LOCUS       NM_001126111            4230 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens oxidative stress induced growth inhibitor family
            member 2 (OSGIN2), transcript variant 1, mRNA.
ACCESSION   NM_001126111
VERSION     NM_001126111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4230)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   2  (bases 1 to 4230)
  AUTHORS   Tauchi,H., Matsuura,S., Isomura,M., Kinjo,T., Nakamura,A.,
            Sakamoto,S., Kondo,N., Endo,S., Komatsu,K. and Nakamura,Y.
  TITLE     Sequence analysis of an 800-kb genomic DNA region on chromosome
            8q21 that contains the Nijmegen breakage syndrome gene, NBS1
  JOURNAL   Genomics 55 (2), 242-247 (1999)
   PUBMED   9933573
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031054.1, BM764021.1, AF061326.1 and BU739360.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001126111.2.
            
            Transcript Variant: This variant (1) uses an alternate 5'UTR that
            includes a translation start site that is upstream and in-frame
            with that used for variant 2. The resulting protein (isoform 1) is
            longer and has a distinct N-terminus compared to isoform 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.272493.1,
                                           SRR1660807.199466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451899.7/ ENSP00000396445.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                BC031054.1         37-103
            68-68               BM764021.1         77-77
            69-233              BC031054.1         105-269
            234-235             BM764021.1         243-244
            236-1929            BC031054.1         270-1963
            1930-4210           AF061326.1         1919-4199
            4211-4230           BU739360.1         16-35               c
FEATURES             Location/Qualifiers
     source          1..4230
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q21.3"
     gene            1..4230
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="oxidative stress induced growth inhibitor family
                     member 2"
                     /db_xref="GeneID:734"
                     /db_xref="HGNC:HGNC:1355"
                     /db_xref="MIM:604598"
     exon            1..268
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     CDS             225..1874
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="isoform 1 is encoded by transcript variant 1;
                     oxidative stress-induced growth inhibitor 2"
                     /codon_start=1
                     /product="oxidative stress-induced growth inhibitor 2
                     isoform 1"
                     /protein_id="NP_001119583.1"
                     /db_xref="CCDS:CCDS47888.1"
                     /db_xref="GeneID:734"
                     /db_xref="HGNC:HGNC:1355"
                     /db_xref="MIM:604598"
                     /translation="MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKA
                     MPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLE
                     EARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHY
                     IPHVVLGKGPPGGAWHNMEGSMLTISFGSWMELPGLKFKDWVSSKRRSLKGDRVMPEE
                     IARYYKHYVKVMGLQKNFRENTYITSVSRLYRDQDDDDIQDRDISTKHLQIEKSNFIK
                     RNWEIRGYQRIADGSHVPFCLFAENVALATGTLDSPAHLEIEGEDFPFVFHSMPEFGA
                     AINKGKLRGKVDPVLIVGSGLTAADAVLCAYNSNIPVIHVFRRRVTDPSLIFKQLPKK
