LOCUS       NM_020530               1865 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens oncostatin M (OSM), transcript variant 1, mRNA.
ACCESSION   NM_020530
VERSION     NM_020530.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1865)
  AUTHORS   Gong,W., Zhou,J., Hou,Y., Zhang,J., He,P. and Yu,Q.
  TITLE     The causal relationship between immune cells mediating FIT3L, CCL4,
            OSM, and skin-derived deteriorated tumors
  JOURNAL   Skin Res Technol 30 (7), e13774 (2024)
   PUBMED   38953214
  REMARK    GeneRIF: The causal relationship between immune cells mediating
            FIT3L, CCL4, OSM, and skin-derived deteriorated tumors.
REFERENCE   2  (bases 1 to 1865)
  AUTHORS   Dollet,L., Lundell,L.S., Chibalin,A.V., Pendergrast,L.A.,
            Pillon,N.J., Lansbury,E.L., Elmastas,M., Frendo-Cumbo,S.,
            Jalkanen,J., de Castro Barbosa,T., Cervone,D.T., Caidahl,K.,
            Dmytriyeva,O., Deshmukh,A.S., Barres,R., Ryden,M.,
            Wallberg-Henriksson,H., Zierath,J.R. and Krook,A.
  TITLE     Exercise-induced crosstalk between immune cells and adipocytes in
            humans: Role of oncostatin-M
  JOURNAL   Cell Rep Med 5 (1), 101348 (2024)
   PUBMED   38151020
  REMARK    GeneRIF: Exercise-induced crosstalk between immune cells and
            adipocytes in humans: Role of oncostatin-M.
REFERENCE   3  (bases 1 to 1865)
  AUTHORS   Setiadi,H., El-Banayosy,A.M., Long,J.W., Maybauer,M.O., Mihu,M.R.
            and El Banayosy,A.
  TITLE     Oncostatin M for characterizing the inflammatory burden and outcome
            of V-V ECMO in ARDS patients
  JOURNAL   Artif Organs 47 (12), 1885-1892 (2023)
   PUBMED   37476931
  REMARK    GeneRIF: Oncostatin M for characterizing the inflammatory burden
            and outcome of V-V ECMO in ARDS patients.
REFERENCE   4  (bases 1 to 1865)
  AUTHORS   Suehiro,M., Numata,T., Saito,R., Yanagida,N., Ishikawa,C.,
            Uchida,K., Kawaguchi,T., Yanase,Y., Ishiuji,Y., McGrath,J. and
            Tanaka,A.
  TITLE     Oncostatin M suppresses IL31RA expression in dorsal root ganglia
            and interleukin-31-induced itching
  JOURNAL   Front Immunol 14, 1251031 (2023)
   PUBMED   38035099
  REMARK    GeneRIF: Oncostatin M suppresses IL31RA expression in dorsal root
            ganglia and interleukin-31-induced itching.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1865)
  AUTHORS   Tatsuda,D., Yoshida,J., Ohishi,T. and Kawada,M.
  TITLE     Pancreatic Stromal Cell-derived Oncostatin M Confers Drug
            Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic
            Cancer Cells
  JOURNAL   Anticancer Res 43 (6), 2477-2489 (2023)
   PUBMED   37247926
  REMARK    GeneRIF: Pancreatic Stromal Cell-derived Oncostatin M Confers Drug
            Resistance to a Multi-tyrosine Kinase Inhibitor in Pancreatic
            Cancer Cells.
REFERENCE   6  (bases 1 to 1865)
  AUTHORS   Richards,C.D.
  TITLE     The enigmatic cytokine oncostatin m and roles in disease
  JOURNAL   ISRN Inflamm 2013, 512103 (2013)
   PUBMED   24381786
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1865)
  AUTHORS   Gearing,D.P., Comeau,M.R., Friend,D.J., Gimpel,S.D., Thut,C.J.,
            McGourty,J., Brasher,K.K., King,J.A., Gillis,S., Mosley,B. et al.
  TITLE     The IL-6 signal transducer, gp130: an oncostatin M receptor and
            affinity converter for the LIF receptor
  JOURNAL   Science 255 (5050), 1434-1437 (1992)
   PUBMED   1542794
REFERENCE   8  (bases 1 to 1865)
  AUTHORS   Miles,S.A., Martinez-Maza,O., Rezai,A., Magpantay,L., Kishimoto,T.,
            Nakamura,S., Radka,S.F. and Linsley,P.S.
  TITLE     Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived
            cells
  JOURNAL   Science 255 (5050), 1432-1434 (1992)
   PUBMED   1542793
REFERENCE   9  (bases 1 to 1865)
  AUTHORS   Gearing,D.P. and Bruce,A.G.
  TITLE     Oncostatin M binds the high-affinity leukemia inhibitory factor
            receptor
  JOURNAL   New Biol 4 (1), 61-65 (1992)
   PUBMED   1536831
REFERENCE   10 (bases 1 to 1865)
  AUTHORS   Rose,T.M. and Bruce,A.G.
  TITLE     Oncostatin M is a member of a cytokine family that includes
            leukemia-inhibitory factor, granulocyte colony-stimulating factor,
            and interleukin 6
  JOURNAL   Proc Natl Acad Sci U S A 88 (19), 8641-8645 (1991)
   PUBMED   1717982
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004264.1, CR981101.1 and
            BC011589.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020530.5.
            
            Summary: This gene encodes a member of the leukemia inhibitory
            factor/oncostatin-M (LIF/OSM) family of proteins. The encoded
            preproprotein is proteolytically processed to generate the mature
            protein. This protein is a secreted cytokine and growth regulator
            that inhibits the proliferation of a number of tumor cell lines.
