LOCUS       NM_012383               1348 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens osteoclast stimulating factor 1 (OSTF1), mRNA.
ACCESSION   NM_012383
VERSION     NM_012383.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1348)
  AUTHORS   Lyraki,R., Lokaj,M., Soares,D.C., Little,A., Vermeren,M.,
            Marsh,J.A., Wittinghofer,A. and Hurd,T.
  TITLE     Characterization of a novel RP2-OSTF1 interaction and its
            implication for actin remodelling
  JOURNAL   J Cell Sci 131 (4) (2018)
   PUBMED   29361551
  REMARK    GeneRIF: We utilized a structure-based approach to pinpoint the
            binding interface to a strictly conserved cluster of residues on
            the surface of RP2 that spans both the C- and N-terminal domains of
            the protein, and which is structurally distinct from the
            ARL3-binding site.RP2 is a positive regulator of cell motility in
            vitro, recruiting OSTF1 to the cell membrane and preventing its
            interaction with the migration regulator Myo1E.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1348)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1348)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 1348)
  AUTHORS   Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
  TITLE     Preferred SH3 domain partners of ADAM metalloproteases include
            shared and ADAM-specific SH3 interactions
  JOURNAL   PLoS One 10 (3), e0121301 (2015)
   PUBMED   25825872
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1348)
  AUTHORS   Szymkiewicz,I., Destaing,O., Jurdic,P. and Dikic,I.
  TITLE     SH3P2 in complex with Cbl and Src
  JOURNAL   FEBS Lett 565 (1-3), 33-38 (2004)
   PUBMED   15135048
  REMARK    GeneRIF: SH3P2, a novel component of adhesion sites, is involved in
            Cbl and Src-mediated pathways
REFERENCE   7  (bases 1 to 1348)
  AUTHORS   Kurihara,N., Menaa,C., Maeda,H., Haile,D.J. and Reddy,S.V.
  TITLE     Osteoclast-stimulating factor interacts with the spinal muscular
            atrophy gene product to stimulate osteoclast formation
  JOURNAL   J Biol Chem 276 (44), 41035-41039 (2001)
   PUBMED   11551898
REFERENCE   8  (bases 1 to 1348)
  AUTHORS   Schaub,R., Dupont,B., Roodman,G.D., Leach,R.J. and Reddy,S.V.
  TITLE     Assignment of OSTF1 to human chromosome bands 12q24.1-->q24.2 by in
            situ hybridization
  JOURNAL   Cytogenet Cell Genet 88 (1-2), 87-88 (2000)
   PUBMED   10773673
REFERENCE   9  (bases 1 to 1348)
  AUTHORS   Reddy,S., Devlin,R., Menaa,C., Nishimura,R., Choi,S.J., Dallas,M.,
            Yoneda,T. and Roodman,G.D.
  TITLE     Isolation and characterization of a cDNA clone encoding a novel
            peptide (OSF) that enhances osteoclast formation and bone
            resorption
  JOURNAL   J Cell Physiol 177 (4), 636-645 (1998)
   PUBMED   10092216
REFERENCE   10 (bases 1 to 1348)
  AUTHORS   Sparks,A.B., Hoffman,N.G., McConnell,S.J., Fowlkes,D.M. and
            Kay,B.K.
  TITLE     Cloning of ligand targets: systematic isolation of SH3
            domain-containing proteins
  JOURNAL   Nat Biotechnol 14 (6), 741-744 (1996)
   PUBMED   9630982
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP312980.1, AK222596.1 and AL133548.6.
            
            On May 17, 2019 this sequence version replaced NM_012383.4.
