LOCUS       NM_017807               1976 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens O-sialoglycoprotein endopeptidase (OSGEP), mRNA.
ACCESSION   NM_017807
VERSION     NM_017807.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1976)
  AUTHORS   Teng,H., Liang,C., Liang,D., Li,Z. and Wu,L.
  TITLE     Novel variants in OSGEP leading to Galloway-Mowat syndrome by
            altering its subcellular localization
  JOURNAL   Clin Chim Acta 523, 297-303 (2021)
   PUBMED   34666032
  REMARK    GeneRIF: Novel variants in OSGEP leading to Galloway-Mowat syndrome
            by altering its subcellular localization.
REFERENCE   2  (bases 1 to 1976)
  AUTHORS   Beenstock,J. and Sicheri,F.
  TITLE     The structural and functional workings of KEOPS
  JOURNAL   Nucleic Acids Res 49 (19), 10818-10834 (2021)
   PUBMED   34614169
  REMARK    GeneRIF: The structural and functional workings of KEOPS.
            Review article
REFERENCE   3  (bases 1 to 1976)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1976)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   5  (bases 1 to 1976)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1976)
  AUTHORS   Seki,Y., Ikeda,S., Kiyohara,H., Ayabe,H., Seki,T. and Matsui,H.
  TITLE     Sequencing analysis of a putative human O-sialoglycoprotein
            endopeptidase gene (OSGEP) and analysis of a bidirectional promoter
            between the OSGEP and APEX genes
  JOURNAL   Gene 285 (1-2), 101-108 (2002)
   PUBMED   12039036
REFERENCE   7  (bases 1 to 1976)
  AUTHORS   Armerding,D., Fuhlbrigge,R.C., Kieffer,J.D. and Kupper,T.S.
  TITLE     Tonsillar B cells do not express PSGL-1, but a significant fraction
            displays the cutaneous lymphocyte antigen and exhibits effective E-
            and P-selectin ligand activity
  JOURNAL   Int Arch Allergy Immunol 126 (1), 78-90 (2001)
   PUBMED   11641609
REFERENCE   8  (bases 1 to 1976)
  AUTHORS   Kinoshita,M., Nakamura,T., Ihara,M., Haraguchi,T., Hiraoka,Y.,
            Tashiro,K. and Noda,M.
  TITLE     Identification of human endomucin-1 and -2 as membrane-bound
            O-sialoglycoproteins with anti-adhesive activity
  JOURNAL   FEBS Lett 499 (1-2), 121-126 (2001)
   PUBMED   11418125
REFERENCE   9  (bases 1 to 1976)
  AUTHORS   Chervenak,J.L. and Illsley,N.P.
  TITLE     Episialin acts as an antiadhesive factor in an in vitro model of
            human endometrial-blastocyst attachment
  JOURNAL   Biol Reprod 63 (1), 294-300 (2000)
   PUBMED   10859271
REFERENCE   10 (bases 1 to 1976)
  AUTHORS   Vickers,J.D., Packham,M.A. and Kinlough-Rathbone,R.L.
  TITLE     Differences between platelet phosphoinositide metabolism stimulated
            by thrombin or SFLLRN are not accounted for by interaction of
            thrombin with glycoprotein Ib
  JOURNAL   Am J Hematol 54 (4), 288-295 (1997)
   PUBMED   9092683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL355075.6 and CD365329.1.
            
            On Nov 23, 2018 this sequence version replaced NM_017807.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000418.1, BC032310.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000206542.9/ ENSP00000206542.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-244               AL355075.6         65153-65396
            245-364             AL355075.6         67517-67636
            365-540             AL355075.6         67816-67991
            541-636             AL355075.6         70699-70794
            637-686             AL355075.6         70952-71001
            687-765             AL355075.6         71154-71232
            766-831             AL355075.6         71794-71859
            832-922             AL355075.6         71971-72061
            923-998             AL355075.6         72275-72350
            999-1097            AL355075.6         72445-72543
            1098-1316           AL355075.6         72686-72904
            1317-1329           CD365329.1         18-30               c
            1330-1976           AL355075.6         72918-73564
FEATURES             Location/Qualifiers
     source          1..1976
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1976
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="O-sialoglycoprotein endopeptidase"
                     /db_xref="GeneID:55644"
                     /db_xref="HGNC:HGNC:18028"
                     /db_xref="MIM:610107"
     exon            1..244
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             130..1137
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /EC_number="2.3.1.234"
                     /note="probable O-sialoglycoprotein endopeptidase;
                     probable tRNA threonylcarbamoyladenosine biosynthesis
                     protein OSGEP; hOSGEP; t(6)A37 threonylcarbamoyladenosine
                     biosynthesis protein OSGEP; probable tRNA N6-adenosine
                     threonylcarbamoyltransferase; t(6)A synthase;
