LOCUS       NM_182981               1922 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens oxidative stress induced growth inhibitor 1 (OSGIN1),
            mRNA.
ACCESSION   NM_182981
VERSION     NM_182981.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Tang,X., Zhu,H., Zhou,M., Zhang,H., Xiao,Q., Yuan,Q., Sun,G.,
            Zhang,Z. and Chu,H.
  TITLE     OSGIN1 regulates PM2.5-induced fibrosis via mediating autophagy in
            an in vitro model of COPD
  JOURNAL   Toxicol Lett 401, 35-43 (2024)
   PUBMED   39260748
  REMARK    GeneRIF: OSGIN1 regulates PM2.5-induced fibrosis via mediating
            autophagy in an in vitro model of COPD.
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Xie,X., Laster,K.V., Li,J., Nie,W., Yi,Y.W., Liu,K., Seong,Y.S.,
            Dong,Z. and Kim,D.J.
  TITLE     OSGIN1 is a novel TUBB3 regulator that promotes tumor progression
            and gefitinib resistance in non-small cell lung cancer
  JOURNAL   Cell Mol Life Sci 80 (9), 272 (2023)
   PUBMED   37646890
  REMARK    GeneRIF: OSGIN1 is a novel TUBB3 regulator that promotes tumor
            progression and gefitinib resistance in non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Zhou,J.B., Wang,Y., Zeng,Q.Y., Meng,S.X., Wang,E.D. and Zhou,X.L.
  TITLE     Molecular basis for t6A modification in human mitochondria
  JOURNAL   Nucleic Acids Res 48 (6), 3181-3194 (2020)
   PUBMED   32047918
  REMARK    GeneRIF: using purified OSGEPL1, we identified multiple acetylation
            sites, and OSGEPL1 activity was readily affected by acetylation via
            multiple mechanisms in vitro and in vivo.
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Yao,H., Li,P., Venters,B.J., Zheng,S., Thompson,P.R., Pugh,B.F. and
            Wang,Y.
  TITLE     Histone Arg modifications and p53 regulate the expression of OKL38,
            a mediator of apoptosis
  JOURNAL   J Biol Chem 283 (29), 20060-20068 (2008)
   PUBMED   18499678
  REMARK    GeneRIF: identify OKL38 as a novel p53 target gene that is
            regulated by Peptidylarginine deiminase 4 and plays a role in
            apoptosis
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Li,R., Chen,W., Yanes,R., Lee,S. and Berliner,J.A.
  TITLE     OKL38 is an oxidative stress response gene stimulated by oxidized
            phospholipids
  JOURNAL   J Lipid Res 48 (3), 709-715 (2007)
   PUBMED   17192422
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   Ong,C.K., Leong,C., Tan,P.H., Van,T. and Huynh,H.
  TITLE     The role of 5' untranslated region in translational suppression of
            OKL38 mRNA in hepatocellular carcinoma
  JOURNAL   Oncogene 26 (8), 1155-1165 (2007)
   PUBMED   16924236
  REMARK    GeneRIF: The 5'UTRs of OKL38 might play an important role in
            downregulation of its protein and the absence of OKL38 could lead
            to the development or progression of hepatocellular carcinoma.
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Ong,C.K., Ng,C.Y., Leong,C., Ng,C.P., Foo,K.T., Tan,P.H. and
            Huynh,H.
  TITLE     Genomic structure of human OKL38 gene and its differential
            expression in kidney carcinogenesis
  JOURNAL   J Biol Chem 279 (1), 743-754 (2004)
   PUBMED   14570898
  REMARK    GeneRIF: Expression in cultured tumor cells resulted in growth
            inhibition and cell death.
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Riou,P., Saffroy,R., Comoy,J., Gross-Goupil,M., Thiery,J.P.,
            Emile,J.F., Azoulay,D., Piatier-Tonneau,D., Lemoine,A. and
            Debuire,B.
  TITLE     Investigation in liver tissues and cell lines of the transcription
            of 13 genes mapping to the 16q24 region that are frequently deleted
            in hepatocellular carcinoma
  JOURNAL   Clin Cancer Res 8 (10), 3178-3186 (2002)
   PUBMED   12374686
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Huynh,H., Ng,C.Y., Ong,C.K., Lim,K.B. and Chan,T.W.
  TITLE     Cloning and characterization of a novel pregnancy-induced growth
            inhibitor in mammary gland
  JOURNAL   Endocrinology 142 (8), 3607-3615 (2001)
   PUBMED   11459809
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC040169.7, AY258068.1 and
            BM976366.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_182981.2.
