LOCUS       NM_001323505            5265 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens oncostatin M receptor (OSMR), transcript variant 4,
            mRNA.
ACCESSION   NM_001323505
VERSION     NM_001323505.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5265)
  AUTHORS   Carvalho,V.M.F., Oliveira,P.S.S., Albuquerque,A.P.B.,
            Rego,M.J.B.M., Rosa,M.M.D., Oliveira,D.C., Pereira,M.C. and
            Pitta,M.G.D.R.
  TITLE     Decreased Serum Levels of Soluble Oncostatin M Receptor (sOSMR) and
            Glycoprotein 130 (sgp130) in Patients with Coronary Artery Disease
  JOURNAL   Arq Bras Cardiol 120 (4), e20220326 (2023)
   PUBMED   37098986
  REMARK    GeneRIF: Decreased Serum Levels of Soluble Oncostatin M Receptor
            (sOSMR) and Glycoprotein 130 (sgp130) in Patients with Coronary
            Artery Disease.
REFERENCE   2  (bases 1 to 5265)
  AUTHORS   Geng,Q., Wang,J., Zhang,W., Zhou,W., Tang,G. and Gu,M.
  TITLE     Oncostatin M receptor is overexpressed in oral squamous cell
            carcinoma and connected to poor prognosis
  JOURNAL   J Oral Pathol Med 52 (2), 136-144 (2023)
   PUBMED   36207791
  REMARK    GeneRIF: Oncostatin M receptor is overexpressed in oral squamous
            cell carcinoma and connected to poor prognosis.
REFERENCE   3  (bases 1 to 5265)
  AUTHORS   Li,Q., Wang,Y., Li,Z., Su,M., Song,Y., Hu,Q., Zhou,B. and Zhang,L.
  TITLE     Association of oncostatin M receptor polymorphisms with clinical
            recurrence of ovarian cancer in the Chinese Han population
  JOURNAL   Biomark Med 16 (6), 461-471 (2022)
   PUBMED   35321549
  REMARK    GeneRIF: Association of oncostatin M receptor polymorphisms with
            clinical recurrence of ovarian cancer in the Chinese Han
            population.
REFERENCE   4  (bases 1 to 5265)
  AUTHORS   Kubin,T., Gajawada,P., Bramlage,P., Hein,S., Berge,B.,
            Cetinkaya,A., Burger,H., Schonburg,M., Schaper,W., Choi,Y.H. and
            Richter,M.
  TITLE     The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure
  JOURNAL   Int J Mol Sci 23 (3), 1811 (2022)
   PUBMED   35163735
  REMARK    GeneRIF: The Role of Oncostatin M and Its Receptor Complexes in
            Cardiomyocyte Protection, Regeneration, and Failure.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5265)
  AUTHORS   Lee,B.Y., Hogg,E.K.J., Below,C.R., Kononov,A., Blanco-Gomez,A.,
            Heider,F., Xu,J., Hutton,C., Zhang,X., Scheidt,T., Beattie,K.,
            Lamarca,A., McNamara,M., Valle,J.W. and Jorgensen,C.
  TITLE     Heterocellular OSM-OSMR signalling reprograms fibroblasts to
            promote pancreatic cancer growth and metastasis
  JOURNAL   Nat Commun 12 (1), 7336 (2021)
   PUBMED   34921158
  REMARK    GeneRIF: Heterocellular OSM-OSMR signalling reprograms fibroblasts
            to promote pancreatic cancer growth and metastasis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5265)
  AUTHORS   Hermanns,H.M., Radtke,S., Haan,C., Schmitz-Van de Leur,H.,
            Tavernier,J., Heinrich,P.C. and Behrmann,I.
  TITLE     Contributions of leukemia inhibitory factor receptor and oncostatin
            M receptor to signal transduction in heterodimeric complexes with
            glycoprotein 130
  JOURNAL   J Immunol 163 (12), 6651-6658 (1999)
   PUBMED   10586060
REFERENCE   7  (bases 1 to 5265)
  AUTHORS   Cichy,J., Rose-John,S. and Pure,E.
