LOCUS       NM_003999               5526 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens oncostatin M receptor (OSMR), transcript variant 1,
            mRNA.
ACCESSION   NM_003999
VERSION     NM_003999.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5526)
  AUTHORS   Carvalho,V.M.F., Oliveira,P.S.S., Albuquerque,A.P.B.,
            Rego,M.J.B.M., Rosa,M.M.D., Oliveira,D.C., Pereira,M.C. and
            Pitta,M.G.D.R.
  TITLE     Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and
            Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease
  JOURNAL   Arq Bras Cardiol 120 (4), e20220326 (2023)
   PUBMED   37098986
  REMARK    GeneRIF: Decreased Serum Levels of Soluble Oncostatin M Receptor
            (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary
            Artery Disease.
REFERENCE   2  (bases 1 to 5526)
  AUTHORS   Geng,Q., Wang,J., Zhang,W., Zhou,W., Tang,G. and Gu,M.
  TITLE     Oncostatin M receptor is overexpressed in oral squamous cell
            carcinoma and connected to poor prognosis
  JOURNAL   J Oral Pathol Med 52 (2), 136-144 (2023)
   PUBMED   36207791
  REMARK    GeneRIF: Oncostatin M receptor is overexpressed in oral squamous
            cell carcinoma and connected to poor prognosis.
REFERENCE   3  (bases 1 to 5526)
  AUTHORS   Li,Q., Wang,Y., Li,Z., Su,M., Song,Y., Hu,Q., Zhou,B. and Zhang,L.
  TITLE     Association of oncostatin M receptor polymorphisms with clinical
            recurrence of ovarian cancer in the Chinese Han population
  JOURNAL   Biomark Med 16 (6), 461-471 (2022)
   PUBMED   35321549
  REMARK    GeneRIF: Association of oncostatin M receptor polymorphisms with
            clinical recurrence of ovarian cancer in the Chinese Han
            population.
REFERENCE   4  (bases 1 to 5526)
  AUTHORS   Kubin,T., Gajawada,P., Bramlage,P., Hein,S., Berge,B.,
            Cetinkaya,A., Burger,H., Schonburg,M., Schaper,W., Choi,Y.H. and
            Richter,M.
  TITLE     The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure
  JOURNAL   Int J Mol Sci 23 (3), 1811 (2022)
   PUBMED   35163735
  REMARK    GeneRIF: The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5526)
  AUTHORS   Lee,B.Y., Hogg,E.K.J., Below,C.R., Kononov,A., Blanco-Gomez,A.,
            Heider,F., Xu,J., Hutton,C., Zhang,X., Scheidt,T., Beattie,K.,
            Lamarca,A., McNamara,M., Valle,J.W. and Jorgensen,C.
  TITLE     Heterocellular OSM-OSMR signalling reprograms fibroblasts to
            promote pancreatic cancer growth and metastasis
  JOURNAL   Nat Commun 12 (1), 7336 (2021)
   PUBMED   34921158
  REMARK    GeneRIF: Heterocellular OSM-OSMR signalling reprograms fibroblasts
            to promote pancreatic cancer growth and metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5526)
  AUTHORS   Hermanns,H.M., Radtke,S., Haan,C., Schmitz-Van de Leur,H.,
            Tavernier,J., Heinrich,P.C. and Behrmann,I.
  TITLE     Contributions of leukemia inhibitory factor receptor and oncostatin
            M receptor to signal transduction in heterodimeric complexes with
            glycoprotein 130
  JOURNAL   J Immunol 163 (12), 6651-6658 (1999)
   PUBMED   10586060
REFERENCE   7  (bases 1 to 5526)
  AUTHORS   Cichy,J., Rose-John,S. and Pure,E.
  TITLE     Regulation of the type II oncostatin M receptor expression in
            lung-derived epithelial cells
  JOURNAL   FEBS Lett 429 (3), 412-416 (1998)
   PUBMED   9662460
REFERENCE   8  (bases 1 to 5526)
  AUTHORS   Liu,J., Hadjokas,N., Mosley,B., Estrov,Z., Spence,M.J. and
            Vestal,R.E.