            
            Summary: This gene encodes an oxidative stress response protein
            that regulates cell death. Expression of the gene is regulated by
            p53 and is induced by DNA damage. The protein regulates apoptosis
            by inducing cytochrome c release from mitochondria. It also appears
            to be a key regulator of both inflammatory and anti-inflammatory
            molecules. The loss of this protein correlates with uncontrolled
            cell growth and tumor formation. Naturally occurring read-through
            transcription exists between this gene and the neighboring upstream
            malonyl-CoA decarboxylase (MLYCD) gene, but the read-through
            transcripts are unlikely to produce a protein product. [provided by
            RefSeq, Aug 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1060693.1, AY258068.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 18499678
            MANE Ensembl match                 :: ENST00000393306.6/
                                                  ENSP00000376983.1
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               AC040169.7         9766-9896
            132-1637            AY258068.1         131-1636
            1638-1922           BM976366.1         19-303              c
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q23.3"
     gene            1..1922
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /note="oxidative stress induced growth inhibitor 1"
                     /db_xref="GeneID:29948"
                     /db_xref="HGNC:HGNC:30093"
                     /db_xref="MIM:607975"
     exon            1..131
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     exon            132..230
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1597
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /note="bone marrow stromal cell-derived growth inhibitor;
                     ovary, kidney and liver protein 38; pregnancy-induced
                     growth inhibitor OKL38; BMSC-derived growth inhibitor"
                     /codon_start=1
                     /product="oxidative stress-induced growth inhibitor 1"
                     /protein_id="NP_892026.1"
                     /db_xref="CCDS:CCDS10939.1"
                     /db_xref="GeneID:29948"
                     /db_xref="HGNC:HGNC:30093"
                     /db_xref="MIM:607975"
                     /translation="MSSSRKDHLGASSSEPLPVIIVGNGPSGICLSYLLSGYTPYTKP
                     DAIHPHPLLQRKLTEAPGVSILDQDLDYLSEGLEGRSQSPVALLFDALLRPDTDFGGN
                     MKSVLTWKHRKEHAIPHVVLGRNLPGGAWHSIEGSMVILSQGQWMGLPDLEVKDWMQK
                     KRRGLRNSRATAGDIAHYYRDYVVKKGLGHNFVSGAVVTAVEWGTPDPSSCGAQDSSP
                     LFQVSGFLTRNQAQQPFSLWARNVVLATGTFDSPARLGIPGEALPFIHHELSALEAAT
                     RVGAVTPASDPVLIIGAGLSAADAVLYARHYNIPVIHAFRRAVDDPGLVFNQLPKMLY
                     PEYHKVHQMMREQSILSPSPYEGYRSLPRHQLLCFKEDCQAVFQDLEGVEKVFGVSLV
                     LVLIGSHPDLSFLPGAGADFAVDPDQPLSAKRNPIDVDPFTYQSTRQEGLYAMGPLAG
                     DNFVRFVQGGALAVASSLLRKETRKPP"
     exon            231..367
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     exon            368..559
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     exon            560..651
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     exon            652..1922
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1901..1906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /note="hexamer: AATAAA"
     polyA_site      1922
                     /gene="OSGIN1"
                     /gene_synonym="BDGI; OKL38"
                     /note="major polyA site"
ORIGIN      
        1 agagcctctt ggatccccac agggtaatgg gtgtcccgat ctcgcggggg actctgtgat
       61 ccgtgttccc ctgaccctcc tagtgcacaa cttggccggg ctcactgggc tcctgcacca
      121 ctgcctgtca ggtccgctgc cagccccaag ccccccacca gccatgagct cctccagaaa
      181 ggaccacctc ggcgccagca gctcagagcc cctcccggtc atcattgtgg gtaacggccc
      241 ctctggtatc tgcctgtcct acctgctctc cggctacaca ccctacacga agccagatgc
      301 catccaccca caccccctgc tgcagaggaa gctcaccgag gccccggggg tctccatcct
      361 ggaccaggac ctggactacc tgtccgaagg cctcgaaggc cgatcccaaa gccccgtggc
      421 cctgctcttt gatgcccttc tacgcccaga cacagacttt gggggaaaca tgaagtcggt
      481 cctcacctgg aagcaccgga aggagcacgc catcccccac gtggttctgg gccggaacct
      541 ccccggggga gcctggcact ccatcgaagg ctccatggtg atcctgagcc aaggccagtg
      601 gatggggctc ccggacctgg aggtcaagga ctggatgcag aagaagcgaa gaggtcttcg
      661 caacagccgg gccactgccg gggacatcgc ccactactac agggactacg tggtcaagaa
      721 gggtctgggg cataactttg tgtccggtgc tgtagtcaca gccgtggagt gggggacccc
      781 cgatcccagc agctgtgggg cccaggactc cagccccctc ttccaggtga gcggcttcct
      841 gaccaggaac caggcccagc agcccttctc gctgtgggcc cgcaacgtgg tcctcgccac
      901 aggcacgttc gacagcccgg cccggctggg catccccggg gaggccctgc ccttcatcca
      961 ccatgagctg tctgccctgg aggccgccac aagggtgggt gcggtgaccc cggcctcaga
     1021 ccctgtcctc atcattggcg cggggctgtc agcggccgac gcggtcctct acgcccgcca
     1081 ctacaacatc ccggtgatcc atgccttccg ccgggccgtg gacgaccctg gcctggtgtt
     1141 caaccagctg cccaagatgc tgtaccccga gtaccacaag gtgcaccaga tgatgcggga
     1201 gcagtccatc ctgtcgccca gcccctatga gggttaccgc agcctcccca ggcaccagct
     1261 gctgtgcttc aaggaagact gccaggccgt gttccaggac ctcgagggtg tcgagaaggt
     1321 gtttggggtc tccctggtgc tggtcctcat cggctcccac cccgacctct ccttcctgcc
     1381 tggggcaggg gctgactttg cagtggatcc tgaccagccg ctgagcgcca agaggaaccc
     1441 cattgacgtg gaccccttca cctaccagag cacccgccag gagggcctgt acgccatggg
     1501 gccgctggcc ggggacaact tcgtgaggtt tgtgcagggg ggcgccttgg ctgtggccag
     1561 ctccctgcta aggaaggaga ccaggaagcc accctaacac tcggccagac ccgctggctc
     1621 ccaggccctg agaggacaga gatgaccaca tccctgctgg atgcaggacc cgtccaaaga
     1681 tgccccgggg aggggtgtca gcccacgttg ctggcctttg gggtcaagag gagtagggat
     1741 cccaggctgc cctggactta gaccagtgtc tgaggtggta acagcggccg caggccaggg
     1801 ttggcctaga cctgggattt gtggggaaag ctgctggtgt gaccagctga gcacccagcc
     1861 aggagacctg cagccctgcg ccttccagaa gcaggtccca aataaagcca gtgcccacct
     1921 gc
//