                     N6-L-threonylcarbamoyladenine synthase"
                     /codon_start=1
                     /product="tRNA N6-adenosine threonylcarbamoyltransferase"
                     /protein_id="NP_060277.1"
                     /db_xref="CCDS:CCDS9549.1"
                     /db_xref="GeneID:55644"
                     /db_xref="HGNC:HGNC:18028"
                     /db_xref="MIM:610107"
                     /translation="MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGD
                     TARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNK
                     PLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNC
                     LDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRM
                     LATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATM
                     CQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWR
                     D"
     exon            245..364
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            365..540
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            541..636
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            637..686
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            687..765
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            766..831
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..922
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..998
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1097
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1976
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1290..1295
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="hexamer: AATAAA"
     polyA_site      1320
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="major polyA site"
     regulatory      1370..1375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="hexamer: GATAAA"
     polyA_site      1402
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
     regulatory      1907..1912
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="hexamer: AACAAA"
     regulatory      1936..1941
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
                     /note="hexamer: AACAAA"
     polyA_site      1937
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
     polyA_site      1976
                     /gene="OSGEP"
                     /gene_synonym="GAMOS3; GCPL1; KAE1; OSGEP1; PRSMG1; TCS3"
ORIGIN      
        1 agtgctatct gcaggctggc cagcttcctc tgcgctccgg aaagctgcgg cccagcgcgg
       61 actagtgagg acctccacag ctcctgacat tgccaggagt cctgtcggcg ttttctccca
      121 gcctccgcca tgccggcggt gctgggtttt gaaggcagcg ccaataagat tggcgtgggc
      181 gtggtgcggg atggcaaggt gctggcgaac ccgcggcgga cttacgtcac gcctcctggc
      241 acaggattcc ttccaggtga tacagccagg catcaccgag ctgttatcct agacctgctg
      301 caggaggcac taacagagtc tggattaacc tcccaggata tcgactgcat tgcatacacc
      361 aagggccctg gcatgggtgc cccactggtt tctgtggctg ttgtggcccg tactgtggcc
      421 caactgtgga ataagccatt ggtgggtgtg aaccactgta taggccacat tgagatgggc
      481 cgcctcatca ctggagccac cagcccaacc gtgttgtatg tgagtggagg aaatacgcag
      541 gtgattgcat actcggaaca tcgttaccgt atctttgggg aaaccatcga tattgcagtg
      601 ggtaattgtc tggatcgttt tgctcgagtg ctgaagattt ctaacgaccc aagtccagga
      661 tacaacattg aacagatggc aaagcgaggc aagaagctag ttgagctgcc atacactgta
      721 aaggggatgg acgtctcatt ctcagggatc ctgtctttca ttgaggatgt agcccatcgg
      781 atgctggcca caggcgagtg tactcctgag gatctgtgtt tctccctgca ggaaactgtg
      841 tttgcaatgc tggtagagat cacagagcga gccatggcac attgtggctc ccaggaggcc
      901 ctcattgtgg gaggagtggg gtgtaatgtg aggctacagg agatgatggc aacaatgtgc
      961 caggaacgtg gagcccggct ttttgctaca gatgagagat tctgtattga caatggagcg
     1021 atgatagccc aggctggctg ggagatgttt cgggctggac acaggacccc actcagtgat
     1081 tctggggtta cacagaggta tcggacagat gaagtagagg tgacctggag ggactaataa
     1141 gatcaacaga atcagagtag atagttcctt aatcggaacc caaaggaccc cgtgcctcaa
     1201 tctctatcct gatgtcatgg gagtcctagc aaagctatag actccaagca aggcttgggg
     1261 tcctttatgg aaccccagga tgactcagca ataaaatatt tttggttttt tggttttgta
     1321 tgttggtgat tggattgtgt tgttcaggac caatgtagat ttggtgctgg ataaattctt
     1381 gttggagctt gctgctgtgg aaccaagaat gaggtatctt tttttttttt tttaagaaac
     1441 ggaatcttgc tgtgtttccc aggctggtct cgaactgggc tcaagcagtc ttaccacctc
     1501 agcctcctga gtaaggatgc cattgtgcct ggcaacaata gtagtatcat aactattatt
     1561 atagcatcgg gtcccgtgct aactgcttta cattcattct ctcatttaaa ttctttgaag
     1621 taggtgtgca agacttctct caaaatagcc tggaggctca cacctgttat cccagtgctg
     1681 tgggaggcca agtcaggagg atcccttgag cccaggagtt tgagcccagc ctgggcaaat
     1741 agcaagacac catctatttg aaaaatgtaa aaattatctg ggcatggtgg cgcacatctg
     1801 tagtcccagc tccaagggag gctgaggcgg gaagatagct tgagcccagg agtttgaggt
     1861 tgcagtgagc tgtgattgag ccactgcatt ccagcctgag tgacagaaca aaaccttgtc
     1921 tcttaaaaac aaacaaacaa acagcctgga gattggtcta acttgtaact ctaaaa
//