  TITLE     Oncostatin M-specific receptor expression and function in
            regulating cell proliferation of normal and malignant mammary
            epithelial cells
  JOURNAL   Cytokine 10 (4), 295-302 (1998)
   PUBMED   9617575
REFERENCE   9  (bases 1 to 5526)
  AUTHORS   Auguste,P., Guillet,C., Fourcin,M., Olivier,C., Veziers,J.,
            Pouplard-Barthelaix,A. and Gascan,H.
  TITLE     Signaling of type II oncostatin M receptor
  JOURNAL   J Biol Chem 272 (25), 15760-15764 (1997)
   PUBMED   9188471
REFERENCE   10 (bases 1 to 5526)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DR006275.1, U60805.1,
            BP352496.1, CB265977.1, CA439576.1 and BU619548.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003999.2.
            
            Summary: This gene encodes a member of the type I cytokine receptor
            family. The encoded protein heterodimerizes with interleukin 6
            signal transducer to form the type II oncostatin M receptor and
            with interleukin 31 receptor A to form the interleukin 31 receptor,
            and thus transduces oncostatin M and interleukin 31 induced
            signaling events. Mutations in this gene have been associated with
            familial primary localized cutaneous amyloidosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.216015.1,
                                           SRR1803614.257595.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274276.8/ ENSP00000274276.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-22                DR006275.1         21-42
            23-3427             U60805.1           1-3405
            3428-3839           BP352496.1         19-430
            3840-4185           U60805.1           3818-4163
            4186-4764           CB265977.1         64-642
            4765-5275           CA439576.1         46-556
            5276-5526           BU619548.1         18-268              c
FEATURES             Location/Qualifiers
     source          1..5526
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..5526
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:9180"
                     /db_xref="HGNC:HGNC:8507"
                     /db_xref="MIM:601743"
     exon            1..376
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            377..462
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            463..635
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            636..807
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1092
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1228
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1229..1380
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1381..1523
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1524..1674
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1751
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1974
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2154
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2155..2259
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2260..2433
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2601
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2602..2683
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..2756
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2757..5526
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5496..5501
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="hexamer: AATAAA"
     polyA_site      5526