  TITLE     Regulation of the type II oncostatin M receptor expression in
            lung-derived epithelial cells
  JOURNAL   FEBS Lett 429 (3), 412-416 (1998)
   PUBMED   9662460
REFERENCE   8  (bases 1 to 5265)
  AUTHORS   Liu,J., Hadjokas,N., Mosley,B., Estrov,Z., Spence,M.J. and
            Vestal,R.E.
  TITLE     Oncostatin M-specific receptor expression and function in
            regulating cell proliferation of normal and malignant mammary
            epithelial cells
  JOURNAL   Cytokine 10 (4), 295-302 (1998)
   PUBMED   9617575
REFERENCE   9  (bases 1 to 5265)
  AUTHORS   Auguste,P., Guillet,C., Fourcin,M., Olivier,C., Veziers,J.,
            Pouplard-Barthelaix,A. and Gascan,H.
  TITLE     Signaling of type II oncostatin M receptor
  JOURNAL   J Biol Chem 272 (25), 15760-15764 (1997)
   PUBMED   9188471
REFERENCE   10 (bases 1 to 5265)
  AUTHORS   Mosley,B., De Imus,C., Friend,D., Boiani,N., Thoma,B., Park,L.S.
            and Cosman,D.
  TITLE     Dual oncostatin M (OSM) receptors. Cloning and characterization of
            an alternative signaling subunit conferring OSM-specific receptor
            activation
  JOURNAL   J Biol Chem 271 (51), 32635-32643 (1996)
   PUBMED   8999038
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AI417125.1, U60805.1,
            AC026713.5, CB265977.1, CA439576.1 and BU619548.1.
            
            On May 31, 2019 this sequence version replaced NM_001323505.1.
            
            Summary: This gene encodes a member of the type I cytokine receptor
            family. The encoded protein heterodimerizes with interleukin 6
            signal transducer to form the type II oncostatin M receptor and
            with interleukin 31 receptor A to form the interleukin 31 receptor,
            and thus transduces oncostatin M and interleukin 31 induced
            signaling events. Mutations in this gene have been associated with
            familial primary localized cutaneous amyloidosis. Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.187871.1,
                                           SRR1803614.12963.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AI417125.1         155-269
            116-3166            U60805.1           355-3405
            3167-3167           AC026713.5         7775-7775           c
            3168-3924           U60805.1           3407-4163
            3925-4503           CB265977.1         64-642
            4504-5014           CA439576.1         46-556
            5015-5265           BU619548.1         18-268              c
FEATURES             Location/Qualifiers
     source          1..5265
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.1"
     gene            1..5265
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="oncostatin M receptor"
                     /db_xref="GeneID:9180"
                     /db_xref="HGNC:HGNC:8507"
                     /db_xref="MIM:601743"
     exon            1..115
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..201
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..3068
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 4; oncostatin-M-specific receptor subunit beta;
                     oncostatin-M specific receptor beta subunit; IL-31R
                     subunit beta; IL-31 receptor subunit beta; interleukin-31
