,J.H., Shin,Y.K. and Jung,T.W.
  TITLE     Musclin attenuates lipid deposition in hepatocytes through
            SIRT7/autophagy-mediated suppression of ER stress
  JOURNAL   Biochem Biophys Res Commun 658, 62-68 (2023)
   PUBMED   37023616
  REMARK    GeneRIF: Musclin attenuates lipid deposition in hepatocytes through
            SIRT7/autophagy-mediated suppression of ER stress.
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Jakobsen,J.R., Schjerling,P., Kjaer,M., Mackey,A.L. and
            Krogsgaard,M.R.
  TITLE     Nestin and osteocrin mRNA increases in human semitendinosus
            myotendinous junction 7 days after a single bout of eccentric
            exercise
  JOURNAL   Histochem Cell Biol 158 (1), 49-64 (2022)
   PUBMED   35428952
  REMARK    GeneRIF: Nestin and osteocrin mRNA increases in human
            semitendinosus myotendinous junction 7 days after a single bout of
            eccentric exercise.
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Szaroszyk,M., Kattih,B., Martin-Garrido,A., Trogisch,F.A.,
            Dittrich,G.M., Grund,A., Abouissa,A., Derlin,K., Meier,M.,
            Holler,T., Korf-Klingebiel,M., Volker,K., Garfias Macedo,T., Pablo
            Tortola,C., Boschmann,M., Huang,N., Froese,N., Zwadlo,C., Malek
            Mohammadi,M., Luo,X., Wagner,M., Cordero,J., Geffers,R., Batkai,S.,
            Thum,T., Bork,N., Nikolaev,V.O., Muller,O.J., Katus,H.A.,
            El-Armouche,A., Kraft,T., Springer,J., Dobreva,G., Wollert,K.C.,
            Fielitz,J., von Haehling,S., Kuhn,M., Bauersachs,J. and Heineke,J.
  TITLE     Skeletal muscle derived Musclin protects the heart during
            pathological overload
  JOURNAL   Nat Commun 13 (1), 149 (2022)
   PUBMED   35013221
  REMARK    GeneRIF: Skeletal muscle derived Musclin protects the heart during
            pathological overload.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Wang,J.S., Kamath,T., Mazur,C.M., Mirzamohammadi,F., Rotter,D.,
            Hojo,H., Castro,C.D., Tokavanich,N., Patel,R., Govea,N., Enishi,T.,
            Wu,Y., da Silva Martins,J., Bruce,M., Brooks,D.J., Bouxsein,M.L.,
            Tokarz,D., Lin,C.P., Abdul,A., Macosko,E.Z., Fiscaletti,M.,
            Munns,C.F., Ryder,P., Kost-Alimova,M., Byrne,P., Cimini,B.,
            Fujiwara,M., Kronenberg,H.M. and Wein,M.N.
  TITLE     Control of osteocyte dendrite formation by Sp7 and its target gene
            osteocrin
  JOURNAL   Nat Commun 12 (1), 6271 (2021)
   PUBMED   34725346
  REMARK    GeneRIF: Control of osteocyte dendrite formation by Sp7 and its
            target gene osteocrin.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Moffatt,P., Thomas,G., Sellin,K., Bessette,M.C., Lafreniere,F.,
            Akhouayri,O., St-Arnaud,R. and Lanctot,C.
  TITLE     Osteocrin is a specific ligand of the natriuretic Peptide clearance
            receptor that modulates bone growth
  JOURNAL   J Biol Chem 282 (50), 36454-36462 (2007)
   PUBMED   17951249
  REMARK    GeneRIF: Ostn is a naturally occurring ligand of the NPR-C
            clearance receptor and may act to locally modulate the actions of
            the natriuretic system in bone by blocking the clearance action of
            NPR-C, thus locally elevating levels of C-type natriuretic peptide.
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   Yasui,A., Nishizawa,H., Okuno,Y., Morita,K., Kobayashi,H.,
            Kawai,K., Matsuda,M., Kishida,K., Kihara,S., Kamei,Y., Ogawa,Y.,
            Funahashi,T. and Shimomura,I.
  TITLE     Foxo1 represses expression of musclin, a skeletal muscle-derived
            secretory factor
  JOURNAL   Biochem Biophys Res Commun 364 (2), 358-365 (2007)
   PUBMED   17950246
  REMARK    GeneRIF: Foxo1 downregulates musclin mRNA expression both in vitro
            and in vivo, which should explain insulin-mediated upregulation of
            this gene in muscle cells.
