LOCUS       NM_145260               1906 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens odd-skipped related transcription factor 1 (OSR1),
            mRNA.
ACCESSION   NM_145260
VERSION     NM_145260.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Lofrano-Porto,A., Pereira,S.A., Dauber,A., Bloom,J.C., Fontes,A.N.,
            Asimow,N., de Moraes,O.L., Araujo,P.A.T., Abreu,A.P., Guo,M.H., De
            Oliveira,S.F., Liu,H., Lee,C., Kuohung,W., Coelho,M.S.,
            Carroll,R.S., Jiang,R. and Kaiser,U.B.
  TITLE     OSR1 disruption contributes to uterine factor infertility via
            impaired Mullerian duct development and endometrial receptivity
  JOURNAL   J Clin Invest 133 (23), e161701 (2023)
   PUBMED   37847567
  REMARK    GeneRIF: OSR1 disruption contributes to uterine factor infertility
            via impaired Mullerian duct development and endometrial
            receptivity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Yu,Z. and Ouyang,L.
  TITLE     Odd-skipped related 1 plays a tumor suppressor role in ovarian
            cancer via promoting follistatin-like protein 1 transcription
  JOURNAL   Hum Cell 35 (6), 1824-1837 (2022)
   PUBMED   35964260
  REMARK    GeneRIF: Odd-skipped related 1 plays a tumor suppressor role in
            ovarian cancer via promoting follistatin-like protein 1
            transcription.
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Elvers,K.T., Lipka-Lloyd,M., Trueman,R.C., Bax,B.D. and Mehellou,Y.
  TITLE     Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT)
            Domains
  JOURNAL   Chembiochem 23 (1), e202100441 (2022)
   PUBMED   34726826
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Dhiani,B.A. and Mehellou,Y.
  TITLE     The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a
            Phosphorylation-Dependent Manner
  JOURNAL   Chembiochem 21 (5), 638-643 (2020)
   PUBMED   31614064
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Chen,W., Wu,K., Zhang,H., Fu,X., Yao,F. and Yang,A.
  TITLE     Odd-skipped related transcription factor 1 (OSR1) suppresses tongue
            squamous cell carcinoma migration and invasion through inhibiting
            NF-kappaB pathway
  JOURNAL   Eur J Pharmacol 839, 33-39 (2018)
   PUBMED   30244004
  REMARK    GeneRIF: OSR1 inhibited TSCC cell migration and invasion through
            inhibiting NF-kappaB pathway
            Erratum:[Eur J Pharmacol. 2019 Mar 15;847:158. doi:
            10.1016/j.ejphar.2018.11.042.. Zou A [removed], Wu K [added]. PMID:
            30529035]
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Vieira,A.R., McHenry,T.G., Daack-Hirsch,S., Murray,J.C. and
            Marazita,M.L.
  TITLE     Candidate gene/loci studies in cleft lip/palate and dental
            anomalies finds novel susceptibility genes for clefts
  JOURNAL   Genet Med 10 (9), 668-674 (2008)
   PUBMED   18978678
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Barrios-Rodiles,M., Brown,K.R., Ozdamar,B., Bose,R., Liu,Z.,
            Donovan,R.S., Shinjo,F., Liu,Y., Dembowy,J., Taylor,I.W., Luga,V.,
            Przulj,N., Robinson,M., Suzuki,H., Hayashizaki,Y., Jurisica,I. and
            Wrana,J.L.
  TITLE     High-throughput mapping of a dynamic signaling network in mammalian
            cells
  JOURNAL   Science 307 (5715), 1621-1625 (2005)
   PUBMED   15761153
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Katoh,M.
  TITLE     Molecular cloning and characterization of OSR1 on human chromosome
            2p24
  JOURNAL   Int J Mol Med 10 (2), 221-225 (2002)
   PUBMED   12119563
  REMARK    GeneRIF: first report on molecular cloning and characterization of
            human OSR1
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 1906)
  AUTHORS   Coulter,D.E., Swaykus,E.A., Beran-Koehn,M.A., Goldberg,D.,
            Wieschaus,E. and Schedl,P.