                     receptor subunit beta"
                     /codon_start=1
                     /product="oncostatin-M-specific receptor subunit beta
                     isoform 1 precursor"
                     /protein_id="NP_001310434.1"
                     /db_xref="CCDS:CCDS3928.1"
                     /db_xref="GeneID:9180"
                     /db_xref="HGNC:HGNC:8507"
                     /db_xref="MIM:601743"
                     /translation="MALFAVFQTTFFLTLLSLRTYQSEVLAERLPLTPVSLKVSTNST
                     RQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKWNQVLHWSWESE
                     LPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVSVQDSTGQDILFVFPKDKLVEE
                     GTNVTICYVSRNIQNNVSCYLEGKQIHGEQLDPHVTAFNLNSVPFIRNKGTNIYCEAS
                     QGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGWSKQPSQSYT
                     LFESFSGEKKLCTHKNWCNWQITQDSQETYNFTLIAENYLRKRSVNILFNLTHRVYLM
                     NPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLS
                     ELEPATEYMARVRCADASHFWKWSEWSGQNFTTLEAAPSEAPDVWRIVSLEPGNHTVT
                     LFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPANSTKLILDRCSYQICVIA
                     NNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQPGDVIGYVVDWCDHTQ
                     DVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIACLLEKKTGYSQELA
                     PSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQCHPRFEKAVLSD
                     GSECCKYKIDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFTKVTTPDEHSSM
                     LIHILLPMVFCVLLIMVMCYLKSQWIKETCYPDIPDPYKSSILSLIKFKENPHLIIMN
                     VSDCIPDAIEVVSKPEGTKIQFLGTRKSLTETELTKPNYLYLLPTEKNHSGPGPCICF
                     ENLTYNQAASDSGSCGHVPVSPKAPSMLGLMTSPENVLKALEKNYMNSLGEIPAGETS
                     LNYVSQLASPMFGDKDSLPTNPVEAPHCSEYKMQMAVSLRLALPPPTENSSLSSITLL
                     DPGEHYC"
     exon            202..374
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            375..546
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            547..831
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..967
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1119
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1262
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1413
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1490
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1713
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1893
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..1998
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1999..2172
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2340
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2422
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2495
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..5265
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5235..5240
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="hexamer: AATAAA"
     polyA_site      5265
                     /gene="OSMR"
                     /gene_synonym="IL-31R-beta; IL-31RB; OSMRB; OSMRbeta;
                     PLCA1"
                     /note="major polyA site"
ORIGIN      
        1 agctgattca tagccccggc ccgggccgcc tctgcacgtc cgccccggag cccgcacccg