            
            Summary: Osteoclast-stimulating factor-1 is an intracellular
            protein produced by osteoclasts that indirectly induces osteoclast
            formation and bone resorption (Reddy et al., 1998 [PubMed
            10092216]).[supplied by OMIM, Mar 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.357175.1,
                                           SRR1803615.389348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346234.7/ ENSP00000340836.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                BP312980.1         33-125
            94-1023             AK222596.1         70-999
            1024-1281           AL133548.6         118122-118379
            1282-1348           AL133548.6         118380-118446
FEATURES             Location/Qualifiers
     source          1..1348
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..1348
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /note="osteoclast stimulating factor 1"
                     /db_xref="GeneID:26578"
                     /db_xref="HGNC:HGNC:8510"
                     /db_xref="MIM:610180"
     exon            1..213
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     CDS             180..824
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /codon_start=1
                     /product="osteoclast-stimulating factor 1"
                     /protein_id="NP_036515.4"
                     /db_xref="CCDS:CCDS6651.1"
                     /db_xref="GeneID:26578"
                     /db_xref="HGNC:HGNC:8510"
                     /db_xref="MIM:610180"
                     /translation="MSKPPPKPVKPGQVKVFRALYTFEPRTPDELYFEEGDIIYITDM
                     SDTNWWKGTSKGRTGLIPSNYVAEQAESIDNPLHEAAKRGNLSWLRECLDNRVGVNGL
                     DKAGSTALYWACHGGHKDIVEMLFTQPNIELNQQNKLGDTALHAAAWKGYADIVQLLL
                     AKGARTDLRNIEKKLAFDMATNAACASLLKKKQGTDAVRTLSNAEDYLDDEDSD"
     exon            214..260
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..311
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            312..375
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            376..429
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            430..537
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            538..587
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            588..666
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..765
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..1348
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      913..918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /note="hexamer: AAGAAA"
     polyA_site      930
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
     regulatory      1259..1264
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /note="hexamer: AATAAA"
     polyA_site      1281
                     /gene="OSTF1"
                     /gene_synonym="bA235O14.1; OSF; SH3P2"
                     /note="major polyA site"
ORIGIN      
        1 actcggcgga gccgctctgc ctgcgtccgc tcttcccgca gccaagggtg ggcgccggtc
       61 ctaggaggcg cacggttgta agccagacaa aaagaactgg ggtgcccgga gtgccaggtg
      121 gcgggcaagc ggtgggcttt tcggcggggt ctttaggatt tgcagctcca ggaagcgaga
      181 tgtcgaagcc gccacccaaa ccagtcaaac cagggcaagt taaagtcttc agagccctgt
      241 atacgtttga acccagaact ccagatgaat tatactttga ggaaggtgat attatctaca
      301 ttactgacat gagcgatacc aattggtgga aaggcacctc caaaggcagg actggactaa
      361 ttccaagcaa ctatgtggct gagcaggcag aatccattga caatccattg catgaagcag
      421 caaaaagagg caacttgagc tggttgagag agtgtttgga caacagagtg ggtgttaatg
      481 gcttagacaa agctggaagc actgccttat actgggcttg ccacgggggc cacaaagata
      541 tagtggaaat gctatttact caaccaaata ttgaactgaa ccagcagaac aagttgggag
      601 atacagcttt gcatgctgct gcctggaagg gttatgcaga tatcgtccag ttgcttctgg
      661 caaaaggtgc tagaacagac ttaagaaaca ttgagaagaa gctggccttc gacatggcta
      721 ccaatgctgc ctgtgcatct ctcctgaaaa agaaacaggg aacagatgca gttcgaacat
      781 taagcaatgc cgaggactat ctcgatgatg aagactcaga ttaattcctt tctggagctt
      841 tgagatctaa aacttctgtt gcttttgcca ttccaaaact ttgtctttgc cagaaaagtg
      901 ttggtaacta taaagaaaat tatatatgaa cacggcagtg ttgcactgtg tttgagtaga
      961 acgtgtaaat gaattgttcc cacctttggt ttgccagtaa gtgactggat tcttggcaca
     1021 tttatgttca ccaaagtaga acaagaagat attatttcta tttatcaagc aaaaggaatt
     1081 ttaagatttt tttttttctt taaaaacaaa ttaggatttt tttttttttt ttttttttag
     1141 ttaaaatgct ttacctcaat ggttgagata ttttgaatgg atttttcaag ggggggaaat
     1201 gcttattata ataataaacc aaaatactta acagaaaatt gtcagctatt ctgacaaaaa
     1261 taaacatttt gagagacttt atttcttttg tccgtttctg tggtatcact cattgtcgtt
     1321 aagtaagtaa agctttttat atttaggt
//