  TITLE     Molecular analysis of odd-skipped, a zinc finger encoding
            segmentation gene with a novel pair-rule expression pattern
  JOURNAL   EMBO J 9 (11), 3795-3804 (1990)
   PUBMED   2120051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC018741.5, AK074591.1 and AI391506.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145260.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK074591.1, BC025712.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA2148093 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272223.3/ ENSP00000272223.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC018741.5         89877-89888
            13-1239             AK074591.1         13-1239
            1240-1836           AC018741.5         96349-96945
            1837-1906           AI391506.1         18-87               c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p24.1"
     gene            1..1906
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /note="odd-skipped related transcription factor 1"
                     /db_xref="GeneID:130497"
                     /db_xref="HGNC:HGNC:8111"
                     /db_xref="MIM:608891"
     exon            1..283
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /inference="alignment:Splign:2.1.0"
     exon            284..980
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1116
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /note="odd-skipped homolog; odd-skipped related 1;
                     odd-skipped related transciption factor 1"
                     /codon_start=1
                     /product="protein odd-skipped-related 1"
                     /protein_id="NP_660303.1"
                     /db_xref="CCDS:CCDS1694.1"
                     /db_xref="GeneID:130497"
                     /db_xref="HGNC:HGNC:8111"
                     /db_xref="MIM:608891"
                     /translation="MGSKTLPAPVPIHPSLQLTNYSFLQAVNGLPTVPSDHLPNLYGF
                     SALHAVHLHQWTLGYPAMHLPRSSFSKVPGTVSSLVDARFQLPAFPWFPHVIQPKPEI
                     TAGGSVPALKTKPRFDFANLALAATQEDPAKLGRGEGPGSPAGGLGALLDVTKLSPEK
                     KPTRGRLPSKTKKEFVCKFCGRHFTKSYNLLIHERTHTDERPYTCDICHKAFRRQDHL
                     RDHRYIHSKEKPFKCQECGKGFCQSRTLAVHKTLHSQVKELKTSKIKC"
     exon            981..1906
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="OSR1"
                     /gene_synonym="ODD"
                     /note="major polyA site"
ORIGIN      
        1 gagtgagtcg gagctcggcc tctccccggc acgttctcag ctgctcctgg ttcagaccca
       61 gcgagggagc cgcgagcgag gctcaccgtc cccggcgtgc aggatccggg gctgctgagc
      121 gctcgctccc gcgtgtccgg cgcttggagt ccccgcggca ggagaggagt cgggacacta
      181 gagctccagg ggcgcctgtg ggctccaggg cctccggctt ccccagtccc cttcagctaa
      241 agccccagag acgtgctcag ccccaggacc tctgcggaac aagatccgga ttgagaagcc
      301 actgcaacta ccgaaatggg cagcaaaacc ttgccggcgc cggtgcctat ccacccttcc
      361 ctgcagctca ccaactactc cttccttcag gcagtgaacg gcctgcccac agtgccttcg
      421 gaccatctgc ccaacctgta tggtttcagc gcgttgcacg ctgtgcacct gcatcagtgg
      481 acgctgggct acccggccat gcacttgccg cgctcttctt tctccaaagt gccgggcacg
      541 gtgtccagct tggtggatgc gcgcttccag ctgcccgcct ttccctggtt ccctcatgtc
      601 attcaaccca agcccgagat caccgctgga ggcagcgttc cagcgctcaa gaccaagccg
      661 cgctttgatt ttgccaacct ggccttggca gcaacgcaag aagatccggc caagctcggt
      721 cgcggggagg gcccaggctc ccctgcaggt gggctgggtg ccctcctcga cgtgaccaag
      781 ctgtctccag aaaagaagcc cacaagggga cgtctgcctt ccaagaccaa gaaggaattc
      841 gtctgcaagt tctgtggccg ccacttcacc aagtcctaca acctacttat ccatgagcgg
      901 acgcacaccg acgagcggcc ctacacctgt gacatctgcc acaaagcctt ccggaggcaa
      961 gaccacctgc gagaccacag atatattcac tccaaagaga agcccttcaa gtgtcaagag
     1021 tgtgggaaag gattctgcca gtccaggact ctcgctgtcc acaagacgct acactcacag
     1081 gtgaaggagc tcaaaacctc caagatcaaa tgctaaatag aacctgtggg tcacaaggac
     1141 cctaggccca gcggccctct cctccatagg gaccagaagc ctgactctgg cgggcagcgg
     1201 gagaggcgct cgctcgggac cttccacctc tccaacattg tcccctgggt ccctggcgca
     1261 cgcggcactt cagagccccg cccggggccg cgaccccgac cgtccctgct gctcccctag
     1321 gacgcggcta aactcttggc caaaaggcgg tactcacgtg gcggaaggga aactgcatta
     1381 aaaaaagaac gaaagctccg cggagccgca gcggcgcctc tcccagaagt attacttttt
     1441 ctattgttat tttatacgtt ttctttttta tttttgtctt tgaccatata agcttgtaac
     1501 tctgactgcg gagagtgagt ggagagagga gaggcaacga agtccttagc actggcagct
     1561 cccacctcct cctcccgccc ctgcccccac ccccggagcc tgcaaaagtg taatccctgt
     1621 atctgcttca gcctcctgcc ctagggaccg cggggcagcc ccctcccagc tcttgcagct
     1681 cagctggcgg ccgtgggctc cgggactagg agagcgggac ggggacctcg ggcctggggt
     1741 ctgcaggggg cccggcctcc gctgccgcga cactgcgagg gagcagccag ccaagagccg
     1801 ggcgttatat tgcgattggc actttatgct gaccatcggt aacggacatt tatcactgga
     1861 gttttttttt tttttaacta ttaaataaac ggttatttta caggca
//