                     LYPEYHKVYHMMCTQSYSVDSNLLSDYTSFPEHRVLSFKSDMKCVLQSVSGLKKIFKL
                     SAAVVLIGSHPNLSFLKDQGCYLGHKSSQPITCKGNPVEIDTYTYECIKEANLFALGP
                     LVGDNFVRFLKGGALGVTRCLATRQKKKHLFVERGGGDGIA"
     exon            269..423
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     exon            424..560
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     exon            561..752
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     exon            753..844
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     exon            845..4230
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2718..2723
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: AATAAA"
     polyA_site      2742
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="major polyA site"
     regulatory      3165..3170
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: ATTAAA"
     polyA_site      3185
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="major polyA site"
     regulatory      3662..3667
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: AATAAA"
     regulatory      3685..3690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: AATAAA"
     polyA_site      3686
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="major polyA site"
     polyA_site      3707
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
     regulatory      4192..4197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: AATAAA"
     regulatory      4209..4214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
                     /note="hexamer: AATAAA"
     polyA_site      4214
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
     polyA_site      4230
                     /gene="OSGIN2"
                     /gene_synonym="C8orf1; hT41"
ORIGIN      
        1 ctccggcgcc tggctccctg caggcgagga gcggaagccg ctatctggag gcggactccg
       61 gcgccacaga gccggggcag ccgcggcaac ggcgaggcgc gaggcagggg cgcccggcag
      121 accccgcgac cccgagccag cgggcgcccc gagcgggcag cctcgccggg ggaggcggag
      181 gcggccacgg cggccgcgct cgggcgcccc tcgcgcagcg ctccatgccc gtgtggtgct
      241 gccgctgctc cctggccggt catttcagaa actatagtga cactgaaact gaaggagaga
      301 tttttaattc cttagtgcaa tactttggtg acaacttggg gcgaaaagtt aaagcgatgc
      361 cattagttga agaaacttct ttactggaag attcgtcagt gacttttcct gtggtaataa
      421 taggaaatgg accctcagga atatgccttt cttatatgtt atcaggctac agaccgtatt
      481 tatcatcaga agcaatacac ccaaatacaa tcttaaatag taaattagaa gaagcaagac
      541 atctttccat tgttgatcag gacttagaat acttgtctga gggccttgag ggccgatcat
      601 ccaatccagt tgcagtactt ttcgatacac ttcttcatcc agatgctgac tttgggtatg
      661 attatccatc cgttttgcat tggaaattag agcaacatca ttatatccct cacgtagttc
      721 ttggtaaagg tccacctggt ggggcttggc ataatatgga aggctccatg ttgacaatca
      781 gctttggaag ttggatggaa ctacctggac ttaaatttaa ggactgggta tcaagtaaac
      841 gaaggagcct aaaaggggat cgagttatgc cagaggaaat agctcgctac tataaacatt
      901 atgtaaaagt catgggtctt cagaagaatt tcagagagaa tacttacata acttccgtat
      961 caagactcta cagagatcaa gatgatgatg atattcaaga cagagatatt tcaacaaagc
     1021 atttacagat agagaagtca aactttatca agagaaactg ggaaattagg ggttatcagc
     1081 gaatagctga tggttctcat gttcccttct gcctctttgc tgagaatgta gcgctggcaa
     1141 ctggaacgct ggattctcct gcccatctgg aaattgaagg ggaagatttt ccttttgtgt
     1201 ttcattcaat gcctgaattt ggagctgcta taaacaaagg aaagttgcgt ggcaaagtgg
     1261 atccagtgtt aattgtaggt tctgggctta ctgccgctga cgcagtactg tgtgcttaca
     1321 acagtaatat ccctgtgatt catgtgtttc gcagacgagt aactgatcca agcttaattt
     1381 tcaaacagct tcccaaaaag ctgtatcctg aatatcataa agtctatcat atgatgtgta
