LOCUS       NM_001142462            1834 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens odd-skipped related transciption factor 2 (OSR2),
            transcript variant 1, mRNA.
ACCESSION   NM_001142462
VERSION     NM_001142462.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1834)
  AUTHORS   Zhang,J., Li,J., Hou,Y., Lin,Y., Zhao,H., Shi,Y., Chen,K., Nian,C.,
            Tang,J., Pan,L., Xing,Y., Gao,H., Yang,B., Song,Z., Cheng,Y.,
            Liu,Y., Sun,M., Linghu,Y., Li,J., Huang,H., Lai,Z., Zhou,Z., Li,Z.,
            Sun,X., Chen,Q., Su,D., Li,W., Peng,Z., Liu,P., Chen,W., Huang,H.,
            Chen,Y., Xiao,B., Ye,L., Chen,L. and Zhou,D.
  TITLE     Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T
            cell exhaustion in tumor
  JOURNAL   Cell 187 (13), 3409-3426 (2024)
   PUBMED   38744281
  REMARK    GeneRIF: Osr2 functions as a biomechanical checkpoint to aggravate
            CD8[+] T cell exhaustion in tumor.
REFERENCE   2  (bases 1 to 1834)
  AUTHORS   Uysal,D., Kowalewski,K.F., Kriegmair,M.C., Wirtz,R., Popovic,Z.V.
            and Erben,P.
  TITLE     A comprehensive molecular characterization of the 8q22.2 region
            reveals the prognostic relevance of OSR2 mRNA in muscle invasive
            bladder cancer
  JOURNAL   PLoS One 16 (3), e0248342 (2021)
   PUBMED   33711044
  REMARK    GeneRIF: A comprehensive molecular characterization of the 8q22.2
            region reveals the prognostic relevance of OSR2 mRNA in muscle
            invasive bladder cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1834)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1834)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   5  (bases 1 to 1834)
  AUTHORS   Li,W.H., Zhou,Z.J., Huang,T.H., Guo,K., Chen,W., Wang,Y., Zhang,H.,
            Song,Y.C. and Chang,D.M.
  TITLE     Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of
            Patients with Gastric Cancer
  JOURNAL   Dis Markers 2016, 5780538 (2016)
   PUBMED   27143812
  REMARK    GeneRIF: Results found that OSR2, VAV3, and PPFIA3 were
            significantly hypermethylated in gastric cancer (GC) patients
            offering a good alternative in a simple, promising, and noninvasive
            detection of GC.
REFERENCE   6  (bases 1 to 1834)
  AUTHORS   Jugessur,A., Shi,M., Gjessing,H.K., Lie,R.T., Wilcox,A.J.,
            Weinberg,C.R., Christensen,K., Boyles,A.L., Daack-Hirsch,S.,
            Nguyen,T.T., Christiansen,L., Lidral,A.C. and Murray,J.C.
  TITLE     Maternal genes and facial clefts in offspring: a comprehensive
            search for genetic associations in two population-based cleft
            studies from Scandinavia
  JOURNAL   PLoS One 5 (7), e11493 (2010)
   PUBMED   20634891
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1834)
  AUTHORS   Kawai,S., Kato,T., Inaba,H., Okahashi,N. and Amano,A.
  TITLE     Odd-skipped related 2 splicing variants show opposite
            transcriptional activity
  JOURNAL   Biochem Biophys Res Commun 328 (1), 306-311 (2005)
   PUBMED   15670784
REFERENCE   8  (bases 1 to 1834)
  AUTHORS   Lan,Y., Ovitt,C.E., Cho,E.S., Maltby,K.M., Wang,Q. and Jiang,R.
  TITLE     Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of
            secondary palate growth and morphogenesis
  JOURNAL   Development 131 (13), 3207-3216 (2004)
   PUBMED   15175245
REFERENCE   9  (bases 1 to 1834)
  AUTHORS   Lan,Y., Kingsley,P.D., Cho,E.S. and Jiang,R.
  TITLE     Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits
            dynamic expression patterns during craniofacial, limb, and kidney
            development
  JOURNAL   Mech Dev 107 (1-2), 175-179 (2001)
   PUBMED   11520675
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074518.1 and AC016877.11.
            
            On Jun 2, 2019 this sequence version replaced NM_001142462.2.
            
            Summary: OSR2 is a mammalian homolog of the Drosophila odd-skipped
            family of transcription factors (Lan et al., 2004 [PubMed
            15175245]).[supplied by OMIM, Mar 2008].
            
