LOCUS       NM_001323507            2064 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens oncostatin M receptor (OSMR), transcript variant 6,
            mRNA.
ACCESSION   NM_001323507
VERSION     NM_001323507.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2064)
  AUTHORS   Carvalho,V.M.F., Oliveira,P.S.S., Albuquerque,A.P.B.,
            Rego,M.J.B.M., Rosa,M.M.D., Oliveira,D.C., Pereira,M.C. and
            Pitta,M.G.D.R.
  TITLE     Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and
            Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease
  JOURNAL   Arq Bras Cardiol 120 (4), e20220326 (2023)
   PUBMED   37098986
  REMARK    GeneRIF: Decreased Serum Levels of Soluble Oncostatin M Receptor
            (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary
            Artery Disease.
REFERENCE   2  (bases 1 to 2064)
  AUTHORS   Geng,Q., Wang,J., Zhang,W., Zhou,W., Tang,G. and Gu,M.
  TITLE     Oncostatin M receptor is overexpressed in oral squamous cell
            carcinoma and connected to poor prognosis
  JOURNAL   J Oral Pathol Med 52 (2), 136-144 (2023)
   PUBMED   36207791
  REMARK    GeneRIF: Oncostatin M receptor is overexpressed in oral squamous
            cell carcinoma and connected to poor prognosis.
REFERENCE   3  (bases 1 to 2064)
  AUTHORS   Li,Q., Wang,Y., Li,Z., Su,M., Song,Y., Hu,Q., Zhou,B. and Zhang,L.
  TITLE     Association of oncostatin M receptor polymorphisms with clinical
            recurrence of ovarian cancer in the Chinese Han population
  JOURNAL   Biomark Med 16 (6), 461-471 (2022)
   PUBMED   35321549
  REMARK    GeneRIF: Association of oncostatin M receptor polymorphisms with
            clinical recurrence of ovarian cancer in the Chinese Han
            population.
REFERENCE   4  (bases 1 to 2064)
  AUTHORS   Kubin,T., Gajawada,P., Bramlage,P., Hein,S., Berge,B.,
            Cetinkaya,A., Burger,H., Schonburg,M., Schaper,W., Choi,Y.H. and
            Richter,M.
  TITLE     The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure
  JOURNAL   Int J Mol Sci 23 (3), 1811 (2022)
   PUBMED   35163735
  REMARK    GeneRIF: The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2064)
  AUTHORS   Lee,B.Y., Hogg,E.K.J., Below,C.R., Kononov,A., Blanco-Gomez,A.,
            Heider,F., Xu,J., Hutton,C., Zhang,X., Scheidt,T., Beattie,K.,
            Lamarca,A., McNamara,M., Valle,J.W. and Jorgensen,C.
  TITLE     Heterocellular OSM-OSMR signalling reprograms fibroblasts to
            promote pancreatic cancer growth and metastasis
  JOURNAL   Nat Commun 12 (1), 7336 (2021)
   PUBMED   34921158
  REMARK    GeneRIF: Heterocellular OSM-OSMR signalling reprograms fibroblasts
            to promote pancreatic cancer growth and metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2064)
  AUTHORS   Hermanns,H.M., Radtke,S., Haan,C., Schmitz-Van de Leur,H.,
            Tavernier,J., Heinrich,P.C. and Behrmann,I.
  TITLE     Contributions of leukemia inhibitory factor receptor and oncostatin
            M receptor to signal transduction in heterodimeric complexes with
            glycoprotein 130
  JOURNAL   J Immunol 163 (12), 6651-6658 (1999)
   PUBMED   10586060
REFERENCE   7  (bases 1 to 2064)
  AUTHORS   Cichy,J., Rose-John,S. and Pure,E.
  TITLE     Regulation of the type II oncostatin M receptor expression in
            lung-derived epithelial cells
  JOURNAL   FEBS Lett 429 (3), 412-416 (1998)
   PUBMED   9662460
REFERENCE   8  (bases 1 to 2064)
  AUTHORS   Liu,J., Hadjokas,N., Mosley,B., Estrov,Z., Spence,M.J. and
            Vestal,R.E.
  TITLE     Oncostatin M-specific receptor expression and function in
            regulating cell proliferation of normal and malignant mammary
            epithelial cells
  JOURNAL   Cytokine 10 (4), 295-302 (1998)
   PUBMED   9617575
REFERENCE   9  (bases 1 to 2064)
  AUTHORS   Auguste,P., Guillet,C., Fourcin,M., Olivier,C., Veziers,J.,
            Pouplard-Barthelaix,A. and Gascan,H.
  TITLE     Signaling of type II oncostatin M receptor
  JOURNAL   J Biol Chem 272 (25), 15760-15764 (1997)
   PUBMED   9188471
REFERENCE   10 (bases 1 to 2064)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI417125.1, U60805.1 and
            BQ772952.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001323507.1.