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Bord,S., Ireland,D.C., Moffatt,P., Thomas,G.P. and Compston,J.E.
  TITLE     Characterization of osteocrin expression in human bone
  JOURNAL   J Histochem Cytochem 53 (10), 1181-1187 (2005)
   PUBMED   15923362
REFERENCE   9  (bases 1 to 3231)
  AUTHORS   Nishizawa,H., Matsuda,M., Yamada,Y., Kawai,K., Suzuki,E.,
            Makishima,M., Kitamura,T. and Shimomura,I.
  TITLE     Musclin, a novel skeletal muscle-derived secretory factor
  JOURNAL   J Biol Chem 279 (19), 19391-19395 (2004)
   PUBMED   15044443
REFERENCE   10 (bases 1 to 3231)
  AUTHORS   Thomas,G., Moffatt,P., Salois,P., Gaumond,M.H., Gingras,R.,
            Godin,E., Miao,D., Goltzman,D. and Lanctot,C.
  TITLE     Osteocrin, a novel bone-specific secreted protein that modulates
            the osteoblast phenotype
  JOURNAL   J Biol Chem 278 (50), 50563-50571 (2003)
   PUBMED   14523025
  REMARK    GeneRIF: osteocrin represents a novel, unique vitamin D-regulated
            bone-specific protein that appears to act as a soluble osteoblast
            regulator
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126567.8 and AY398681.1.
            
            On or before Aug 24, 2016 this sequence version replaced
            XM_005247428.4, NM_198184.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.16739.1,
                                           SRR1660805.110908.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682035.1/ ENSP00000508312.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC126567.8         100661-100727       c
            68-469              AY398681.1         1-402
            470-481             AC126567.8         49835-49846         c
            482-3231            AC126567.8         34353-37102         c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q28"
     gene            1..3231
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /note="osteocrin"
                     /db_xref="GeneID:344901"
                     /db_xref="HGNC:HGNC:29961"
                     /db_xref="MIM:610280"
     exon            1..67
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..469
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /codon_start=1
                     /product="osteocrin precursor"
                     /protein_id="NP_937827.1"
                     /db_xref="CCDS:CCDS3299.1"
                     /db_xref="GeneID:344901"
                     /db_xref="HGNC:HGNC:29961"
                     /db_xref="MIM:610280"
                     /translation="MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTTEAFDSGVIDVQ
                     STPTVREEKSATDLTAKLLLLDELVSLENDVIETKKKRSFSGFGSPLDRLSAGSVDHK
                     GKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG"
     exon            68..169
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            170..384
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            385..481
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /inference="alignment:Splign:2.1.0"
     exon            482..3231
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3215..3220
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /note="hexamer: AACAAG"
     polyA_site      3231
                     /gene="OSTN"
                     /gene_synonym="MUSCLIN"
                     /note="major polyA site"
ORIGIN      
        1 agggctgagt tttggagaaa ctgcagagac agtactctaa agttagaatc tcctgatctt
       61 tcacgagatg ctggactgga gattggcaag tgcacatttc atcctggctg tgacactgac
      121 actgtggagc tcaggaaaag tcctctcagt agatgtaaca acaacagagg cctttgattc
      181 tggagtcata gatgtgcagt caacacccac agtcagggaa gagaaatcag ccactgacct
      241 gacagcaaaa ctcttgcttc ttgatgaatt ggtgtcccta gaaaatgatg tgattgagac
