LOCUS       NM_145047               1455 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens organic solute carrier partner 1 (OSCP1), transcript
            variant 1, mRNA.
ACCESSION   NM_145047
VERSION     NM_145047.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1455)
  AUTHORS   Chen,S., Zheng,P., Wang,W., Yi,M., Chen,P., Cai,J., Li,J., Peng,Q.,
            Ban,Y., Zhou,Y., Zeng,Z., Li,X., Xiong,W., Li,G. and Xiang,B.
  TITLE     Abberent expression of NOR1 protein in tumor associated macrophages
            contributes to the development of DEN-induced hepatocellular
            carcinoma
  JOURNAL   J Cell Physiol 233 (6), 5002-5013 (2018)
   PUBMED   29227538
  REMARK    GeneRIF: Abberant expression of NOR1 protein in tumor associated
            macrophages contributes to the development of DEN-induced
            hepatocellular carcinoma.
REFERENCE   2  (bases 1 to 1455)
  AUTHORS   Gui,R., Huang,R., Zhang,J.H., Wen,X.H. and Nie,X.M.
  TITLE     MicroRNA-199a-5p inhibits VEGF-induced tumorigenesis through
            targeting oxidored-nitro domain-containing protein 1 in human HepG2
            cells
  JOURNAL   Oncol Rep 35 (4), 2216-2222 (2016)
   PUBMED   26781989
  REMARK    GeneRIF: Results identified NOR1 as a downstream target gene of
            miR-199a which is critical for regulating cell proliferation and
            migration by targeting and upregulating NOR1 in human HepG2 cells.
REFERENCE   3  (bases 1 to 1455)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   4  (bases 1 to 1455)
  AUTHORS   Li,W., Li,X., Wang,W., Yi,M., Zhou,Y., Zheng,P., Xiong,W., Yang,J.,
            Peng,S., McCarthy,J.B., Xiang,B. and Li,G.
  TITLE     Tumor suppressor gene Oxidored-nitro domain-containing protein 1
            regulates nasopharyngeal cancer cell autophagy, metabolism, and
            apoptosis in vitro
  JOURNAL   Int J Biochem Cell Biol 45 (9), 2016-2026 (2013)
   PUBMED   23831407
  REMARK    GeneRIF: Data revealed novel aspects of the interplay between
            autophagy and apoptosis in nasopharyngeal carcinoma cells, which
            underlies the tumor suppression function of NOR1.
REFERENCE   5  (bases 1 to 1455)
  AUTHORS   Li,W., Li,X., Wang,W., Li,X., Tan,Y., Yi,M., Yang,J.,
            McCarthy,J.B., Xiong,W., Wu,M., Ma,J., Su,B., Zhang,Z., Liao,Q.,
            Xiang,B. and Li,G.
  TITLE     NOR1 is an HSF1- and NRF1-regulated putative tumor suppressor
            inactivated by promoter hypermethylation in nasopharyngeal
            carcinoma
  JOURNAL   Carcinogenesis 32 (9), 1305-1314 (2011)
   PUBMED   21803736
  REMARK    GeneRIF: Frequent epigenetic inactivation of the NOR1 gene in
            nasopharyngeal carcinoma (NPC) suggests that it may be a critical
            tumor suppressor involved in the development of nasopharyngeal
            carcinoma.
REFERENCE   6  (bases 1 to 1455)
  AUTHORS   Grassi,M.A., Tikhomirov,A., Ramalingam,S., Below,J.E., Cox,N.J. and
            Nicolae,D.L.
  TITLE     Genome-wide meta-analysis for severe diabetic retinopathy
  JOURNAL   Hum Mol Genet 20 (12), 2472-2481 (2011)
   PUBMED   21441570
REFERENCE   7  (bases 1 to 1455)
  AUTHORS   Xiang,B., Yi,M., Wang,L., Liu,W., Zhang,W., Ouyang,J., Peng,Y.,
            Li,W., Yin,D., Zhou,M., Liu,H., Wu,M., Wang,R., Li,X. and Li,G.
  TITLE     Preparation of polyclonal antibody specific for NOR1 and detection
            of its expression pattern in human tissues and nasopharyngeal
            carcinoma
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 41 (9), 754-762 (2009)
   PUBMED   19727524
  REMARK    GeneRIF: NOR1 protein is predominantly expressed in human
            nasopharynx and tracheal tissues and is frequently down-expressed
            in NPC.
REFERENCE   8  (bases 1 to 1455)
  AUTHORS   Nie,X.M., Zhou,J.D., Huang,Z.Y., Gui,R., Li,D.Q. and Tang,H.
  TITLE     [Effects of a novel gene NOR(1) on the protein expression of HepG2
            cell line]
  JOURNAL   Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 24 (2), 164-166 (2008)
   PUBMED   18237537
  REMARK    GeneRIF: NOR(1) gene may have some effects on liver cancer by
            up-regulating the expression of these proteins.
REFERENCE   9  (bases 1 to 1455)
  AUTHORS   Kobayashi,Y., Shibusawa,A., Saito,H., Ohshiro,N., Ohbayashi,M.,
            Kohyama,N. and Yamamoto,T.
  TITLE     Isolation and functional characterization of a novel organic solute
            carrier protein, hOSCP1
  JOURNAL   J Biol Chem 280 (37), 32332-32339 (2005)
   PUBMED   16006562
  REMARK    GeneRIF: hOSCP1 is a novel polyspecific organic solute carrier
            protein responsible for drug clearance from the human placenta
REFERENCE   10 (bases 1 to 1455)
  AUTHORS   Nie,X., Zhang,B., Li,X., Xiang,J., Xiao,B., Ma,J., Zhou,M., Zhu,S.,
            Lu,H., Gui,R., Shen,S. and Li,G.