       61 cgccccacgc gccgccgagg actcggcccg gctcgtggag cccttcgccc gcggcaaaac
      121 cagaactgat ggctctattt gcagtctttc agacaacatt cttcttaaca ttgctgtcct
      181 tgaggactta ccagagtgaa gtcttggctg aacgtttacc attgactcct gtatcactta
      241 aagtttccac caattctacg cgtcagagtt tgcacttaca atggactgtc cacaaccttc
      301 cttatcatca ggaattgaaa atggtatttc agatccagat cagtaggatt gaaacatcca
      361 atgtcatctg ggtggggaat tacagcacca ctgtgaagtg gaaccaggtt ctgcattgga
      421 gctgggaatc tgagctccct ttggaatgtg ccacacactt tgtaagaata aagagtttgg
      481 tggacgatgc caagttccct gagccaaatt tctggagcaa ctggagttcc tgggaggaag
      541 tcagtgtaca agattctact ggacaggata tattgttcgt tttccctaaa gataagctgg
      601 tggaagaagg caccaatgtt accatttgtt acgtttctag gaacattcaa aataatgtat
      661 cctgttattt ggaagggaaa cagattcatg gagaacaact tgatccacat gtaactgcat
      721 tcaacttgaa tagtgtgcct ttcattagga ataaagggac aaatatctat tgtgaggcaa
      781 gtcaaggaaa tgtcagtgaa ggcatgaaag gcatcgttct ttttgtctca aaagtacttg
      841 aggagcccaa ggacttttct tgtgaaaccg aggacttcaa gactttgcac tgtacttggg
      901 atcctgggac ggacactgcc ttggggtggt ctaaacaacc ttcccaaagc tacactttat
      961 ttgaatcatt ttctggggaa aagaaacttt gtacacacaa aaactggtgt aattggcaaa
     1021 taactcaaga ctcacaagaa acctataact tcacactcat agctgaaaat tacttaagga
     1081 agagaagtgt caatatcctt tttaacctga ctcatcgagt ttatttaatg aatcctttta
     1141 gtgtcaactt tgaaaatgta aatgccacaa atgccatcat gacctggaag gtgcactcca
     1201 taaggaataa tttcacatat ttgtgtcaga ttgaactcca tggtgaagga aaaatgatgc
     1261 aatacaatgt ttccatcaag gtgaacggtg agtacttctt aagtgaactg gaacctgcca
     1321 cagagtacat ggcgcgagta cggtgtgctg atgccagcca cttctggaaa tggagtgaat
     1381 ggagtggtca gaacttcacc acacttgaag ctgctccctc agaggcccct gatgtctgga
     1441 gaattgtgag cttggagcca ggaaatcata ctgtgacctt attctggaag ccattatcaa
     1501 aactgcatgc caatggaaag atcctgttct ataatgtagt tgtagaaaac ctagacaaac
     1561 catccagttc agagctccat tccattccag caccagccaa cagcacaaaa ctaatccttg
     1621 acaggtgttc ctaccaaatc tgcgtcatag ccaacaacag tgtgggtgct tctcctgctt
     1681 ctgtaatagt catctctgca gaccccgaaa acaaagaggt tgaggaagaa agaattgcag
     1741 gcacagaggg tggattctct ctgtcttgga aaccccaacc tggagatgtt ataggctatg
     1801 ttgtggactg gtgtgaccat acccaggatg tgctcggtga tttccagtgg aagaatgtag
     1861 gtcccaatac cacaagcaca gtcattagca cagatgcttt taggccagga gttcgatatg
     1921 acttcagaat ttatgggtta tctacaaaaa ggattgcttg tttattagag aaaaaaacag
     1981 gatactctca ggaacttgct ccttcagaca accctcacgt gctggtggat acattgacat
     2041 cccactcctt cactctgagt tggaaagatt actctactga atctcaacct ggttttatac
     2101 aagggtacca tgtctatctg aaatccaagg cgaggcagtg ccacccacga tttgaaaagg
     2161 cagttctttc agatggttca gaatgttgca aatacaaaat tgacaacccg gaagaaaagg
     2221 cattgattgt ggacaaccta aagccagaat ccttctatga gtttttcatc actccattca
     2281 ctagtgctgg tgaaggcccc agtgctacgt tcacgaaggt cacgactccg gatgaacact
     2341 cctcgatgct gattcatatc ctactgccca tggttttctg cgtcttgctc atcatggtca
     2401 tgtgctactt gaaaagtcag tggatcaagg agacctgtta tcctgacatc cctgaccctt
     2461 acaagagcag catcctgtca ttaataaaat tcaaggagaa ccctcaccta ataataatga
     2521 atgtcagtga ctgtatccca gatgctattg aagttgtaag caagccagaa gggacaaaga
     2581 tacagttcct aggcactagg aagtcactca cagaaaccga gttgactaag cctaactacc