      301 aaagaagaaa aggagtttct ctggttttgg gtctcccctt gacagactct cagctggctc
      361 tgtagatcac aaaggtaaac agaggaaagt agtagatcat ccaaaaaggc gatttggtat
      421 ccccatggat cggattggta gaaaccggct ttcaaattcc agaggctaat tgattccaat
      481 tatgcaactt ccttgggtga aatgtcacag caatatggaa gatgcttcac tgaagttatt
      541 cacacttctt aatgattaaa cttttaagga actgaccttc tgcaaatcct ttccaaagct
      601 tgaacttcag tccatcacat tacagcattg ttacagcttc aattaaattg tgtaaatcat
      661 tttgatgcac gtacatttta aaattatata ttttaattat tcaagaatgg ttaacttccc
      721 cttaaacctt acttttaaaa ataataatta aatacacaat acagtgaaat gccttctgta
      781 tggatttacc atgcacatgt ttgtagtcaa agaataataa caaaagacag atttgcttct
      841 gtaaaattta gttataatct gtccattatt ggggaatgag gaaaggcaat gctgtgtatt
      901 ttctgttgag tactttcact tccctgtatt ccatttttcc aagagtctga tcggtaataa
      961 ttatgaaatt aggcttctct tttcatattc aagtttcagt catgttcaga aaaataaaac
     1021 acagccccaa tgagcctatt gacttagaat taagaaagtg aaggacatta ctcatttgtc
     1081 aaacttagat atcacttgtc ccctaaaaac tttccatttt tctaaattct gacagttaag
     1141 agcagtagtg tctcattagg aggggagtaa gctcacacag aggtaaaaat gaaagtagga
     1201 gggaagtcaa agaattacca ccagaacagg ttaggaccag ctaagcacac atcattttag
     1261 ctcagtacac ttcagcatag tacaatgtga tctttttgat atcttggatt aatctaagaa
     1321 actgtttact gtgtttcaca tattggcttc tttggcttca attgtcttat tatccttagt
     1381 aagccaattg aagagcataa tgattttgag aatgatttct taaaaatcat tcagattatt
     1441 tttgaatgac ttattaaaac ataagttttc gtattgtaga aaactcagtt ctcagtaata
     1501 actatgatgt tactgtagct tggacacata ggtccattgt gcattggata tactttgaaa
     1561 acacacaaaa aaaactttct atggaacaga gattcatcat aagttactta gcagaagttt
     1621 ataaagcatc gaaaaacact tcctctgtaa accctaaaaa tcactgtctg atacgtggga
     1681 ggaaaaaagt tttgtccagt agagcaaagg cttatttcag cataaaaaga gagtgttgtg
     1741 agttgtgaga aggtgtctta attttaaagg aagaggagag aaatgggcaa ttgctaatct
     1801 taactaaaaa ttaatggact tgtatgatcc aaagaataaa ataaactcaa agaaacataa
     1861 caaaaatata ttagaaaaag agttaaacta agaaattgac ctttatgaag gactaatttt
     1921 tcagttatcc aatgtgcttt ttaaagataa agtttaaaag aggcaaaaag aggtgaaaga
     1981 aatgaacatg tgtacttaga atatatatat tggttttgta tgtaacttct tagtttttct
     2041 ggatattttt aaaattgaaa gtcttcaaaa ttaatttagg aaaaatagta aataattttt
     2101 tttcattgta gtagagggct gtagccaaga gaagtgaatt ttgggaaatc taaccaattc
     2161 tttttttcat aaacttgtgt tagaaagcta gcaatagcac atagggaagt atcctggagg
     2221 actcaggagt tgaaagaatt atttaagaag ttgtgatatc cttgtctgcc tttccccaac
     2281 cttgtgatga actatagaaa tgtttcctat tgcttagaag ctctttcttt ccttgtatgc
     2341 acatttgggt atttgtaagc ttctaatcca attgggttct gcttcatgct ttgacaaaag
     2401 gtattaaaac ctactttagc ctaaaacttt ctcatggtaa atattggaag ttggattatg
     2461 caaattgatt tcctccattc tttatttttt aattcaaaat tagactatga catccaactt
     2521 aattaaaata agaagtcaca atatagtgat ttatgctata gtttcatgtg taatgtattt
     2581 tcacctaata tacacacaat ttccatgaag ggaagaaaat gttttctcca cttataactc
     2641 tattttattt catattttaa tttttaccac tacttcattc agagtagaaa ataagtcagc
     2701 aatatactaa ataatggggc tattctttta acatagcagt aaattaagac agaatttttg
     2761 ttaagaatat gacaagtcat ctcacttatt tatccaatgc attaggtatt actaatccaa
     2821 ctatatttca acttgaaggg acttttttgt tttgtttcaa aataatgcat tacttttttc
     2881 tctttgcttc tgtatgaacc tttatagagc aaatgaatat atgtatatgg agttctgggt
     2941 tctagtgtca attacataat caaatttcat aaaaggatgt tagttactgg ctatgttgtc
     3001 ctaaaattta cacacactaa aaaatgtctg tcaagttgta cctttaacct gttcatagct
     3061 ttagggaatt aagtttctta aaccaaatta tgaaaaaata acttaatgga atcttctaaa
     3121 aggaaaaagt ataaaaagct ttctgaatga tattacccct tatacctaaa ggctcaagat
     3181 gcttgaatat ggttcaactt ttccaaagtt aataaacaag ggatgatgaa a
//