  TITLE     Cloning, expression, and mutation analysis of NOR1, a novel human
            gene down-regulated in HNE1 nasopharyngeal carcinoma cell line
  JOURNAL   J Cancer Res Clin Oncol 129 (7), 410-414 (2003)
   PUBMED   12819961
  REMARK    GeneRIF: We cloned a novel gene NOR(1), and the Glu58Gly
            polymorphism of NOR(1) may be involved in the development and/or
            progression of NPC suggesting that NOR(1) could be a candidate
            tumor repressor gene related with NPC.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA297022.1, BC018069.1 and AW136490.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145047.4.
            
            Transcript Variant: This variant (1) lacks an alternate in-frame
            exon compared to variant 3. The resulting isoform (1) has the same
            N- and C-termini but is shorter compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018069.1, AF462348.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000235532.9/ ENSP00000235532.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               DA297022.1         35-208
            175-327             BC018069.1         175-327
            328-328             DA297022.1         392-392
            329-1180            BC018069.1         329-1180
            1181-1455           AW136490.1         17-291              c
FEATURES             Location/Qualifiers
     source          1..1455
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..1455
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /note="organic solute carrier partner 1"
                     /db_xref="GeneID:127700"
                     /db_xref="HGNC:HGNC:29971"
                     /db_xref="MIM:608854"
     exon            1..194
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1222
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     organic solute carrier protein 1; oxidored nitro domain
                     containing protein; protein OSCP1; organic solute
                     transport protein 1; oxidored-nitro domain-containing
                     protein 1"
                     /codon_start=1
                     /product="protein OSCP1 isoform 1"
                     /protein_id="NP_659484.4"
                     /db_xref="CCDS:CCDS409.2"
                     /db_xref="GeneID:127700"
                     /db_xref="HGNC:HGNC:29971"
                     /db_xref="MIM:608854"
                     /translation="MSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKVLNDIIS
                     TMFNRKFMEELFKPQELYSKKALRTVYERLAHASIMKLNQASMDKLYDLMTMAFKYQV
                     LLCPRPKDVLLVTFNHLDTIKGFIRDSPTILQQVDETLRQLTEIYGGLSAGEFQLIRQ
                     TLLIFFQDLHIRVSMFLKDKVQNNNGRFVLPVSGPVPWGTEVPGLIRMFNNKGEEVKR
                     IEFKHGGNYVPAPKEGSFELYGDRVLKLGTNMYSVNQPVETHVSGSSKNLASWTQESI
                     APNPLAKEELNFLARLMGGMEIKKPSGPEPGFRLNLFTTDEEEEQAALTRPEELSYEV
                     INIQATQDQQRSEELARIMGEFEITEQPRLSTSKGDDLLAMMDEL"
     exon            195..349
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            350..517
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            518..598
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            599..702
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            703..831
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            832..901
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1041
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1105
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1106..1455
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1431..1436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /note="hexamer: AATATA"
     polyA_site      1455
                     /gene="OSCP1"
                     /gene_synonym="C1orf102; NOR1"
                     /note="major polyA site"
ORIGIN      
        1 attgggacgc tgcggcctgg ccttcaggcc actggctacc gaaccccggg gctcttcacc
       61 agtccagctc gtttccagca ccatgtcggt gcggacgcta ccgctgctct tcttgaactt
      121 gggcggggag atgctttaca tcctcgacca acggctgcgg gcccagaaca tcccgggaga
      181 caaggcccgc aaagttctga atgacatcat ctccaccatg ttcaatagaa agtttatgga
      241 ggaattattc aagcctcaag agctctactc caagaaggcc ctgaggactg tctatgagcg
      301 cctggctcat gcctccatta tgaaactgaa ccaggccagc atggataagc tctatgacct
      361 gatgaccatg gctttcaaat atcaagtatt gctgtgtccc cgacccaagg atgtgctgct
      421 ggtcactttc aatcacttgg ataccatcaa gggattcatc cgagactccc caaccatcct
      481 gcagcaagtg gacgagactt tgcggcagct gacagaaata tatggtggtc tctctgcagg
      541 ggagttccag ctgatccggc agacactcct catcttcttc caagacctgc acatccgagt
      601 atccatgttt ctaaaggaca aagttcagaa taataacggt cgctttgtgt tgccggtgtc
      661 cgggcctgtt ccttggggaa ctgaagttcc aggactcatc agaatgttca acaacaaagg
      721 tgaagaagtg aagaggatag aattcaagca tggtggaaac tatgtccctg cacccaaaga
      781 aggttctttt gaactttatg gagaccgagt cctgaaactg ggaactaaca tgtacagcgt
      841 gaatcagcct gtggaaactc atgtgtctgg atcatcaaag aacttagcct catggaccca
      901 ggaaagcatt gctccaaacc ctcttgctaa agaagagctg aatttcttgg ccaggctgat
      961 gggagggatg gagattaaga aacccagtgg ccctgagccc ggattccggt tgaatctctt
     1021 taccaccgat gaagaagagg aacaagcagc gctaaccagg ccagaagagt tatcctatga
     1081 agttatcaac atacaagcca cccaggacca gcaacggagc gaggagctgg ctcgaatcat
     1141 gggggagttt gagatcacgg agcagccaag gctgagcacc agcaaagggg acgatttgct
     1201 cgccatgatg gatgagttat agctgttctg accaggcgtc ctctgccccc agggagaggc
     1261 tgctggatgg tgacccctgg ggaatgcccc atggcccaga atgatgctgc tagttttcta
     1321 ctgagtgaag ccattacgtc tatttcttat ttatgttgta aggaactgtg tgagtctccc
     1381 ttgaggagca ctcactcttg aaggcacaca catacacata ttttcagtga aatatattct
     1441 gacttttaaa cttga
//