            This protein also regulates the production of other cytokines,
            including interleukin 6, granulocyte-colony stimulating factor and
            granulocyte-macrophage colony stimulating factor in endothelial
            cells. This gene and the related gene, leukemia inhibitory factor,
            also present on chromosome 22, may have resulted from the
            duplication of a common ancestral gene. Alternative splicing
            results in multiple transcript variants, at least one of which
            encodes an isoform that is proteolytically processed. [provided by
            RefSeq, Jan 2016].
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011589.1, BM544068.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000215781.3/ ENSP00000215781.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC004264.1         31547-31554         c
            9-11                CR981101.1         1-3
            12-1865             BC011589.1         1-1854
FEATURES             Location/Qualifiers
     source          1..1865
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.2"
     gene            1..1865
                     /gene="OSM"
                     /note="oncostatin M"
                     /db_xref="GeneID:5008"
                     /db_xref="HGNC:HGNC:8506"
                     /db_xref="MIM:165095"
     exon            1..86
                     /gene="OSM"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..811
                     /gene="OSM"
                     /note="isoform 1 preproprotein is encoded by transcript
                     variant 1"
                     /codon_start=1
                     /product="oncostatin-M isoform 1 preproprotein"
                     /protein_id="NP_065391.1"
                     /db_xref="CCDS:CCDS13873.1"
                     /db_xref="GeneID:5008"
                     /db_xref="HGNC:HGNC:8506"
                     /db_xref="MIM:165095"
                     /translation="MGVLLTQRTLLSLVLALLFPSMASMAAIGSCSKEYRVLLGQLQK
                     QTDLMQDTSRLLDPYIRIQGLDVPKLREHCRERPGAFPSEETLRGLGRRGFLQTLNAT
                     LGCVLHRLADLEQRLPKAQDLERSGLNIEDLEKLQMARPNILGLRNNIYCMAQLLDNS
                     DTAEPTKAGRGASQPPTPTPASDAFQRKLEGCRFLHGYHRFMHSVGRVFSKWGESPNR
                     SRRHSPHQALRKGVRRTRPSRKGKRLMTRGQLPR"
     exon            87..229
                     /gene="OSM"
                     /inference="alignment:Splign:2.1.0"
     exon            230..1865
                     /gene="OSM"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1865
                     /gene="OSM"
                     /note="major polyA site"
ORIGIN      
        1 agccgagagg tgtcaccccc agcgggcgcg ggccggagca cgggcaccca gcatgggggt
       61 actgctcaca cagaggacgc tgctcagtct ggtccttgca ctcctgtttc caagcatggc
      121 gagcatggcg gctataggca gctgctcgaa agagtaccgc gtgctccttg gccagctcca
      181 gaagcagaca gatctcatgc aggacaccag cagactcctg gacccctata tacgtatcca
      241 aggcctggat gttcctaaac tgagagagca ctgcagggag cgccccgggg ccttccccag
      301 tgaggagacc ctgagggggc tgggcaggcg gggcttcctg cagaccctca atgccacact
      361 gggctgcgtc ctgcacagac tggccgactt agagcagcgc ctccccaagg cccaggattt
      421 ggagaggtct gggctgaaca tcgaggactt ggagaagctg cagatggcga ggccgaacat
      481 cctcgggctc aggaacaaca tctactgcat ggcccagctg ctggacaact cagacacggc
      541 tgagcccacg aaggctggcc ggggggcctc tcagccgccc acccccaccc ctgcctcgga
      601 tgcttttcag cgcaagctgg agggctgcag gttcctgcat ggctaccatc gcttcatgca
      661 ctcagtgggg cgggtcttca gcaagtgggg ggagagcccg aaccggagcc ggagacacag
      721 cccccaccag gccctgagga agggggtgcg caggaccaga ccctccagga aaggcaagag
      781 actcatgacc aggggacagc tgccccggta gcctcgagag caccccttgc cggtgaagga
      841 tgcggcaggt gctctgtgga tgagaggaac catcgcagga tgacagctcc cgggtcccca
      901 aacctgttcc cctctgctac tagccactga gaagtgcact ttaagaggtg ggagctgggc
      961 agacccctct acctcctcca ggctgggaga cagagtcagg ctgttgcgct cccacctcag
     1021 ccccaagttc cccaggccca gtggggtggc cgggcgggcc acgcgggacc gactttccat
     1081 tgattcaggg gtctgatgac acaggctgac tcatggccgg gctgactgcc cccctgcctt
     1141 gctccccgag gcctgccggt ccttccctct catgacttgc agggccgttg cccccagact
     1201 tcctcctttc cgtgtttctg aaggggaggt cacagcctga gctggcctcc tatgcctcat
     1261 catgtcccaa accagacacc tggatgtctg ggtgacctca ctttaggcag ctgtaacagc
     1321 ggcagggtgt cccaggagcc ctgatccggg ggtccaggga atggagctca ggtcccaggc
     1381 cagccccgaa gtcgccacgt ggcctggggc aggtcacttt acctctgtgg acctgttttc
     1441 tctttgtgaa gctagggagt tagaggctgt acaaggcccc cactgcctgt cggttgcttg
     1501 gattccctga cgtaaggtgg atattaaaaa tctgtaaatc aggacaggtg gtgcaaatgg
     1561 cgctgggagg tgtacacgga ggtctctgta aaagcagacc cacctcccag cgccgggaag
     1621 cccgtcttgg gtcctcgctg ctggctgctc cccctggtgg tggatcctgg aattttctca
     1681 cgcaggagcc attgctctcc tagagggggt ctcagaaact gcgaggccag ttccttggag
     1741 ggacatgact aatttatcga tttttatcaa tttttatcag ttttatattt ataagcctta
     1801 tttatgatgt atatttaatg ttaatattgt gcaaacttat atttaaaact tgcctggttt
     1861 ctaaa
//