     1441 ctcagtcata ttctgtagac tcaaatcttt tatctgatta taccagcttt cccgagcacc
     1501 gtgtgctttc ctttaagtcg gacatgaaat gtgttctcca aagcgtttct ggattgaaga
     1561 aaatatttaa gctgtctgca gcagtagtat tgataggttc tcatcctaat ctgtcttttc
     1621 tgaaggatca agggtgttac ctaggccata agtcaagcca gccaatcaca tgtaagggta
     1681 atcctgtgga aatagataca tatacctatg agtgtattaa agaagccaac ctttttgcat
     1741 tgggtccttt ggttggagac aattttgttc gatttttaaa gggaggggcg ctgggtgtta
     1801 cacgctgttt agctacaaga cagaagaaaa agcatttgtt tgttgaaaga ggaggaggag
     1861 atgggatagc ttaaagcaag tttacaagta attaaaatgg acagtttgcc attaaagatt
     1921 tttaatagtg gttttgcagt gtactggctt gaattttctg gacttgagtt aactgaagga
     1981 gagcctcaaa ctatagtaac ttcattttta aaagttacta gaatttggta tcctgattta
     2041 tattgcagtg tttcaaaggt gtcactgtca gacaaataga aacactgcca acttggtgta
     2101 acttaagctt tcatttaact aaaacattct tttcttgcaa aacttatttt tcatgatcat
     2161 ttttggttat ttattatact tgattccaaa atagtacagc cttgaatcta taaaactgtg
     2221 cagtcattat gccagaaatt atcttaaata tataatgggt caccttgctg ttcaaagggt
     2281 ggtgcaaggt cctgcagcat cttacatctg tagcttgtta gaaatgtaaa ctctcaggcc
     2341 ccacaactta cttcctgcat tttaacaaga tccccaaggg atatgtatgc tcataaaaat
     2401 ttgagacact ggtttaaatg aaaatggata taaggtatgt ataactgggg gtggggtgag
     2461 ggtaggaggc atttacaact cagattttat ttattttgaa attatcaatt gtataaatct
     2521 aatttattac caaatagggt cttttaaaaa atatttttat cgttgaaacc ttgacaggta
     2581 cttcatattc ttctaataat ttaaacagtc caataatgtg gtatacactt tgacatccaa
     2641 gaactcacca agatgttttt cagagattta ttctcgattt aactatcata gcatttaatg
     2701 aatctgattt gtagttcaat aaattgtggg ttgaactact tatccctgtg tgaacattga
     2761 attactttct gtcactgaaa ctgaggtatt tgggtgtggt aagtacttcg aaaattgtaa
     2821 tactgtttgg gcattgtcta aattattaaa ggttaaaata gaaaataaag tcagaatttt
     2881 tcttttccat tccaaaggtg tacttagaga tctctattag tattcattcg agatgacata
     2941 gcagctcata tcatggttgt ttattggatt tatctgttct aattatataa gtgtgtttac
     3001 tgtctgtgtt ttcacacaaa ctgctagaat ttttaatgtt aagacgaaaa catctgaagt
     3061 tctccatggc aaattgaatt tttcagtcat tttcttttct ttttttggta caattacttc
     3121 atctggaatg tcttcattga actcgttatt ctatttttct tagaattaaa agtggattaa
     3181 tgtgggtttt tctgttcatt ttattgcagt attaaatgct taagcttatt aggaccataa
     3241 ttcactttaa atataattgt atagaatata tttgcgtcga tcaaataatt gcttcagatg
     3301 aattcttaga ctcttgataa tatcacacct aatttaactt gattttacaa gctgtacaat
     3361 ccagttttag ttttctattg tgataataac ttttttcaaa ccagtttcac atcttaatga
     3421 aataacattc tctgactgca cttgcttcag tactctcttg cctgcctgtt tttgacctct
     3481 gcatgagttg gattagatgt ttttcttact gtcacttcta aatagaaaat gacagtgtta
     3541 taaaaaaggg aaggataaaa cctttgacat ccccttgtgt ctcaaaagtc cacagttatt
     3601 caaacaatgg ctttttttgt gatgagagta tttgttaaaa aaaaaaaaag acttcaagaa
     3661 aaataaaagt tcagtggagc tgcaaataaa tctggtgaat aatttcatct ttggtaatct
     3721 cccatttcct gagttcttcc tcaatccaag ctgtcctgtg tagtatataa catttgggca
     3781 ttttctctga tatactatac tctcatgttc tataaatttc tgtcccgtaa ttctaacact
     3841 ttacattttt tctttgctat cagctatagc tattcatgga agggaagaat cactaaatac
     3901 ttgtctagtt atagcatgat gtgagcatct cctccttatc cctcgatgcc tggcttggtg
     3961 tctggcaaac agtccataat tagcagatgt tgaaagaccg tttacaaagc agaatttggg
     4021 gatttaaagt gcaatgatac aacaaaaaga tttaattaca gcttccagtg ttttgactat
     4081 gtgaaccata tccaactact tttttgaaaa tctagttcta tgtaatatat ttctgtggca
     4141 tcaaatttta gttgattgta ttagtcaata ggaagtggtg gaaaatttct aaataaattc
     4201 aactattaaa taaatgcaag ttccactaaa
//