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="major polyA site"
ORIGIN      
        1 agctgattca tagccccggc ccgggccgcc tctgcacgtc cgccccggag cccgcacccg
       61 cgccccacgc gccgccgagg actcggcccg gctcgtggag cccttcgccc gcggcgtgag
      121 tacccccgac ccgcccgtcc ccgctctgct cgcgccctgc cgctgcgccg ccctcggtgg
      181 cttttccgac gggcgagccc cgtgctgtgc gggaaagaat ccgacaactt cgcagcccat
      241 cccggctgga cgcgaccggg agtgcagcag cccgttcccc tcctcggtgc cgcctctgcc
      301 cagcgtttgc ttggctgggc taccacctgc gctcggacgg cgctcggagg gtcctcgccc
      361 ccggcctgcc tacctgaaaa ccagaactga tggctctatt tgcagtcttt cagacaacat
      421 tcttcttaac attgctgtcc ttgaggactt accagagtga agtcttggct gaacgtttac
      481 cattgactcc tgtatcactt aaagtttcca ccaattctac gcgtcagagt ttgcacttac
      541 aatggactgt ccacaacctt ccttatcatc aggaattgaa aatggtattt cagatccaga
      601 tcagtaggat tgaaacatcc aatgtcatct gggtggggaa ttacagcacc actgtgaagt
      661 ggaaccaggt tctgcattgg agctgggaat ctgagctccc tttggaatgt gccacacact
      721 ttgtaagaat aaagagtttg gtggacgatg ccaagttccc tgagccaaat ttctggagca
      781 actggagttc ctgggaggaa gtcagtgtac aagattctac tggacaggat atattgttcg
      841 ttttccctaa agataagctg gtggaagaag gcaccaatgt taccatttgt tacgtttcta
      901 ggaacattca aaataatgta tcctgttatt tggaagggaa acagattcat ggagaacaac
      961 ttgatccaca tgtaactgca ttcaacttga atagtgtgcc tttcattagg aataaaggga
     1021 caaatatcta ttgtgaggca agtcaaggaa atgtcagtga aggcatgaaa ggcatcgttc
     1081 tttttgtctc aaaagtactt gaggagccca aggacttttc ttgtgaaacc gaggacttca
     1141 agactttgca ctgtacttgg gatcctggga cggacactgc cttggggtgg tctaaacaac
     1201 cttcccaaag ctacacttta tttgaatcat tttctgggga aaagaaactt tgtacacaca
     1261 aaaactggtg taattggcaa ataactcaag actcacaaga aacctataac ttcacactca
     1321 tagctgaaaa ttacttaagg aagagaagtg tcaatatcct ttttaacctg actcatcgag
     1381 tttatttaat gaatcctttt agtgtcaact ttgaaaatgt aaatgccaca aatgccatca
     1441 tgacctggaa ggtgcactcc ataaggaata atttcacata tttgtgtcag attgaactcc
     1501 atggtgaagg aaaaatgatg caatacaatg tttccatcaa ggtgaacggt gagtacttct
     1561 taagtgaact ggaacctgcc acagagtaca tggcgcgagt acggtgtgct gatgccagcc
     1621 acttctggaa atggagtgaa tggagtggtc agaacttcac cacacttgaa gctgctccct
     1681 cagaggcccc tgatgtctgg agaattgtga gcttggagcc aggaaatcat actgtgacct
     1741 tattctggaa gccattatca aaactgcatg ccaatggaaa gatcctgttc tataatgtag
     1801 ttgtagaaaa cctagacaaa ccatccagtt cagagctcca ttccattcca gcaccagcca
     1861 acagcacaaa actaatcctt gacaggtgtt cctaccaaat ctgcgtcata gccaacaaca
     1921 gtgtgggtgc ttctcctgct tctgtaatag tcatctctgc agaccccgaa aacaaagagg
     1981 ttgaggaaga aagaattgca ggcacagagg gtggattctc tctgtcttgg aaaccccaac
     2041 ctggagatgt tataggctat gttgtggact ggtgtgacca tacccaggat gtgctcggtg
     2101 atttccagtg gaagaatgta ggtcccaata ccacaagcac agtcattagc acagatgctt
     2161 ttaggccagg agttcgatat gacttcagaa tttatgggtt atctacaaaa aggattgctt
     2221 gtttattaga gaaaaaaaca ggatactctc aggaacttgc tccttcagac aaccctcacg
     2281 tgctggtgga tacattgaca tcccactcct tcactctgag ttggaaagat tactctactg
     2341 aatctcaacc tggttttata caagggtacc atgtctatct gaaatccaag gcgaggcagt
     2401 gccacccacg atttgaaaag gcagttcttt cagatggttc agaatgttgc aaatacaaaa
     2461 ttgacaaccc ggaagaaaag gcattgattg tggacaacct aaagccagaa tccttctatg
     2521 agtttttcat cactccattc actagtgctg gtgaaggccc cagtgctacg ttcacgaagg
     2581 tcacgactcc ggatgaacac tcctcgatgc tgattcatat cctactgccc atggttttct
     2641 gcgtcttgct catcatggtc atgtgctact tgaaaagtca gtggatcaag gagacctgtt
     2701 atcctgacat ccctgaccct tacaagagca gcatcctgtc attaataaaa ttcaaggaga