            
            Summary: This gene encodes a member of the type I cytokine receptor
            family. The encoded protein heterodimerizes with interleukin 6
            signal transducer to form the type II oncostatin M receptor and
            with interleukin 31 receptor A to form the interleukin 31 receptor,
            and thus transduces oncostatin M and interleukin 31 induced
            signaling events. Mutations in this gene have been associated with
            familial primary localized cutaneous amyloidosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.24674.1,
                                           SRR14038194.1542674.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AI417125.1         155-269
            116-1713            U60805.1           355-1952
            1714-2064           BQ772952.1         17-367              c
FEATURES             Location/Qualifiers
     source          1..2064
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..2064
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:9180"
                     /db_xref="HGNC:HGNC:8507"
                     /db_xref="MIM:601743"
     exon            1..115
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..201
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1874
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 6; oncostatin-M-specific receptor subunit beta;
                     oncostatin-M specific receptor beta subunit; IL-31R
                     subunit beta; IL-31 receptor subunit beta; interleukin-31
                     receptor subunit beta"
                     /codon_start=1
                     /product="oncostatin-M-specific receptor subunit beta
                     isoform 4 precursor"
                     /protein_id="NP_001310436.1"
                     /db_xref="GeneID:9180"
                     /db_xref="HGNC:HGNC:8507"
                     /db_xref="MIM:601743"
                     /translation="MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNST
                     RQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESE
                     LPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEE
                     GTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEAS
                     QGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYT
                     LFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLM
                     NPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLS
                     ELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVT
                     LFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIA
                     NNSVGASPASVIVISADPENSVSTCFSGTVPSVWGEGDFSHGSGHFCPGDSSTYMGNY
                     LKFIQVTATLTNSHH"
     exon            202..374
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..546
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..831
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..967
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1119
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1262
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1413
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1490
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1713
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..2064
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2042..2047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="hexamer: AATAAA"
     polyA_site      2064
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="major polyA site"
ORIGIN      
        1 agctgattca tagccccggc ccgggccgcc tctgcacgtc cgccccggag cccgcacccg
       61 cgccccacgc gccgccgagg actcggcccg gctcgtggag cccttcgccc gcggcaaaac
      121 cagaactgat ggctctattt gcagtctttc agacaacatt cttcttaaca ttgctgtcct
      181 tgaggactta ccagagtgaa gtcttggctg aacgtttacc attgactcct gtatcactta
      241 aagtttccac caattctacg cgtcagagtt tgcacttaca atggactgtc cacaaccttc
      301 cttatcatca ggaattgaaa atggtatttc agatccagat cagtaggatt gaaacatcca
      361 atgtcatctg ggtggggaat tacagcacca ctgtgaagtg gaaccaggtt ctgcattgga
      421 gctgggaatc tgagctccct ttggaatgtg ccacacactt tgtaagaata aagagtttgg
      481 tggacgatgc caagttccct gagccaaatt tctggagcaa ctggagttcc tgggaggaag
      541 tcagtgtaca agattctact ggacaggata tattgttcgt tttccctaaa gataagctgg
      601 tggaagaagg caccaatgtt accatttgtt acgtttctag gaacattcaa aataatgtat
      661 cctgttattt ggaagggaaa cagattcatg gagaacaact tgatccacat gtaactgcat
      721 tcaacttgaa tagtgtgcct ttcattagga ataaagggac aaatatctat tgtgaggcaa
      781 gtcaaggaaa tgtcagtgaa ggcatgaaag gcatcgttct ttttgtctca aaagtacttg
      841 aggagcccaa ggacttttct tgtgaaaccg aggacttcaa gactttgcac tgtacttggg
      901 atcctgggac ggacactgcc ttggggtggt ctaaacaacc ttcccaaagc tacactttat
      961 ttgaatcatt ttctggggaa aagaaacttt gtacacacaa aaactggtgt aattggcaaa
     1021 taactcaaga ctcacaagaa acctataact tcacactcat agctgaaaat tacttaagga
     1081 agagaagtgt caatatcctt tttaacctga ctcatcgagt ttatttaatg aatcctttta
     1141 gtgtcaactt tgaaaatgta aatgccacaa atgccatcat gacctggaag gtgcactcca
     1201 taaggaataa tttcacatat ttgtgtcaga ttgaactcca tggtgaagga aaaatgatgc
     1261 aatacaatgt ttccatcaag gtgaacggtg agtacttctt aagtgaactg gaacctgcca
     1321 cagagtacat ggcgcgagta cggtgtgctg atgccagcca cttctggaaa tggagtgaat
     1381 ggagtggtca gaacttcacc acacttgaag ctgctccctc agaggcccct gatgtctgga
     1441 gaattgtgag cttggagcca ggaaatcata ctgtgacctt attctggaag ccattatcaa
     1501 aactgcatgc caatggaaag atcctgttct ataatgtagt tgtagaaaac ctagacaaac
     1561 catccagttc agagctccat tccattccag caccagccaa cagcacaaaa ctaatccttg
     1621 acaggtgttc ctaccaaatc tgcgtcatag ccaacaacag tgtgggtgct tctcctgctt
     1681 ctgtaatagt catctctgca gaccccgaaa acagtgtgtc aacgtgtttc agtgggacag
     1741 tcccctcagt gtggggagaa ggagacttca gccatggctc aggacatttc tgtccagggg
     1801 attcttcaac atacatggga aattatctca aatttattca agtaactgca accctaacaa
     1861 acagtcacca ctgagagttg gagttactat ttatgatctt tgtggcttgt gaaataggaa
     1921 ttgcatttac tattttgtaa aaagtgttgt cagtctttgc acctggaaag agtccatgaa
     1981 catttccaga gatcatcaga actggcatca actttcacca cagactctgc caactttgta
     2041 gaataaaaga taataactgg ctaa
//