     2641 tttatctcct tccaacagaa aagaatcact ctggccctgg cccctgcatc tgttttgaga
     2701 acttgaccta taaccaggca gcttctgact ctggctcttg tggccatgtt ccagtatccc
     2761 caaaagcccc aagtatgctg ggactaatga cctcacctga aaatgtacta aaggcactag
     2821 aaaaaaacta catgaactcc ctgggagaaa tcccagctgg agaaacaagt ttgaattatg
     2881 tgtcccagtt ggcttcaccc atgtttggag acaaggacag tctcccaaca aacccagtag
     2941 aggcaccaca ctgttcagag tataaaatgc aaatggcagt ctccctgcgt cttgccttgc
     3001 ctcccccgac cgagaatagc agcctctcct caattaccct tttagatcca ggtgaacact
     3061 actgctaacc agcatgccga tttcatacct tatgctacac agacattaag aagagcagag
     3121 ctggcaccct gtcatcacca gtggccttgg tccttaatcc cagtacgatt tgcaggtctg
     3181 gtttatataa gaccactaca gtctggctag gttaaaggcc agaggctatg gaacttaaca
     3241 ctccccattg gagcaagctt gccctagaga cggcaggatc atgggagcat gcttaccttc
     3301 tgctgtttgt tccaggctca cctttagaac aggagacttg agcttgacct aaggatatgc
     3361 attaaccact ctacagactc ccactcagta ctgtacaggg tggctgtggt cctagaagtt
     3421 cagtttttac tgaggaaata tttccattaa cagcaattat tatattgaag gctttaataa
     3481 aggccacagg agacattact atagcataga ttgtcaaatg taaatttact gagcgtgttt
     3541 tataaaaaac tcacaggtgt ttgaggccaa aacagatttt agacttacct tgaacggata
     3601 agaatctata gttcactgac acagtaaaat taactctgtg ggtgggggcg gggggcatag
     3661 ctctaatcta atatataaaa tgtgtgatga atcaacaaga tttccacaat tcttctgtca
     3721 agcttactac agtgaaagaa tgggattggc aagtaacttc tgacttactg tcagttgtac
     3781 ttctgctcca tagacatcag tattctgcca tcatttttga tgactacctc agaacataaa
     3841 aaggaacgta tatcacataa ttccagtcac agtttttggt tcctcttttc tttcaagaac
     3901 tatatataaa tgacctgttt tcacttagca tcctttggac tctgcagtag gttgtctggg
     3961 tcaagataac tctcagtcac atttatattc atattatgct aaaatagtaa aatgaaacct
     4021 cattgttgga cataatttag atataactaa aaagttctat gaagtgggaa attccgtgtt
     4081 ggctctggag cagctttgtc tcctctgaac caatatatcc caaaccaata tatgcaaagc
     4141 acctggtaca caactggtat tttagtacat gttggttctt ttggtgcaat ctcagctcac
     4201 tgcagcttcc gcctcctaga ttcaaacaaa cagttctcct gccccagcct ccagagcacc
     4261 taggactcca ggtgcatgct accacacctg actagttttt atatttttag tagagattgg
     4321 gttttaccat attggccagg ctggtctcaa actcctgacc gcaggtgatc cacctgcctc
     4381 agcttcccca agggctggga ttacaggtgt gagccaccat gcccagccta tttgtcacat
     4441 tatttgtcac atttatttta cttttattta ttttttgaga tgaaatttcg ctcttgttgc
     4501 ccaggctgga gtgcaatggt gcagccttgg ctcactgcaa cctccgcctc ccagggtcaa
     4561 gcaattctcc tgcctcagcc tcctgagtag ctgggattac aggcatgcac caccacaccc
     4621 aggtaatttt gtatctttag tagagatggg gtttcaccat gttggtcagg ctgttctcga
     4681 actcctgacc tcaggtgatc tgcctgcctt ggcctcccaa agtgctggga ttacaggcgt
     4741 gagccactgc gcctagccgt cacatttcta aacaagcatg aaaggggttc atttttgtct
     4801 tcttcttgcc tgccgtcagc atggtggaaa tggctctgcc tatgctcatg cttctggtgc
     4861 ccaatgcctt gcactgtgcc attcaacact atgaagagaa acaagtagcc acacctcaaa
     4921 ataatgtggc tgtcaacaac tggcctaaat aaacctacac aaaccagtac ttgccttttg
     4981 ctggaaacat tgattatgtg ctcctcacgt agtagaaagc ggtatcctga ttagtctaac
     5041 agttgtgtta gactttaggg ccagtattgt cagcatttat ttatttatgt acctttgtta
     5101 tgatgggata tttttcattt gaaacttgtt cataaaaatg tcaatgacat tgatgactga
     5161 tttgtacata tttttcatat agttttgttt aaaaaataat tcacgcaaaa tcttgaagtc
     5221 atttttgcta ttgaaataaa ccttaattaa aatatttcat catca
//