     2761 accctcacct aataataatg aatgtcagtg actgtatccc agatgctatt gaagttgtaa
     2821 gcaagccaga agggacaaag atacagttcc taggcactag gaagtcactc acagaaaccg
     2881 agttgactaa gcctaactac ctttatctcc ttccaacaga aaagaatcac tctggccctg
     2941 gcccctgcat ctgttttgag aacttgacct ataaccaggc agcttctgac tctggctctt
     3001 gtggccatgt tccagtatcc ccaaaagccc caagtatgct gggactaatg acctcacctg
     3061 aaaatgtact aaaggcacta gaaaaaaact acatgaactc cctgggagaa atcccagctg
     3121 gagaaacaag tttgaattat gtgtcccagt tggcttcacc catgtttgga gacaaggaca
     3181 gtctcccaac aaacccagta gaggcaccac actgttcaga gtataaaatg caaatggcag
     3241 tctccctgcg tcttgccttg cctcccccga ccgagaatag cagcctctcc tcaattaccc
     3301 ttttagatcc aggtgaacac tactgctaac cagcatgccg atttcatacc ttatgctaca
     3361 cagacattaa gaagagcaga gctggcaccc tgtcatcacc agtggccttg gtccttaatc
     3421 ccagtacgat ttgcaggtct ggtttatata agaccactac agtctggcta ggttaaaggc
     3481 cagaggctat ggaacttaac actccccatt ggagcaagct tgccctagag acggcaggat
     3541 catgggagca tgcttacctt ctgctgtttg ttccaggctc acctttagaa caggagactt
     3601 gagcttgacc taaggatatg cattaaccac tctacagact cccactcagt actgtacagg
     3661 gtggctgtgg tcctagaagt tcagttttta ctgaggaaat atttccatta acagcaatta
     3721 ttatattgaa ggctttaata aaggccacag gagacattac tatagcatag attgtcaaat
     3781 gtaaatttac tgagcgtgtt ttataaaaaa ctcacaggtg tttgaggcca aaacagattt
     3841 tagacttacc ttgaacggat aagaatctat agttcactga cacagtaaaa ttaactctgt
     3901 gggtgggggc ggggggcata gctctaatct aatatataaa atgtgtgatg aatcaacaag
     3961 atttccacaa ttcttctgtc aagcttacta cagtgaaaga atgggattgg caagtaactt
     4021 ctgacttact gtcagttgta cttctgctcc atagacatca gtattctgcc atcatttttg
     4081 atgactacct cagaacataa aaaggaacgt atatcacata attccagtca cagtttttgg
     4141 ttcctctttt ctttcaagaa ctatatataa atgacctgtt ttcacttagc atcctttgga
     4201 ctctgcagta ggttgtctgg gtcaagataa ctctcagtca catttatatt catattatgc
     4261 taaaatagta aaatgaaacc tcattgttgg acataattta gatataacta aaaagttcta
     4321 tgaagtggga aattccgtgt tggctctgga gcagctttgt ctcctctgaa ccaatatatc
     4381 ccaaaccaat atatgcaaag cacctggtac acaactggta ttttagtaca tgttggttct
     4441 tttggtgcaa tctcagctca ctgcagcttc cgcctcctag attcaaacaa acagttctcc
     4501 tgccccagcc tccagagcac ctaggactcc aggtgcatgc taccacacct gactagtttt
     4561 tatattttta gtagagattg ggttttacca tattggccag gctggtctca aactcctgac
     4621 cgcaggtgat ccacctgcct cagcttcccc aagggctggg attacaggtg tgagccacca
     4681 tgcccagcct atttgtcaca ttatttgtca catttatttt acttttattt attttttgag
     4741 atgaaatttc gctcttgttg cccaggctgg agtgcaatgg tgcagccttg gctcactgca
     4801 acctccgcct cccagggtca agcaattctc ctgcctcagc ctcctgagta gctgggatta
     4861 caggcatgca ccaccacacc caggtaattt tgtatcttta gtagagatgg ggtttcacca
     4921 tgttggtcag gctgttctcg aactcctgac ctcaggtgat ctgcctgcct tggcctccca
     4981 aagtgctggg attacaggcg tgagccactg cgcctagccg tcacatttct aaacaagcat
     5041 gaaaggggtt catttttgtc ttcttcttgc ctgccgtcag catggtggaa atggctctgc
     5101 ctatgctcat gcttctggtg cccaatgcct tgcactgtgc cattcaacac tatgaagaga
     5161 aacaagtagc cacacctcaa aataatgtgg ctgtcaacaa ctggcctaaa taaacctaca
     5221 caaaccagta cttgcctttt gctggaaaca ttgattatgt gctcctcacg tagtagaaag
     5281 cggtatcctg attagtctaa cagttgtgtt agactttagg gccagtattg tcagcattta
     5341 tttatttatg tacctttgtt atgatgggat atttttcatt tgaaacttgt tcataaaaat
     5401 gtcaatgaca ttgatgactg atttgtacat atttttcata tagttttgtt taaaaaataa
     5461 ttcacgcaaa atcttgaagt catttttgct attgaaataa accttaatta aaatatttca
     5521 tcatca
//