            Transcript Variant: This variant (1) differs in the  5' UTR and 5'
            coding region differences, compared to variant 1. These differences
            cause translation initiation at a downstream AUG and result in an
            isoform (a) with a shorter N-terminus, compared to isoform c.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074518.1, AY038072.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297565.9/ ENSP00000297565.4
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1351              AK074518.1         1-1351
            1352-1352           AC016877.11        163935-163935
            1353-1834           AK074518.1         1353-1834
FEATURES             Location/Qualifiers
     source          1..1834
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q22.2"
     gene            1..1834
                     /gene="OSR2"
                     /note="odd-skipped related transciption factor 2"
                     /db_xref="GeneID:116039"
                     /db_xref="HGNC:HGNC:15830"
                     /db_xref="MIM:611297"
     exon            1..382
                     /gene="OSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            383..1152
                     /gene="OSR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             497..1435
                     /gene="OSR2"
                     /note="isoform a is encoded by transcript variant 1;
                     protein odd-skipped-related 2; odd-skipped related 2"
                     /codon_start=1
                     /product="protein odd-skipped-related 2 isoform a"
                     /protein_id="NP_001135934.1"
                     /db_xref="CCDS:CCDS47901.1"
                     /db_xref="GeneID:116039"
                     /db_xref="HGNC:HGNC:15830"
                     /db_xref="MIM:611297"
                     /translation="MGSKALPAPIPLHPSLQLTNYSFLQAVNTFPATVDHLQGLYGLS
                     AVQTMHMNHWTLGYPNVHEITRSTITEMAAAQGLVDARFPFPALPFTTHLFHPKQGAI
                     AHVLPALHKDRPRFDFANLAVAATQEDPPKMGDLSKLSPGLGSPISGLSKLTPDRKPS
                     RGRLPSKTKKEFICKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHLRDH
                     RYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHMQESPHKCPTCGRTFNQRSNLKTHLL
                     THTDIKPYSCEQCGKVFRRNCDLRRHSLTHTPRQDF"
     exon            1153..1252
                     /gene="OSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1834
                     /gene="OSR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSR2"
                     /note="hexamer: AATAAA"
     polyA_site      1834
                     /gene="OSR2"
                     /note="major polyA site"
ORIGIN      
        1 agcctgggga gggacgcggg cggggacgga gctcggcgtg cttgctgctg gagggtgatg
       61 gccctgcaag gctgtgggct ccgacctcac cgggagtcga cagcgagagg ttcgccgaag
      121 agcgaggttc tgggcgagcg ctgaacgccg gccccaagca ccccgggtct ttacacagtc
      181 cgcgtccaca gactctgacg aagacgtgga tctgctctcg ctttagctgc tcgcggtcct
      241 ccagatcatg tccgcgactc ctgcgactcc gcgcggaaaa aaaagtttgc caggcgtgga
      301 ctcaatgacc tttccaagct gtgcgcctcg ctgcctggac cgggtctgag cgcggctgcc
      361 caggttgacc tttctgcggg agggctttct ctacgtgctg ttgtctcact gggtttttgt
      421 cggagcccca cgccctccgg cctctgattc ctggaagaaa gggttggtcc cctcagcacc
      481 cccagcatcc cggaaaatgg ggagcaaggc tctgccagcg cccatcccgc tccacccgtc
      541 gctgcagctc accaattact ccttcctgca ggccgtgaac accttcccgg ccacggtgga
      601 ccacctgcag ggcctgtacg gtctcagcgc ggtacagacc atgcacatga accactggac
      661 gctggggtat cccaatgtgc acgagatcac ccgctccacc atcacggaga tggcggcggc
      721 gcagggcctc gtggacgcgc gcttcccctt cccggccctg ccttttacca cccacctatt
      781 ccaccccaag cagggggcca ttgcccacgt cctcccagcc ctgcacaagg accggccccg
      841 ttttgacttt gccaatttgg cggtggctgc cacgcaagag gatccgccta agatgggaga
      901 cctgagcaag ctgagcccag gactgggtag ccccatctcg ggcctcagta aattgactcc
      961 ggacagaaag ccctctcgag gaaggttgcc ctccaaaacg aaaaaagagt ttatctgcaa
     1021 gttttgcggc agacacttta ccaaatccta caatttgctc atccatgaga ggacccacac
     1081 ggacgagagg ccgtacacgt gtgacatctg ccacaaggcc ttccggaggc aagatcacct
     1141 gcgggatcac agatacatcc attccaaaga aaaacccttc aaatgtcagg agtgtgggaa
     1201 aggattttgt cagtctagaa ctctagcagt tcacaaaact ttacacatgc aggaatctcc
     1261 acacaaatgt cccacatgtg gaagaacctt taatcagaga agtaatctga aaactcacct
     1321 tctcacccat acagacatca agccctacag ctgcgagcag tgcggcaaag tgttcaggcg
     1381 aaactgtgat ctgcggcggc acagcctgac tcacaccccg cggcaggact tctagagaag
     1441 cccaggatct gtcccgtgcc gccgctgctc ccctccccag acacctctcc acgtctccta
     1501 cccagggggt cgcatcccta gcccttcact gaccccagct cttcccttgc tgcagccgca
     1561 cctgcagctc cagggagtta actcttcttc tgggggactg agaactgtag aaagccacac
     1621 actactacat cccttcacaa agagtatatg ctagtttctt gtagatattc acagctcatt
     1681 ttagagctct gtacataatg ttgtgggtct ttgttttgtt gttttgtttg ctttgggatc
     1741 ttgttggatg cacttagata tggaaaatgg aagccaaatt ttatctttaa agactgtatt
     1801 ttcaaaataa aactttttct tgtttgtttc aaaa
//
